242044202 1 MAMVTTSPATLQPSSSSCKHASRGVARCCPAPPPPLLSWKRRSSGQQQVTTTRATAASSRGQptigvagv---------- 70 145341312 1 -------------------------------------------------------------M------------------ 1 159475048 -------------------------------------------------------------------------------- 219126191 51 SVLAATVQPDKDQAFTTKSSTRIAQSRTGRNDQSPPDFLTLAFASTECDNVNRPPSLNVLIR------------------ 112 224101859 1 ------------------------------------------------------------MD------------------ 2 225424281 3 STSTLSLPLQRNARKKGFPSSPVTKPFTANLTFSFSLRLTKAIHVKSSSTAKFNEVVVDEEId----------------- 65 255073709 1 -----------------------------------MVTTQFIPHATAAEDGTPVLVTTTTPA------------------ 27 255573758 6 TSSISLQNNVPNTSFKSPPSLPTKPFQNNIKFSFPPLTLTKVTRIKSSRTTKYNEVIVDEEMd----------------- 68 297838899 7 SSLMASKTVISKTTLFSSLPGIFYRNFITFAPASPSVKPLRTKSSNGTKFDEVTNSLDEDMD------------------ 68 302843790 23 AAALPHPKSHRRPHTHTPSPLTPFRPRGSGGPSDPIPKKPRPHTFVAAAAAPSSPGPAPGSSpgpgsnaghagsttaggs 102
242044202 71 ----------aggeeegdSIRRLQNGS------DVRGVALEGEK----------------CRAVDLTPLAVEAIAESFGE 118 145341312 2 ------------------RVKKLQNGS------DIRGVALDGVE----------------GEAITLDAATASAIGRAFAD 41 159475048 1 ----------------------LQNGS------DIRGIALEGVP----------------NEPVTLSAGAVFFIGVAFAR 36 219126191 113 ------------------SIEHLTTASdghmltDVRGVFVDHARlgsiaavahaigqlpvGSVPPLTPLAVYCLGHAFAS 174 224101859 3 ------------------KIRRLQNGS------DVRGVALQGEK----------------GRTVDLSPPAVEAIAESFGE 42 225424281 66 ------------------KIRRLQNGS------DVRGVAVEGEK----------------GRTVDLTPPAVEAIAESFGE 105 255073709 28 ------------------ILKKLQNGS------DVRGVALEGVP----------------GEPVTLNEEAAYLIGAAFVD 67 255573758 69 ------------------KVRRLQNGS------DVRGVALEGEK----------------GRTVDLTPPAVEAIAESFGE 108 297838899 69 ------------------QIRRLQNGS------DVRGVALEGEK----------------GRTVDLTPAAVEAIAESFGE 108 302843790 103 rragagpilgpalsdlvaRFRRLQNGS------DIRGIALEGVP----------------NEPVTLSPGAVFFIGVAFAR 160
242044202 119 WLREeelrlRGEEPQQQLRVSVGRDPRLSGPRLGAALFAGLASAGCS--VFDMGLATTPACFMSTILPR----------- 185 145341312 42 WLR------ARNPNAKDISVGVGRDPRLSGETLRDGMFAGMVEGGAR--VIDMGLATTPACFMACVTEG----------- 102 159475048 37 WLRSk--------GHSAPKVSVGRDPRLSGPLLESAFAAGLIHGGAAv-VHLFGLATTPAMFYSIVLSG----------- 96 219126191 175 QLLEd---tP---AEENVTILVGRDPRIHGMRLADALGRGAEAADPRirVVYTGIATTPGCASFVRSGR----------- 237 224101859 