Conserved Protein Domain Family
DUF4050

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pfam13259: DUF4050 
Protein of unknown function (DUF4050)
This family of proteins is functionally uncharacterized. This family of proteins is found in eukaryotes. Proteins in this family are typically between 109 and 173 amino acids in length. There are two conserved sequence motifs: IPL and FLVD.
Statistics
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PSSM-Id: 463820
Aligned: 84 rows
Threshold Bit Score: 86.9519
Created: 25-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
EPE07745     198 SPFRFD---------SPDA--VGGAAAKNATp---dERKAKARRDVRAEMAWNDGLACFNARRDAWT-------GAQTVR 256
XP_002308983  62 STCDLDnst----vqSQRS--ISSISLPNKNp---aSSTGGMS---SNSEFVNHGLLLWQLSRLQWI-------GSGTSG 122
XP_002524505  62 STCDLEnsa----iqSQRS--VSSISVSNANl---cIGTSGTS---STSEFVNQGFLLWQQSRLQWT-------GNNNSR 122
EES00224      83 TTIEVEp-------aDLRG--VSPMSTSNWAf---dQHGTGSSH--NLPGLGNNGLILWEQTRQEWT-------EIRSLR 141
XP_011272001 173 EENQLNiin----esSYEN--FDSVL----------EAKKLHKELGEDKPFIN-GEDIWQKRRNAWL-------YSNNEL 228
EMG50606     213 VYNDIDiielrkefeTWVN--NTNTLSDSDSkstllSST-------------NIGTNLWEYRRSKWLnntnpisISNNEE 277
EER34605     216 LFHDIDiielrkefeTWVN--SKST-TDTDSkstllSQS-------------NIGSNLWEYRRSKWL-------QCDDPN 272
XP_004197649 164 SFQDLDvcelrelwdAYVA--QGAPETDDSKvailkDELPSLESIDTN----NIGEKLWELRRSKWL-------AKDADS 230
ABN66603     219 NFRDLDlcklkqefeIHAK--NESPAM---------DSGSSRTTLHMNLQIDNIGTSLWEYRRSKWL-------ANDDPQ 280
Q6BS68       190 sYHDVDickmredlsLLLKqiVSSESIADTSkstlrERGSQI----------NLGEMLWEYRRSKWL-------ITNPEG 252 Debaryomyces ha...
EPE07745     257 VK--PAKP---IvssspssprrslfrfhshsksqqvatpavsipatiasstatvSspapvlplspvmsnsrhsqysqqsh 331
XP_002308983 123 NQ--NQRRqe---------------------------------------------------------------------- 130
XP_002524505 123 GK--THYRle---------------------------------------------------------------------- 130
EES00224     142 PK--VKQVre---------------------------------------------------------------------- 149
XP_011272001 229 KS--KAKQrslDn-----------------------------------------S------------------------- 240
EMG50606     278 KL--KKRLre---------------------------------------------------------------------- 285
EER34605     273 KL--NNRLkq---------------------------------------------------------------------- 280
XP_004197649 231 DKklEHRIee---------------------------------------------------------------------- 240
ABN66603     281 KV--EKRLrk---------------------------------------------------------------------- 288
Q6BS68       253 ELraEEHLrq---------------------------------------------------------------------- 262 Debaryomyces ha...
EPE07745     332 qtqqsrnsqqsagldtvattpitsddgaegvdgaggallhlaisntapikptrsratqgssrrissnqpgfvqhpeyave 411
XP_002308983     --------------------------------------------------------------------------------    
XP_002524505     --------------------------------------------------------------------------------    
EES00224         --------------------------------------------------------------------------------    
XP_011272001     --------------------------------------------------------------------------------    
EMG50606         --------------------------------------------------------------------------------    
EER34605         --------------------------------------------------------------------------------    
XP_004197649     --------------------------------------------------------------------------------    
ABN66603         --------------------------------------------------------------------------------    
Q6BS68           --------------------------------------------------------------------------------     Debaryomyces ha...
EPE07745     412 tlvpvshpllppnnpMRQSITPALYLSLYDKLVTGLTPPS--CPINLSDMIRSCVAGWKRDNEWP 474
XP_002308983 131 --------------------sRLSWNATYEGLLGSRNPFP--KPIPLSEMVNFLVDVWEQEGLYD 173
XP_002524505 131 --------------------hRLSWNATYEGLLGSRNPFR--RPIPLSEMVDFLVDIWEQEGLYD 173
EES00224     150 --------------------pVLSWNAAYESLLGSNKPFP--QPIPLHEMVDFLVDIWEQEGLYD 192
XP_011272001 241 ----------------LVGISKDNYPIIYNSLIEKQKTLK--KPMNLKDALKVINAGWIASKKWE 287
EMG50606     286 --------------tSISYIPKESYIKIYSSLIDKNKVLRndKHINLSDLIKIMNIGWIAEDKWE 336
EER34605     281 --------------tSISYIPKDSYVQIYSSLIDKNKTLKndKHINLSDLLKIINAGWIAEDKWE 331
XP_004197649 241 --------------mSISHIPRESYARIYCNLVDKEKPLKggRRLNLADLIQVINAGWIAEERWE 291
ABN66603     289 --------------sSISHIPRDLYVKIYNNLVDKGRLLKneKRINLEDLVKIINAGWIAEEKWE 339
Q6BS68       263 --------------lSIAHIPKNSYVRIYNNLVDKGRLLKddKRINLSDLIKVINAGWIAEERWD 313 Debaryomyces hansenii
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