1M5I


Conserved Protein Domain Family
Suppressor_APC

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pfam11414: Suppressor_APC 
Adenomatous polyposis coli tumour suppressor protein
The tumour suppressor protein, APC, has a nuclear export activity as well as many different intracellular functions. The structure consists of three alpha-helices forming two separate antiparallel coiled coils.
Statistics
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PSSM-Id: 463275
Aligned: 25 rows
Threshold Bit Score: 59.9616
Created: 24-Mar-2022
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
1M5I_A          2 SRESTGYLEELEKERSLLLADLDKEEKEKDWYYAQLQNLTKRIDSLPLTEN--FSLQTDMTRRQLEYEARQIRVAMEEQL 79  
XP_008215405  279 DYNMMKRMKQIEQEKDVLLQGLAAVEKARDWYHKQISITQEKIKHLGQMGSh-VEQWTEAQQERLELQRARVLEVNRHLA 357 
XP_004929264  261 DYNLLKRMKQIEQEKDILLQGLSAIEEAREWYLKQLTEVQEKMRYAGRMGAy-VEPWSEAHQERLELLRARVLELNRQLG 339 
XP_001950357  244 DYNMLKRIKQIEQEKEVLMHGLQAVERARDWYHKQISAVQEKMKYLGRTNSh-TDQWTEAQQERIELQRARVLEVNRHLS 322 
XP_002430363  177 DYNMLKRIKQIEQEKDVLMQGLTAVERAREWYLKQVAIVQEKMKYLGRIGSh-AEQWSEAQAEKLELQKARVLEVNRHLT 255 
EFX73731      309 DQSMLRRIHILEQERQVLTSGMQALDKARDWFNSQLIDVNERIKSFGKSSIgsSDYSTDAASERLGFKISRIEEVSRQLL 388 
XP_009075736  102 sRESTGYLEELEKERSLLLAELEKEEKEKDWYYAQLQNLTKRIDSLPLTEN--FSLQTDMTRRQLEYEARQIRAAMEEQL 179 
ELK19314      124 SRATIRLLEELDRERCFLLNEIEKEEKEKLWYYSQLQGLSKRLDELPHVETq-FSMQMDLIRQQLEFEAQHIRSLMEERF 202 
XP_015220786  189 grvtAQHLEDLCKERTLLLSEIEKEERERRWYYSQLQGLSQRLAELPRVET--FSMQMDLIRQQLEFEAQQLRSVMEERF 266 
XP_002131251  555 DYNVLKLIQQLEQEKDVLLQGLDALERGRDWFQERISDVQEKQRLLSNNGM---KPTRDVTENDATVTQSRIDNLLTKVS 631 
1M5I_A         80 GTC 82  
XP_008215405  358 ALI 360 
XP_004929264  340 ALA 342 
XP_001950357  323 ALT 325 
XP_002430363  256 TLT 258 
EFX73731      389 VLI 391 
XP_009075736  180 GTC 182 
ELK19314      203 GTS 205 
XP_015220786  267 GTS 269 
XP_002131251  632 EMS 634 
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