Conserved Protein Domain Family
Mgr1

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pfam08602: Mgr1 
Mgr1-like, i-AAA protease complex subunit
The S. cerevisiae Mgr1 protein has been shown to be required for mitochondrial viability in yeast lacking mitochondrial DNA. It is a mitochondrial inner membrane protein, which interacts with Yme1 and is a new subunit of the i-AAA protease complex.
Statistics
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PSSM-Id: 369991
Aligned: 13 rows
Threshold Bit Score: 516.145
Created: 23-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
XP_003675349     1 MALYTPPDKPDs--sNGDDHPKNGSINDSNNDNDefemkrhKFYPRPSLGLKLWGPLVPASDNKNGLWTLIGVQTAMGVF 78 
CCH58541         1 MAVYTPPNKST----DNSSKSPTDTTDDSSRDIE-------KFYIRPSLGLKMWGPLVPASDNKTGLWALVGTQTVIGIL 69 
XP_003685903     1 MTLYTPPDKN-----QKDKGDAAKNVDSSNEPL--------KLYPRPSLGLKMWGPLVPASDNRVGLWSLVGAQTLIGLF 67 
EDO18959         1 MALYTPPEKSDnsgqASTSTKKGNEGDDLDDSK--------RFFVRPSIGLKMWGPLVPASDNRAGLWTLIGLQTGIGVL 72 
CAR23819        47 MGLYSPPDGSKa--pNAPALAQKEAPDKPNDGALi------KFYPRPSLGLRFWGPLVPASDNREGLWTLVGIQTVFGLL 118
Q751V6           1 MALFTPPSE------DKDGRDRSGGGDKASGVVRt------PFHLRPSLGLALWGPLVPASDNRAGLWTLVGLQTLMGAF 68  Eremothecium ...
ybcl:Ecym_1035   1 MSLFTPPTGGKg---SSFNRVPSKDPEKPEKDIRs------QFYSRPSLGLKFWGPLVPASDNRVGLWSLVTAQTLVGLF 71 
XP_002497981     1 MALYTPPDKSsp-pkAHENEEDKGGSNREQDDIK-------KFYVRPSLGLRLWGPLVPASDNKMGLWSLIGIQTAVGTF 72 
CCE91562         1 MALYTPPGKSPsrpqAKENENDKK--DDPKDDIS-------KFYVRPSLGLRLWGPLVPASDNKVGLWSLIGIQSAVGIF 71 
CCD22190         1 MALYTPPDNSDs--sSNDSKSYGKDNNDISDDTKkl----eKFYSRPSLGLRLWGPLVPASDNQNGLWTLITIQTGIGLF 74 
P25573           1 MAVFTPPSGNSn---STDHTHTQDDHDKDDNDIK-------KFYIRPSLGLKLWGPLVPAPDNLPGLYTLITIQSAVGFF 70  Saccharomyces...
CCF57676         1 MAVYTPSGNNNnsgiNDNDVGSASEME--------------KFFVRPSLGLKLWGPLVPASDNRTGLWTLLTIQTVVGIG 66 
Q6FX96           1 MGIFTPPGKSDkrdaNEEKPTLLGSNSKDETDVE-------KFWVRPSLGLKLWGPLVPASDNKTGLWTLVAVQSMVGLL 73  [Candida] gla...
XP_003675349    79 CFYRFRKLGIRPFStsptasplgfi----------------knattfkqngkNTIKDIADLPSLNRFSTSHGELLVndsa 142
CCH58541        70 CVQRFRMLRLRPISqstst----------------------------lgfkkLSGRNIADIPSLNRFSTANGSLMT---- 117
XP_003685903    68 FLRRGWTIRKNVNMrnlat-----------------------------gvspAFKTDISNIPTLNRFS--NGPVATgt-- 114
EDO18959        73 CMIRFRQLRKLNTIsk-----------------------------------nVIKKDIAEIPSLNRFSQSHGTVYVpkpm 117
CAR23819       119 CLRRSRSIGSS-----------------------------------------IVKREISKIPSLNRFSVTRGSMYVs--- 154
Q751V6          69 FVSRFRALRPK-----------------------------------------LLKRDIADFPSLNRFSKTSGDMHVg--- 104 Eremothecium ...
ybcl:Ecym_1035  72 FMCKFRNLGPK-----------------------------------------VIKRDISDFPSLNRFSTTFGGMYVt--- 107
XP_002497981    73 CLHRIRVLRASMK---------------------------------------FVSKDIANIPSLNRFSKTHGAMVLnpv- 112
CCE91562        72 CMYRIRRLRGSLN---------------------------------------TVRKNIADIPSLNRFSTTQGELVMppp- 111
CCD22190        75 FLYRYRALGKHYSK--------------------------------------SIIRDIADVPSLNRFSTTHGQIPLtnni 116
P25573          71 ALWRLRRLYKLPPPrriatgthsdlsf------------gelpsemivngktKIKKDIADFPTLNRFSTTHGDIVL---- 134 Saccharomyces...
