1J85,1MXI,4JAK,5CO4,3E5Y,3N4K,3L8U,4KDZ,3N4J,4PZK


Conserved Protein Domain Family
SpoU-like_TrmL
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cd18094: SpoU-like_TrmL 
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SAM-dependent tRNA methylase related to TrmL
tRNA (Um34/Cm34) methyltransferase TrmL catalyzes the methyl transfer from S-adenosyl-L-methionine (AdoMet) to the 2'-OH at position 34 in both tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). It is part of the SpoU family of MTases, a subfamily of the SPOUT methyltransferase superfamily. The SPOUT methyltransferase superfamily is a large class of S-adenosyl-L-methionine (AdoMet or SAM)-dependent RNA MTases which are structurally characterized by a deep trefoil knot.
Links
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Statistics
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PSSM-Id: 349967
Aligned: 111 rows
Threshold Bit Score: 190.356
Created: 15-Jul-2009
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
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SAM bindingdimer interface
Conserved site includes 19 residues -Click on image for an interactive view with Cn3D
Feature 1:SAM binding site [chemical binding site]
Evidence:
  • Structure:1MXI, Haemophilus influenzae YibK with bound SAM, contacts 4A
Scroll to Sequence Alignment Display
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                                                                                  ###
1J85_A      3 DIVLYEPEIPQNTGNIIRLCANTGFRLHLIEPLGFTwDDKRLRRSGLDYHEfAEIKRHktFEAFLESEKp--kRLFALTT 80  Haemophilus influe...
1MXI_A      3 DIVLYEPEIPQNTGNIIRLCANTGFRLHLIEPLGFTwDDKRLRRSGLDYHEfAEIKRHktFEAFLESEKp--kRLFALTT 80  Haemophilus influe...
EAU52517    2 RLASYQPDIAPNLGSMIRLCACFGVSLDIIEPCGFPlSLKSLRRSAMDYADiTDMVRHdsWETFQANREp--gRLILLTT 79  Rhodobacterales ba...
ACT58438    2 QIAFYQPDIPQNLGSNFRIAACFSTKVDIIGPCGFPlTAKALRRSAMDYGPmVDVEQHdsWTSFKNSPDrkkgRLVLFTT 81  Hirschia baltica A...
AIL12435    2 RIALYQPEIPQNTGTLLRLGACLNVGIDIIEPCGFVfSNQRLQRSGMDYIQeCDYHRYpsWSDFYYNRQt---RLILLTP 78  Candidatus Caediba...
AEP09989    3 RIALYQPDIPQNTGAMMRLAACMGVGLDVIEPTAFPwDERKIRRGALDYIDhIDLTRHgdWTAFLKHYEnqnrRIVLMTT 82  Micavibrio aerugin...
AFS48980    6 SVCLYQPDMPQNLGVIIRTAACLEFPLHIIKPLSFSmTDKRFKGAVMDYIDhCTLQLHdsWEDFKNFCSssnyRLILATT 85  alpha proteobacter...
EMH79764    3 NIALYQPDIPQNTAAIIRTCACLGLKLEIIKPAGFVlNEKKLDRIYMDYLKdCEIFYHesFDTFVKSKKq--kRIILFTT 80  alpha proteobacter...
NP_875367  10 SIALYEPRIPQNTGNIGRTCLAFDFDLHLILPLGFEiNNKRLKRAGLDYWKyINLELHesFAHYSKFINp--sRIIGFSK 87  Prochlorococcus ma...
EDY84078    3 HVVLFQPEIPQNTGNIGRTCAITESRLHLIHPLGFViKDKHLKRSGMDYWKsLDVHHHesWEAFKASDVgp-kRLFLFTT 81  Verrucomicrobiae b...

Feature 1                       #### ###             ### #            ### #  #            
1J85_A     81 KgCPAHSQVKFKLGDYLMFGPETRGIPMSILNempmeqKIRIPMTan--------sRSMNLSNSVAVTVYEAWRQL 148 Haemophilus influenzae...
1MXI_A     81 KgCPAHSQVKFKLGDYLMFGPETRGIPMSILNempmeqKIRIPMTan--------sRSMNLSNSVAVTVYEAWRQL 148 Haemophilus influenzae
EAU52517   80 KaDAILWDFKFKSTDTLVMGRESAGVPNEVHNac--dsHIKLPMYgk--------aRSLNVAMTAGMALSEALKQV 145 Rhodobacterales bacter...
ACT58438   82 KgATPLLETKFESGDTLLFGRESAGVPDEVHDsa--qiRCVIPLNpe--------aRSLNVSVSAAIALHEALRQT 147 Hirschia baltica ATCC ...
AIL12435   79 TaHTPYYEFAFQSDDTLLLGRESDGVPEEVAVlc--pyLLQIPMIpk--------rRSINIALAASMVLGEALRQT 144 Candidatus Caedibacter...
AEP09989   83 KgAIPYTAHEFRADDILLAGSESSGVPDHVHDra--dsRIIIPMRpg--------lRSLNVVNATSMILGEALRQT 148 Micavibrio aeruginosav...
AFS48980   86 KtQNSLYDYRFKEKDIILFGKETAGVPDFVHNqi--seKITIPMSsk--------tRSLNLATSVAIVSSTIINSI 151 alpha proteobacterium ...
EMH79764   81 KtTNNYTKFIFKKNDTLLFGSESKGVSEEVHGti--knKLNIPIKnn--------tRSLNLATSVAIASSEALRQF 146 alpha proteobacterium ...
NP_875367  88 EgGIPLSKIEFQSNDSLLFGREDLGLPSHVKNkc--dfMATIPMPgksnskndngvRSLNLSVACGIASFCSFNCL 161 Prochlorococcus marinu...
EDY84078   82 KsSQPYWDVQYEEGDGLLFGNEGHGAPDWLHDevgedrRLNIPQYns-------slRSLNLATAAGVATFEVMRQL 150 Verrucomicrobiae bacte...

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