Conserved Protein Domain Family
ART10-like
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cd22952: ART10-like 
Arrestin-related trafficking adapter 10 and similar proteins
Arrestin-related trafficking adaptors (ARTs) function by targeting specific plasma membrane proteins to the endocytic system. They contain multiple PY motifs that are required for recruitment of Rsp5/Nedd4-like ubiquitin ligase which modifies the cargoes. It has been proposed that ARTs remodel the cell surface in response to environmental cues and may serve as part of a quality-control system at the plasma membrane, targeting damaged and misfolded membrane proteins for ubiquitination and subsequent degradation in the lysosome/vacuole. The specific target protein for ART10 is not yet known.
Links
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Statistics
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PSSM-Id: 438568
Aligned: 222 rows
Threshold Bit Score: 83.1833
Created: 21-Apr-2021
Updated: 17-Oct-2022
Structure
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Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
A7A1R7         6 SISLNPPYNGEFYSSNDQMSGivSLQLTKALSIRKISVILKGFSETLTKIDQeymfqqng--mmmpgqdnKSFHTLMKFE 83  Saccharomyces c...
XP_028889391   2 SNLRIELDHDKVYTTGDIVSGkiHLTVDEKVDLTSIEISLYGESRSRNRVHSgqly-----------mtkLEKHTLLELV 70  [Candida] auris
XP_024716342   2 TEFTIELDHQKVYTSGDIVSGrvHLAVDEKVDLSAIDVTLFGYSKSRNKVHSgqgy-----------vtkQEKHLLFKEE 70  [Candida] pseud...
XP_028892387   2 TNLKLEIDHDKVYTTGDIVSGkvHLTVDDKVDLTSIDVTLYGQSRSRNKVHTgqgy-----------vtkLEKHTLLELV 70  [Candida] auris
XP_020049679  16 ERPADSTYNSNVYTNNDSLSGtiVLTVAKPIRISTLEVSFVGHAAVALSEFIttnnnsnnivlsgpanmiNYDNNFLNEN 95  Ascoidea rubesc...
XP_025344399   6 EFKIKLDSPGKQFRPGDAVTGkvDLQVIKSITVRDINVTLRGVAESANYTYVtnynavtrr-herrkmtnSITYHFFAYG 84  [Candida] haemu...
XP_028892412   4 NSLFLHITNPQLYTSGSKVEGiaQVLVKDRLNLEAVEVELFGLAKSKNYQYNngvr-----------isgQESHKLLHIT 72  [Candida] auris
XP_025334493   6 QFQIQLENPNRQFHPGDTVRGnvALEVHKSMTVRDITVSLSGQCKSANYKYVtqynaftkr-yeqrkvsnSIGFNLFGFS 84  [Candida] duobu...
XP_028888963   6 DFKIALNHPNRQFRPGEAVTGnvVLKVEKSMTVKEIYVELSGELESCNYKYMhqynyatkr-hesrrisnTIKYDLFRYG 84  [Candida] auris
KND99274       6 SFKLIPDNPPVPFGPGDKVIGnvELEVFKQMTVKEIVVSLSGNTESCNYKIEtrynpvtkr-tetraiseKIRYHLFDHT 84  [Candida] auris

A7A1R7        84 QRVFPPdnvwnal------------------------dgsskpFKVKPGSYNYSFQFdkf--prKPECLKNHTAKTVAFv 137 Saccharomyces c...
XP_028889391  71 STVFPPpeiqsi--------------------------ssndqYTLTEGEYTYPFAFtfpdkshDADCEVEKRFFHSRG- 123 [Candida] auris
XP_024716342  71 TTLFPPpdiqav--------------------------sktesYTLTEGSYSYNFTFtfpgkehKADCKVDKKFFHSHG- 123 [Candida] pseud...
XP_028892387  71 TTVFPPpdiqsi--------------------------stkgqYTLTEGEYTYPFAFtfpdkshEADCKVEKKFFHSRG- 123 [Candida] auris
XP_020049679  96 IILFPPndmrsalsvtnaeskesescpgtpetinfidnnkkydFTLNPGTYNYPFSFkip--vkINSIPNELLQYRSTFl 173 Ascoidea rubesc...
XP_025344399  85 VKVFPPpnlqqh--------------------------gsageYTLAEGQYSYPFELsfpsgpvEAKSSSHFDVSRTYMs 138 [Candida] haemu...
XP_028892412  73 NKVFPPphvrnv--------------------------amsksYTLTSGRYNYPFEFvfpgkehVIQCVKDKRILHKRE- 125 [Candida] auris
XP_025334493  85 TKVFPPpnlqqh--------------------------gqaeeYTLAEGKYNYPFELa-----fPNGTVEAKAMSHFDVs 133 [Candida] duobu...
XP_028888963  85 VKVFPPpniqqf--------------------------gsagdYTLAEGSYTYPFELefpegpvEARTYSQFEVGNSYMs 138 [Candida] auris
KND99274      85 VKVFPPpnvqkm--------------------------gcaddYTLLEGTYKYPFEVvfpsgsvEARMSSSFGTSNYARs 138 [Candida] auris

