2Q0Z,3IM1


Conserved Protein Domain Family
Sec63
?
smart00973: Sec63 
Click on image for an interactive view with Cn3D
Sec63 Brl domain
This domain was named after the yeast Sec63 (or NPL1) (also known as the Brl domain) protein in which it was found. This protein is required for assembly of functional endoplasmic reticulum translocons. Other yeast proteins containing this domain include pre-mRNA splicing helicase BRR2, HFM1 protein and putative helicases.
Links
?
Statistics
?
PSSM-Id: 214946
Aligned: 123 rows
Threshold Bit Score: 70.4651
Created: 13-Jul-2011
Updated: 2-Oct-2020
Structure
?
Program:
Drawing:
Aligned Rows:
Download Cn3D
PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection: 
2Q0Z_X      15 PLNLGXIAAYYYINYTTIELFSXSL--------------------------------NaKTKVRGLIEIISNAAEYENIP 62   human
XP_751185  714 STPFGDAMARYYVQFDTMKTLLA-L--------------------------------KpHATVSQVLSAIAEAEEFREIR 760  Aspergillus fumi...
XP_829521  637 STRVGRAMARRYILFKTVETLNRELlhrfshqsgrqgapqimgaamaeeegqiqqktGeSFTLHQVLRVFCHSSEFDGLR 716  Trypanosoma bruc...
CAY79523   616 STAYGNAMTRHYISFESMKQFI-NA--------------------------------KkFLSLQGILNLLATSEEFSVMR 662  Saccharomyces ce...
XP_960191  651 CTEYGRAMSKYMVEFETMKLILKIP--------------------------------Ra-ATIDILINALAEAVEFKEFR 697  Neurospora crass...
XP_453572  547 asgYGQAMTRHYILGDTVKNIIRS---------------------------------NtSLKSLEVLKILANASEFDSIR 593  Kluyveromyces la...
XP_447128  609 STLIGSAMSRHCIDFKTMKSLIT-A--------------------------------ApKNTVKAILKIVSKVEVFSIYR 655  Candida glabrata...
XP_460707  634 CTEYGDVMTKYYILYPTMRNIIRS---------------------------------KaGNTLLDVLTIFSRSSEFSEFS 680  Debaryomyces han...
XP_759506  683 CTEYGVIMSRFFIRHKTMLVLMRIP--------------------------------P-AANTRTILEALSQAEELGDVR 729  Ustilago maydis 521
CBZ36877   687 GM-QPHSTAADATVCS-----SRRP--------------------------------MmpfNLREVLQLLCHCQELVEVR 728  Leishmania donov...

2Q0Z_X      63 IRHHEDNLLRQLAQk------vPHKLN-------N-----P------KFNd-------PHVKTNLLLQAHLSR-----XQ 106  human
XP_751185  761 LKAGEKSLYKELNRan----giRFPAK-------V-----D------IALp-------AH-KILLLIQSELGG-----VE 805  Aspergillus fumi...
XP_829521  717 LRQGDKKHLNELNKv------iRFPLN-------C-----GmrggreVREd-------WH-KVYVLIQAHLDR-----VA 765  Trypanosoma bruc...
CAY79523   663 VRHNEKKLFKEINLs------pLLKYPfltekkqS-----Q------IIDr-------VSQKVSLLIQYELGG-----LE 713  Saccharomyces ce...
XP_960191  698 MKPAERTLFREINKnp----liMYPVK-------E-----Q------VQHt-------QH-KISLIVQLHLGS-----VQ 742  Neurospora crass...
XP_453572  594 LKHNEKKLYREINAnp----llRYPFT-------DkkkqlM------SITs-------KEQKISLLIQYELSG-----LE 644  Kluyveromyces la...
XP_447128  656 VRLNEKATLKELNNsqiwfrllTEGGK-------P-----Q------IIDq-------PWQKIFLLIQYNLSKpksqlLV 710  Candida glabrata...
XP_460707  681 IKYNEKKLYKAINSsp----yiRFPLH-------S-----T------EFQd--------SDKVMLLLQYELCG-----LD 725  Debaryomyces han...
XP_759506  730 MRTGEKSFYNSLRThp----eiRFPPR-------Q-----V------AS---------VADKISLLIQAQLSA-----IN 773  Ustilago maydis 521
CBZ36877   729 LRQGDRGPLNELNKtvky--------------------------plhSGRrggrevreDWQKAYVLIQVHIGL-----LP 777  Leishmania donov...

