1YNP


Conserved Protein Domain Family
AKR_AKR11C1
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cd19086: AKR_AKR11C1 
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AKR11C family of aldo-keto reductase (AKR)
Bacillus subtilis uncharacterized oxidoreductase YqkF is a founding member of aldo-keto reductase family 11 member C1 (AKR11C1). It may function as oxidoreductase. This family also includes Bacillus halodurans AKR11C1, an NADPH-dependent 4-hydroxy-2,3-trans-nonenal reductase.
Links
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Statistics
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PSSM-Id: 381312
Aligned: 129 rows
Threshold Bit Score: 203.863
Created: 13-Mar-2018
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
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putative activecatalytic
Conserved site includes 28 residues -Click on image for an interactive view with Cn3D
Feature 1:putative active site [active site]
Evidence:
  • Comment:Based on the structure evidence that Rattus norvegicus voltage-dependent K+ channel beta subunit (3EAU) in complex with cortisone and cofactor NADPH.
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1             ###                                #    #                         #     
1YNP_A     31 LHVSELGFGCMSLgt--------dETKARRIMDEVLELGINYLDTADLYnqGLNEQFVGKALKg-rRQDIILATKVGNRF 101 Bacillus haloduran...
CDR30887   10 TRVSQLGFGAWPLgnesr-girmsEDYGVTLVKKAIQSGINFFDTAPNYslGLSESILGIAIKd-mRDKVIINTKFGHHV 87  Acholeplasma oculi
AFG35285   11 VYISEIGFGGWQLanplw--gamtYEEGVKLVRAAYEMGINFFDTAPGYsnGLSERIIGEALKd-vRENVFINTKFGHNH 87  Fervidobacterium p...
SMB84763   11 LHVSELGLGAWQLanpsw--gvpeGRDAQAIVRAALEEGCTFFDTAPGYsaGRSEETLGAVLKp-vRSEVVLCSKFGHTA 87  Deinococcus hopien...
ACL69154   12 LEVSEIGFGCWQLgntkd-wrgatGEDAIRLVHKAIEMGCNFFDTAPNYagGKSEELLGKALKg-kRDKVIISSKFGHTP 89  Halothermothrix or...
EES73610   11 KQVSEIGFGAWQLgnkqd-waameDDEAIRLVHEALDLGVNFFDTAPNYgqGKSEVLLGKALEr-kRDKAVINTKFGHSP 88  Paenibacillus sp. ...
KQC33476   11 VPVSEIGLGAWQLgaqsg-wknmsERDAIRLVQEATDLGVNFFDTAPNYghGTSEERLGKSLKnvnRSDIVINTKFGHSK 89  Nonlabens sp. YIK11
SDS17800   11 IIVSEIGFGGWQLanpvw--gmqdADEALRMVQVARDAGCNFFDTAPGYseGRSEDLLGRALKn-vRGQVVLCSKFGHTA 87  Opitutus sp. GAS368
ATX78432   12 LLVSEVGFGAWQLgngdq-wggmtDALAHNLVHQAIDLGCNLFDTAPNYalSHSERLLGEALQg-kRDKVVIVSKFGHQP 89  Reinekea sp. Hel1_...
ADB34634   13 IDVSTIGLGAWQLgrstswptgptPDEAVRIVHAALDAGVNFIDTAPAYadGQSELTLGRALKsvpRDQVVLCTKVGPTH 92  Kribbella flavida ...

Feature 1                                          ##                               ##        
1YNP_A    102 eqgkegwwwDPSKAYIKEAVKDSLRRLqTDYIDLYQLHGGTidd---piDETIEAFEELKQEGvIRYYGISSIrpNVIKE 178 Bacillus haloduran...
CDR30887   88 dd-----qiDFSSSRIKESLLGSLNRLnTNYIDTLMLHNPPfevl-egkTDHFVILDNLKKEGyIKGYGVSIDskLELET 161 Acholeplasma oculi
AFG35285   88 lg-----etDFSEEAIERSINESLKRLqTTYIDSVILHNPPreil-egkTNHEEEFKKIKRMGkIRGYGVSIDtlEELEL 161 Fervidobacterium p...
SMB84763   88 dg-----rtNFDVGALQSALQQSLERLqTDYLDVYLLHNPPaalldgnvTPLYEELEQLKSEGrIRAYGVSIDsrAEIEM 162 Deinococcus hopien...
ACL69154   90 dg-----qtSFDPSLLKKSVEESLGRLeTDYLDILLLHSPPvevi-kgsQGHYQIMEELKKEGkIRFYGASVDtgQQMLD 163 Halothermothrix or...
EES73610   89 eg------tDYSASQIRNSVERSLTRLqTDYLDSVLIHNPPfdyl-dgkYGHYQVLEDLKAEGkILAYGVSVDssREMLE 161 Paenibacillus sp. ...
KQC33476   90 eg-----qiNFDAANIRTSLEASLKRLqTDYVDSLIIHSPPasyldgfkNDHYDILEQLVIEGkIKGYGASLDtyEDMKT 164 Nonlabens sp. YIK11
SDS17800   88 eg-----etNFDIAALRPAVAASLRRLqTDYLDVLLVHNPPaalmdgnrTALYGELERLKKEGwLRCYGVSLDsgCDLAQ 162 Opitutus sp. GAS368
ATX78432   90 gg-----glDFSADGFWRSLHGSLARLkTDYLDVFLAHSPPmdvl-ngqHEIWPALREAQQQGkIRHYGASVDyaHEVRE 163 Reinekea sp. Hel1_...
ADB34634   93 dg-----rtDWSVDAIAASVEGSAVRMgVDHLDLVVLHSPPpev--ldsPEHYAALETLRVKGrIRAFGASVDhgQDVRT 165 Kribbella flavida ...

