Conserved Protein Domain Family
asnS

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TIGR00457: asnS 
asparaginyl-tRNA synthetase
In a multiple sequence alignment of representative asparaginyl-tRNA synthetases (asnS), archaeal/eukaryotic type aspartyl-tRNA synthetases (aspS_arch), and bacterial type aspartyl-tRNA synthetases (aspS_bact), there is a striking similarity between asnS and aspS_arch in gap pattern and in sequence, and a striking divergence of aspS_bact. Consequently, a separate model was built for each of the three groups. This model, asnS, represents asparaginyl-tRNA synthetases from the three domains of life. Some species lack this enzyme and charge tRNA(asn) by misacylation with Asp, followed by transamidation of Asp to Asn. [Protein synthesis, tRNA aminoacylation]
Statistics
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Structure
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TIGR00457 is classified as a model that may span more than one domain.
TIGR00457 is the only member of the superfamily cl36660
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
O51128         2 FASIKDILK--NPILNSNVTINGWIRTKR-SNGKIGFIEINDGSTLKGIQAVINEE-ENQFsEKDLKKLTTGTSISLTGL 77  Borrelia burgdo...
P47359         3 SVTVKQLLQtpRKFNNKQIKLSGWVKNKR-ASANIIFLAISDGSSINTLQAVVKQE-DNPQvFSLLQTVNLASAVMVWGE 80  Mycoplasma geni...
P75521         3 ATAISDLFEkpAQFKNKKIKLTGWLKNKR-TSANIIFLEVNDGSTLLNLQAVVKQ--DQPElFALAESISLASAVSVSGT 79  Mycoplasma pneu...
P25345        16 SLTVKSLYEqvHHTSHDPISINGWIKSIR-LLKRIAFLDLQDGTSVNPLRIVIPLT--NTDeVQFLKILKTGQTLSISNA 92  Saccharomyces c...
P39772         1 ---MKTTINqvYKHVGEEVTIGAWVANKR-SSGKIAFLQLRDGT--GFIQGVVVKAeVEESiFQTAKSVTQETSLYIKGI 74  Bacillus subtil...
P38707       114 PAAIKTRIYdsYSKVGQRVKVSGWIHRLR-SNKKVIFVVLRDGS--GFIQCVLSG---DLAlAQQTLDLTLESTVTLYGT 187 Saccharomyces c...
WP_000117881   3 VVPVADVLQg-RVAVDSEVTVRGWVRTRRdSKAGISFLAVYDGSCFDPVQAVINNS-LPNY-NEDVLRLTTGCSVIVTGK 79  Enterobacteriaceae
WP_010869177   4 VASIVDVLQg-KVAIGETVTVRGWVRTRRdSKAGLSFLAVYDGSCFDPIQAIINND-IENY-ESEILRLTTGCSVIVTGK 80  Haemophilus inf...
WP_015390164  54 KRRIIEVLR--HGQADDQVMVQGWLRTKR-TLKDFSFVEVNDGSSLANLQVVLDGS-LADY-DRLLSQLQTGAALVVEGK 128 Synechocystis s...
O51128        78 LVE-SPAKG--QNYEIKTH----SFNVIGETDp--ETYPLQKKR-HSFEFLREIPHLRIRTNTFGAIARVRNKISYKIHE 147 Borrelia burgdo...
P47359        81 IIL-TPKAK--QPLELKLK----QVSLLAQAE---SDYPLQKKE-HSQEFFRSNAHLRVRAKTYFAVMKIRSVLSHAIFE 149 Mycoplasma geni...
P75521        80 VAL-TPKSK--QPLELVVK----QINVLSTAR---ADYPLQKKE-HSLEFFRNNAYLRVRARTYFAIMKVRSLLSQAIFD 148 Mycoplasma pneu...
P25345        93 TWQsTPNRK--QPFELQIKnpvkSIKLVGPVS---ENYPLQKKY-QTLRYLRSLPTLKYRTAYLSAILRLRSFVEFQFML 166 Saccharomyces c...
P39772        75 VKE-DERSP--LGYELAVT----DIEVIHEAT----DYPITPKE-HGTEFLMDHRHLWLRSKRQHAIMKIRNEIIRATYE 142 Bacillus subtil...
P38707       188 IVKlPEGKTapGGVELNVD----YYEVVGLAPggeDSFTNKIAEgSDPSLLLDQRHLALRGDALSAVMKVRAALLKSVRR 263 Saccharomyces c...
WP_000117881  80 VVA-SPGQG--QQFEIQAS----KVEVAGWVEd-pDTYPMAAKR-HSIEYLREVAHLRPRTNLIGAVARVRHTLAQALHR 150 Enterobacteriaceae
WP_010869177  81 VVE-SPAEG--QAVELQAE----KVEVTGFVEd-pDTYPMAAKR-HSIEYLREVAHLRPRTNIIGAVARVRHCLSQAIHR 151 Haemophilus inf...