43 WVINgl-ekEKGRVVENVRVSLGRDPRLSGASLSVAVFSGLVRAGCL--AFDMGLATTPACFMSTLLTP----------- 108 225424281 106 WVMNrl-esEGGVPVEGVRVSLGRDPRISGASLSAAVFSGLARAGCL--AFDMGLATTPACFMSTLLPP----------- 171 255073709 68 WLAD-----KKGKKPSELSIAVGRDPRLSGPALANAMFAGFGSKDVGr-VVDMGIATTPACFMATVTPG----------- 130 255573758 109 WVINgl-ekEKGRVVEDVRVSLGKDPRVTGASLSVAVFAGLSRAGCM--VFDMGLATTPACFMSTLLHP----------- 174 297838899 109 WVTA-----TESNGNGVIKVSLGRDPRVSGGKLSTAVFAGLARAGCL--AFDMGLATTPACFMSTLLSP----------- 170 302843790 161 WLRSk--------GQGAPKVSVGRDPRLSGPILESVFAAGLLQGGAAv-VHLFGLATTPAMFYSIVLSGclwgsyyvlty 231
242044202 186 ---------FNYDAS----IMLTASHLPYTRNGLKFFTK---------RGGLTSGDVETICDRAAQKYva---------- 233 145341312 103 -------------AKydgsVMLTASHLPFNRNGMKFFTS---------EGGLDKPDITDICARAAA-------------- 146 159475048 97 ---------ERGDEGggggDYIHDYHLPYNANGLKFFVA---------AGGLDKPDIAELLQTAAAAAae---------- 148 219126191 238 ---------ADAA------VMVTASHLPRDRNGLKFFRRartldarvgDDSASAVSIADLGARAIQCAte---------- 292 224101859 109 ---------FAYDAS----IMMTASHLPYTRNGLKFFTR---------RGGLTSPEVEEICGKAARKY------------ 154 225424281 172 ---------FAYDAS----IMMTASHLPYTRNGLKFFTR---------KGGLTSPEVEAICDKAARKY------------ 217 255073709 131 ---------VAYDAG----IMLTASHLPFNRNGAKFFTS---------DGGLDKADIKRICEDAAAACqaapdghaipld 188 255573758 175 ---------FAYDAS----IMMTASHLPYTRNGLKFFTK---------KGGLTSPEVEEICEKAARKY------------ 220 297838899 171 ---------FEYDAS----IMMTASHLPYTRNGLKFFTK---------RGGLTSPEVEKICDLAARKY------------ 216 302843790 232 vfmyvyiyvYTY-------VMITASHLPYNANGLKFFTA---------AGGLDKPDITELLQLAAVAAaqagvmlgdpls 295
242044202 234 -rRKMGLGDTPPPPPVVMR--VDLMSAYAQHLRDIIKQRVAHPEH---------YDTPLRGFKVVVNAGNGCGGFFTRDV 301 145341312 147 --YVEAGVGSVTAPSGVVS--APFLPTYAAQLCDIIRKGVNFTDN---------YDKPLTGMKIVVDAGNGSGGFFADMV 213 159475048 149 agSHLLAVSLSLDPARLAR--LPFLPTYSASLRDLIKRGVNSPAN---------YHFPLLGCHVVVDAGNGAGGFFAEQV 217 219126191 293 whSAGILPPASGKDSVMCSawVDWMPYYAKELRQAIVDQVGHQSCdktsandqiSQQPLRGLKIVLNAGNGSGAFF-HKI 371 224101859 155 --ANRLAKVSTMLKTPPER--VDFMSTYAKHLRNIIKERVNHPFH---------YDTPLKEFQIIVNAGNGSGGFFTWDV 221 225424281 218 --ANRLTKVSTTLSIPPTK--VDFMSTYAKHLRDIIKERVNHPLH---------YDTPLKGFQIIVNSGNGSGGFFTWDV 284 255073709 189 gdDAVES--------------VPFLEDYAAQLRDLIKKGANHPTA---------YDEPLTGMKIIVDAGNGSGGFFAKSV 245 255573758 221 --ANRLMKVSTLLNTPPTR--VDFMSTYAKHLRDIIKERVSHPLH---------YDTPLKGFQIIVNAGNGSGGFFKWDV 287 297838899 217 --ATRQTKVSTLIRRRPKQ--VDFMSAYSKHLREIIKERINHPEH---------YDTPLKGFQIVVNAGNGSGGFFTWDV 283 302843790 296 ehSHLLSAALATDPSRLAR--LPFLPAYSAALRDLIKRGVNSPTN---------YHFPLLGCKLVVNAGNGAGGFFGEQV 364
