Conserved Protein Domain Family
TMCO5

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pfam14992: TMCO5 
TMCO5 family
The TMCO5 family includes human transmembrane and coiled-coil domain-containing proteins 5A and 5B.
Statistics
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PSSM-Id: 464427
Aligned: 18 rows
Threshold Bit Score: 208.033
Created: 26-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
XP_012401336  30 LNSLNMDLEKDLQRIDEANQSLLLKIQKEEDENNRLE--NELARlaH-LAEEQERKELECTLTDKEQDLKELEQETSKLE 106
XP_007480058  29 LENLNSDLEKDMQNLDEANQSLLVQIREKELKIQSLE--KEITK--S-IDLAGERDEINRTASEREDALKDLELETTKLE 103
Q8N6Q1        13 IISLNMDLERDTQRIDEANQKLLLKIQEREDKIQRLE--SEIIQtrG-LVEDEEWEKENRTTMERERALQELEEETARLE 89  human
XP_008773695  36 IISLNMDLERDMQRIDEANQELLLKIQEKESEVQRLE--HEITQtgD-PAEDEEWEKENYTVMEREQALQELEEETARLE 112
XP_005316439  28 IISLNMDLEKDMQRIDEANQELLLQIQEKESEIQRLE--NEVTQirD-AVEDEEWEKENCATMEREKALQEVEEETARLE 104
XP_003418779  28 INSLNMDLERDMQKIDDANQDLFLKIQEKEEEIQRLE--SELTQtgD-LAEDEEWEKEHCATIERERALQELEEETARLE 104
XP_001927934  28 INSLNMDLERDMQRIDEANQELLLKIHEKEDEIQRLE--SEIIQtrD-LAEEEEWEKENFTTMERERALQELEEETARLE 104
XP_012036536  57 LDFLNSDLEKDLQRMDEANQVLLKKIQEKEETIQSLE--RDITL--S-VRQAREREELNHFISKKEEALRDLELETAKLE 131
XP_003418775  28 LDYLNSYLEKDLQRLDEVNQVCLRKIQEKEEAIE--SleRELAL--SlELAKAKEXLNDSV--SEEEALRDLELETAKLE 101 African savanna...
XP_027975227  28 INSLNMDLERDMQRIDEANQELLLKIHEKENEIQRLE--NEITQtrD-LAEDEEWEKENCTAMEREKALQELEEETARLD 104 Steller sea lion
XP_012401336 107 KINEALTQGIAALQNQLSGKThVPKVLVPeeENLSESPEVAKMKIQQAEVSLAEQEKELAKVLDEYESVQRLCEAQAYCI 186
XP_007480058 104 KSNEILAKSVNELRIKLSRKPpQKIEVEK--ESLKQMLDESKEKLQKATAFCAEQEKELAKVTSEYQSVNQLCDDQARYI 181
Q8N6Q1        90 RKNKTLVHSITELQQKLTRKSqKITNCEQ--SSPDGALEETKVKLQQLEASYACQEKELLKVMKEYAFVTQLCEDQALYI 167 human
XP_008773695 113 RKNETLVHSISELQRKLTRKSqKIVRCEQ--GDLERTPEESKVKLQLLESSCADQEKELGKIMEDYVFVSQLCEDQALCI 190
XP_005316439 105 RKNETLVHSITELQRKLTRKSrKKNKHEE--GDQDETSEDSTFKLQQLEASCADQEKELVKVMEDYAFVARLCEDQALCI 182
XP_003418779 105 RKNETLVQSITELKRKLTRRIhKTTRCEQ--GNLDETPEEPKVRLQQLEASCADQEMELAKVMEDYAFVIQLCEDQALCI 182
XP_001927934 105 RKNETLVHSIAELERKLTRKSqKATKCEQ--GNLKGTPEESKAKLQQLEASCVDQEKDLAKVIEDYAFVAQLCEDQALCI 182
XP_012036536 132 KNKEILSRSVVEVQKEISRKC-KNVGLDK--EALKQMLAELKVKLQKSTESCASQEKELVKIESDYQSVYQLCEDQAHYI 208
XP_003418775 102 KNNKILTKSVLELQKKILRKF-NDVGLDK--ETLRQMLTDLKLRLQKATESCAKQEKKLVKTENDYQSVHQLCEDKAHYI 178 African savanna...