2Q0Z_X     107 --------L-S--------A--------E--------LQSDTEEILSKAIRLIQACVDVLSSNGWLSP-ALAAXELAQXV 152  human
XP_751185  806 --------YpDgeqyqkhkF--------A--------FQQDKNFVFSHINRLIRCVIDCQISLGDSIT-ARNALELARSF 860  Aspergillus fumi...
XP_829521  766 --------VsD--------F--------S--------LRNDCVRLWTVAPRVARFVVDYATTHPCFSL-IQQSSLLCRCI 812  Trypanosoma bruc...
CAY79523   714 --------FpS--------YegasklhqT--------LVQDKFLVFRHCFRLLKCMVDTFIEKSDGTS-LKNTLFLLRSL 768  Saccharomyces ce...
XP_960191  743 --------YpD--------S--------AeaaklrrqLIMEKKMIFERLQRLIRAVIDCKGFDRDAPG-VKNALDLARAL 797  Neurospora crass...
XP_453572  645 --------YpS--------YkdaqkhhqT--------LVQDKMLVFRHAPRVLKCMIDCFIEKYDGDS-LKSTLFLLRSV 699  Kluyveromyces la...
XP_447128  711 --------RlT--------P--------K--------LIYELCSIERHFIRVLKCLIDIFIAKNDGIS-LKNALFVLRSL 757  Candida glabrata...
XP_460707  726 --------FpN--------SpelmklyyS--------FEGDKCYVFKQASRIIRCMIDVFRYKKDCVS-LLNTLRFSRCV 780  Debaryomyces han...
XP_759506  774 lsqvvqpsVgE--------A--------S--------PYMDLKRIVPHATRIARAIVDITIHRRDGAA-CKASLDLARSI 828  Ustilago maydis 521
CBZ36877   778 --------LtE--------V--------S--------LRNDSLRLWAVVPRMSRFLEEYAWAATTSYSlATQANLLARCI 825  Leishmania donov...

2Q0Z_X     153 TQAXWSk-DSYLKQLPHfTsehikrctdkgVESVFDIXEXEDEERNaLLQLTDsqIADVARFCNr-YPNIELSYEVVDKD 230  human
XP_751185  861 GAKVWDncPLQMKQIDQvG-----------IVAV--RKLAAAGITS-IDALEAtePHCIDMIMSrnPPFGMKLLARVADF 926  Aspergillus fumi...
XP_829521  813 EQGTWWdgL-IIKQIEG-------------IGENMAKALHEGGIKN-FSDVLQanPRKLEALCGknPPFGTDLQEKCHSR 877  Trypanosoma bruc...
CAY79523   769 NGHCWEntPMVLRQLK--T-----------IGLVSVRRLIRHGITN-LEEMGHlsDTQIEYYLNlkIGNGIKIKNDISLL 834  Saccharomyces ce...
XP_960191  798 SAESWEgrPTQLTQIPN-------------IGPVGMRKLASQDIRT-VLELAEkeSVELERLMSrqPPFGKKLKADLNKF 863  Neurospora crass...
XP_453572  700 AGKGWEdtPMILRQLn--T-----------IGLVSLRKLVSHGVCT-FADMEKltEQQIEYYLSlrPGNGYKIKSDLQMI 765  Kluyveromyces la...
XP_447128  758 NVGCWEstPYILKQVKGmS-----------INAV--EKLSKMGINS-LQQLTSmnREQLELYLGlkPGAGTKLLDEIRRL 823  Candida glabrata...
XP_460707  781 AGRCWEnsVTELKQLDG-------------IDEECIKKLRKNNISG-FAEAKYlsQSQLEYFLGiePGTGKNIAQSLQSL 846  Debaryomyces han...
XP_759506  829 AAEAWDgsPAMLRQVDQ-------------IGERSLKALANAGITT-WQSLASttPAKIEMILNrnPPFGRKVIAAAQSV 894  Ustilago maydis 521
CBZ36877   826 ERRVWPd-gLVLRQLKH-------------VSDSVAKALLRGGYST-FESLGSvnARQLEVLCSrlPPFGSQILSEVRRL 890  Leishmania donov...

