Conserved Protein Domain Family
SANTA

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pfam09133: SANTA 
SANTA (SANT Associated)
The SANTA domain (SANT Associated domain) is approximately 90 amino acids in length and is conserved in Eukaryota. It is sometimes found in association with the SANT domain (pfam00249, also known as Myb-like DNA-binding domain) implying a putative function in regulating chromatin remodelling. Sequence analysis has showed that the SANTA domain is likely to form four central beta-sheets with three flanking alpha- helixes. Many conserved hydrophobic residues are present which implying a possible role in protein-protein interactions.
Statistics
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PSSM-Id: 462689
Aligned: 30 rows
Threshold Bit Score: 96.9416
Created: 23-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
XP_001747655  200 TALLDWWVFF------SSSgVRIRGYipDTTRQQlgpgtsstmMRTTIIVKRVESRLVMSKSGSQYKLTGNFVEEECRQA 273 
EHY66402      128 VTLSSWAIKLientsgTLE-VIILGMikDTNDII----------QSSFIKKRISSHSVMSKN-TTYILENACDCTVLPYA 195 
XP_016154324  252 ICLNSWRIKVlsg----ntaICIEGKrkDMGQLL---------WHSSAVAERLTHTQVRTSTGAVYLLQGKIDSAAMRKE 318 
XP_014341973  480 ISLSNWILKVine----ntgVCVEGKrlDLDDYY---------WHSSMIVERVAYNQVTTVTGNLYHLSGYIDAFTMKET 546 
XP_015206060  433 IRLRKWGIRI------LSDgVCVEGQrvDMNGII---------WHSNLVAERIKYNILRTISGSIYVLIGKMCMDTRLSK 497 
XP_011615860  413 IHLRKWFLRHn-----QKG-LFVEGIhrEENIA----------WNSNIIAERVSHYAVKTITGRVYILVGKMNLHM--DS 474 
XP_005477097  425 IYLKKWFLRKn-----SKG-LFVDGIhgEDNIP----------WNSNVIMHRVSKSMIKTISGRVYILVGKMNLKV--ES 486 
EHB13020      316 IQLQEWVIKIinn----ntaVCVEGKltDMTHLY---------WHSNVIVERIKHNELRTLSGNIYILKGLIDQISMKEE 382 
XP_019688534  379 VQLQEWMIKVinn----ntaICVEGKltDITNIY---------WHSNVIIERIKHNKLKTLSGNIYILKGMIDRISMKEA 445 
XP_008117062  405 VHISEWRIKVinn----ntaVCLEGKrrDMNDAE---------WHSSAIVERISCKQVKTLTGNIYVLEGSVNSSAMKKE 471 
XP_001747655  274 GVDDRLIDAFARcnngkgGFPSNWRTV 300 
EHY66402      196 GFRESTQKKFEN------GFPSTWSII 216 
XP_016154324  319 GFPHRFIKKFTF------GFSRRWKEY 339 
XP_014341973  547 GFSQSFIRKFSS------GFPRDWKKR 567 
XP_015206060  498 ALPRSFLKKFLF------GFPEKWKDY 518 
XP_011615860  475 DFPRWFLKKFLT------GFPVIWKEV 495 
XP_005477097  487 EFPRWFLKKFER------GFPPNWKAL 507 
EHB13020      383 GYPYYLTRKFMF------GFPKNWKEY 403 
XP_019688534  446 GYPNYLIRKFMF------GFPEKWKEH 466 
XP_008117062  472 GMPSTFIKRFSF------GIPENWKKF 492 
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