Conserved Protein Domain Family
OPT
?
pfam03169: OPT 
OPT oligopeptide transporter protein
The OPT family of oligopeptide transporters is distinct from the ABC pfam00005 and PTR pfam00854 transporter families. OPT transporters were first recognized in fungi (Candida albicans and Schizosaccharomyces pombe), but this alignment also includes orthologues from Arabidopsis thaliana. OPT transporters are thought to have 12-14 transmembrane domains and contain the following motif: SPYxEVRxxVxxxDDP.
Links
?
Statistics
?
PSSM-Id: 367370
Aligned: 40 rows
Threshold Bit Score: 189.452
Created: 21-Aug-2024
Updated: 4-Dec-2024
Structure
?
Aligned Rows:
Download Cn3D
PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection: 
Q5BFI0         5 SFTLRSLLVGIVIGALITFSNTYFGLQTGWISTMAMPSALIGFSVFKVF--SKYLSY----P-FTPIENVLIQTVAGAVG 77  Aspergillus nid...
P71749        10 EITIRGVVLGALITLVFTAANVYLGLRVGLTFATSIPAAVISMGVLRLF------AN------HSVVENNIVQTIASAAG 77  Mycobacterium t...
Q5FUH5        26 ELTLRGIILGALITVVFTAANVYLGLKIGLTFGSSIPATIISMAVLRLMg-----------G-GTMLENNMVQTQASAAG 93  Gluconobacter o...
Q9HHR4        38 ELTVKAVLIGLALNVLLLTANMYLGMRSGLTISASIPAAVISMGLFYALryAGIG--------GTILENNIVQTMTSAGE 109 Halobacterium s...
Q7MWY5        36 EITSYSVLLGLVMTVIFSAAAAYLGLKVGQVFEAAIPIAILAVGIGTISg-----------RrNMLGQNVIIQSIGACSG 104 Porphyromonas g...
WP_005787253  37 EVNLWSVAWGIAMAILFSAAAAYLGLKVGQVFEAAIPIAIIAVGV----------SGaakrK-NALGENVIIQSIGACSG 105 Bacteroides
Q8RD87        37 ELTAVAVIVGSLFAILFAAANAYLGLKAGMTISAAIPAAVLATALLKG------VFK----R-DSILESNLVMAIAATGE 105 Caldanaerobacte...
Q48839        29 vGNTAILIMGSLLAIIFAASTAYSGMKPGLTVAAGIPGSIIGSGLVGAF------AK----S-KGILGKNIMQGMSSGGE 97  Lactobacillus s...
Q1DDT0        33 ELTTRALGMGLLIGGLLAITNVYMGLKTGWWESGSVTAAVLGFSALASV------SRrrgaP-YTPLENNLTQTAAAAVG 105 Myxococcus xant...
Q88B71        15 ELSLRAVITGIVLGILLTPSNVYAGLKIGWSFNMSIIALLIGYAIWQGL--AKRSPHq---PpWTLHESNINQTVASAAA 89  Pseudomonas syr...

Q5BFI0        78 TMPLGCGFVGVIPALEFlirdgEDGPSGgegtgeggplklnFGKLVLWSLGVCLFGVVFAVPLRKEVIIR--EKLRFPSG 155 Aspergillus nid...
P71749        78 TL---SSIIFVLPALLM-----IGWWSGf-----------pYWTTAAVCALGGILGVMYSIPLRRALVTG--SDLPYPEG 136 Mycobacterium t...
Q5FUH5        94 TL---SCVFAALPALIM-----VGYWHEf-----------pYVITLLLTMAGGMTGVVFTIPLRRALVSN--SDLPYPEG 152 Gluconobacter o...
Q9HHR4       110 AL--AAGVIFTIAGVTF-----LDQSIN-------------IVETAAVAALGGLLGVLFMIPMRRYLIVDkhEQLPYPEG 169 Halobacterium s...
Q7MWY5       105 VI--VAGAIFTLPALYI-----LGLEAS-------------FLQIFLSSFIGGCLGILLLIPFRKYFVKDmhGKYPFPEA 164 Porphyromonas g...
WP_005787253 106 VI--VAGAIFTLPALYIlqakyPDMSVT-------------FMQVFISSLLGGVLGILFLIPFRKYFVSDmhGKYPFPEA 170 Bacteroides
Q8RD87       106 SL--AGGIIFTLPAIVLw-----GLKDEf-----------tLTRIVFVILIGGLLGALFVIPLRRYLTVEehGKLIYPEG 167 Caldanaerobacte...
Q48839        98 SI--ASGMIYVLPAIVL-----IGGHIN-------------FIEGLIVGILAILFSIGTSSLVHNYLVVEehGNLVYPEA 157 Lactobacillus s...
Q1DDT0       106 AMPAAAGLLGALPALAL-----LGTSVP-------------GWGVAVWSVALGVLGVLAAHLLRRRLVAQ--EALPFPTG 165 Myxococcus xant...
Q88B71        90 SI-ISGGLVAPIPAYTLl----TGQQLD-------------AIPMMAWVFSVSFLGIWIAWYLRPSLLND--TSLKFPEG 149 Pseudomonas syr...

