Conserved Protein Domain Family
DUF4690
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pfam15756: DUF4690 
Small Novel Rich in Cartilage
This family of proteins is found in eukaryotes and include SNORC, a cartilage specific small membrane proteoglycan that plays a role in the regulation of chondrocyte maturation and postnatal endochondral ossification. There are two conserved sequence motifs: LGPGAI and LRKF.
Links
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Statistics
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PSSM-Id: 464849
Aligned: 7 rows
Threshold Bit Score: 96.8139
Created: 26-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
EOA94168       9 EYPQGPVPTLWNEPPELPSGAGPFDaATTTARLSDATAFPPYTSELEPEDTTHLHRLDTGDGSLGPGAIGAIVIASLLGT 88 
XP_018877812  26 DVPQEPVPTLWNEPAELPSGEGPVE-STSPGREPVDTGPPAPTVAPGPEDSTAQERLDQGGGSLGPGAIAAIVIAALLAT 104
Q9CXL7        26 EGPQEPDPTLWNEPIELPSGEGPLE-STSHNQEFAVSGPPFPTSAPAPEDSTPPARVDQDGGSLGPGAIAAIVIAALLAT 104 house mouse
XP_016847623  25 EYPQGPFPTLWNDPPELPSGGGPLE-TTPSPRFSDSPGFPPYTSDYEPEDTTHLHQLDNGNGSLGPGAIGAIVIAALLGT 103
XP_003438183  27 DTVSDTAPAT-RDNQDTVSGDEPPSdTTTK--PPYLTD---PPSTIDYDDATEV--FNEEEGAMGPGAITAIVIAVFLGA 98 
XP_017207798  29 ETVADSSPTFQKD--DTVSGDGSFD-VTTK--AQELIE---STVIADYEDSTHIITLEEE-VVLGPGAIAAIVIAVFLGA 99 
XP_015216977  25 ETAADPAPTPQSESQETCSGGGSYD-VTTRDPPHDLTD---NTFTFEYEDTTHSQPMDRGdGVLGPGAIAAIVIAVILGA 100 spotted gar

EOA94168      89 SVLVALVVITLRKFSAS 105
XP_018877812 105 CVVLALVVVALRKFSAS 121
Q9CXL7       105 CVVLALVVVALRKFSAS 121 house mouse
XP_016847623 104 SVIVALIVITLRKFSAS 120
XP_003438183  99 SVLLALIVITLRKFTAS 115
XP_017207798 100 SVLLALIVITLRKFTAS 116
XP_015216977 101 SVLIALVVITLKRFT-T 116 spotted gar
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