7B6H


Conserved Protein Domain Family
Foie-gras_1

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pfam11817: Foie-gras_1 
Foie gras liver health family 1
Mutating the gene foie gras in zebrafish has been shown to affect development; the mutants develop large, lipid-filled hepatocytes in the liver, resembling those in individuals with fatty liver disease. Foie-gras protein is long and has several well-defined domains though none of them has a known function. We have annotated this one as the first. The C-terminus of this region contains TPR repeats.
Statistics
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PSSM-Id: 463359
Aligned: 19 rows
Threshold Bit Score: 195.298
Created: 24-Mar-2022
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
7B6H_A        265 NCLEIKTLAGFLNYKI----------CRLMFKLKTPR--DAINQFIIHVEKHKSR------VGFKD--L--AFEH-HAWL 321 
Q0CCQ2        358 RFNDTRLIADTIAIRI----------IRCLLQMGQTT--AAVRSWVRHRTRSQDI------INRRGkgT--RNYGwEAWE 417  Aspergillus t...
NP_201396     270 RLVEIKIIAEQLHFKI----------STLLLHGGKLI--EAVTWFHQHKTSYEKV------VGS----TefIFLHw-DWM 326 
Q6ZFT6        256 RLVEVKAVAEQFHFKI----------STILLHGGKVV--GAITWFRKHIRSYERV------VGSp---Ev-AFLHw-EWF 312  Japanese rice
Q7Q5C6        260 NCLELKTIAGFVNYKM----------CKLFFRLNAPK--DSISQFKNHIGKYRQR------SGFke----lLFEHy-AWL 316  Anopheles gam...
Q8IRE3        265 NCLEIKTLAGFLNYKI----------CRLMFKLKTPR--DAINQFIIHVEKHKSR------VGFkd----lAFEHh-AWL 321  fruit fly
Q1RLX4        263 NVLEIKTMAGFINYKI----------CRLCFQHNTPL--DAIAQFRKHIDLCKKK------IGSa---El-AFEHt-AWM 319  zebrafish
EDO31414      261 NMLEVKVVAGFINYKI----------CRLSFHASAPL--DAISQFRKHVDLWKEK------IGCpq----lAFEHv-AWL 317 
EDK46926      351 QFM---TLLDVIAFHI----------VRAYFSIEEPI--KALKKHKTHIVNVVEV------VKRd-----------HDWV 398 
XP_001544926  229 RMATNLDMKSIFVVQPepsqldisefIKALFANLRGPsvEYYRDLSKHARRKKNRgtipppTAPPTsgTs-QTLSlQGWN 307 
7B6H_A        322 STQ---HSVFAELFCEAIKNGLPALQTQ-------------------------------HPGIYYHKAAE-FVMKRRdaa 366 
Q0CCQ2        418 ARW---SMVMAQLIRQARIPYFTSVGISqdqfneqysifvprektthpgdiikpweqlhHEGYWLYRSAK-HSMQRR--- 490  Aspergillus t...
NP_201396     327 SRQ---FLVFAELLETSSATGQSLTSSNqgtaeis------------------ltefefYPAYYYQLAAH-YLKDKK--- 381 
Q6ZFT6        313 SRQ---FLVFGELIETTSTTVPDTLSPRfgtadna------------------ltewefQPAYYYQLAAN-YLREKR--- 367  Japanese rice
Q7Q5C6        317 SVQ---YSAFAELFCDAVKNGLAPLQTQh-------------------------------PGIYFHKAAE-YIGLRK--- 358  Anopheles gam...
Q8IRE3        322 STQ---HSVFAELFCEAIKNGLPALQTQh-------------------------------PGIYYHKAAE-FVMKRR--- 363  fruit fly
Q1RLX4        320 SKQ---FQSFGDLFDEAIKLGLTAIQTQn-------------------------------PGFYYQQAAY-YAQERK--- 361  zebrafish
EDO31414      318 SKQ---FSMFGDLFDEAIRSGLTALQTQh-------------------------------PGFYYQQAAN-NAIIRR--- 359 
EDK46926      399 SRQ---YEWLAQLMRLVPYSIITNLNTT--------------------------------AILKQQLENRrNARPQS--- 440 
XP_001544926  308 VRYdfkLGVFAEFRQEMD------------------------------------------AACRSYEAAY-EGLFGE--- 341 
7B6H_A        367 meaYAAMQA-------------SSEATPTPIQNPLS-LYTEFFGIRavkTG-----------DLVAEQQANMQLCDqeRS 421 
Q0CCQ2        491 ---LLAEQI-------------PAEDRIPPGQSPASqIASKAYLYD---TY-----------LAPETHIEAPQAGS--TG 538  Aspergillus t...