Q5BFI0       156 TASALMLRVLHGSGQSEkgansridqsmedqrdaedvqpllaqgsaqteavlqqdmtstdnlKRDWRSKMRLLIGAFVvS 235 Aspergillus nid...
P71749       137 VAGAEVLKIGDSAREM----------------------------------------------EHNRRGIGVIALGAAA-A 169 Mycobacterium t...
Q5FUH5       153 TACAEILRA-SSPEGD----------------------------------------------ARSLRSLTL---GTIV-S 181 Gluconobacter o...
Q9HHR4       170 TACADVLETGSEGDG-------------------------------------------------GVKLISL----GFF-V 195 Halobacterium s...
Q7MWY5       165 TATTEVLVTGENAGK-------------------------------------------------QMKLLVA---SGLV-G 191 Porphyromonas g...
WP_005787253 171 TATTQVLVSGEKGGS-------------------------------------------------QAKPLLM---AGLI-G 197 Bacteroides
Q8RD87       168 MAAAEVLVTSNQGG----------------------------------------------------TGFMTVLSGMIV-G 194 Caldanaerobacte...
Q48839       158 MAISEALVASDTGGD-------------------------------------------------SLKYMGI---GFGI-G 184 Lactobacillus s...
Q1DDT0       166 IATAELITAMHASTGDTv-------------------------------------------rAGRGRLLAG---AGVA-A 198 Myxococcus xant...
Q88B71       150 MATLETLLHIYNHGREA---------------------------------------------ATRLKVLLN---AALL-S 180 Pseudomonas syr...

Q5BFI0       236 GVYTLFSyfVPQVRDI-PIL--------------GLPLAQn--WLWTLNPSPAYVGQGIIMGPSTCAHMLFGAVLGWGVL 298 Aspergillus nid...
P71749       170 AG-------YALLASL-RVInnsl------satfRVGSGA---TMIGASLSLALIGVGHLVGVTVGVAMIVGLAIAFGVM 232 Mycobacterium t...
Q5FUH5       182 G---AVA--F-ATSGL-RLLsdgf------saatVVGSSA---FRLNGSFSLALLGTGYLVGIGGGIAMLLGVFLAWGIM 245 Gluconobacter o...
Q9HHR4       196 SF--IYM--W-LANGM-AVMktt--------letAFSAGQtrgFAIGGDFTPALIGVGYIIGPRIAAYVFGGGLVAWMML 261 Halobacterium s...
Q7MWY5       192 G---LYD--F-IVGTF-GWWtenvstrlaewgavLAEKYK---LVFKVNTGAAVLGLGYIIGLPYATIICAGSFLVWFVI 261 Porphyromonas g...
WP_005787253 198 G---LYD--F-IVATF-GWWnenfttrvcgvgemLADKAK---LVFKVNTGAAVLGLGYIVGLKYASIICFGSLAVWWII 267 Bacteroides
Q8RD87       195 GIYKLLSggFGMWSENpSWVikr-----------------fesTEVGVNVLASLMGVGFIVGLDVAMYMLAGSVLAWLGL 257 Caldanaerobacte...
Q48839       185 G---VIT--MLTTSVF-GVVnnmm-------nyvGSSFYK---WKLDVEVNPLLAGXGFIVGLEVALTMFAGALLSNFAI 248 Lactobacillus s...
Q1DDT0       199 V---AVT--A-ARDAF-KWLpgmt------alpgTLAGLPaasLTWGVGWSPMLLAIGMMTGPRLGLSMLAGAAVAWGLL 265 Myxococcus xant...
Q88B71       181 GL-------AKWVDTF-VWAfprw------spsaSLER-----LTFTADPSLLLVGFGAIIGIRVGVTLLLGALLAWGGL 241 Pseudomonas syr...