A7A1R7       138 tr------------snaRLPPTFNSHWQefnKIDNLDLYFYSFGKVIYMVQVQIElgkSSSWFKPFHKLIREIETf---- 201 Saccharomyces c...
XP_028889391 124 -----------------YTRRDDIKHVSl-aPTYSYKWSFDEYCRVEYSVSVTVH---NPSFFKFDTKVSEIIKF----- 177 [Candida] auris
XP_024716342 124 -----------------YTKKEHLDSVAl-aPTYFNKTSFDNYCKIEYYLEAVVR---NPSIFRFNSKATKDLMF----- 177 [Candida] pseud...
XP_028892387 124 -----------------FTRRENIESVAl-aPTYSYKWSFDEYCRVEYSVNVAIH---NPSFFKFDTKVSEIIKF----- 177 [Candida] auris
XP_020049679 174 tld----------teysTVNDNDMFHYL---PPSFIYTTDDSFIKILYYLKVVLK---RASIFKLNNKIYKPIRFrpknl 237 Ascoidea rubesc...
XP_025344399 139 tpsmfmp---pwanrgsGSASSMTISLP---PAFRMYRDYDDHAIVDYVLEAHAD---RKGFLKSDFSDKQLLRF----- 204 [Candida] haemu...
XP_028892412 126 -----------------YLWNERRYHATl-pGSFFDGVNLGDYCFVQYSVKARVK---TASSFRFNIKQSVPIYF----- 179 [Candida] auris
XP_025334493 134 ssyvgnsflygpnlprrGTQNMGPVTVSl-pPSFNMTQASDDYAIVQYNVDARAD---RKGWFKSDVFDRQQLRF----- 204 [Candida] duobu...
XP_028888963 139 tplmfi-----ppqlasGSSGSTLMSLP---PSFSMYTDDDNHAYVNYVVEATVD---RKGFLKSDFGCRKALNF----- 202 [Candida] auris
KND99274     139 lgsl--------spfrvGGAGQALTKLP---PSFNAHFEDRDYAWVHYTLDGKVG---RKGFFKPDIVESTRLSY----- 199 [Candida] auris

A7A1R7       202 -EFIPEPKDLIiepdeddneelnafsnnsrgnsmvtnneffnssnlkvpskdvkvvngvgyiksdRNFSQANSILIENGD 280 Saccharomyces c...
XP_028889391 178 -YPQNEDLTFSskhlldngqlkpd-----------------------------fdsctkdlkylpDGTMKVEGFFTKLFS 227 [Candida] auris
XP_024716342 178 -HPANQDMTYSvnhimdkksiled-----------------------------yeicekklkyasDGKLKEDGFFNRLFL 227 [Candida] pseud...
XP_028892387 178 -YPQNEDLTFStkhlsdkwalkpd-----------------------------fdscvkdlkylpDGTMKVEGFFTRLFS 227 [Candida] auris
XP_020049679 238 fLNYEFPCPETsiskfyf-----------------------------------------lnlskyLPKDHDRKIFHINEY 276 Ascoidea rubesc...
XP_025344399 205 -SPNLDSVMFSfapitqngvfipny---------------------------fqgasrlkfeigkSKRHEGKSFFKRVFS 256 [Candida] haemu...
XP_028892412 180 -APRNSDSFFSllslcdasskdllp--------------------------deshackkvkyaidSDLKKNKSFLRSLFS 232 [Candida] auris
XP_025334493 205 -SPRLDSVMFSfgplmssqgvstnnssf--------------------iannstgnarlkfdiekSKRSEGRSFLRRVFT 263 [Candida] duobu...
XP_028888963 203 -APHLEQVMFSlgplmdrnsfmnnf---------------------------gmgnstlrieiskNKRREGKSFFKKVFS 254 [Candida] auris
KND99274     200 -SPSLEEVVCSfgslmqngsfidnv---------------------------srgntrlkfkiekDKRQEGRGFFRKMFS 251 [Candida] auris