XP_027975227 105 RKNETLVHSIAELQRKLTRKSyKATKCEQ--DNTKGSPEESKAKLQQLEASCADQEKQLAKVMEDYAFVAQLCEDQALCI 182 Steller sea lion
XP_012401336 187 KKYQEALRKMEEEVENRFLERE------------------------------------------------VSKVLSISSQ 218
XP_007480058 182 KKYQEILRLMEEDREILLLETE------------------------------------------------VNKAQSLYNQ 213
Q8N6Q1       168 KKYQETLKKIEEELEALFLERE------------------------------------------------VSKLVSMNPV 199 human
XP_008773695 191 KKYQEALKRIEEELETG------------------------------------------------------SKVLSMDSE 216
XP_005316439 183 KKYQETLRKIEEELETRFLERE------------------------------------------------VSKVLSMDSV 214
XP_003418779 183 KKYQETLRKIEEELETRFLERE------------------------------------------------VSKVLSMNTA 214
XP_001927934 183 KKYQETLRKIEEELETRFLERE------------------------------------------------VSKVMSMNSA 214
XP_012036536 209 KKYQEILRQMEKEKEMMLLEKE------------------------------------------------VCKAQNNSVQ 240
XP_003418775 179 KKYQEILRKVEKEKEMVLLEKEraefettkaagkkiesqrwrvrnsvsvtlpkylddakpcnlkevceqhRSKAQNDTFQ 258 African savanna...
XP_027975227 183 KKYQETLRKIEEELETRFLERE------------------------------------------------VSKVLSMNSV 214 Steller sea lion
XP_012401336 219 TARrglmLVDDIQNDAEKITVGRKRNLFWYKTLGYLFFTILLFTRLQGYLLFHINHVNPDLILDTLPKMLGRSTLYKLRC 298
XP_007480058 214 TGKppliLAEV----MEEKLFKEWQRHLWFSISLLIFLMILFLTRVLSFGFLYLHFINPDFLLNNLPKIMDRNTLWRLRG 289
Q8N6Q1       200 EK-------EHTSQNNEGTPTQKTARLFSKKIFCCLFFITLFFIRLLSYMFFHVRFINPDLLVNVLPKVLGRSTLWKLRC 272 human
XP_008773695 217 RE-------KTVSLNEKDGFISNGALRFSKRIFRSLLFSTLFFIRLLGYLIFHLSFINPDLLVNALPKILSRDVLWKLRC 289
XP_005316439 215 RK-------DCNSQNNEYNSIRKRAALFSKRVFRYLFFTTLFFIRLLGYVLFHLSFINPDLLVNLLPKLLNRGVLWKLRC 287
XP_003418779 215 RK-------KYNSQSNEDNSIQRKAILFCKRVSRCLFFTILFFVRLLGYMFFHISYINPDLLINILPRILNRGILWKLRS 287
XP_001927934 215 SK-------ECNSQNNQDNSLQKKKTGFFKRIFRYFFFTTLFFIRLLGYLFFHISFINPDLFVNILPKILSRNILWKLRC 287
XP_012036536 241 IVKpgstLMETIQSNMEKTIIKKQKRIFWYRHFRYFISMVMIFFRLLGYMLFYLQYINPDLLVDALPVVMSRETLKRLQE 320
XP_003418775 259 IVKpgsvLLETIQTNVEKTIIKEQRRIFGHRHFRCLVFMITIFIRLLDCVLFHIQYINCHLLVDILPVVMSRGTLKRLRD 338 African savanna...
XP_027975227 215 RK-------ESNSQNN---------KV-----------SISLHLQLLSVSLP----------SREFPKHYQPPNTYQSFH 257 Steller sea lion
XP_012401336 299 FLLPFFTLEAEDVLP 313
XP_007480058 290 FLLPSLNLRVEDFLP 304
Q8N6Q1       273 FFFPSLTLETEDMLP 287 human
XP_008773695 290 FLFPSLTLETEDMLP 304
XP_005316439 288 FLFPSLTLETEDMLP 302
XP_003418779 288 FLFPSLTLETEDMLP 302
XP_001927934 288 FLFPSLTLETEDVLP 302
XP_012036536 321 ALFPFLTLEVEEVLP 335
XP_003418775 339 FLFPFLTLEVEEVLP 353 African savanna elephant
XP_027975227 258 VHFP-------RIVP 265 Steller sea lion
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