2Q0Z_X     231 SIRSGGPVVVL------VQL---E---------REEEVTGPVIAPLFpQ--KREEGWWVVIGDAKSNSLISIKRLTLQQK 290  human
XP_751185  927 PKLRVNVKLAG------KVS---EikigkpvriRFEAEIAFMNEKTPtFfqRRPVYVCFLAETSDGHLIDF-RRISANKL 996  Aspergillus fumi...
XP_829521  878 PMYNLALEHVT------EAG---Tvr------vVVSYKAGVSTRRDPpLeqCHMILLVGDLELDRTHLLRQIDCRTANRR 942  Trypanosoma bruc...
CAY79523   835 PCLNIRTKLEN------CKIeneElw------lTFKVEISATFKSs--IwhGQHLSLDIETEKSSGELIDF-RRLQLNKL 899  Saccharomyces ce...
XP_960191  864 PRLDLDVSVVKyitpkrRNE---Dvt------lNVQTTLKYLNKNGPpNwlGRCPMLTFMIESSNENLLYFW-RGSLRKI 933  Neurospora crass...
XP_453572  766 PLLSLEYSVEE------KTV---Tqna---ihvSFKVEVQANFKSa--SwhGQQLCMLIML-KTDTGILIDFRRTFLSKL 830  Kluyveromyces la...
XP_447128  824 PILSFHYQAF-------IDD---Kns------lNISPYISAKVAKp--IgkSNEISVNFLALDKNGHLIDFRRFPMILLn 885  Candida glabrata...
XP_460707  847 PKFKINATLAS------NKV---Rtdl---etlEISLIVSIGIDNMErGnsKIKHNFINTIIGLSTGELLDFRRIAILEL 914  Debaryomyces han...
XP_759506  895 PRIGLEVMQRT------TSP---Q-----------------------------RSSRLLLAENRSdDSTPSTQLIASs-- 934  Ustilago maydis 521
CBZ36877   891 PRISLDISFMA------SPA---Esd-----giDNQHRVPSGVVQLTlSpgteAVTDEGVPNAARrQRSETASSKAAGGK 956  Leishmania donov...

2Q0Z_X     291 AK---VKLDFVAPAT--GAHNYTLYFXSDAYXGCDQEYKFSV 327  human
XP_751185  997 QQsqkIPLSAELKSPg---lHITCYAMCDEMAGtlrfaelkp 1035 Aspergillus fumigatus Af293
XP_829521  943 P------LVFTFQVSpgYRGQIMGSLTNGNFLGNDCNATLKV 978  Trypanosoma brucei TREU927
CAY79523   900 QSprgFRISAKIs---pKLEKIEFSIHCQEIAGLGKTIVYSt 938  Saccharomyces cerevisiae EC1118
XP_960191  934 DKqigLVLPVSVPLKs-pDERIICHLSCEEIVGtlvskvlkh 974  Neurospora crassa OR74A
XP_453572  831 KTpkaFRITIQVDRNtnFIEFVY---SCEQIGGSNREIRYYL 869  Kluyveromyces lactis NRRL Y-1140
XP_447128  886 k---eQSFTIMVDLTr-vNEYIELILNVEEIPGIGLSRILKL 923  Candida glabrata CBS 138
XP_460707  915 VEgniNSFRLTANVTd-RQQKIHCHILSEDMVNIDARYVLSL 955  Debaryomyces hansenii CBS767
XP_759506  935 -----IKVVLDVTVR---IENRATCMLKSKTS----KMALSV 964  Ustilago maydis 521
CBZ36877   957 P----QLLSDVVALDs-TRVLLLVGMPSEDRVLLKRFVPLSA 993  Leishmania donovani BPK282A1
| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap