5X62,5YF0


Conserved Protein Domain Family
CARME
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pfam07942: CARME 
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Carnosine N-methyltransferase
This family includes Carnosine N-methyltransferase (E.C:2.1.1.22), conserved from yeast to human, that catalyzes the formation of anserine (beta-alanyl-N(Pi)-methyl-L-histidine) from carnosine. Anserine, a methylated derivative of carnosine (beta-alanyl-L-histidine), is an abundant constituent of vertebrate skeletal muscles. It also methylates other L-histidine-containing di- and tripeptides such as Gly-Gly-His, Gly-His and homocarnosine (GABA-His).
Links
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Statistics
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PSSM-Id: 400340
Aligned: 12 rows
Threshold Bit Score: 325.431
Created: 22-Mar-2022
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
5X62_B     94 PGEIVQPNDLDMSKTCSLLTQVYREWSAEAISERNCLNSRLVPFLKTLSPp------KADILIPGCGTGRLLVDLSRM-- 165  Saccharomyces cer...
O62483     98 IHQTRRPSSDFMSKVFSTMRQICREWSSEGQPEREATFKPIIDQLTELYPpethprhNVRILVPGCGLGRLAYDLMEQ-- 175  Caenorhabditis el...
O77329    688 PTLDDYNLIQNMSKVRSTLRQFVRDWSMEGQEERDKAYIPLINSLDKYLPihd--nyIPKILCPGSGLGRLPYEIAKK-- 763  Plasmodium falcip...
Q03648    192 FVFPIVSSRGSQSVVHEALAHLCRDFSSYYSVERDPLQNFIISRINHHVIsagdmkeKILIVTPGAGVGGLSHTLATTfp 271  Saccharomyces cer...
Q756C9    177 NHEVVLGYFSKLHVVTDSINHIVRDYHPAYEVERKPLLEFIEGALKRVps------gKTLLVVPGSGCGGTAWHVATAhp 250  Eremothecium goss...
Q9Y7J3     90 QNELFHVNVDMMQKVSSTLKQIARDWSTECVEERRTTYAPFIEELNSLFPsdsidrsKIRVLVPGSGLGRLAFDIAVE-- 167  Schizosaccharomyc...
XP_961468 112 pRWRGCAKRLDIDKARSTLRQFYRDWSAEGKSEREICFGPVFRALEAQKEsrprdasPMRVLVPGAGLGRLVFELCAK-- 189 
Q75CK4     84 PDEWPIPTIADMQKTVLIFTQLVREWSVECNDERSVLLSRMAAFMDEAYPre---rdQVSILVPGAGLGRVVVDLVRM-- 158  Eremothecium goss...
Q9I7X6    114 DEPPPNVRHGDMDQAQSTLKLIARDWSTEGALEREQSYKPIIDSIVAYFKhsdfelkDIKILVPGAGLGRLTYELACL-- 191  fruit fly
5YF0_B     97 NGKIMPASTFDMDKLKSTLKQFVRDWSETGKAERDACYQPIIKEILKNFPkerwdpsKVNILVPGAGLGRLAWEIAML-- 174  human
Q6L536    216 PSLQLNVPPIDVDKVRCIIRNIVRDWAQEGQKERDECYKPILEELNRLFPnrs-kerPPSCLVPGAGLGRLALEISTL-- 292  Japanese rice
Q8RWX2    229 SSLQTHVPLVDVDKVRCIIRNIVRDWAAEGQRERDQCYKPILEELDSLFPdrlkestPPACLVPGAGLGRLALEISCL-- 306  thale cress

