Conserved Protein Domain Family
apgM

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TIGR00306: apgM 
phosphoglycerate mutase (2,3-diphosphoglycerate-independent), archaeal form
Experimentally characterized in archaea as 2,3-bisphosphoglycerate-independent phosphoglycerate mutase. This model describes a set of proteins in the Archaea (two each in Methanococcus jannaschii, Methanobacterium thermoautotrophicum, and Archaeoglobus fulgidus) and in Aquifex aeolicus (1 member). [Energy metabolism, Glycolysis/gluconeogenesis]
Statistics
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PSSM-Id: 273005
Aligned: 7 rows
Threshold Bit Score: 410.322
Created: 7-Oct-2014
Updated: 25-Oct-2021
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Q59007     7 VIFIIDGLGDRPNEK--GLTPLKEAKTPTMDKIAKEGICGLMNAIDIGIRPGSDTAHLAILGYNPYEVYTGRGPLEAFGV 84  Methanocaldococcus ...
O27628     4 VIMIIDGMADRPLEKlsGRTPLEAASTPNMDRIAESGINGIMDPIKPGVRAGSDTSHLSILGYDPYRVYTGRGPFEAAGV 83  Methanothermobacter...
O28523     4 LLIVVDGLSDRPIDG---KTPLSVARKPNLDRLAEMGINGIMDTIAPGIRPGSDTSHLALLGYDPYKYYSGRGPIEAAGV 80  Archaeoglobus fulgi...
O26518     7 VILVGDGMADYPLDEldGKTPLQVADKPNMDQLAGMGACGLLRTVPEGMEAGSDVANLSIMGYDPRRYYTGRGPLEAASI 86  Methanothermobacter...
O28847     4 LLLIPDGMADWEVEEldGRTPLEVAETENMDFLAKEGACGIAKTVPDGFEPGSDVANLTILGVDVRKHYTGRGPIEALAR 83  Archaeoglobus fulgi...
Q60326     4 ILILLDGLGDRASEIlnNKTPLQFAKTPNLDRLAENGMCGLMTTYKEGIPLGTEVAHFLLWGYS-LEEFPGRGVIEALGE 82  Methanocaldococcus ...
BAA93685   1 -------mallgydpvthytgrgpleglgMDFWQPDGYSVAFRVNFASWDP--DTGRLDRRTSRDLEEDDQTALVEEITA 71  Streptomyces hygros...
Q59007    85 GLDLKEGDIAFRCNFATVD-----ENFVVLDRRAGRISpEEAEELEKEIDGLEIDGv---KVIFKSSKGYRGALVLRGEG 156 Methanocaldococcus ...
O27628    84 GLDVKPGDIAFRCNFATAD-----EDMIITDRRAGRIR-SGTSSIARTINSMTIEGfedvEIIFRESTGHRAVLVLRGPG 157 Methanothermobacter...
O28523    81 GIEIKPGDVAFRANFATVEgegsiFDKTVVDRRAGRIE--DTSELIKALREIELPV----ELLVERGTGHRAAVVFRGEG 154 Archaeoglobus fulgi...
O26518    87 GVELGDDDVAFRCNLIN-------ADERIVDFNAGHIEtAEASSLIDALN-HELET----RGRFYAGVSYRNLFVIEGR- 153 Methanothermobacter...
O28847    84 GVKG---KLVFRCNLVKV------EDGVMVDYSGGRISdEEARKVIEELNRAKPYD----FVKFYAGKSYRNLLVINKD- 149 Archaeoglobus fulgi...
Q60326    83 DIEIEKNAIYLRASLGFVKkd--eKGFLVIDRRTKDISrEEIEKLVDSLP-TCVDGy--kFELFYSFDVHFILKIKERNG 157 Methanocaldococcus ...
BAA93685  72 QVTLG-DDVAFRLTGFG-------RHRGILALTSGTVP---------------LSG-------Q--VTNTDPGFVSRGP- 118 Streptomyces hygros...
Q59007   157 -LSCRVSDGDP--HEE-GVKVSEIKPLDDSE----EAKRTAEILNKLLKIVYEKLNNHPINEERRKKGLPPANIILPRGA 228 Methanocaldococcus ...
O27628   158 -LGDKVSDADP--KVE-GKPPKKIKALDGSP----ESRKTAEVLNRIVKESYEILRDHPVNTGRIERGEAPANIILPRGA 229 Methanothermobacter...
O28523   155 -LSDRVSDTDP--KAV-GKKVKRCVPLADDA----KAKKTAEIVNEFMQKAHEVLENHPLNRERAEKGLLKANALLLRGA 226 Archaeoglobus fulgi...
O26518   154 -GYTSVRVEPP--HDIvGESVAAHLPS-GSE----E----ADHIRELMLESAGVLRSHEVNLKRESMGKRPATMIWLWGQ 221 Methanothermobacter...
