1VL0,1KC3


Conserved Protein Domain Family
RmlD_sub_bind
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pfam04321: RmlD_sub_bind 
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RmlD substrate binding domain
L-rhamnose is a saccharide required for the virulence of some bacteria. Its precursor, dTDP-L-rhamnose, is synthesized by four different enzymes the final one of which is RmlD. The RmlD substrate binding domain is responsible for binding a sugar nucleotide.
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Statistics
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PSSM-Id: 427865
Aligned: 22 rows
Threshold Bit Score: 319.989
Created: 22-Mar-2022
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
1VL0_B  15 ILITGANGQLGREIQKQLKGKNVEVIPT-DVQ-----------DLDITNVLAVNKFFNEkKPNVVINCAAHTAVDKCEEQ 82  Clostridium acetobuty...
Q832N2  21 ILITGGNGQLGTELRHLLDEQGIEYVST-DST-----------ELDITDADSTLAKVKEiQPSVIYHCAAYTAVDKAEDE 88  Enterococcus faecalis
Q9CJ07   2 ILITGGNGQLGTELRHLLDERGMAYTAT-DAK-----------ELDITDGVAVDKFFDEnKPELVYHCAAYTAVDKAEDE 69  Lactococcus lactis su...
Q8DUS5   2 ILITGSNGQLGTELRHLLDERNEDYVAV-DVA-----------EMDITKAEKVDEVFLQvKPSLVYHCAAYTAVDAAEDE 69  Streptococcus mutans
Q8F5L8   2 IYYTGKNGQLGWELAERFKSNGLEAVGF-GRE-----------EWDLADLDSAARILKD-SPRILVHCGAYTAVDKAESD 68  Leptospira interrogans
O27820   3 ILITGSSGMLGSDLVDILSRRHEVVTSG---------------SLDIRDLEGVMELLREtRPDAVVHAAAFTDVDCAETE 67  Methanothermobacter t...
Q9YCT2   3 LLVTGGTGLLGYNLVQQLLKKGYSVYPTyNKNtpfklagarwsKVNLEDPSQLTQLFRDiKPDAVIHTAAYTDVDGCELH 82  Aeropyrum pernix
Q99LB6  31 VLITGATGLLGRAVYKEFQQSNWHTVGCgFRRarp-----kfeQVNLLDSEAVHHLIHDfQPHVIVHCAAERRPDVVESQ 105 house mouse
Q9K7J6   4 LLITGANGQVGMELSKQGK-QHFQVTAL-TKQ-----------ELNILDRNTVMNKIKGvNPDWIIHVAAFTAVDQCEDE 70  Bacillus halodurans
Q5ZXH4   3 ILVTGANGQVGTEIIKRFSSSEHEVYAC-TRD-----------ILDCSKLERVHDVLSEiKPDLIINAAAYTAVDKAEDE 70  Legionella pneumophil...

1VL0_B  83 -YDLAYKINAIGPKNLAAAAYSVGAEIVQISTDYVFDGE------AKEP-ITEFDEVNPQSAYGKTKLEGENFVKA---L 151 Clostridium acetobuty...
Q832N2  89 gKELDEKVNVDGTRHVAEAAKAVGATLVYVSTDYIFDGT------KKEGvYAIDDQPNPLNEYGRTKLLGEQAVQE---I 159 Enterococcus faecalis
Q9CJ07  70 gRELDEKINVDGTKNVAEAAARVGATLVYISTDYVFGGTl-----PIGQeWPVDAPKAPESEYGRTKHLGEEAVVA---S 141 Lactococcus lactis su...
Q8DUS5  70 gKELDYAINVTGTENIAKACEKYNATLVYISTDYVFDGEk----pVGQE-WEVDDKPDPKTEYGRTKRLGEEAVEK---Y 141 Streptococcus mutans
Q8F5L8  69 -SENAYKINSLSVKKISEECLKRKIHLIYVSTDFVFDANsetigdTIRF-WKPDSTLSPKGIYGLSKAEGEKWIRNtfvD 146 Leptospira interrogans
O27820  68 -RDKAYQVNVLGTRNIAAAASAVGSSILYISTDYVFDGE------KGDG-YLEFDEPNPLNFYGKTKYLGEVSVRQ---L 136 Methanothermobacter t...
Q9YCT2  83 -RERAYRINFLASMTVARLAARHGSLLIYVSTDYVFDGD------KGM--YREEEAPNPINYYGLSKLLGEVATLSa-mD 152 Aeropyrum pernix
Q99LB6 106 -PDAASQLNVGASGNLAKEAAAIGAFLIYISSDYVFDGT--------NPpYTEEDIPSPLNLYGKTKLDGEKAVLE---N 173 house mouse
Q9K7J6  71 -QRKAYHVNGLGAANVARAARETGAKLIYISTDYVFDGN------KNSP-YETCDLPNPLNVYGNSKWLGERLVQK---Y 139 Bacillus halodurans
Q5ZXH4  71 -PDLAHIVNAEFVCRLVNYCTLKNVPLIHLSTDYVFDGE------KEGA-YHETDIPHPVSTYGRTKWEGEQAILS---Q 139 Legionella pneumophil...