Q5BFI0       299 SPL--AKSR-------GWAPGPVD-------------SW-ENGSKAWIVWVSLAIMLADSIVSLGWLVlkpaLVIAPKVL 355 Aspergillus nid...
P71749       233 LPI--------------RTAGQLPpdg-------dyaVAvARIFSTDVRFIGAGAIAVAAAWTF--------LKILGPIL 283 Mycobacterium t...
Q5FUH5       246 VPVl----G-------HIAPSATPl------------ADaTGLWLHKVRFIGAGTIAVAAIWTL--------LALAKPV- 293 Gluconobacter o...
Q9HHR4       262 IPL--LITG-------GFVPDQAAnlt--------lmGQaHAVWDQYVRYIGAGAMIVGGFYAIISM-----AGTIRDAL 319 Halobacterium s...
Q7MWY5       262 MPLi----G-------YFAPGMTQaigdgvsltiglmSP-EDIFAVYARPLGIGGIAMAGIIGILRSS----GIIGRAVK 325 Porphyromonas g...
WP_005787253 268 VPGmsLFFGdsv--lnQWNPDITAtv---------gsMSpEQIFSHYAKSIGIGGIAMAGVIG---------IIKSWSII 327 Bacteroides
Q8RD87       258 IPLikFFGA-------GLTTPVYPatdl------irdMSaGAIWSKYIRYIGAGGVLAGGFISL--------IKALPTII 316 Caldanaerobacte...
Q48839       249 APLigYFTDmagngahVWNNASLAvn----------qMTvNDLASSYVKYIGAGMMLCGGLIGA--------IKLIPTIV 310 Lactobacillus s...
Q1DDT0       266 APGlaGMGA-------LADTRYET-------------------LSAWLTWPGVGLMVGSALAAL--------LAQARDFL 311 Myxococcus xant...
Q88B71       242 APWllAQGL-------VTLPAGSSgp-------------qFAALVEWLLWPGVSLMVCSTLASL--------AIRLWGLH 293 Pseudomonas syr...

Q5BFI0       356 KRISNTRAGSWIAskspkivprsynysalspiteESsgpssLAHAETRWRADededappsqlISMR------TVLFLL-- 427 Aspergillus nid...
P71749       284 RGIADAAVSARTRr---------------------------RGQAVGQTERD----------IPI-------HIVAMV-- 317 Mycobacterium t...
Q5FUH5       294 --AQGLKEALSVT----------------------------HLATGDDSDHD----------LTPR------TLIALCag 327 Gluconobacter o...
Q9HHR4       320 ASAAAELSGSKSE----------------------------TATQIPRTQRD----------LSMK------VVVLG--- 352 Halobacterium s...
Q7MWY5       326 LAGTELTGKRTST------------------------------IDEPRTQRD----------LSMK------FITLGV-- 357 Porphyromonas g...
WP_005787253 328 RSAVGLAAKEMGG---------------------KSd----AEKNIIRTQRD----------LSMK------IIAIGS-- 364 Bacteroides
Q8RD87       317 KAFRESIVGLGM-----------------------------KGKELKRTDVD----------VSLT------WVIFGA-- 349 Caldanaerobacte...
Q48839       311 TSIKKTLNAKNTT----------------------------GEDKNT---------------LGMV------SIVLGA-- 339 Lactobacillus s...
Q1DDT0       312 SAARDVSSLGRGA--------------------------------------A----------VPSWalgaglAACVLA-- 341 Myxococcus xant...
Q88B71       294 RSTKANSGTIWAV---------------------------------PKAGPA----------LGLL------LSIILV-- 322 Pseudomonas syr...

