Conserved Protein Domain Family
XTBD
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pfam11952: XTBD 
XRN-Two Binding Domain, XTBD
XTBD is a family of eukaryotic proteins that act as an XRN2-binding module. XRN2 is an essential exoribonuclease in eukaryotes that processes and degrades a number of different substrates. XTBD is found on a number of different proteins to link them to XRN, such as PAXT-1.
Links
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Statistics
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PSSM-Id: 463409
Aligned: 38 rows
Threshold Bit Score: 57.6737
Created: 24-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Q8BI72        19 VETLRCEGETDKHWRHRREFLLRNAGDLvpatdetadaesgartrQLQQLVSFSMAWANHVFLG--CRYPQKVMDKILSM 96  house mouse
EFX73990      11 I---RKPYERDLQWNMRRAFIERNEEKT-----------------DRRKLLQLSDNLMKMEFVGqqIRYPIKVYHELHNL 70 
Q21738         7 VEAEKKLWESDDAWELRKAFMLAHYDDY-----------------PKIQLQCLSQLFINVTLLG--CEYSQTLMQKIRTM 67  Caenorhabditis ...
NP_001012905  14 LEQWRQYSESERHWAVRRRFILRHLHSYpg--------------aAIDQLLALSVLWSNHVFMG--CRYGSQVMEKVLKM 77 
XP_008102974  16 PEQFRAYSESEKHWQARRAFLLRNMPDAggg-----------gplHTDQLLSLSMVWANRLFLG--CSYSKDLLDKVTEM 82 
Q9D211        24 AEQFRSYSESEKQWKARMEFILRHLPDYrdpp---------dgggRLDQLLSLSMVWANHLFLG--CSYNKDLLDKVMEM 92  house mouse
CAG08802      20 VETYRGYWESDKHWEARREFILRNIKDFpp--------------eQLDQLLSLSMVWANKVFLG--CRYSTELLDKVVEM 83 
XP_001629431   3 DEAYS--WETDFQWRSRRNFIETWRDEY-----------------PEDRLASLAMCWSNMKFFG--CRYPEKVESLVNEM 61 
XP_005807254  20 AETFRGYWESDKHWEARREFILRNMSDFea--------------dRLDHLLSLSMVWANNVFMG--CRYSAALLEKVKEM 83  southern platyfish
XP_028451919  20 VETFRGYWESEKHWQARREFILRNISDFed--------------pHLDHLISLSMVWANNVFLG--CRYSTELLEKVKEM 83  yellow perch

Q8BI72        97 AEGI--KVTDAPIHT-TRDELVAK 117 house mouse
EFX73990      71 AGNLweEFRREKKLArIRDYMCQR 94 
Q21738        68 GAGIaaNKDRTKTGSyVKASAAKK 91  Caenorhabditis elegans
NP_001012905  78 AEGI--DIGEMQTFElVPSKKLKR 99 
XP_008102974  83 AEGI--EVGDVPHFT-TRDELMKK 103
Q9D211        93 ADGI--EVEDLPQFT-TRSELMRK 113 house mouse
CAG08802      84 AEGI--DVADAPVFR-TRDEIMKN 104
XP_001629431  62 ESKCp-PVPKPEKRPpKRSIIIEN 84 
XP_005807254  84 ADGI--MVEDAPVFK-TRDEIIKS 104 southern platyfish
XP_028451919  84 AEGV--VVEDAPVFK-TRDEIMKK 104 yellow perch
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