2H6L,2DT4,2NMU,2P6Y,3HTN,3HWU


Conserved Protein Domain Family
DUF296
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cd11378: DUF296 
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Domain of unknown function found in archaea, bacteria, and plants
This domain is found in proteins that contain AT-hook motifs, which suggests a role in DNA-binding for the proteins as a whole. Three conserved histidine residues appear to form a zinc-binding site, and the domain has been observed to form homotrimers. It co-occurs with a thioredoxin-like domain in uncharacterized cyanobacterial proteins.
Links
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Statistics
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PSSM-Id: 211390
Aligned: 75 rows
Threshold Bit Score: 45.269
Created: 5-Apr-2011
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
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putative Zntrimer
Conserved site includes 3 residues -Click on image for an interactive view with Cn3D
Feature 1: putative Zn binding site [ion binding site], 3 residue positions
Conserved feature residue pattern:H H HClick to see conserved feature residue pattern help
Evidence:
  • Structure:2P6Y: Vibrio cholerae protein Q9KM02 binds zinc, contacts at 4A
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                                                                                        
2H6L_A        10 KGFLLRLDYGKDLVRQIEEFLEEKGihaAHI-SAIGAVRSAVIGyydqe--------kkeyvKKELXEpLEILSLSGNVS 80  Archaeoglobus f...
2P6Y_A         3 HLIALRLTRGXDLKQQIVQLVQQHRihaGSIaSCVGCLSTLHIRlad------------svsTLQVSApFEILSLSGTLT 70  Vibrio cholerae
O49662       133 RTHVMEIGDGCDLVESVATFARRRQrgvCVM-SGTGNVTNVTIRqpgsh--------pspgsVVSLHGrFEILSLSGSFL 203 thale cress
ABL63120     128 SPYVLELPGGIDIVESITSFCRKRNmglCIL-NGSGTVTNVTLRqpst----------tpgaSVTFHGrFDILSLSATVI 196 Madagascar peri...
NP_177776    100 RSHVLEVSSGADIVESVTTYARRRGrgvSIL-SGNGTVANVSLRqpattaah--ganggtggVVALHGrFEILSLTGTVL 176 thale cress
Q6ZJC3       102 RSHVLEIPGGGDVAGALAGYARRRGlgiCVL-AGTGAVANVSLRhplpsgaaaeigggaaaaVVVFHGrYEILSISATFL 180 Oryza sativa Ja...
Q9M9R4        31 SPYILEVPSGNDVVEALNRFCRGKAigfCVL-SGSGSVADVTLRqpspa---------apgsTITFHGkFDLLSVSATFL 100 thale cress
Q7XPV1       156 TPHIITASPSEDVAGKIVAFANHSSravCVL-SATGSVSRVVLRhpadgamsrvhasshyknPAIYEGlYEILSMSGCYN 234 Oryza sativa Ja...
Q9SJQ2       106 TPHSFTVNKGEDIIKRIMSFTANGSrgiSVL-SVNGAVANVTILphgs-----------srrVMTFKEeYEIVSLTNNTM 173 thale cress
XP_002276021  95 KPIVIEVAPGNDLFETVVQFARRRRvgiTIL-HGFGTISNVTFRqpvp-----------hapTYSLHGpLCIIYISGWYL 162 wine grape

Feature 1                        # #              #                   
2H6L_A        81 xkds--------kpfcHIHVLLGK--DGEVYGGHLf-SAEVf--ACEVFVLPL 120 Archaeoglobus fulgidus
2P6Y_A        71 yq------------hcHLHIAVADa-QGRVWGGHLleGNLIn-tTAELXIHHY 109 Vibrio cholerae
O49662       204 pppap-------ptatGLSVYLAGg-QGQVVGGSVv-GPLLcagPVVVMAASF 247 thale cress
ABL63120     197 psntlsaialsngianGFTISLAGp-QGQVVGGAVv-GSLFsagTVYLIAASF 247 Madagascar periwinkle
NP_177776    177 pppap-------pgsgGLSIFLSGv-QGQVIGGNVv-APLVasgPVILMAASF 220 thale cress
Q6ZJC3       181 ppamaaa--apraalgGLSISLAGp-HGQIFGGAVa-GPLVa-aTTVVVVAAA 228 Oryza sativa Japonica Group
Q9M9R4       101 pplppts--lsppvsnFFTVSLAGp-QGKVIGGFVa-GPLVaagTVYFVATSF 149 thale cress
Q7XPV1       235 lmne--------gqsdGLSVTLCSp-ERHIIGGVLg-GALVaasTVQVVLGSF 277 Oryza sativa Japonica Group
Q9SJQ2       174 aisesgg---vknktgGWRITIGGaaGGRVHGGALa-GSLIaasPVQVVIGSF 222 thale cress
XP_002276021 163 gcptpat---patsraSFSVSVAGt-QGQIYGGQVa-GKVTasgPVTLIASTF 210 wine grape

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