Conserved Protein Domain Family
PME_inhib
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TIGR01614: PME_inhib 
pectinesterase inhibitor domain
This model describes a plant domain of about 200 amino acids, characterized by four conserved Cys residues, shown in a pectinesterase inhibitor from Kiwi to form two disulfide bonds: first to second and third to fourth. Roughly half the members of this family have the region described by this model followed immediately by a pectinesterase domain, pfam01095. This suggests that the pairing of the enzymatic domain and its inhibitor reflects a conserved regulatory mechanism for this enzyme family.
Links
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Statistics
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PSSM-Id: 273717
Aligned: 23 rows
Threshold Bit Score: 117.136
Created: 8-Oct-2014
Updated: 25-Oct-2021
Structure
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Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
CAA23066   5 VVLSLTLMVFINSSNFPKTaatpp--gtyqnHTTYVKTACNSTT------YPTMCYNCLSSYSSTIKS-DPIKLCTTSLN 75  thale cress
CAA72315   3 TKFTLVFLLLTLLSIATST------------PTNFIKSSCSTTS------YPTLCVESLSVYATTIQQ-DPHQLVQTALS 63  Medicago sativa sub...
CAB83132   5 MSSSITFALVFFLLSLNPTssl------pskRESYVQNACSVTR------YQDLCAKTLLPFASVAKN-SPSKWARAGVS 71  thale cress
BAB09799  40 AVLVVGVVCFGIFAGIRAVdsgktepkltrkPTQAISRTCSKSL------YPNLCIDTLLDFPGSLTA-DENELIHISFN 112 thale cress
AAK32841   2 MAFRAYIINFVILCILVAStvs-------gyNQKDVKAWCSQTP------NPKPCEYFLTHNSNNEPIkSESEFLKISMK 68  thale cress
BAB10238   1 MKLLFYLVVFFLLLNGFTAnr---------vANSLIRDSCKKASkmsephYYKFCIASISENPESQKVrNIDELIGVGVK 71  thale cress
BAB01120   5 VDKNFSLACFLVLLLFVDSsyarf---ntlvTKDQIHTICTKQEi-----NSSFCFQVLNTNPEIAKL-DFPSLFKFVLN 75  thale cress
BAB02727   7 KRNVFSLLPLLVLLSITPLsssls--psdkiTKDLLQQLCASPHi-----DHPFCITWLTADPTTFTL-DLQGLLDLVFQ 78  thale cress
AAG52190  27 LMSLLIFITFKSSISVVPDp----------pTQNLINRICKQTI------DFKFCNQTITSQLVRRQT-SIKTIAKLTAA 89  thale cress
AAC33197   1 MHHILSIVLAIILASSVAEafl------dekTQQRVNGICKQTM------DTRFCSSLLIKNLNTFPA-SNKEIMNVTVS 67  thale cress

CAA23066  76 LNVKSAKNATLVVSnLLQKAKAaKSHEVSILKDCVDEMKDTIDELKQAVAEMKyvrgggkttEEHLKNVKTWVSSALTDE 155 thale cress
CAA72315  64 LSLNKTQSTKSFVT-KCKSFRGlKPREYAALHDCVEEITDSVDRLRRSLKGLKlckiqgedfSWHISNVETWVSSALTDE 142 Medicago sativa sub...
CAB83132  72 VAITDNKDVLRHLL-KTRLSTI-GKRDRIALSDCRELLQDSLDSLHKSLAVLRtlra--sefQQQMSDLATWLSSSLTDK 147 thale cress
BAB09799 113 ATLQKFSKALYTSS-TITYTQM-PPRVRSAYDSCLELLDDSVDALTRALSSVVvv-----sgDESHSDVMTWLSSAMTNH 185 thale cress
AAK32841  69 LVLDRAILAKTHAF--TLGPKCrDTREKAAWEDCIKLYDLTVSKINETMDPNV---------KCSKLDAQTWLSTALTNL 137 thale cress
BAB10238  72 NAISNMTNVKGIVErILKDRKYtSKMSEKMLRVCVKLYSEGTNLLTKCLEYIK---------LRDFDKVHNTIRHARVVP 142 thale cress
BAB01120  76 YQAQNISDTLKQFK--LSGGYM--PDVESQYSLCIELYGYAFDNRDITLRYLA---------AKDYNSVNTRVSGTLEDI 142 thale cress
BAB02727  79 KTQLLGYKSLAAMK-GAVRTTT-DPTLRTSYETCVRDYEGAIKAIEEAQGSVT---------SKAYQLASQGAAKAFVSI 147 thale cress
AAG52190  90 KAWINAIQTLDNIE-DSLLPKAkDKRDKAEFDACRKAYKLVDAHLDNALKYLY---------LRDYRFMRAYQALALVNI 159 thale cress
AAC33197  68 EAERFAANTYFFIS-TLLRNAG---DERPDLQACAEAYAIVNSAFTKAVTFFK---------QAYYSKIVNIEKKVSMAV 134 thale cress

CAA23066 156 GTCTDGFEEGRVn-vETKKKVKKAISELSKTTSNTLALLTHYL 197 thale cress
CAA72315 143 STCSDGFGGKALd-gRMKASIRSRMVNVAQVTSNALSLINQYA 184 Medicago sativa subsp. x varia
CAB83132 148 DTCLDGFEKTSTrssSTVRMIRKRVTTSMYLSSNSLALLNKLA 190 thale cress
BAB09799 186 DTCTDGFDEIEGqggEVKDQVIGAVKDLSEMVSNCLAIFAGKV 228 thale cress
AAK32841 138 DTCRAGFLELG----VTDIVLPLMSNNVSNLLCNTLAINKVPF 176 thale cress
BAB10238 143 RECEMGFNDDN----KQKSPVTKENDVLFDTVDIAQSFNYYAH 181 thale cress
BAB01120 143 FTCTDDLSTMK----PIPQFFMTESNLIKELSKILLFPYLWLT 181 thale cress
BAB02727 148 SVCEAQFEGRD----DVPVYVTKLNLFFKRFCNIDRVFSDVLT 186 thale cress
AAG52190 160 SMCRTSFFHPT--------PMVYANWNMKMLTDIAIYAGKILS 194 thale cress
AAC33197 135 DICKTDFNVLGYq----INPLIEKNRQTKILLSMEQIVSHMVS 173 thale cress
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