1VL0_B 152 NPKYYIVRTAWLYGD----GNNFVKTXINLG--KTHDELKVVHDQVGTPTSTVDLARVVLKVIDEKN------YGTFHCT 219 Clostridium acetobuty...
Q832N2 160 LDDYYIIRTSWVFGQy---GHNFVFTMQKLA--ETRDQLKVVDDQFGRPTWTRTLAEFMAFVIAEKAp-----FGVYHLS 229 Enterococcus faecalis
Q9CJ07 142 GVKHYIIRTAWVFGSy---GPNFVFTMQNLA--TRFPELTVVNDQHGRPTWTRTLAEFMVYLVSEKAd-----FGFYHLT 211 Lactococcus lactis su...
Q8DUS5 142 VKNFYIIRTAWVFGNy---GKNFVFTMQHLA--KSHNSLTVVNDQHGRPTWTRTLAEFMTYLAENQKe-----YGYYHLS 211 Streptococcus mutans
Q8F5L8 147 SKQANIVRTSWVYSSh---GNNFPKTIVKLLqdSNRHELRVIEDQLGRPTWAGRLADFIIFLIYGILkge-syPEILHFS 222 Leptospira interrogans
O27820 137 SERFYIVRTSWLFGRn---GRNFVGTMVELA--ERGHEISVVDDQYGSPTYTRDLAAAIGNLLERPA------YGVYHLT 205 Methanothermobacter t...
Q9YCT2 153 KENVLVVRVSGLYGYsptgKRNFGINVLEKL--LRGEEVRAFYDQYLSPTYTYFLSRRLIDVLEREIr------GVLHLA 224 Aeropyrum pernix
Q99LB6 174 NLGAAVLRIPVLYGEveklEESAVTVMFDKVq-FSNKSANMDHWQQRFPTHVKDVASVCRQLAEKRMldp-siKGTFHWS 251 house mouse
Q9K7J6 140 VKTCTIARTSWLYGHy---GGNFVKTMLRLL--RKGEPIEVVADQVGCPTYVNDLVYYLFALMEKPS-------GIYHIS 207 Bacillus halodurans
Q5ZXH4 140 LKKYIILRVSWVFGEq---GKNFVKTILNLA--SSRKELNIVSDQSGRPTSARDIARVLFEIVQKIRhssfdyWGLYHYA 214 Legionella pneumophil...

1VL0_B 220 CKGI----CSWYDFAVEIFRLTGId------vKVTPCTTEEFPRPAKRPKYSVLRNYXLELTtGDITrEWKESLKEYIDL 289 Clostridium acetobuty...
Q832N2 230 NENS----CSWYQFAKEILKDTEV--------EVLPVDSTQFPQKAQRPQYSVMDLSKTEAL-GFKIpTWQEALAQMLEN 296 Enterococcus faecalis
Q9CJ07 212 NDAApgedVTWFDFAKEILKDTDV--------LVKPVDSSKFPAKAKRPFNSTMSLEKAKAT-GFVIpTWQEALASMLEK 282 Lactococcus lactis su...
Q8DUS5 212 NDATe--dTTWYDFALEILKDTDV--------VVKPVDSSQFPAKAKRPLNSTMSLTKAKAT-GFVIpTWQEALQEFYKQ 280 Streptococcus mutans
Q8F5L8 223 NSGV----ASWYDFALAVRDFSHSfslienlkPIYPIPTEGYPTPAPRPRYSILDLEETRKIfGVVP-HWREDLTLCLKE 297 Leptospira interrogans
O27820 206 NSGQ----CSWYEFAIDIFNELGMe------vCLKPVKSHEFPRPARRPSFSVLRNYNWSMEgFKPLrNYRDALRDYLKD 275 Methanothermobacter t...
Q9YCT2 225 GER-----LSRLEFAQLIAKVLGAda-----eLIKPISMKEANLPARRPRDSSLDTTMAKKL-GLELpSQEESVKHFVNI 293 Aeropyrum pernix
Q99LB6 252 GNEQ----MTKYEMACAIADAFNLps-----sHLRPI-TDSPVIGAQRPKNAQLDCSKLETLgIGQRtPFRTGIKESLWP 321 house mouse
Q9K7J6 208 NRGS----CNWFEFARAIAKNAGYdp-----sLIRATTTKAFAAKARRPKYSVMSHQQLELAgLQPPrEWELALKEFIQE 278 Bacillus halodurans
Q5ZXH4 215 GQGV----TNWHEFANVFLNMAKEkqllltltDLNPIKSQEYPTRATRPKNSVLDTTKIETIlGIKScSWKNDLPDVIDH 290 Legionella pneumophil...

1VL0_B 290 LQ 291 Clostridium acetobutylicum ATCC 824
Q832N2 297 VQ 298 Enterococcus faecalis
Q9CJ07 283 GD 284 Lactococcus lactis subsp. lactis
Q8DUS5 281 Dv 282 Streptococcus mutans
Q8F5L8 298 LA 299 Leptospira interrogans
O27820 276 AG 277 Methanothermobacter thermautotrophicus str. Delta H
Q9YCT2 294 YR 295 Aeropyrum pernix
Q99LB6 322 FL 323 house mouse
Q9K7J6 279 ET 280 Bacillus halodurans
Q5ZXH4 291 FT 292 Legionella pneumophila subsp. pneumophila str. Philadelphia 1
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