Q5BFI0       428 PLTLLLNVICMHIVFgdVISPLL-----------SSLATLLAVLLSIMGVRALGETDLn--pVSGISKLTQ--------L 486 Aspergillus nid...
P71749       318 VLLSLIPIGWLLADF--TDGTPLddrrpgaiaagVLLVLVIGLMVAAVCGYMAGLIGSsnspISGVGILVVvla---glL 392 Mycobacterium t...
Q5FUH5       328 LAALLAGLFAYFLWPvmPHGGALatli----llgLIACFGLGFLVASACGYMAGIIGSssspISGVGIIAIiai---svA 400 Gluconobacter o...
Q9HHR4       353 ALAITIALVAIPQ----VELGVLg----------GVIAVVAAFLFVAVSAYLVGVVGSssnpVSGMAVATV--------L 410 Halobacterium s...
Q7MWY5       358 IVALVVTMLFFQFN---VLFNWGhtl------isLLIVFIITFLFTTVAANAIAIVGSn--pVSGMTLMTLllt---svV 423 Porphyromonas g...
WP_005787253 365 IITLILVVLFFYFDV--MQGNLVhtl------vaILLVAGISFLFTTVAANAIAIVGTn--pVSGMTLMTLilas-vvmV 433 Bacteroides
Q8RD87       350 --AFVFFVAWLMPS---LGVTALg----------SLMAVLFAFFFAVVSARITGLVGVsnnpISGMTIATLlivtsvlkL 414 Caldanaerobacte...
Q48839       340 VGIFVIGIIIAQNFM--MGIVg------------ALLAVILSLLFVIVSARIAGTIGGsnlpVSGMTIASLvimt-vvfV 404 Lactobacillus s...
Q1DDT0       342 VVVGSALFG--------LGVPy------------MLLALVLVLPLCAVCARGAGQVDVs--pVTQMGQVTQ--------V 391 Myxococcus xant...
Q88B71       323 --VSLQALL--------FGINLWm----------ALLTIPLAICLAAVAARVVGATGIp--pIGAIGQLSQ--------L 372 Pseudomonas syr...

Q5BFI0       487 LFSLATPSsh------fSrrtaLITNLLAGAVSESGALQAGDMMQDLKTGHLLGASPKAQFYGQIIGSLIGAVLSTAVYK 560 Aspergillus nid...
P71749       393 IKTAYGPAtgsq--ipaL----VAYTVFTAALVFGVATISNDNLQDLKTGQLVGATPWKQQVALIIGVLVGSVVMAPILQ 466 Mycobacterium t...
Q5FUH5       401 LWGLESTGllsveqrpiA----IAFGLFVLSAITASAAVSNDNLQDLKTGQLVGAAPWRQEVALLIGCVVGAIVIPWVLQ 476 Gluconobacter o...
Q9HHR4       411 IAALAMKS---------TgvsdPVVVLLTASVVAIAAAVAGDTSQDLKTGYLLGATPRKQQIAQMVGIAISSVFAGWVLS 481 Halobacterium s...
Q7MWY5       424 LVGVGVSGk-------pG----MTAAMIIGGVVCTALSTAGGFITDLKIGYWLGTTPKSQEKWKFLGVLVASVTVAGVMM 492 Porphyromonas g...
WP_005787253 434 AVGLKGPS---------G----MVASLVMGGVVCTALSMAGGFITDLKIGYWLGSTPAKQEAWKFLGTIVSAATVGGVMI 500 Bacteroides
Q8RD87       415 AGVVGNEG--------------MIIAITIGGIVCVAAAIAGANAQSLKTTFIIGGTPKYIEIFTYVGIAVASIFAGLVLI 480 Caldanaerobacte...
Q48839       405 LFGWTSNA---------H----TQILLMFGTFVVTAIAVGGGYMQSQKVTYVIGGSKSEMMKYFMISAFIGVVVVIGTIS 471 Lactobacillus s...
Q1DDT0       392 IFGALLPG---------A----MAPNVAAGAVVSGAAAQTGVSMWSLKAGHLLGASARHQLAAQLVGVLAGSVVGVPVYL 458 Myxococcus xant...
Q88B71       373 SFGIVAPG---------Q----VTINLMSANTAGGSAGQCTDLMNDFKVGKAIGATPRKQLVAQTLGIFVGSIVGVLAYM 439 Pseudomonas syr...