Feature 1               #                          #######                                    
1YNP_A    179 YLKRsniVSIMMQYSILDRrpeeWFPLIQEHgVSVVVRGPVARGLLSRRplpegegylnyryd----------elkllre 248 Bacillus haloduran...
CDR30887  162 TLKHlkvDCIELLFNIFFQetksLFDEVKRRgIALVIKVPLDSGWLTGSyhkdmvfdgvksrwtdavk-nrrdayvkeiq 240 Acholeplasma oculi
AFG35285  162 VLNNwdvDVIEILFNIIHQspkyLFDKVKERgILLAIKVPLDSGWLTGKynanskfegirarwsqdvi-lkramivdkik 240 Fervidobacterium p...
SMB84763  163 VLRTtnsTVLEVLFNAFHQepagAFEEAGAKgVGLVVKVPLDSGWLSGKygahsrfegirgrwtpdviarraalveqlta 242 Deinococcus hopien...
ACL69154  164 VINNsnsSVIEILFNLFHQeprrVFPRAGEEgVGLIVKVPLDSGWLTGKynadstftgirerwsrevikrraslvemvkd 243 Halothermothrix or...
EES73610  162 ALEHsrlGVMEVMFNIFYQetaqAFQAAKEKdVALIIKVPLDSGWLSGKydgnssfsgvrsrwspeviqtraklveqirf 241 Paenibacillus sp. ...
KQC33476  165 LMDTtnaKVIEVFFNMLHQdtakGFDQAQKQnIGIIAKIPLDSGWLTGKysahshfdgirsrwspkdietrallvekiqs 244 Nonlabens sp. YIK11
SDS17800  163 VVATtgsGVIEVLFNAFHQepltAFAGAQKKgVGLIAKVPLDSGWLSGKyrsdsrfdgvrdrwtpevitrraalvkqfad 242 Opitutus sp. GAS368
ATX78432  164 TLQTtdaQVLELMFNVLHQdvrlAFDLVRQHdIGVITKVPLDSGWLSGKyhaqstfdgvrarwdatevrrraaciddlqw 243 Reinekea sp. Hel1_...
ADB34634  166 VLTTtssQALEVRMSALYQetwpAVAEAGTHgAGVIVKVPLESGWLSGRydassrfddvrsrwsaedvalraglveelre 245 Kribbella flavida ...

Feature 1             #                ######  #  ##   
1YNP_A    249 slptdrpLHELALQYCLAHdvVATVAAGASSIDQVKANVQA 289 Bacillus halodurans C-125
CDR30887  241 nktgkktITEVALSFIWSFnaVATIIPGVRSLEQLEEHLNA 281 Acholeplasma oculi
AFG35285  241 tivkdedLVKYAIGFILSFdaVTTVITGVKNLEQLESNIKA 281 Fervidobacterium pennivorans DSM 9078
SMB84763  243 lvpeghsLLHAALQFILSQrhISTVIAGAKDEQQLRENMAA 283 Deinococcus hopiensis KR-140
ACL69154  244 ikddntsMVHEALKYILAYpqVSTVIPGVRTEEHLIENFKA 284 Halothermothrix orenii H 168
EES73610  242 ledeqttMTMAALRFILAYpeVTTVIPGVRSSAQLRENVAA 282 Paenibacillus sp. oral taxon 786 str. D14
KQC33476  245 ivgdehsLLESALAFCRSYdaVSTVIPGTTSVEQLRRNVES 285 Nonlabens sp. YIK11
SDS17800  243 lvppglsLSHAALRYVLAQpeLSTVIPGAKSTGQVLDNIAA 283 Opitutus sp. GAS368
ATX78432  244 lvsadrsLGQQALAYLLSYaeVTAVIPGIRSSEQLQANFSS 284 Reinekea sp. Hel1_31_D35
ADB34634  246 llpaglsLVDAALRFLLANegVCTVIPGTRSLDHLKTSIAA 286 Kribbella flavida DSM 17836

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