CCF57676        67 CFKRFNSLRRAHQ---------------------------------------VIKTNISRLPTLNRFSKTDKIISI---- 103
Q6FX96          74 CFYRFKSLRIIDRNgalnsvgksgirptsvlvnepklynsaftqqeavsgkpLVKKDIADFPTLNRFSTTHGDMFVntt- 152 [Candida] gla...
XP_003675349   143 kgvtpgeistaLKPGLTGS---------SMSSFSKKTSYDGKNnen---------------------------------- 179
CCH58541       118 -----------SSKPKIFQ---------LISQFKLKSSNSYKQ------------------------------------- 140
XP_003685903   115 ----------aTTKPSIFAs--------ILTRFIKRQPTGSRFgarygyq------------------------------ 146
EDO18959       118 memsgntaaspNSAAISNS---------GATTISNIETQNISNnnsntidtgsndsnnknnniaasnaetntnspamaas 188
CAR23819       155 -----------EHGPTAFG---------STNSFSRRGSNLWGFl------------------------------------ 178
Q751V6         105 ----------pVHVFADFG---------GTHSFHRRAGESPGFf------------------------------------ 129 Eremothecium ...
ybcl:Ecym_1035 108 -----------THLFPEFG---------GTYSFHRRVGERTGFf------------------------------------ 131
XP_002497981   113 --------nnpLKKPLNSNsrfr--------------------------------------------------------- 127
CCE91562       112 --------sltGSAPTTFT---------AGHGVQKASYGGTAFggassffkss--------------------------- 147
CCD22190       117 spv--nkvstpNSKLASNTifkgktplfGISSFSKRENPKDTSssgvgeprks--------------------------- 167
P25573         135 ------------APPPIIP------------------------------------------------------------- 141 Saccharomyces...
CCF57676       104 -----------ESKPLQ--------------------------------------------------------------- 109
Q6FX96         153 --------nvnRNTPSLSA---------APVVASPVLSSAGHQseimaksea---------------------------- 187 [Candida] gla...
XP_003675349   180 -----------------------------------fnYSSKFTTFKRALYIFTGALLLSQSLLETCRLEILKYDPWLEEA 224
CCH58541       141 -------------------------------------FKTKYQHFSKYIYLLFGSVILFQSSLETLRLTIIKYDPWCEEV 183
XP_003685903   147 ----------------------------------nqqswqgFRSFASLLYLFVGALVISQSTLEIMRLVLLKYDPWYDEA 192
EDO18959       189 ttlpintaaysslnvvsqglnnkgfqgsegkwrysssRSSRFGNFKSFMFFLAGSVVLFQSFLEAARMTLLKYDPWREEA 268
CAR23819       179 -------------------------------------RSTKFIALRKSLYLVGGTLLLSQSLLEACRLQILKYDPWYEEA 221
Q751V6         130 -------------------------------------QSRRFVSLKRALYLSTGVVLLVQSALESARLTLLVYDPWEEQA 172 Eremothecium ...
ybcl:Ecym_1035 132 -------------------------------------YSKRFANIKRVIYLTTGTVLLAQSMLEASRLTLLEYDPWEEQA 174
XP_002497981   128 ----------------------------------qlfSSPRWSTFKNVVYLLTGTLLLSQSLLEASRLTILKYDPWYEEA 173
CCE91562       148 ----------------------------skengksgfKFASFMTFKQVIYLLTGTLLLSQSLLEACRLTILKYDPWAEEA 199
CCD22190       168 ----------------------------nwngndnfkYSSKFIIFKRILYGLTGAIILSQSLLETCRLKILKYDPWLEEA 219
P25573         142 -------------------------------------RQSRFVSVRKLLWGLFGSLLLSQSLLELTRLNFLKYDPWCDEM 184 Saccharomyces...
