Conserved Protein Domain Family
CDK2AP

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pfam09806: CDK2AP 
Cyclin-dependent kinase 2-associated protein
Members of this family of proteins are cell-growth suppressors, associating with and influencing the biological activities of important cell cycle regulators in the S phase including monomeric non-phosphorylated cyclin-dependent kinase 2 (CDK2) and DNA polymerase alpha/primase. An association between mutations in the gene coding for this protein and oral cancer has been described.
Statistics
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PSSM-Id: 430840
Aligned: 8 rows
Threshold Bit Score: 144.653
Created: 23-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Q9VZ27                1 MDIMDIQAVESKLSDVTVTPIP--------RSQVQNFYNYQQQREQREQQPQIQISAIHHSRGSVgggggs--------- 63  fruit fly
XP_001992100          1 MDIMDIQAVESKLSDVTVTPIP--------RSQVQNFYNYQQQREQREQQPQIQISAIHHSRGSNnstnsgsntgnnsni 72 
WGS:AAPP:GF15097-PA   1 MDYVDIESFRSKYSDITVTAVPtrskrleeAPVEPE----TKASVTKQQEPRVEITRVPGAPGSS--------------- 61 
Q9VJC8                1 MDYLDIESFRSRYSDITVTAVPsrpkadeePAMDTN-----QELAIKTHVPQVEITRVSGAASAG--------------- 60  fruit fly
EDW04122              1 MEFTDLETFRSKYSDLTVTAVPakrqkldaQ---PENLD-AAKHVEKSPTALVEIIPIIASNAAA--------------- 61 
WGS:AAPU:GI22388-PA   1 MDYLDLDSFRSRYSDITVTAVPakpqaveeQETLPDCCDVAGGGAEMMPADRVEIFPISMSSAPG--------------- 65 
WGS:AANI:GJ20285-PA   1 MDYLDLDSFRSRYSDITVTAVPakrqktdgQDEPPEAWD-AAGSSEKAPAARVEIIPITLPNGAA--------------- 64 
XP_002066313          1 MDFLDIESFRSKYSDITVTAVPsggnsstnCNVQKDGDPSMDEPLLVEEPPRVEITRVEVVGGSN--------------- 65 
Q9VZ27               64 --------nssnaaTDYSTSS----------GGKRERDRSSasdysssSSKQSSAAAANAaaaAAAVAALQYSpQFLQAQ 125 fruit fly
XP_001992100         73 nnnnnsnnnnnmvaTDYATNSssssglggggGGGSKRDRNS-------VTQSSAAATAAA---AAAVAALQYSpQFLQAQ 142
WGS:AAPP:GF15097-PA  62 --------------SSGTPTS----------TAMMQRSKQQ----------QNAAALAYAneyKEVMAKLEYT-RYMQAK 106
Q9VJC8               61 --------------SSSTANA-----------AMMLRNRQQ----------TNSAALAYAneyKEVMAKLEYT-KYMQAQ 104 fruit fly
EDW04122             62 --------------STFQQSS----------KRITKQEQQQlqfqqqqQLQQAEDDVAYSneyRQVLAKLEYT-KYAQAQ 116
WGS:AAPU:GI22388-PA  66 -------------------NS----------MVMQQQHPHQle---eqQLKLNQEAAAYSneyQQVLAKLEYT-KYVQAQ 112
WGS:AANI:GJ20285-PA  65 ---------------PTEQCS----------KSMQQQQQHQqk---qqQQQFTQDALAYSneyQQVLAKLEYT-KYVQAQ 115
XP_002066313         66 --------------GGGHGSV----------PPPQTSNEMD----------LKNAATAYAmeyKQVMDKLEHT-RYLQAQ 110
Q9VZ27              126 LALLQQQSntTATP--------AAVAAAALSLANmcsSNGGqRNSgagvsstssgsngqsmglnls----------ssql 187 fruit fly
XP_001992100        143 LALLQKQSntTATPssasasaaAAAAAAALSLANiaaASNGgRSSininsinninnsnssnintnssssnlglnltqsql 222
WGS:AAPP:GF15097-PA 107 IQLMAMASgvGSGAgagmdgslYGMMPTAITVDA---------------------------------------------- 140
Q9VJC8              105 LQIMSAAN--GGGGgfgidsdlFG---TSIGLDE---------------------------------------------- 133 fruit fly
EDW04122            117 LQLMSASN---------------GIAGNSYDSNDiggNSYD-SNG----------------------------------- 145
WGS:AAPU:GI22388-PA 113 LQLMSNNNgfg--------elfYGLPGNQIQVPS---NEADnSGN----------------------------------- 146
WGS:AANI:GJ20285-PA 116 LQLMSSNN---ALGscafgellYGLPGSNMQLPS---AE---SNG----------------------------------- 151
XP_002066313        111 LQLLTLAN-----GgrvldnglFDLIPSGIANDP---------------------------------------------- 139
Q9VZ27              188 kypppstspvvvttqtSANIttpltstas---lpsvgpgngLTKYAQLLAVIEEMGRDIRPTYTGSRSSTERLKRGIVHA 264 fruit fly
XP_001992100        223 kypppstspaivttqtSANIttpltstanlptvgslsvgngLTKYAQLLAVIEEMGRDIRPTYTGSRSSTERLKRGIVHA 302
WGS:AAPP:GF15097-PA 141 ----------------NANI---------------------EDKYSDLLRLLAEMQPNLAPTMMGLRAPKERLQRDIAHA 183
Q9VJC8              134 ----------------NANI---------------------VDKYSDLLNVLGEMRTNVPTTMAGLRAPKERMQRDIAHA 176 fruit fly
EDW04122            146 ----------------TSNI---------------------VDVYDNLLSVIAEMQSCLGPTAMGLRAPKERLLRDIGHA 188
WGS:AAPU:GI22388-PA 147 ----------------SGNI---------------------VDTYDNLLRVIAEMHRNLGPTAIGLRAPKERLLRDIAHA 189
WGS:AANI:GJ20285-PA 152 ----------------TTNI---------------------VDTYDNLLAVIGEMQSNLGPTAIGLRAPKERLLRDIAHA 194
XP_002066313        140 ----------------TANI---------------------VDKYSNILATLASMKMEISPTLMGARGPRERLLRDIAHA 182
Q9VZ27              265 RILVRECLMETERAAR 280 fruit fly
XP_001992100        303 RILVRECLMETERAAR 318
WGS:AAPP:GF15097-PA 184 RVIVRECLLILERDQQ 199
Q9VJC8              177 RLKVRQCLQLLQQAEE 192 fruit fly
EDW04122            189 RVLVRECILmlmhnq- 203
WGS:AAPU:GI22388-PA 190 RVLVRECILMLMRDHR 205
WGS:AANI:GJ20285-PA 195 RVLVRECILMLMRDhq 210
XP_002066313        183 RILVRECIMLIERDQQ 198
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