A7A1R7       281 IRSRPVSSvtstrqstrlvngmkvfpstykmglpdgesnmrIEVRSRDLKQIYRKDylfr--sgsQNFDKVYVVMEGNia 358 Saccharomyces c...
XP_028889391 228 PSGMELPLelkvsfigdev------------dtpegttkrvVKSNNNLSNYIRLSL---------QTPISGRVLREVAgd 286 [Candida] auris
XP_024716342 228 SEGTIVPLsl------------------------------dVEFKEGVETPVGPSKrvv----ktNGHISDFILVSLWtp 273 [Candida] pseud...
XP_028892387 228 SSGIELPMelmvnfigdev------------dtpegktkrvIKSNNKLSRYVHLSL---------QTPISGGTLRDLAgd 286 [Candida] auris
XP_020049679 277 ISSIHDSAlln----------------------------psFNLQIKFTNNLNSRIfkhf--dplNNNFKVNLLFKISnq 326 Ascoidea rubesc...
XP_025344399 257 SRSLKVPFeiv----------------------------geFKQRNAVSYPQGQTSrvlhqgdnlADVLDLRIYTPFSkd 308 [Candida] haemu...
XP_028892412 233 SNAVEVPFdlnvrfkevip-----------ietekgttnrvLQAGSRLSRFVDLDL---------STSFSYSNLMDALgm 292 [Candida] auris
XP_025334493 264 SRSVKIPLelm----------------------------veFKQSNTVAYPQGTTGrvlhqgdnlADIVSLKLFTAFSse 315 [Candida] duobu...
XP_028888963 255 SRHLKVPFelvvefkrsnavqyp---rgqtcrvlhqndnlaDVVNVRLYTPFSKDA---------LQQILIGEVTKKGes 322 [Candida] auris
KND99274     252 SRSVKVPFeav----------------------------veFKQGNAVQYPQGQTSrvlhqgdilKDVIGVKILTIFSae 303 [Candida] auris

A7A1R7       359 -----------------sLSKMQITPLKLQLNLLETTTYLS---QGIANGNYSSLKLieidLNQLKSNKPLLDLNEiren 418 Saccharomyces c...
XP_028889391 287 dnvp---------kgegpRDSFKIRISGVKVRLLSRIRYLS---VKTSRKTHKYDLL----DKALDNEVSFCDFEPvaqe 350 [Candida] auris
XP_024716342 274 sigqsr-----eskkegeNGRLTLRISSIKIKLILRVRYYA---VKHSRRTNKYVLL----DKALDNEISLSDFEPaedn 341 [Candida] pseud...
XP_028892387 287 nnva---------kgdrpSDSFKIRISGVKVKLLSRIRYLA---VKQSRKTHKYEFL----NKALDNEVSFTDFEPvpqe 350 [Candida] auris
XP_020049679 327 lidtfktyglidikndyyLSFKNLFINAIKINLISVTTLKV---KYVKQSRNASVPI----YSNDHLNLPLTNMFKiytq 399 Ascoidea rubesc...
XP_025344399 309 alqri------ligeegkKSGPVAPLSNLLIKEISVTLGRDiyyQGIEEQRTKNEVSv--gKQAFKNEFELSDFEEvdyr 380 [Candida] haemu...
XP_028892412 293 nkl----------dkrgsVPPPAIKFTHIEIKLLSTVRYQG---TRESVLESSFVLR----KHPLELQVDLSDFEKveny 355 [Candida] auris
XP_025334493 316 alqrm------liggdgkKNVPSAPLSNLKVKKIAVSLVHLvyyQGIEPKVQARENLv--gKQSFQNEFEISDFEEveyw 387 [Candida] duobu...
XP_028888963 323 -----------------aNSLCRVVIKELAVSLAQDIRYQG---VEEQRCRRDVRVG----TKSYKHEFDFSDFEQveyw 378 [Candida] auris
KND99274     304 alkqilf---feqgekksNSKRMHRLVFKEMTLSIIQNITY---QGIHTQTKSKQVL----IGQRSLNSEFEFADFevve 373 [Candida] auris