CCF57676       110 -------------------------------------KLSRWDTTKKFIYLFSGTVILSQSLLELCRLSLLKYDPWYEEA 152
Q6FX96         188 -----------------------------knnwksffKSDNWLIFKKVFYLLAGSIILSQSMLEACRLTILRYDPWCEEA 238 [Candida] gla...
XP_003675349   225 KSVRDKKLFNDIIKFYHEGIDPTKVNVRDVMSGN----PVSTNIPEVKQSVALVRAQSEAENPVIKWFGPIEYKPMTFTE 300
CCH58541       184 KSLRNKKLFNDLIKFYHEGIDPNKVKVKDATSGN----ILSINIPEVKQSVALVRAQAESQNPIIKWFGPIQYKPMSFSD 259
XP_003685903   193 KSAREKKFFNDIVKYYHEGIDPTKIKVKDASSGT----ALSTNSPQVRQSVALVRAQAENESILTKWFGPVYFKPMSFND 268
EDO18959       269 KSVREKKFFNDIILFYHEGIDPTKIKVKDAASGN----ALSTNIPQVKQSVALVRAQAEAENPIIKWYGPLDYKPMSFND 344
CAR23819       222 RSVREKQFFNNIIKYYHEGIDPTKFKVKDASNGA----VLPLSSPEVKQSVAFARATLEADSWFTSWFGPIEYKPMSFTE 297
Q751V6         173 RGVRDKQFYNDVVRYYHEGVDPARFIVKDPASGN----TLPVNVPEVKQGVALARAHTNARNIITRWLGPLDCKPLSSSE 248 Eremothecium ...
ybcl:Ecym_1035 175 KCVRDKQFFNDVVKYYHEGVDPMRFKVRDANSGT----TLSVNIPEVKQGVAVARAQANAENLVTKWLGPLDYKPLSFSD 250
XP_002497981   174 KSVRDKKFFNDIIQFYHEGIDPTKVKVKDATNGN----VMSTNIPEVKQSVALVRAQAEAENPIIKWFGPIEYKPMSFTE 249
CCE91562       200 RSVRDKKFFNDIIKFYHEGIDPTKVRVKDASSGN----VMPTNIPEVKQSVALVRAQAEAENPIIKWYGPLEYKPMSFSE 275
CCD22190       220 KCVREKKFFNDIIKYYNEGIDPTKVKVKDSMSGN----PVSTNIPEVKQSVALVRAQNEAENPIIKWFGPIEYKPMSFTE 295
P25573         185 KSVRDKKFFNNIVKYYHEGIDPTKIKVKDAMNGT----PLSTNIPEVKQSVALARAQVEAQNPIIKWFGPLEYKPMSFNE 260 Saccharomyces...
CCF57676       153 RCARDKKFFNDIIKYYNEGIDPTKIQVKVKRSGGddsvSVNPNVNEIKQSVAIVRAQNEASNPIIKWYGPIELEPMSFND 232
Q6FX96         239 KTVREKKFFNNIVKFYHEGIDPTKVKVKDAVSGN----IMPTNVPEVRQSVALVRAQTEAENPIISWFGPIEYKPMTFSE 314 [Candida] gla...
XP_003675349   301 YLDRVEYHLEMFEYFLSKR-------AVNTLLWETIRP----SSIALEEVKNKNDQFKEKIHKKFlksqpslhqqhmnql 369
CCH58541       260 YLDQLEFHLDMLESFQKKNsv----nEASEHLRNQLAN----TDEEIQNFIKKNKENREKALKYVinssnvsfids---- 327
XP_003685903   269 FLDKLEYNLDIQDKIDDKKks----kLISKSIQRKLRH----TPDELHNLKVINEENRKKTLQLLdlnrgi--------- 331
EDO18959       345 FLDRLEFQLDMRVSLDNRRs-----tAVSKSFTSQFKH----TEEELDSLINNNEKNRQLTLEgklsppknn-------- 407
CAR23819       298 YLDRLEYHLEMTDFIRNGRnn----dAASQLLGRPLSH----GTAELEELIQKNRSSRKKIGNLM--------------- 354
Q751V6         249 FLDKLEHYLDTCDFIQDMN---------NKRLFGNPAEvk-aRQKALDALIQANKENRRRIRHIL--------------- 303 Eremothecium ...