5X62_B    166 GYNCEGNEFSYHMLLVSQYMLNAGLLQNQIIIYPFIHCFSHWKKIEDQLSPIKVPDIEAWSSNKG-------MGSMSICA 238  Saccharomyces cer...
O62483    176 GFTVQGNEFAFFMLFTSFFIINNCKQENQFTIYPFVFDKNNSWNYSDQLRPVTFPDKAPVSKKDPnh----rRASFSICA 251  Caenorhabditis el...
O77329    764 GYRSQGNEFSYFMLLGSNFILNYYNEKYSLSIHPYCLCTSNRRGRDDHLKIIQLPDVNTYNKIVL-------NTDFSMCA 836  Plasmodium falcip...
Q03648    272 KIQVDSIELSALMYICNLFALEY---KHDVKIRPFVQQYSCQTVFDNQLRSLSAD----LSKVGH-------RSNLDPLW 337  Saccharomyces cer...
Q756C9    251 EMQVSSVEFDPFMYLCNEYVLG---ESKDISLSSFATHYSGQLTAQNQCKQFHIK----TSEIKR-------PKNLDLHL 316  Eremothecium goss...
Q9Y7J3    168 GFACQGNEFSYFMLLTSHFILNCVKQENQFLVYPYIHSFSNHVMRDDQVRSLNIPDAVPSQYLRN-------SQNFSMAA 240  Schizosaccharomyc...
XP_961468 190 GYVAEGNEISYHQLLASSYILNCVEKPGQHTIYPWIHTFSNHSTRDNHLRKYAIPDVHCANELTRleeegvaIGEMSMTA 269 
Q75CK4    159 GFRTEGNELSYHMLLVSRYLLNGSISCFQHQLYPFVHSFSNQTSRQSQLRAVQVPDMTIYMEVGN-------DCLMSMSA 231  Eremothecium goss...
Q9I7X6    192 GYSCEGNEFSYFMLIASNFVLNLCDNENKYVLYPWVHQYVNNLRREDQVAPVRFPDVCPLK-NPPk-------GHFEIAA 263  fruit fly
5YF0_B    175 GYACQGNEWSFFMLFSSNFVLNRCSEINKYKLYPWIHQFSNNRRSADQIRPIFFPDVDPHS-LPP-------GSNFSMTA 246  human
Q6L536    293 GFVSQGNEFSYYMMICSSFILNHTQETNEWTIYPWIHSNCNSLSDNDQLRPVSFPDIHPSS-SGI-------TEGFSMCA 364  Japanese rice
Q8RWX2    307 GFISQGNEFSYYMMICSSFILNYTQVPGEWTIYPWIHSNCNSLSDNDQLRPIAIPDIHPAS-AGI-------TEGFSMCG 378  thale cress

5X62_B    239 GSFVDCYGRNqgtkisshytfsrrmqlsrakaenSKDVVVTN--FFIDTGSNILDYLDTIGHVLKPGG--IWCNFGPLLY 314  Saccharomyces cer...
O62483    252 GDFLEVVKDT------------------------TFDVIVTA--WFIDTAHNVLEYIDAIYSTLEPGG--VWINVGPLTW 303  Caenorhabditis el...
O77329    837 GELIEVYYYDk----------------------eYFDGVLTC--FFLDTAKNLFMYIRTFASILKPNS--LWSNIGPLLY 890  Plasmodium falcip...
Q03648    338 GDFTRYSPISk-----------------------DYDKIIICsaYFIDTAENMFEYLSSIEALKKYCKelHWVNVGPLKY 394  Saccharomyces cer...
Q756C9    317 GDFRTFKPDQ------------------------QYDNIVVIsaYFIDTAENMLEYFNSIEGLKQHAKnlHWINAGPLKY 372  Eremothecium goss...
Q9Y7J3    241 GDFLEVYGTEes--------------------rdSFQVVATC--FFIDTTKNILDYLDTIKNCLVDGG--YWINLGPLLY 296  Schizosaccharomyc...
XP_961468 270 ADFLCLYTEDyq--------------------aeAWDAVACV--FFLDTAPNLIRYLETILYCLKPGG--LLINHGPLLW 325 
Q75CK4    232 GSFVDLYGPNlnirqsgyysndprmrniraeaasSKHVVVTN--FFIDTGMNVLDYMETIQHVLKPGG--HWVNFGPLLY 307  Eremothecium goss...
Q9I7X6    264 GDFLEVYKTPn-----------------------AYNCVATC--FFIDCANNVIDFIRTIYKILVPGG--IWVNLGPLLY 316  fruit fly
5YF0_B    247 GDFQEIYSECn-----------------------TWDCIATC--FFIDTAHNVIDYIDTIWKILKPGG--IWINLGPLLY 299  human
Q6L536    365 GDFVEVYNEEsq--------------------esSWDAVVTC--FFLDTAHNIVEYIEIISKVLKDGG--VWINLGPLLY 420  Japanese rice
Q8RWX2    379 GDFVEVYNESsh--------------------agMWDAVVTC--FFIDTAHNVIEYIQTISKILKDGG--VWINLGPLLY 434  thale cress