A7A1R7       419 fdgsmfe---------celrlkdhpiLRKLVFNEEDYRHRGnr------lYSFKTCTIKRIFSLQLLIEWGINGirkqs- 482 Saccharomyces c...
XP_028889391 351 kcssr------------ltkkelyglDLDPEWFDCNIADKG---------QSFVTCNIKRDFHLEISVMVASTTdlssev 409 [Candida] auris
XP_024716342 342 arsg---------------vkgmfkfELDPLWYDCDVTDVG---------QSFITCNVKRDFELQVALGVASSEdi---- 393 [Candida] pseud...
XP_028892387 351 kgssi------------lrkkelyklDLDPSWFDCDITDVG---------QSFVTCNIKRDFHLEISVMIAASEdlsnel 409 [Candida] auris
XP_020049679 400 ngdsstnpedsldpssftnsnvfkfeIPNHFFENEIINCQI---------PSFLANDVQRKYKLMVAVDISNLEdl---- 466 Ascoidea rubesc...
XP_025344399 381 gsdifs-----------kikqdyaehYQSGKAYMLEIPPQMyafllscdaQSFSAPNISCDVSLKLNFSLTTTEenpsma 449 [Candida] haemu...
XP_028892412 356 spllsk-----------kspskysekLDENVCYRLSLDRSWwdcyvsdigQTFMLCNIHKTARLYICLRIASAGnpaker 424 [Candida] auris
XP_025334493 388 sqdlvr-----------kvkqdysvyFETGKAFMLEIPPEMtsfilhsdfQSFAAPNISVDYQLRISMSVSTTDespnsa 456 [Candida] duobu...
XP_028888963 379 gaslyqnvk----qehasfaesgkayMLEIPPEMLSMPLNSv-------vQSFTAPNISCDVYLKLSMVLATTEetqnrt 447 [Candida] auris
KND99274     374 gqwsqtl--------inkvkqehlhlTESNKAYMLELPQELlsieltteaQSFDAPNIQCDSVLKIDFVISTSEespnst 445 [Candida] auris

A7A1R7       483 ----------------------------evnidPVQIFCQVREhv----------------------------------- 499 Saccharomyces c...
XP_028889391 410 ---------------------------kfrvecPIILKKGFVSseld--------------------------------- 429 [Candida] auris
XP_024716342 394 --------------------------------tNEVVLKAVGPiilqkl------------------------------- 410 [Candida] pseud...
XP_028892387 410 ---------------------------klkvecPIVLQKGFAS------------------------------------- 425 [Candida] auris
XP_020049679 467 --------------------------------sDYKIYKNKPMsdlsqcfilkylcvgsdivlinnepnsiysteeihdl 514 Ascoidea rubesc...
XP_025344399 450 riicetpivflpgrvntggsdsfvppggpppavNGELSTPLGPpp----------------------------------- 494 [Candida] haemu...
XP_028892412 425 ---------------------------kientsPIVFYRQEGPdapl--------------------------------- 444 [Candida] auris
XP_025334493 457 elvctap--------------ivflpnrvdgasSIEYHPPPNPpletsilq----------------------------p 494 [Candida] duobu...
XP_028888963 448 rifldtpi------------aflpsrnanytsmTVEPPAGPPPntssvpps----------------------------q 487 [Candida] auris
KND99274     446 tlsc-------------------qcpilllpsrNRRTHDVLNPprm---------------------------------- 472 [Candida] auris

A7A1R7       500 ------eAEALPRYVPPPTYT 514 Saccharomyces cerevisiae YJM789
XP_028889391 430 ---ndtgKASFGYGVAPPEYG 447 [Candida] auris
XP_024716342 411 --edvelNRPDGYGNPPPEYG 429 [Candida] pseudohaemulonii
XP_028892387 426 -------ESDDETEKPPPGYG 439 [Candida] auris
XP_020049679 515 ynrlniqTHYQNDDDYLPSYD 535 Ascoidea rubescens DSM 1968
XP_025344399 495 ------sGSEIPEAEELPSYS 509 [Candida] haemuloni
XP_028892412 445 ---cnqvEHLPRYMPAPADYD 462 [Candida] auris
XP_025334493 495 pgaagpdQGGEAKEEELPAYS 515 [Candida] duobushaemulonis
XP_028888963 488 paglapaYDKDLCSDTLPSYT 508 [Candida] auris
KND99274     473 ----pptTVIEHTEEQLPSYN 489 [Candida] auris
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