WP_015390164 129 LAP-SPGKG--QRVELKAT----KLELLGGADp--GSYPLQKKR-HSFEFLRTIGHLRPRTNTIGAVMRVRNACATAIHQ 198 Synechocystis s...
O51128       148 YFQKNGFFYINTPIITSNDGEGAGEMFRVStlkfn--klnnaLsNid-fkDDFFGKEAFLSVTGQLHGEAYAMALSKIYT 224 Borrelia burgdo...
P47359       150 YFFKNDFILVQSPILTSNDCEGAGETFVIK------------D-S-----ETFFNKTTFLTVSGQFGAEAFAQAFKKVFT 211 Mycoplasma geni...
P75521       149 YFFKNDFVLVHSPILTSNDCEGAGETFELK------------Q-G-----KEFFNKTTYLTVSGQFGAECYAQAFKKVFT 210 Mycoplasma pneu...
P25345       167 YFQKNHFTKVSPPILTSNDCEGAGELFQVSt-------------NtsptaSSYFGKPTYLTVSTQLHLEILALSLSRCWT 233 Saccharomyces c...
P39772       143 FFNNEGFVKVDPPILTGSAPEGTTELFATK----------------------YFDEDAYLSQSGQLYMEAAAMALGKVFS 200 Bacillus subtil...
P38707       264 VYDEEHLTEVTPPCMVQTQVEGGSTLFKMN----------------------YYGEEAYLTQSSQLYLETCLASLGDVYT 321 Saccharomyces c...
WP_000117881 151 FFNEQGFFWVSTPLITASDTEGAGEMFRVStldlenlprndqG-Kvd-fdKDFFGKESFLTVSGQLNGETYACALSKIYT 228 Enterobacteriaceae
WP_010869177 152 FFHEQGFYWVATPLITASDTEGAGEMFRVStldlenlprsenG-Kvd-fsQDFFGKESFLTVSGQLNGETYACALSKIYT 229 Haemophilus inf...
WP_015390164 199 FFQERGFLWVHTPIITASDCEGAGDLFKVTtldlqr-vpkngE-Gid-ysQDFFGKQAYLTVSGQLEAEVMALAFQNVYT 275 Synechocystis s...
O51128       225 FGPTFRAENSNTTRHASEFWMIEPEMAFYK-LNDNIALAEDLLKYLLSSILNE----------CSQD---MDFLENYIEK 290 Borrelia burgdo...
P47359       212 FGPTFRAEKSHTNRHLSEFWMIEPEIAFAN-LKDLMQLIQNLIKFLIKKVMEN----------ASDE---LNVLAKQFSN 277 Mycoplasma geni...
P75521       211 FGPTFRAEKSHTSRHLSEFWMIEPEVAFAN-LKDLIKLIESTVKTVIKQVMQK----------AKQE---LDFLEKQFDV 276 Mycoplasma pneu...
P25345       234 LSPCFRAEKSDTPRHLSEFWMLEVEMCFVNsVNELTSFVETTIKHIIKACIDNqqellpkqfiSSQEnnaSSELSINQET 313 Saccharomyces c...
P39772       201 FGPTFRAEKSKTKRHLIEFWMIEPEMAFVE-FEENLQVQENYVSFIVQSVLKN----------CKIE---LNTLGRDTSK 266 Bacillus subtil...
P38707       322 IQESFRAEKSHTRRHLSEYTHIEAELAFLT-FDDLLQHIETLIVKSVQYVLEDp---------IAGPl--VKQLNPNFKA 389 Saccharomyces c...
WP_000117881 229 FGPTFRAENSNTSRHLAEFWMLEPEVAFAN-LNDIAGLAEAMLKYVFKAVLEE----------RADD---MKFFAERVDK 294 Enterobacteriaceae
WP_010869177 230 FGPTFRAENSNTTRHLAEFWMVEPEVAFAT-LADNAKLAEDMLKYVFRAVLAE----------RKDD---LQFFEKHVDK 295 Haemophilus inf...
WP_015390164 276 FGPTFRAENSNTSRHLAEFWMVEPEMAFCD-LEGDRQWAEEFLKYIFKFVLEK----------CPED---MEFFDQRIDN 341 Synechocystis s...
O51128       291 GLIKKLENVINS-NFEVITYTKAIEILENS----KKNFEIKPY-WGIDLQTDHERYLTEETFKK-PVVVIDYPKNFKAFY 363 Borrelia burgdo...
P47359       278 DIISNLKTIISTkKFPIIEYSKALAILKESsdtkKTNFELNDFsFGIDLKTEHERFLCEQYFQNqPLFVINYPKELKAFY 357 Mycoplasma geni...
