Conserved Protein Domain Family
TDT_C4-dicarb_trans
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cd09325: TDT_C4-dicarb_trans 
C4-dicarboxylate transporters of the Tellurite-resistance/Dicarboxylate Transporter (TDT) family
This subfamily contains bacterial C4-dicarboxylate transporters, which is part of the Tellurite-resistance/Dicarboxylate Transporter (TDT) family. It includes Tellurite resistance protein tehA; the tehA gene encodes an integral membrane protein that has been shown to have efflux activity of quaternary ammonium compounds. TehA protein of Escherichia coli functions as a tellurite-resistance uptake permease.
Links
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Statistics
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PSSM-Id: 187765
Aligned: 40 rows
Threshold Bit Score: 170.036
Created: 29-Oct-2010
Updated: 2-Oct-2020
Structure
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Aligned Rows:
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gating
Feature 1:gating phenylalanine in ion channel
Evidence:
  • Comment:Mutational and structural studies in Haemophilus influenzae TehA (HiTehA) show that this residue plays a crucial role in gating of the anion channel
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                                                                                       
Q1VF64        2 GAPTPMAGLALGIASLGWswen-faeLHGYGQWISAGIASILLAILATKFLLHnHLLRQDLAHPVVGSVVPTFAMGTMVV 80  Vibrio alginolyt...
Q6LKP6       10 QVPTAQAALALAFTGLGLawslflpsSGDIIRGICALIGACLLIPVVLKYIFNpQLFIVDLKHPLYGSLMAPMSMTMLVL 89  Photobacterium p...
ZP_01898618  11 LLPTPVAGLALGISSLGAlwes-vtgFNGYIQNATSTIAAVILCILLLRFIIHpKTLWNDLSHHVIGSVVPTFAMATMVV 89  Moritella sp. PE36
ZP_01982954  11 NVPPSQAALALGMIGLGHawvlyypaVGMVIRPYLAFSGALLLLPVLLKYLHW-RTFINDLRHPVSGSLMAPMSMALLIL 89  Vibrio cholerae ...
Q0SWP0       10 NIPIGISGTCLAFITLSNswk---lkGINYFKPIAIFLAVCMLSLMLLRLIRFpKVMYEELKNPVTGTFYPTMGMVVWLV 86  Clostridium perf...
ZP_04861503  10 DMPVALTGLALGISGISGals---tfLGEIPIYIGDFISFFLVAVIFIKDCLHfDQLKNELKHPTLGSFIPTMDMTLMVL 86  Fusobacterium va...
ZP_04566980  10 SLPVAFTGLALGVSGVSGvla---viLSPIFLYVGNFISLMLLLPIIIKNILHfEVFKEELKHPTLGSFIPTLDMALMNF 86  Fusobacterium mo...
ADG72038      7 KMPLALTGLALGIGGIFNawt--iftGIKYFAYIGAVISSILILTIITKIFSSfGAFLNDLEHPVAGSTIPTLDMAVMVI 84  Brachyspira murd...
ZP_05130688  12 NLPIPIIPTMVGAATLSNiys---slGYTWVRHLTMWIATGILIAYLVKILAFyPTCKKEYSNTVPASLYAGITMITMIL 88  Clostridium sp. ...
ZP_04567568   7 KMPVPLLPTMVGACTLSNvyl---aqGFPIVRHITMISALVIWLIYLVRIFLVfETCKSEYKTTVPSSLYAGFTMLMMIL 83  Fusobacterium mo...

Feature 1                                                                                       
Q1VF64       81 SNSLGHFYpLAGDALWLIAVVLHIVFLVSFVYHRAKDFel-hHMVPSWFVPPVGIIVADVSFSGNPml----aPVAQGAL 155 Vibrio alginolyt...
Q6LKP6       90 SDYWSSMHvVSARLLWYPALLLHFTMMILFFSFQLRKFrl-iHLYPSWFLYPVGAISGTLAGAQLGh-----sDLAVTMT 163 Photobacterium p...
ZP_01898618  90 SSSLTATYpATASLLWLAAIVLHIVFLVLFLYHRFQDMql-eHMVPSWFVPPIGLIVAVFTCPQPElf----qPICYAIL 164 Moritella sp. PE36
ZP_01982954  90 CDYLAILSpFIAYPIWAAALLLHLTMMTLFFYFQLRQFkl-aNIVPSWFLYPVGVISSSLAGTQFGh-----tLFSETMV 163 Vibrio cholerae ...
Q0SWP0       87 SGFFYPYFpVVCSLLWIAAVIYHYGIVIFYTVIRIKERkf-eNIMPTCFIVYTGMITGSVASKGMDgvipqipQIAHFML 165 Clostridium perf...
ZP_04861503  87 AGFIANYYlTLGRVLWLIAIAVHIIFCFIFFYHRVKSFdl-dHVIPSWFIPPVGIVVACVSGASMNf-----pNLTHIIF 160 Fusobacterium va...
ZP_04566980  87 SVILYGFSaTLGKGLWLLCIVLHFIFAVSFIYHRFNSWdi-hHMVPSWFVPPIGIVVACVDSTLMGm-----pHLSHALF 160 Fusobacterium mo...
ADG72038     85 SSSVVQFIrPLGIAMWFIAIIVHIIFAFTFIAHRINLKdl-qHMVPSWFVPPVGIVVAAVSGANMGf-----pQVSQIIV 158 Brachyspira murd...
ZP_05130688  89 GGYYFDYNnSFGKMLWVIGVLLHTVHIIIFTYRNVIKGvnkdTFVPSWFVTYNGLMVSTVVGSVMKe-----pLISKIVL 163 Clostridium sp. ...
ZP_04567568  84 GSYIFDFSpEMGKLFWSLGLGLHTLHILIFTYRNIVKDfkmdTFVPSYFVTYNGIMVSVVIGGVMKe-----pTILKIVT 158 Fusobacterium mo...