5X62_B    315 HFEndhgve----ttyevnPYsgfQDKINdytplmgLELSSDDIISIATNhLDFELIRRESgI-----LCGYGryAGPES 385  Saccharomyces cer...
O62483    304 HFS----------------DT---PDEAS-------IELPYSVIMEMIRK-KGFQVVEERV-I-----DSKYT--VNRRA 348  Caenorhabditis el...
O77329    891 HYA----------------EM---PNEMS-------IELAWDEIQIIISK---WFTIKEIKwI-----DNYYT--TNFDS 934  Plasmodium falcip...
Q03648    395 GTK----------------PL---------------VQFTGDELSRLRKI-RGWKDLVEEYeVdsskgLNGYL--TDYES 440  Saccharomyces cer...
Q756C9    373 GTK----------------PM---------------VQFTVEELTALRKV-RGWKDEAFSVsTk---eLNGYL--TNYNA 415  Eremothecium goss...
Q9Y7J3    297 HFE----------------SEg-tSNSNSdsqqqpfVELTLEQLFYVMDS-MGFEVLKHNS-V-----DTTYM--GDKRS 350  Schizosaccharomyc...
XP_961468 326 HFEnnapgghghddddgdyDTtgiADPGS-------FELSDDEVMALVTK-VGFEIVSRETgI-----ESPYL--LDQES 390 
Q75CK4    308 HFEtdhhce----etanfdPLtgvVSDVReep-vkgLELSQEDILSTATSvFGFKLLRHEKnI-----KCGYG--SNNAE 375  Eremothecium goss...
Q9I7X6    317 HFS----------------DV---SGQNS-------IEPAFEDLCIIMES-VGFVIEKSRTgI-----RTKYA--QNPSS 362  fruit fly
5YF0_B    300 HFE----------------NL---ANELS-------IELSYEDIKNVVLQ-YGFKVEVEKEsV-----LSTYT--VNDLS 345  human
Q6L536    421 HFA----------------DSygpDDDMS-------IELSLEDVKRVAYH-YGFVMEVEKM-I-----DTTYT--ANMKS 468  Japanese rice
Q8RWX2    435 HFA----------------DTyghENEMS-------IELSLEDVKRVASH-FGFVIEKERT-I-----ETTYT--TNPRA 482  thale cress

5X62_B    386 CAMPGYMCHYWILKSNP 402  Saccharomyces cerevisiae S288C
O62483    349 MQFNQFACAYFYARKPE 365  Caenorhabditis elegans
O77329    935 MMQVQYHCVFFSAIRND 951  Plasmodium falciparum 3D7
Q03648    441 MYQGYYGLLKFHSVFES 457  Saccharomyces cerevisiae S288C
Q756C9    416 LFQGYYGLVKFHSVYTP 432  Eremothecium gossypii
Q9Y7J3    351 MLEWIYHPHYWVCRLQK 367  Schizosaccharomyces pombe 972h-
XP_961468 391 MLQTVYKASSWVARKPh 407 
Q75CK4    376 MTMLKYTCNFWVLQKCT 392  Eremothecium gossypii
Q9I7X6    363 MKQSEYQSLFWVCRKPD 379  fruit fly
5YF0_B    346 MMKYYYECVLFVVRKPQ 362  human
Q6L536    469 MMQNRYRAAFWTMRKNA 485  Japanese rice
Q8RWX2    483 MMQNRYYTAFWTMRKKC 499  thale cress
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