P75521       277 KLMERLKQITSTkNFHVLEYTKALEILKTAqasgQANFEVQDFnFGLDLKTEHERFLCEQHFHNqPVFVINYPKDFKAFY 356 Mycoplasma pneu...
P25345       314 QQIKTRWEDLINeKWHNITYTNAIEILKKRhn-eVSHFKYEPK-WGQPLQTEHEKFLAGEYFKS-PVFVTDYPRLCKPFY 390 Saccharomyces c...
P39772       267 LEQIKAP-------FPRITYDEAIEFLKEK--------GFDDIeWGDDFGAPHETAIAEHYDKP--VFITRYPTSLKPFY 329 Bacillus subtil...
P38707       390 PKAP----------FMRLQYKDAITWLNEHdi--kNE-EGEDFkFGDDIAEAAERKMTDTIGVP--IFLTRFPVEIKSFY 454 Saccharomyces c...
WP_000117881 295 DAVSRLERFIEA-DFAQVDYTDAVTILENC----GRKFENPVY-WGVDLSSEHERYLAEEHFKA-PVVVKNYPKDIKAFY 367 Enterobacteriaceae
WP_010869177 296 DVITRLENFVNS-DFAQIDYTDAIDVLLKS----GKKFEFPVS-WGIDLSSEHERFLAEEYFKS-PVVVKNYPKDIKAFY 368 Haemophilus inf...
WP_015390164 342 TVLATADNIINN-EFAWLTYSEAIKLLEKA----DQKFEYPVA-WGVDLQSEHERYLAETVFKR-PTIVTDYPKDIKAFY 414 Synechocystis s...
O51128       364 MKAN-KDNKTVKGMDILVPK-IGEIIGGSEREDDLQKLENRIKELNLNIE-HLNWYLDLRRFGSAPHSGFGLGLERLVQY 440 Borrelia burgdo...
P47359       358 MKTN-TDNKTVAAVDLLLPK-IGEICGGSERESDLNQLKNRCQSLNIDTK-SLNWYLDMRKWGYFASAGFGLGFDRLLAY 434 Mycoplasma geni...
P75521       357 MKQN-ADGRTVGAVDLLFPQ-IGEICGGSEREGNLEKLVERCQAMQIDTQ-TLNWYLDMRKWGYFASAGFGLGFDRLLAY 433 Mycoplasma pneu...
P25345       391 MKQNsTPDDTVGCFDLLVPG-MGEIIGGSLREDDYDKLCREMKARGMNRSgELDWYVSLRKEGSAPHGGFGLGFERFISY 469 Saccharomyces c...
P39772       330 MQPAsDREDVVLCADLIAPEgYGEIIGGSERIHDMELLESRLKEHGLDSD-AYKWYAELRKYGSVPHSGFGLGLERTVAW 408 Bacillus subtil...
P38707       455 MKRCsDDPRVTESVDVLMPN-VGEITGGSMRIDDMDELMAGFKREGIDTD-AYYWFIDQRKYGTCPHGGYGIGTERILAW 532 Saccharomyces c...
WP_000117881 368 MRLN-EDGKTVAAMDVLAPG-IGEIIGGSQREERLDVLDERMLEMGLNKE-DYWWYRDLRRYGTVPHSGFGLGFERLIAY 444 Enterobacteriaceae
WP_010869177 369 MRLN-DDEKTVAAMDVLAPG-IGEIIGGSQREERLEVLDKRMEEMGLNPD-DYWWYRDLRKYGSVPHSGFGLGFERLIVY 445 Haemophilus inf...
WP_015390164 415 MRLN-DDGKTVAAMDILAPK-IGEIIGGSQREERLDILTQRMQEQGVPEE-DLWWYLDLRRYGSVPHAGFGLGFERIVQF 491 Synechocystis s...
O51128       441 STGISNIRDSIPFPRT-PKNLYF 462 Borrelia burgdorferi B31
P47359       435 ICGLENIRDAIPFPRV-HGTINF 456 Mycoplasma genitalium G37
P75521       434 ICGLENIRDAIPFPRA-HGSINY 455 Mycoplasma pneumoniae M129
P25345       470 LYGNHNIKDAIPFYRTsAESIDF 492 Saccharomyces cerevisiae S288c
P39772       409 ISGAPHVRETIPFPRL-LNRLYP 430 Bacillus subtilis subsp. subtilis str. 168
P38707       533 LCDRFTVRDCSLYPRF-SGRCKP 554 Saccharomyces cerevisiae S288c
WP_000117881 445 VTGVQNVRDVIPFPRT-PRNASF 466 Enterobacteriaceae
WP_010869177 446 VTGVQNIRDVIPFPRA-PRNANF 467 Haemophilus influenzae
WP_015390164 492 MTGMANIRDVIPFPRT-PMNAEF 513 Synechocystis sp. PCC 6803
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