O28847   150 -FRDDVKTFPP--HDItGKEIDKHLPS-GGE----L----AELLKELMGWSAEILP--EITDK--------ANMIWPWGG 207 Archaeoglobus fulgi...
Q60326   158 wISDKISDSDPfyKNRyVMKVKAIRELCKSEveysKAKDTARALNKYLLNVYKILQNHKINRKRRKLEKMPANFLLTKWA 237 Methanocaldococcus ...
BAA93685 119 ---FGVPVNTP------AATPATCTPFAEDP----AAAATARLVNQFVRASADVMQ-RRRSTSAAGPPAGPANLLLVRDA 184 Streptomyces hygros...
Q59007   229 GV-VPKIEKFSEKYNMKGACICGTGLIKGMAKMIGLDVIEVEGATGTPKTNFMGKAKALVEALK-EYDFVLVNVKGADEA 306 Methanocaldococcus ...
O27628   230 GA-VPHVEKFQERYDLKAACIAETGLIKGIGHLTGMDVIDVEGATGGIDTDLESIKNAISSAIAaDYDFLLINIDGADEA 308 Methanothermobacter...
O28523   227 GE-MPHVPSFKDKTGLRLCVIAATALIKGVGRVVGADVITPEGATGNKNTNLEAKVKAAINALE-SYDVVLLHIKATDEL 304 Archaeoglobus fulgi...
O26518   222 GL-RPSMEPFSERYGIRGATITAVDLIKGLGVYAGLENIHVPGATGYLDTDYRAKGRYAAGALE-EYDFLYVHVEAPDEA 299 Methanothermobacter...
O28847   208 GR-MPSFPNFGQRYGLRGAMITEVDLLEGIARGMGMEVVQVEGITGYIDTNYRGLVRETARALE-EHDFVVLHTEGIDEV 285 Archaeoglobus fulgi...
Q60326   238 SR-YKRVESFKEKWGMNAVILAESSLFKGLAKFLGMDFIKIESFEEGID---------LIPELD--YDFIHLHTKETDEA 305 Methanocaldococcus ...
BAA93685 185 GDtLPRLPGFTERTGLSLSMYGQVPAERGLARLIGARFTRSRPARGQSEPDYYRQVLPQLLADP--ADVVFVHLKGPDEP 262 Streptomyces hygros...
Q59007   307 SHDGNYELKKEVLEKIDEMLAyv-feHINKDE-VYFVLTGDHSTP-IEMKDHSADPIPIVIWGKSVRVDDVTEFNEFACA 383 Methanocaldococcus ...
O27628   309 GHDGDLEGKVRFIERVDSILG-----DLMGDD-IYFILTADHSTP-VSVMDHTGDPVPIAITGPEVRVDDVTSFSERAAA 381 Methanothermobacter...
O28523   305 GHDGDFEGKKAFIEKLDEKIApl--lDLDFSK-TCLILTADHSTP-IKVKDHTADPVPVVIVHEDVRRDEVSSFSEFEAY 380 Archaeoglobus fulgi...
O26518   300 GHAGDAEEKIRAIENIDRFVLgrlldALSDHE-HRIAVLPDHPTP-IEIRTHVPDPVPCILAGDGVDADQVKSYDEFTVR 377 Methanothermobacter...
O28847   286 GHEGDAELKVRAIELYDSKIVgkllnKVDLDE-TRILLLPDHPTP-VKVKTHVAEPVPFTLYGRGR--DEVKVYTEKSCR 361 Archaeoglobus fulgi...
Q60326   306 AHTKNPLNKVKVIEKIDKLIG-----NLKLREdDLLIITADHSTPsVGNLIHSGESVPILFYGKNVRVDNVKEFNEISCS 380 Methanocaldococcus ...
BAA93685 263 GHDGRPHDKVRAIEEIDAHFVgpladALTPAD--TLVVTCDHATP-CELGIHSPDPVPAVAVGPGVAADRVTGFGEKAAL 339 Streptomyces hygros...
Q59007   384 KGALHWIKGEHVMKILLD 401 Methanocaldococcus jannaschii DSM 2661
O27628   382 AGGLCRIRGSDVMDILLD 399 Methanothermobacter thermautotrophicus str. Delta H
O28523   381 KGGLCRIRGMDLLNIALD 398 Archaeoglobus fulgidus DSM 4304
O26518   378 EGSLGTWEAHRLMEIMMD 395 Methanothermobacter thermautotrophicus str. Delta H
O28847   362 RGKFGLVDGLRLMDLLIK 379 Archaeoglobus fulgidus DSM 4304
Q60326   381 NGHL-RIRGEELMHLILN 397 Methanocaldococcus jannaschii DSM 2661
BAA93685 340 GGALGADRAGDLLAALLH 357 Streptomyces hygroscopicus
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