1L1O,1QUQ


Conserved Protein Domain Family
RPA3
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cd04479: RPA3 
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RPA3: A subfamily of OB folds similar to human RPA3 (also called RPA14). RPA3 is the smallest subunit of Replication protein A (RPA). RPA is a nuclear ssDNA binding protein (SSB) which appears to be involved in all aspects of DNA metabolism including replication, recombination, and repair. RPA also mediates specific interactions of various nuclear proteins. In animals, plants, and fungi, RPA is a heterotrimer with subunits of 70KDa (RPA1), 32kDa (RPA2), and 14 KDa (RPA3). RPA3 is believed to have a structural role in assembly of the RPA heterotrimer.
Links
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Statistics
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PSSM-Id: 239925
Aligned: 30 rows
Threshold Bit Score: 79.2293
Created: 4-Sep-2001
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
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Conserved site includes 14 residues -Click on image for an interactive view with Cn3D
Feature 1:trimerization core interface
Evidence:
  • Structure:1L1O_DEF; Human RPA trimerization core interface; defined at 3.5A contacts between subunits in the hetrotrimer.
  • Comment:The RPA trimerization core consists of DBD-D (the central DNA-binding domain of RPA2), DBD-C (the C-terminal DNA-binding domain of RPA1), and intact RPA3. Each contains an OB-fold domain flanked by a helix at the C-terminus, which mediate trimerization.
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1        ## #                                                             #              
1L1O_D         8 PRSRINAG-MLAQFIDkPVCFVGRLEKIHPt--gKMFILSDgegkNGTIELMepl--deeISGIVEVVGRVTAk-ATILC 81  human
BAA84607       6 PAAFVNGE-ILKMFVGrRVRTVVQAQREEGg--lLIGQSTD----GHQLTIKgas--gapMSHYVEIIGIAEPn-QAIRA 75  Oryza sativa (j...
AAF48070       6 PRSIINGG-MLKQFSGqTVSIMVRVESVAGs--tLLASSTD----NHKLKINlpgelgaaEGAWVEVIGVPHGa-DTLRA 77  fruit fly
EAT41037       5 PRSIVNGS-LLKRHSGqSVSIHLFVEKGDKdgrsFVGKSTDg--mPIQVMLSapl--sqiLHGWVEVIGMAGSn-DSVRC 78  yellow fever mo...
XP_968469      6 PLYNIVSGaQIAGFVGkNVAVCGLVNGAHVgdktFTLRSSDg--vLVPVELNkpl--tedIEGYVEVKGVCQQs-KTIRA 80  red flour beetle
BAD69791      18 FIPYVTAG-NLASKNGaKVTLWGKVTRVSAse-gFYVKTVD----DQEVLIRlrkpldepLEGWYEIIGVSQG--KTVLC 89  domestic silkworm
XP_001122477   1 MKKRIDGR-RLAQNIGeQVILLGTIGKKSSngrnLELRTTDg--vQVNITLPepi--dgnAEGYIEVHGTLQSk-STMNC 74  honey bee
XP_319355     40 RRTIVNGA-LMKRHVGqPISIHLKVERADDgcksFSGKSTDg--vNVQVQLSdpl--ngvCSGWVEVIGIAAPn-DTVRG 113 Anopheles gambi...
CAL54530       6 PAPRVNGE-SLERFQGkKVLVVGEVAPVDAq--rATLKTTDd--kTITVTLAegg---efKSKYIEFEATVDGp-MSVTE 76  Ostreococcus tauri
XP_457478      4 ASIRIDST-FLEQHQGrLVRIMGKCQSYDPssnnSILISNG----PVTLISNpge--elvVNKNYEIIGKVGTsdLSVRV 76  Debaryomyces ha...

Feature 1              #        ##     #  # # ##  ##
1L1O_D        82 TSYVQFKEds---hpFDLGLYNEAVKIIHDFPQFY 113 human
BAA84607      76 EVCTDFGEn------FDPAPFNGLCKLANGQMKDL 104 Oryza sativa (japonica cultivar-group)
AAF48070      78 KEVIEFGGen---idFDKDGYNGLSHLINNVKAFY 109 fruit fly
EAT41037      79 KEIITYTGsed-geeFDTDGHNMLCNFLANCRDMY 112 yellow fever mosquito
XP_968469     81 DEFCTFNNe-----kFDSSNHTKLCKILNSLPNVY 110 red flour beetle
BAD69791      90 EDYVSLPDnit--anIDIDGHKALAKLLAALDDPW 122 domestic silkworm
XP_001122477  75 SNYIVFPLslt--eeFDADQYNELMIILNIVGVEK 107 honey bee
XP_319355    114 KEIITYFNsgektesFDVDGHNMLCTLMSVCKEPF 148 Anopheles gambiae str. PEST
CAL54530      77 CSRVEFGDd------FDTFSYGELVKLINTKSRDL 105 Ostreococcus tauri
XP_457478     77 LSAIELSDn------LNFDTAQKLVSYVHKVPELF 105 Debaryomyces hansenii CBS767

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