NP_201396     382 ---SALELLlsms-----eiaqEI-------DSSSAsITPSVYVGQ---FAqllekgeaitlHSITDEEYTRYTISeaKR 443 
Q6ZFT6        368 ---YALEFSsssv-----sltkGV-------NGLPEsVMPSVYVGQ---YVrlfeqgdtvavLPLSDTEYTSYALSeaER 429  Japanese rice
Q7Q5C6        359 ---EAFLQCtalgtag---------tgeqfgTISNSaLYSDFFGIR---GSvk-------tgEPVSEQQIICLVQEneKS 416  Anopheles gam...
Q8IRE3        364 ---DAAMEAyaamqasseatptPI-------QNPLS-LYTEFFGIR---AVkt--------gDLVAEQQANMQLCDqeRS 421  fruit fly
Q1RLX4        362 ---QQAGQLcshepgvgypapdPL-------ETTSGaL--DFYGQR---PWrqghq-sidppDSEKEKQGILALQVkeRD 425  zebrafish
EDO31414      360 ---QLGAVTpqt--------mdPL--------ENAGkL--DFFGQR---PWrqgfq-gieltDQTLEHAGIVALQSqeVM 414 
EDK46926      441 ---SAASSA----------------------AASSSsSSVSLLAFF---GGirtpefdlvtnPGLVYVKAYELSSDpqKR 492 
XP_001544926  342 ---EVFEMIagwnprrqlaeniPDEDRVAPTQPTGPsSLSRATVYD---NY-----------LAPEPYDEYPMSDH--PG 402 
7B6H_A        422 YNHSAAIIALLSQAMAQFKIYKC----LRFRKKLAI---DMAEEYLKSGDHAKALTLYSLM--LPDYRQEKWTTIFTDVL 492 
Q0CCQ2        539 FDHSNVILKALNAALEEFSKRDQ----VRMTERLRL---EIAEEYMRIGSWAEAFNVLQPQwaTLSWRQAGWWSLMERFG 611  Aspergillus t...
NP_201396     444 VQDSLQIIAWLKRSYESFTNLKA----QRMAALCAF---EVAREYFDLADPNNAKFFFDIA--ANLYRQEGWVTLLWEVL 514 
Q6ZFT6        430 FQDSYEIIALFRKAYESFRSLGA----TRMASACSG---GMAIEYYAAGDFSNAKQLFDGV--AGLYRQEGWATLLWENL 500  Japanese rice
Q7Q5C6        417 YNHSGEIIGLLGKAMAQFKVYRC----LRFRKKLAI---DMAEEYLKSGDHSKALTLYSLM--LTDYRVDKWYTIFTQVL 487  Anopheles gam...
Q8IRE3        422 YNHSAAIIALLSQAMAQFKIYKC----LRFRKKLAI---DMAEEYLKSGDHAKALTLYSLM--LPDYRQEKWTTIFTDVL 492  fruit fly
Q1RLX4        426 VLHSELIIALLSNAVAQFKKYKC----PRMKSHLMV---QMGEEYYHAKDYTKALKLLDYV--MCDYRTERWWSLLTSIV 496  zebrafish
EDO31414      415 VDHSWIIIPLLSSAVAQFKKYKS----PRMKRYLMV---QMGEEYYHARDYSKALVLLGRV--TWDYRRERWWALLTSVL 485 
EDK46926      493 IALLTNAIELLETQLLNATYKNLisgkDKLDALISYinwRIAEELIQMKQYQKASDFLEMA--YSLICDSNWFSINHLLL 570 
XP_001544926  403 FAHSKLILGFLESSTEEFSKRQQ----NRIVEQLRL---KMAKEHIRIGQWKDGLALIQPLwlQLSWRREGWWGLMEDFA 475 
7B6H_A        493 LKTLRCALLSGSVADYIACSVEALS 517 
Q0CCQ2        612 WALRKCALQVQDSETILRVDCELLN 636  Aspergillus terreus NIH2624
NP_201396     515 GYLRECSRNLDALKDFVEFSLEMVA 539 
Q6ZFT6        501 GYLRECARKLKSLKDFISYSLEMAA 525  Japanese rice
Q7Q5C6        488 LKTLHSAYLSASVPDFVACSIEALS 512  Anopheles gambiae str. PEST
Q8IRE3        493 LKTLRCALLSGSVADYIACSVEALS 517  fruit fly
Q1RLX4        497 CTALKCSYLMGQVKDYITYSMELVG 521  zebrafish
EDO31414      486 ITSLRCAYLVGNVKEYVTLCFELMG 510 
EDK46926      571 EKLLFCYKNIGDKKMEINTILKLAT 595 
XP_001544926  476 WTLRECAIQAEDRETVLRVDWELMN 500 
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