Feature 1                                                                                       
Q1VF64      156 MFGMVAYAIMLPMMIYRFMftheiPDAAKPTMAIMAAPASLSLAGYLTVtatp--spvIIAMLFGIAVLMTAIIYLAFFK 233 Vibrio alginolyt...
Q6LKP6      164 HFCIAVYFIMLPVVLYRLCfagrmPRPARPTLAIMAAPVNLSLTAYLLNvaep--dpvLVGALAGIGITMTILVYLCYFD 241 Photobacterium p...
ZP_01898618 165 VFGIINYAVLLPVMLNRLIfgdkiPASAKPSIAILAAPASLCLTGYLAFmplp--spvIVAVLLGIALLMTAVIYMALLH 242 Moritella sp. PE36
ZP_01982954 164 NVCIAIYFVMLPLVLYRLVfagtlPKRARPTLAIMAAPINLTLATYLVNfaqp--dpiLTGALAGIAITMTLLIYLCYLR 241 Vibrio cholerae ...
Q0SWP0      166 MFGFIFYTILLPLVLYIVFkseilDDHKLPTVGIICSPAPLGVVGILTIepnp--npyMLAWLVITGLILLVVVYGYILK 243 Clostridium perf...
ZP_04861503 161 YIGFILYLIMLPIMMYRIIfiepiDDGRLPTFAIMAAPPSLCLAGYLTVfsnp--seiIVYILLPLAIFMTLLVYVSFFR 238 Fusobacterium va...
ZP_04566980 161 YIGFIFYIIMLPMMLYRIIfveriDDTRLPTFAIMAAPPNLCLAGYLVAfsnp--npvIINFLFPLGLFMTALIYIAMFR 238 Fusobacterium mo...
ADG72038    159 YIGTVLYIIIFPFIFYRIIfheplPDDRFPAFAVMGAPANLCLCGYLTAfqny--ntaLLNFLLALGLFTTFKVYLSLIR 236 Brachyspira murd...
ZP_05130688 164 YYGIMVLLVILPFMIIRLKti-plKETFFHTQAILLAPSSLCVVSYINVveepnkillYLLYILVFSTLLFVVYKLPKFF 242 Clostridium sp. ...
ZP_04567568 159 YYGIGVFTLIIPFMIYRLVkh-dlKDAFYHTQAIVLAPSSLCTVSYLNSvqnpniyllGYLYICVLLALIFIIYKLPKFF 237 Fusobacterium mo...

Feature 1                     #                                                    
Q1VF64      234 LLrlPFSPGYAAFTFPMVIGATALFKMANwmelqglaahyVQQVRGLAGLELIVATFVVSYVALQYI 300 Vibrio alginolyticus 12G01
Q6LKP6      242 LLkhRFQPSLAAVTFPSVISAVSIDRLTDwlvi---dhphWAWLERLGIFEITVATGLVLWVGWHYI 305 Photobacterium profundum
ZP_01898618 243 LSrlDFNPGFAAFTFPLVISAKALYSTCDwfasigiaehyIAQLHVVALFELWGATAVVTWVSVCYL 309 Moritella sp. PE36
ZP_01982954 242 LLrlQFQPSIAAVTFPSVISAVAMQRLTEffat---dhphWYWLHYFGFLEVTIATLLVAWVSWRYI 305 Vibrio cholerae 623-39
Q0SWP0      244 LFkeGFKPSYAAFTFPLAIATLSAFKLSTyftgl-gyakmANLFKFLGDVEIFIATYVIFFMLLNFL 309 Clostridium perfringens SM101
ZP_04861503 239 ILriSFNPSYASFTFPLAIGATAVLKYSNylytl--nsrhYILWHNIGLFLSLSAALIITVVFIKMI 303 Fusobacterium varium ATCC 27725
ZP_04566980 239 IFkiSFTPVYASFTFPLAISSTAILKYSNyikaf--dlgkGEFWYTFACVAATLATILITGIFIKMM 303 Fusobacterium mortiferum ATCC...
ADG72038    237 AFriKFIPLFAAYTFPLAVGAQALLKYANysksi--ngeyAHIWSAIAIFELIVASMMIIYVFVNMM 301 Brachyspira murdochii DSM 12563
ZP_05130688 243 SY--KFTPAFAGLTFPMAIGTLASIKMSGflind-gyemiGNIIKQISGIQIYITTGIITFVLFNFF 306 Clostridium sp. 7_2_43FAA
ZP_04567568 238 SF--GFSPAFAGLTFPMAIGIVATTKMSGylkti-gyldlAIFLTQLSGIQIYLTSGIIFYILLNMF 301 Fusobacterium mortiferum ATCC...

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