1Q7S,1RLK,1RZW,1XTY,1WN2


Conserved Protein Domain Family
PTH2
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cd02430: PTH2 
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Peptidyl-tRNA hydrolase, type 2 (PTH2). Peptidyl-tRNA hydrolase (PTH) activity releases tRNA from the premature translation termination product peptidyl-tRNA, therefore allowing the tRNA and peptide to be reused in protein synthesis. PTH2 is present in archaea and eukaryotes.
Links
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Statistics
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PSSM-Id: 239108
Aligned: 45 rows
Threshold Bit Score: 146.514
Created: 14-Apr-2005
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
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dimer interfaceputative active
Conserved site includes 11 residues -Click on image for an interactive view with Cn3D
Feature 1:dimer interface [polypeptide binding site]
Evidence:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                   #      ###  #  ##  #              #     #                         
1Q7S_A      3 YKMILVVRNDLKMGKGKVAAQCSHAAVSAYKQIQRrnpe----mlkQWEYCGQPKVVVKAPDeeTLIALLAHAKMLGLTV 78  Homo sapiens
AAB86169    1 MKQVIIVRSDLKMGKGKIAAQACHASIGSFKRTEEdk-------irKWELEGSKKVIVSVNSldELLEIYRAVKEAGISN 73  Methanothermobacte...
AAV46669   25 MKQAIVARADIGMGEGKLAAQVAHASLSAYEDAGPkp-------rkAWKGAGQKKVVLKATSesELFELADVAEREGLPH 97  Haloarcula marismo...
2495766     1 MKMVVVIRNDLGMGKGKMVAQGGHAIIEAFLDAKRknpr----avdEWLREGQKKVVVKVNSekELIDIYNKARSEGLPC 76  Methanocaldococcus...
NP_444185   1 MKQVIAARTDIGMGQGKLAAQVAHASLNAYEYTDDra-------vrRWKDEGQTKVVVKVGSerELYERSEEAKRAGLPT 73  Halobacterium sp. ...
NP_987729   2 YEQAIVIRNDLKMGKGKMAAQACHASIQAFLHAQKisss----avsGWMNEGQKKVVLKVNSekELLEIFKNVNIEGLPC 77  Methanococcus mari...
CAD25259   42 YGMNIIINKDYPMSKGKIISQICHGMSFVMCHLLKndee----llsEWRRNGEAKIVLKASGc-EIQEMIKLARKNGVYH 116 Encephalitozoon cu...
NP_148083   6 YKQAIVVRRDLGMGRGKAAAQAAHASCEAVFLILEsgrpewrrwleMWRLQGQAKVVLRVESlaELQEVYSKAVEEGLPA 85  Aeropyrum pernix K1
EAA38647   99 MKLVILVRTDIKMTRGKACAQCSHAAVRACQVAHRyapq----klrAWLSQGQKKITLKVTEq-ELSSLLDKLHQTDIIC 173 Giardia lamblia AT...
YP_448180   1 MKQVIIMRTDLKMGKGKIAAQACHASLNCYKNADKsr-------lrAWELSGQKKVVLKVSSekELLELNSIVKETDLPH 73  Methanosphaera sta...

Feature 1                                           #
1Q7S_A     79 SLIQDAGRTQIAPGSQTVLGIgpGPADLIDKVTGHLKLY 117 Homo sapiens
AAB86169   74 YLVRDAGHTQIPAGTITCLGIgpDDDEKIDKITGDLKLL 112 Methanothermobacter thermautotrophicus str. Delta H
AAV46669   98 AVVRDAGHTQLDPGTVTALAVgpAEDELVDRVTGDLPLF 136 Haloarcula marismortui ATCC 43049
2495766    77 SIIRDAGHTQLEPGTLTAVAIgpEKDEKIDKITGHLKLL 115 Methanocaldococcus jannaschii
NP_444185  74 GLISDAGRTQLEPGTPTALAIgpAPDADVDQITGDLSLF 112 Halobacterium sp. NRC-1
NP_987729  78 SLIRDAGRTQIEPGSLTAVGIgpEKEEKISKVKKDLKLL 116 Methanococcus maripaludis S2
CAD25259  117 HKICDAGRTQVPPGTNTVLMLgpALRPRLEVISGHLKLY 155 Encephalitozoon cuniculi GB-M1
NP_148083  86 SFVRDAGKTQLEPGTPTAAAVgpAPSRLVDRITGGLKLF 124 Aeropyrum pernix K1
EAA38647  174 GRIQDAGHTQVDPGTVTVGFVgpWDEAELDKITGHLKLY 212 Giardia lamblia ATCC 50803
YP_448180  74 SLITDAGHTQIEPSTRTCLGIgpGSDEEIDKLTGHLKLL 112 Methanosphaera stadtmanae DSM 3091

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