ybcl:Ecym_1035 251 FLDKLEHNLDMYDILHHTN---------SKKIIDDTKHas-eRKAELEFLTEINRKNRERIRTLL--------------- 305
XP_002497981   250 YLDRMEYHLDIDALLHDKRtl----kENQQHLNTQITH----TEGELDSIVRHNQEVKERTKDLV--------------- 306
CCE91562       276 YLDKLEYHLEMIVFLQEDKka----kETAMEIMHKITY----SATEVEELGKKNVENRKKAYELV--------------- 332
CCD22190       296 YLDRLEYHLDMFDFFQKKR-------AANALLWNSITH----TTNDLEEIIRKNEAARKKICKKFeknkpsahqkhlqdl 364
P25573         261 YLNRMEFHLDMFEFFQNKRni----rENSIELINSISHnpqsSSTGLEGLSESKKLHLQNVEKRLhf------------- 323 Saccharomyces...
CCF57676       233 YLGRMEYYLHMMELLQSRKirnnddnNSTNMLLNIISY----SNDEIEKVIEKNKQTRDVIMSDLskeislqqdnsndae 308
Q6FX96         315 FLDRLEYHLDMFEYFQGKRaa----nETALGFLTGIKT-------ETSNLRDQNAQNRSRILKELksedql--------- 374 [Candida] gla...
XP_003675349   370 ---lpegsssektntesKHPTEHALPPAMg--------rRGIVFDE-SIKSPEDIDLKDIWSLYDPWMSLALDTSLSIKF 437
CCH58541       328 ------sdsqpnenseaDITERKKLRRSN----------RSIILGP-DKRNITDLDIPELWTMYNPWTSLALDTSLSIKF 390
XP_003685903   332 ------------gesdhQGQKSEHPP-------------RGIIMDD-ALTSPEEVDLGEMWYLYNPWMNLALDTSLSIKF 385
EDO18959       408 --------svpefdvikENTKDGTIPL------------RGIVFQH-EQTSPDDIDLEETWSLYNPWMNLALDTSLSIKF 466
CAR23819       355 -----------------ESAPRQSMPVVSgqrq---sslKGILLDP-NIQSSEDIDLDETWSAFNPWLDLALETSLSIKF 413
Q751V6         304 -----------------DITPPRGLPLSPkavd---qglRSIILDP-DHESTEDLDLHELWSIYNPWVDLALDTSLSIKF 362 Eremothecium ...
ybcl:Ecym_1035 306 -----------------DSTPSHSIPLSIklsd---qgiRGVTMDI-TYDSADDIDLREMWSLHNPWINLALDTSLSIKF 364
XP_002497981   307 -----------------KNAPEGSMALSSvasq--gfplRSVILEV-DPQDPDSMDLNEVWSLYDPWMNLALDTSLSIKF 366
CCE91562       333 -----------------TNAHKGSIPLSDkvqt---ypmRGVLMET-DNQSPEDFDLEEMWNLYDPWMNLALDTSLSIKF 391
CCD22190       365 lpdppltllpptpsadgEAASSQMLPPTLn--------rNSIVLDQ-SLQHSKEIDLKEFWRLHDPWMNLGLETSLSIKF 435
P25573         324 ---------------laSSGDSISAPVKKrsst---tlsRGVILPH-DTKGPQDIDLDTIRSLYDPWMTLALETSLSIKF 384 Saccharomyces...
CCF57676       309 eepglrqditksissmmEQKRKQKVEHSSnll----vppRNVILDPiQVKTSEDIDLNEIWSLYDPWMNLGLDTSLSIKF 384
Q6FX96         375 ------------sndlsIKTGNAKIPKGTqrhgfsaaanRSIILEE-DVAVPEDIDLNEIWTLYDPWLNLALETSLSIKF 441 [Candida] gla...
XP_003675349   438 IPTV 441
CCH58541       391 LPTV 394
XP_003685903   386 LPTV 389
EDO18959       467 LPTV 470
CAR23819       414 LPTV 417
Q751V6         363 LPTV 366 Eremothecium gossypii ATCC 10895
ybcl:Ecym_1035 365 LPTV 368
XP_002497981   367 LPTV 370
CCE91562       392 LPTV 395
CCD22190       436 IPTV 439
P25573         385 IPTT 388 Saccharomyces cerevisiae S288C
CCF57676       385 IPTV 388
Q6FX96         442 IPTV 445 [Candida] glabrata CBS 138
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