Q5BFI0       561 MYVNVYPVPGP----------MFQTPTAYVWIFTAR-LVTGQ-----GLPP-MAWeasSVAGIIFVAITIlrivaaspIA 623 Aspergillus nid...
P71749       467 LMQAGFGFQGApga----tanALAAPQAALMSALAK-GVFGG-----SLNW-SLV---GVGALTGVIAVA--------LD 524 Mycobacterium t...
Q5FUH5       477 VLYQAYGFAGAmpregmdpsrALAAPQPALMAAIAT-GILTH-----QLDW-LML---EIGAALGVLLVV--------LD 538 Gluconobacter o...
Q9HHR4       482 FFNQAYGIGs----------eTIPAPQAGMMALISE-GVLTG-----SAQW-GMI---LIGAVFAIVLIM--------MD 533 Halobacterium s...
Q7MWY5       493 ILNKTYGftg---------dqALVAPQANAMAAVIKpLMEGG-----NTPW-ILY---GVGAILALILTS--------IG 546 Porphyromonas g...
WP_005787253 501 ILNKTYGFTs----------gQLAAPQANAMAAVIEpLMSGV-----GAPW-MLY---GIGAVLAIVLTL--------LK 553 Bacteroides
Q8RD87       481 LLNNAYGFGt----------kDIPAPQATIMSMVVK-GIMTG-----DLPW-TFI---IAGIFMGIMAEM--------MH 532 Caldanaerobacte...
Q48839       472 ILSPQFVTdsa--------tpAFGLPQANLIATLTS-GIMSG-----ELPW-IMI---IVGVAMAIVLYF--------LE 525 Lactobacillus s...
Q1DDT0       459 LLSRTYGLGs----------eALPAPFAHQFRAVAEvAVRGLdglppHAALaACV---AVGVGALLTWVS---------- 515 Myxococcus xant...
Q88B71       440 ALIPDPQSMLLt--------eEWPAPAVATWKAVAQtLTHGLdslsaSIRW-AIF---IA-GLTGLLLGV--------LD 498 Pseudomonas syr...

Q5BFI0       624 NgGRPVGTPAPWrswiPGGIAVAVGIFNVPSF-TL--ARAIGGLIAWWWSRahtnhtkkddgfkpatepaqsvlsrrpve 700 Aspergillus nid...
P71749       525 EtLAKTTTNLRL-----PPLAVGMGMYLSAALtLMipIGAFLGRIYDSWARw---------------------------- 571 Mycobacterium t...
Q5FUH5       539 V-VLHRRNLA------LPPLAVGMGIYLPADV-SV--TIGIGAGLGWLLRR----------------------------- 579 Gluconobacter o...
Q9HHR4       534 V----------------PVLPFSVGIYLPITL-AT--PIFLGGLLRAGVDRyvdwr------------------------ 570 Halobacterium s...
Q7MWY5       547 V----------------PALPFALGMFIPLQL-NT--PLLIGGLVSWFVSTrs--------------------------- 580 Porphyromonas g...
WP_005787253 554 V----------------PALAFALGMFIPLEL-NI--PLVVGGAINWYVTTrs--------------------------- 587 Bacteroides
Q8RD87       533 V----------------PVLPFAIGLYLPFEL-SA--AIAVGGIIRWIVDQqyr-------------------------- 567 Caldanaerobacte...
Q48839       526 L----------------PIMTVAIGFYLPIST-TS--IILIGALIKVFIDKvt--------------------------- 559 Lactobacillus s...
Q1DDT0       516 -----RGRAARWl---PLPVALGIGFILPAYY-AV--TLCLGALGLAAARW----------------------------- 555 Myxococcus xant...
Q88B71       499 S-TLPARRARYL----PSAAALGLAFVLPASV-SL--MMALGAVLTWTVSG----------------------------- 541 Pseudomonas syr...

Q5BFI0       701 senrkptspvagnaDDDADAASSSVVVLASGLILGEGIVSIVNLLLA 747 Aspergillus nidulans
P71749       572 -------------sGDDDERKKRLGVMLATGLIVGESLYGVLFAVIV 605 Mycobacterium tuberculosis
Q5FUH5       580 -------------------FPKEQGTMIASGFIVGESLIGVALAAMA 607 Gluconobacter oxydans
Q9HHR4       571 ---------sddgdGAAKERATYRGRIIAAGLITGEAIMGIVVGGIY 608 Halobacterium salinarum
Q7MWY5       581 ------------kdASVNKFRKERGTLIASGFIAGGALMGVVSAILK 615 Porphyromonas gingivalis
WP_005787253 588 ------------kdASLNTERGEKGTLLASGFIAGGALMGVVSAAMR 622 Bacteroides
Q8RD87       568 ------------kdEQLRKEKVEKGILVASGLVAGDALMGLVIAIFA 602 Caldanaerobacter subterraneus subsp. tengcongensis
Q48839       560 ------------gdEAVKNNRIQSGISLSSGLIAGGSIIGLIGIILH 594 Lactobacillus sakei
Q1DDT0       556 ---------------RWPQAADRNTSTLAAGAIAGESLAGVLIAALM 587 Myxococcus xanthus DK 1622
Q88B71       542 ---------------RWASLTERFAITAAAGLIAGESITGVGASLWQ 573 Pseudomonas syringae pv. tomato
| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap