7ZM7,6GCS,6X89,6G2J,5LC5,7A23,5O31,5XTC,7AR9,7TGH


Conserved Protein Domain Family
NDUFS5-like
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cd24141: NDUFS5-like 
mitochondrial complex I subunit NDUFS5 and similar proteins
Ndufs5 (NADH dehydrogenase [ubiquinone] iron-sulfur protein 5) is an accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I). Complex I is a 45-subunit complex that functions in the transfer of electrons from NADH to the respiratory chain. It plays a key role in cellular energy metabolism, generating a major portion of the proton motive force that drives aerobic ATP synthesis. Ndufs5 is a component of the iron-sulfur (IP) subcomplex and does not seem to be involved in catalysis.
Links
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Statistics
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PSSM-Id: 467941
Aligned: 68 rows
Threshold Bit Score: 64.9891
Created: 14-Mar-2023
Updated: 27-Apr-2023
Structure
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Program:
Drawing:
Aligned Rows:
Download Cn3D
 
oligomer
Conserved site includes 54 residues -Click on image for an interactive view with Cn3D
Feature 1:oligomer interface [polypeptide binding site]
Evidence:
  • Structure:7ZM7; Thermochaetoides thermophila NADH-ubiquinone oxidoreductase (Complex I) subunit NDUFS5 interacts with other subunits, contacts 4A
  • Structure:6GCS: Yarrowia lipolytica NIPM subunit interacts with other subunits of respiratory complex I; contacts at 4A
  • Structure:6G2J: NDUFS5 of complex I from mouse heart mitochondria interacts with other subunits; contacts at 4A
Scroll to Sequence Alignment Display
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1         #########   ## ######### ###         ## ### ################## ###### ##
7ZM7_9         1 MASGYGLNGGp--SRCFPFWQELLACYVTnssednpdgKNKCIPVMEDYYECLHHRKEAARVRALQAAYREAE 71  Thermochaetoides therm...
CAF96329      20 TQSGPQPHQRa--ARCHVFEKEWIECSHGigq---traKKECQLEFEDFYECLHRQKTHQRLQAIRQQRDKMV 87  spotted green pufferfish
XP_001233575  20 RQSTTQPYGVa--GACHAFEREWVECGHGlgq---traRRECQPEYEDFMECMHRTKLALRLKKILEQRDKMI 87  Gallus gallus
XP_029318984   3 IQQVSRVGGP---NRCFGTFQKAIECMTNant----knNEECKPFLDDYVECRRHRLETYKMVIVKQHLEKDR 68  Pichia kudriavzevii
NP_001079882  20 LQSSKQPYRWt--TSCHAFEKEWVECSHGigq---iraQKECKLEYEDFYECMHRNKLRQRLQAIQEQKKKLE 87  Xenopus laevis
XP_019330849   1 MQPYSRSGGT---RRCFYEFQSWMSCVTSadt----tsVKQCKPVFEDYEECLHGLKEKEKVRLMVQQLKDNE 66  Candida albicans SC5314
XP_036663409   1 MQPYSRFGGT---RRCFYEFQLLVDCHTSadt----ksKKQCLPKFEDYNECLHGLKEREKVRTLINQLDENA 66  Candida parapsilosis
XP_035664468  14 MLSGASSDENgqtHRCFHFEKEFLECAGEigk---traIRECKPEYLDFLECIHMYKQKERLRIIRERRDKLI 83  Branchiostoma floridae
XP_003729500  16 HQGLDGYGGLp-dPKCKYYEADYIRCAAEigv---traQKECAPELADFRECITGSKRIERMKTIIKHRDQLI 84  Strongylocentrotus pur...
XP_013078381  23 QLNWENTQGGpcgNQYMDFMRCASRTGMEk-------aKYECKNELADFHECLRKGKQLERVKIMNAERKRQK 88  Biomphalaria glabrata

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