242044202 302 LEKLGADTTGSLHLDPDGRFPNHMPNPEDATAMSLTRGAVLAQGADLGVVFDTDVDRSGVV------DAGGAAINGDRLI 375 145341312 214 LEALGADTSGSQFLDPNGNFPNHSPNPEDKEAMAAGVQCVLNAKADLGIVFDTDVDRSAVI------DSSGKEINRNKLI 287 159475048 218 LAPLGADTSGSVFLDPDGTFPNHPPNPEHPAAMASGAAAVKASAAELGIVFDTDVDRSAIV------DASGREINSNRFI 291 219126191 372 LQELGADTTGSLHLEYNGEFPNGVPNPESPAMVSETEQACALVKADLGILLDTDADRCGFVvpsrhdKNTYEPLNRNRLI 451 224101859 222 LDKLGAETFGSLHLNPDGMFPNHIPNPEDKIAMALTRAAVLENSADLGIVFDTDVDRSGVV------DKEGNPINGDRLI 295 225424281 285 LDKLGADTFGSLNLSPDGMFPNHIPNPEDKTAMALTKAAVLENNADLGIVFDTDVDRSGVV------DSSGNPINGDKLI 358 255073709 246 LEPLGADVYGSQFLDPDGKFPNHSPNPEDAEAMDSAVEATVKAKADLGVIFDTDVDRSAVI------DGDGNPINRNKLI 319 255573758 288 LDKLGADTFGSLHLNPDGMFPNHIPNPEDKTAMALTRAAVLDNSADLGIVFDTDVDRSGVV------DNKGNPINGDKLI 361 297838899 284 LDKLGANTFGSLYLNPDGMFPNHIPNPENKIAMSHTRAAVLENSADLGVVFDTDVDRSGVV------DNRGNPINGDKLI 357 302843790 365 LAPLGADVSGSVFLDPDGTFPNHPPNPEHPAAMAAGAEAVRAAEAELGIVFDTDVDRSAIV------DGAGREINSNRFI 438
242044202 376 ALMSAIVLGEHGGTMVVTDARASDGLTRFIESR-GGRHCLYRVGYRNVIDKGVQLNDDGV-ETHLMMETTGHGALRENYF 453 145341312 288 ALLSEIVLKESPGATIVTDSVTSDGLHKFITAK-GGKHVRFMRGYKNVINKGKELNASGV-VTPLMIETSGHGAMKENYD 365 159475048 292 ALMAAVVLRQHPGTTVVTDSVTSNGLTDFITAL-GGKHMRYKRGYKNVIGAGVRLNAQGE-DCALMMETSGHGALRENFF 369 219126191 452 ALLGVIMSRSSPGSAIVTDSVTSEGLATFLQGSlGLQHVRYLKGYANVIGKARSLSESNVvAANLAIETSGHCAFRENDY 531 224101859 296 ALMSAIVLTEHPGTTIVTDARTSMALTRFIIDR-GGQHCLYRVGYRNVIDKGVQLNKNGI-ETHLMMETSGHGALKENYF 373 225424281 359 ALMAAIVLREHPGSTIVTDARTSMALTQFIANR-GGHHCLYRVGYRNVIDKGVQLNKDGI-EAHLMMETSGHGALKENHF 436 255073709 320 ALLAAIILDEHPGSTVVTDSVTSDGLAEFIEGK-GGKHVRYMRGYKNVINEGVRRDKAGE-PCHLMIETSGHGAMKENYC 397 255573758 362 ALMSAIVLREHPGTTIVTDARTSMALSRFITDR-GGQHCLYRVGYRNVIDKGVHLNEDGI-EAHLMMETSGHGALKENYF 439 297838899 358 ALMSAIVLKEHPGSTIVTDARTSMGLTRFITER-GGRHCLYRVGYRNVIDKGVELNKDGI-ETHLMMETSGHGAVKENHF 435 302843790 439 ALMAAVVLRQHPGTTIVTDSVTSNGLTKFIEQL-GGKHMRFKRGYKNVIAAGVKLNSDGE-DCQLMMETSGHGALKENYF 516
