Conserved Protein Domain Family
TMEM187

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pfam15100: TMEM187 
TMEM187 protein family
The function of this family, TMEM187, is not known, however it is predicted to be a multi-pass membrane protein. Members of this family are as yet uncharacterized. This protein family is also alternatively named ITBA1. This family of proteins are found in eukaryotes. Proteins in this family are typically between 239 and 267 amino acids in length.
Statistics
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PSSM-Id: 464502
Aligned: 15 rows
Threshold Bit Score: 283.076
Created: 26-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
XP_002600051   8 AAISVVIPVAMATAITWLGCFDSVITDLGFQHYGEHPdhdIPLLPSQLKMPANTLVNLGYTLLGFLWI--NKfvkdRNDG 85 
XP_015223109   4 ALLHVSLPAALCLAVAASGLFDSVAVELGYEHYAETP---VPGLPAWLAMPCNSLVNVGYIALGLFWLraER-------- 72 
XP_005462918   5 AVVHVSVGFLLCAGLVNTGMFADVDVELSSEHYAERR---VDGLPAFLAMPCNCVVNVGYVCVGLYWL--LW----RGDD 75 
XP_005811007   4 ALLHVTVPLTFCAALVNTNLFGEVEVDLTYEHYAERA---AENMPALLVMPFNCLVNVAYIFMGLYWLlwRS------GV 74 
XP_001341471   5 AAVHVLIPFLLCIALANTHIFDKVLVDVSYDHYAEKK---VDNLPAFLAMPFNCLINVGYILLAIYWLlqRM-----PDG 76 
XP_006001507   9 ALLHVIIPYLLCIATALGGFFDGVFTELGYEHYAERA---VPWLPLAIAMPLNSLINLGYALVGVFWLcqDH----PKAR 81 
XP_001641839   5 SLFYVLVPLCLAASITLYGVLDRAKVELGFEHYTEKA-----DPNSMLKMPANALVNFGYLILGIYWIlvTK-----KTQ 74 
Q0VCM2         8 ALFHVALASCLCVATVHTGIFEHVSVQVGYEYYAEAP---VTSLPAFLAMPFNSLVNMAYVFLGVYWL--RSqaraPGGP 82  cattle
XP_008248529   8 ALCHVALASCLCAAAVHMGVFAGVVVQVGHEHYAEVP---VASLPAFLSMPCNSLVNLAYVCLGLHWL--RR-------D 75 
XP_010599387   8 ALFHVALGACLCVATVYTGVFEDVFIQVGHEHYAEAP---VASLPAFVIMPFNSLINLAYVLLGWYWL--HRdegtLGCL 82 
XP_002600051  86 AITDGDRFVGSTFCWMAVAYGPVQFLRIVTQRHRFAVLDQWFTLPFFAWVVVMSDYLMDG---WNARRILTVMVLSFASY 162
XP_015223109  73 -TSEGAAYMKDVFASMAIAYGPVQWARLATFARLPAVLDQWFTLPIFAWVPVWCRYITHG---WQPRLCLAAELCSLGSF 148
XP_005462918  76 GESERARYMRHVFALMAVFYGPVQWTRLAMLRRAPAVLDQWLTLPIFAWVPVWIDFIERRt-eWRASHAAALELGSVLSY 154
XP_005811007  75 AETEQSCYLRQVFALMAVFYAPVQWTRLATMRRAPAVLDQWLTLPIFAWVPVWIDFIERApgkWRASHAATLELCSVASY 154
XP_001341471  77 KSNRAAAYSKEVFALMALAYGPVQWIRLATLRRAPSVLDQWFTLPIFAWVLVWCQVIDKG---WSSRYALMVESCSLLSY 153
XP_006001507  82 GKTSPADYFKDVFAFMAMAYTPVQWARIATQTHRSAILDQWFTLPIFAWVPAWCDYIHDG---WKPTHLLKLEATSILSY 158
XP_001641839  75 QKLKEEAFFYYVFSWLAVFYSAVQFGRIVTQTRVFAILDQWLTLPFFAWVVCWNEYVYRDy-lWQSSRFMFIMRLSILSY 153
Q0VCM2        83 AERRRARYLKDVFAGMALVYGPVQWLRIGMQTQPTAVLDQWLTLPIFAWPVAWCLCLDRG---WKPWLFLAVEGLSLCSY 159 cattle
XP_008248529  76 ASSPAARYLKDAFAAMALVYGPVQWLRIGTQAHPAAVLDQWFTLPIFAWPVAWCLSLDSG---WKPWRLLAVEFVSLFSY 152
XP_010599387  83 AEAPRARYLKDVFAAMALLYGPVQWLRIGTQAHPAAVLDQWLTLPIFAWPVAWCFYLDKG---WRPWLFLSIECLSLASY 159
XP_002600051 163 TFALLHELGFEVALGFHILFAVMYGMQIfrasQSEQLKSKLLWALLLAVLSCAGFVGLKLLDLHLARFSLFHRFSGHFWS 242
XP_015223109 149 ALALLHDRGFEAALGLHIALAAGQGLRV----QRRQGDALSRRYLCLALLSCAGFVALKLLDLPLARYRGFRRLSGHFWS 224
XP_005462918 155 GLAMAHRRGFDTALAGHVLFAVYKGVGV----QRTHGDVRTRRHLVLAVLSCAGFVLLKLLDHHLAQYRLFQRLTGHFWS 230
XP_005811007 155 GLALAHQRGFEVALGCHVALALYRGVRV----QVARGDSRTAGYLLLAGLSCAGFVVLKLLDHWLARYWVFQSLTGHFWS 230
XP_001341471 154 GLSLLHPRGFEAALGLHIASAAFAGVRA----QLKHGDSASMRYFCLALLSCAGFVILKLLDHHLAEYWMFQTLTGHFWS 229
XP_006001507 159 SLALLHEQGFELTLGLHILLAVIKGVNV----QWKYGDTTSLKYMCLGILSCMGFVILKLLDHWLAQWTVFQRLTGHFWS 234
XP_001641839 154 AAALFHDQGFEFSLGLHILAAVAYSVRT----QTRIGNKTSLKYFVYACVSCSGFVFLKLADHYLGQFDIFQRFSGHFWS 229
Q0VCM2       160 SLALLHPHGFELALGLHIAAAVGQALRI----QGRHGNISSGTYLALGVLSCLGFVVLKLCDHELAQWHLFQQLTGHFWS 235 cattle
XP_008248529 153 SLALLHPQGFEVALGAHIVAAVGQALRT----QGRHGNTSTAAWLALGVLSCLGFVVFKLWDRELAQCRLFQRLTGHFWS 228
XP_010599387 160 CLALLHPCGFEVALGMHILATVGLALRA----QAGAGSATSGTYLALGMLSCLGFVVLKLWDHQLAQWHPFQQLTGHFWS 235
XP_002600051 243 KVADIMQIHFVCKFFH 258
XP_015223109 225 KVCDVLQFHYSFRFLT 240
XP_005462918 231 KVCDVLQFHFSFCFLT 246
XP_005811007 231 KVCDVLQFHYSFRFLT 246
XP_001341471 230 KVCDILQFHYSFCFLT 245
XP_006001507 235 KVCDILQIHYSFKFLV 250
XP_001641839 230 KIADIGQIYCVLKYFQ 245
Q0VCM2       236 KVCDVLQFHFAFLFLT 251 cattle
XP_008248529 229 KLCDVLQFHFAFLFLT 244
XP_010599387 236 KVCDVFQFHFAFLFLT 251
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