242044202 454 LDDGAYMVVKIIIEMVRMKLAGVEGGVGSLIADLEEPAESVLLRMDVLGE-----PKHAKQRATQAVEAFKKYIME---- 524 145341312 366 LDDGAYLAVKIIIEAVRRRLANEPS-IGQVLETLEEPLEEAEVRLKIADP-------DFKAYGLNVIENLLAAVNDpahs 437 159475048 370 LDDGAYLAVKAIIEHVRRKQEGAAGGLAELLAGLAEPAESREWRVRIQHT-------DFKAVGGRVLAAFHDWGAVpa-- 440 219126191 532 LDDGTYCAVKVLSLMARERAANAKSNLLDLIADLVELDEVAELRMATLDDsldtmQQVFDLCALELERHAQNSd------ 605 224101859 374 LDDGAYMVVKIIIEMVRMKLAGSDEGIGSLIKDLEEPLESVELRMNIISE-----PRHAKARGIDAIETFRSYVEE---- 444 225424281 437 LDDGAYMVVKIIIEMVRMKLAGSYEGIGSLIEDLQEPFESVELRMNVISE-----PKHAKAKGAEAIEAFRNYIEE---- 507 255073709 398 LDDGAYIAVKIIIEAVRRRLSGGKG-ISDLLSELREPLEEKEVRLKITCD-------DFKAYGGDVLEQLKEAVGSm--- 466 255573758 440 LDDGAYMVVKIIIEMVRMKLAGSDEGIGSLIKDLEEPREVIELRMNVISE-----PRHAKAKAVEVIEKFRNFIEE---- 510 297838899 436 LDDGAYMVVKIIIEMVRMRLAGSNEGIGSLIEDLEEPLEAVELRLNILSK-----PRDAKANGIEAIETFRQYIEE---- 506 302843790 517 LDDGAYLAVKAIIEHVRRRNEGAGG-ISELLAGLQEPLESTEWRIRIQHP-------DFKEAGAKVLAHFYDLVLSgt-- 586
242044202 525 --DKLSGWVLDDCGdcsvsegcledsndrpidvdaymyrAKLY-DENERALGMVHLRQSVHNPNIALNMQSYVPGGCKSM 601 145341312 438 lfGKCKPAPDNYEG-------------------------LRVCvDEGDGRQGWFLLRCSLHDPVMVLNFESQTQCGVQTM 492 159475048 441 apSSWSLESVNHEG-------------------------WRVNmDEGEGRRGWLLLRQSLHDPLLVLNVESELPGGAAEA 495 219126191 606 --IEWEIDVDNLEG-------------------------IRIRi----GDGQFFMLRKSLHDPIISLQIEASSKDIARRR 654 224101859 445 --GRIEGWELDSCGdcwvadgclvdsnddpaavdahmyrAKVS-DEKLGQHGWIHLRQSIHNPNIAVNMQSMAPGGCLSM 521 225424281 508 --GKLEGWELDSCGdcwvsegclvdlndtpaaidaymyrAKVS-DKEHGQHGWIHLRQSIHNPNIAVNIQSSVPSGCQSM 584 255073709 467 --KGYTPVDVNYEG-------------------------YRVNrDEGDGKRGWFLLRQSLHDPVMVLNFESEIPGGVDAM 519 255573758 511 --GKLEGWELDYCGdcwvsdgclvdsndtpaavdaymyrTKVS-DEEHGQHGWVHLRQSIHNPNIAVNMQSMVPGACQSM 587 297838899 507 --GKLRGWELGTCGdcwvsegclvdsndhpsaidahmyrARVSdEESGEEYGWVHMRQSIHNPNIALNMQSMLPGGCLSM 584 302843790 587 -yPDWRLEAVNHEG-------------------------WRVSvDEGEGRKGWALLRQSLHDPLLVLNVESEVEGGAQTT 640
242044202 602 AKDLHQRF----------LLASGLNEFVDI 621 145341312 493 AEEFGTWIlden---ydkLDGSAVYALYDT 519 159475048 496 AVRVAAWL---------------------- 503 219126191 655 IMVPIIELfdsleqiqaqLDLSVLRQF--- 681 224101859 522 TKTLRDKF----------LVASGMDKILDV 541 225424281 585 ARVLREKF----------LIASGMEKSLDI 604 255073709 520 AKDVVAWLkekd---fasLDASAVYAILDK 546 255573758 588 TEVLRDKF----------LVASGIDKFLDI 607 297838899 585 TRVFRDQF----------LEASGIARFLDL 604 302843790 641 AARVGAFLrsetqkggpaLNLGPLAALLPQ 670