Conserved Protein Domain Family
PAP2_Aur1_like

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cd03386: PAP2_Aur1_like 
PAP2_like proteins, Aur1_like subfamily. Yeast Aur1p or Ipc1p is necessary for the addition of inositol phosphate to ceramide, an essential step in yeast sphingolipid synthesis, and is the target of several antifungal compounds such as aureobasidin.
Statistics
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PSSM-Id: 239481
Aligned: 58 rows
Threshold Bit Score: 76.5822
Created: 29-Dec-2005
Updated: 2-Oct-2020
Structure
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Aligned Rows:
 
active site
Feature 1:active site [active site]
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                                                                                       
P36107      122 PAVETILYGDNLsdilatst---------------------nsfldilaWLPYGLFHFGAPFvvaai-lfvfgPPTVLQG 179 baker's yeast
ZP_00563632  76 YADVMVMIEGNAvtyiqafa---------------------npwltyfsAFIYMIGFSVLLIgtfli-flykkDAKGLQE 133 Methanococcoides...
ABB13875     77 YSYFIAKIEAPLiiklqsfq---------------------pawlvfllSYVYVFLFPVLFAailyy--glinDQKTLIA 133 Carboxydothermus...
ABA90016     26 SLLFILVYGGCSwitaqrsgigtlv-----------fgwersipfipamIVPYMSIDLLFVGapflc-sdiaeRRLLAKR 93  Pelobacter carbi...
AAZ70944     80 YDRYMLMLEGTKvsifqsian--------------------ptltyfcgAVYLVGFPFLLIFtfilf--lfsqDDEALKE 137 Methanosarcina b...
NP_795262    14 VVWLVLLAPFFFasygfatwytaqrtdvg----slvfdweahmpfwawtILPYWSIDLLYGFsllacltrrqlDTHALRL 89  Pseudomonas syri...
Q58076       53 QSLPNIVIEFFKi------------------------------------IYLYGFSSMIIGGiayy----lfiKRDFLKS 92  Methanocaldococc...
ZP_00145129  29 YTYTVDNVPSYFmewerni------------------------pflpifMLPYMTSAPFFLVtifle--kdksSLKLLMK 82  Fusobacterium nu...
ZP_00831314  12 VLWLLLLAPLFFisygqtnhftasrvgvg----svvygwehhipflpwtIVPYWSIDLLYGLslfictslreqTRHAWRL 87  Yersinia frederi...
P76093        5 AGWLLLLAPFFFftygslnqftavqdlnshdipsqvfgwetaipflpwtIVPYWSLDLLYGFslfvc-sttfeQRRLVHR 83  Escherichia coli
Feature 1                       #       #                                                  ###  
P36107      180 YAFAFGYMNl--FGVIMQNVFPAAPPWYKILYGlqsanydmhgspgglaridkllginmyttafsnssvifGAFPSLHSG 257 baker's yeast
ZP_00563632 134 FSIAFTLIYl--VAYPFYILFPVSVTSNTLPNMapllygldpsiv---------------kimhicdptldNCFPSLHTA 196 Methanococcoides...
ABB13875    134 GLFYIYLINy-lVAMPFYVNLPVYEAWSIHPGIklllvkyypqf----------------nveyrsfsginNNFPSLHTA 196 Carboxydothermus...
ABA90016     94 LCFVILVAGg--FFLLMPLRFAFPRPVPEDWTApifrflh-------------------------gfdrpyNMFPSLHIA 146 Pelobacter carbi...
AAZ70944    138 YTITFILIYl--IAYVFYIFFPVNVTGHVLPGVipllyqlnpail---------------givticsprlnNCFPSLHAA 200 Methanosarcina b...
NP_795262    90 FSAQLIAVT---CFLLWPLRFTFERPELDGIFGwlfavla-------------------------gfdkpfNQAPSLHIA 141 Pseudomonas syri...
Q58076       93 DIILIDLALgwlFAGLIYTFVVVKSPFQVGVAKdlinmhyf-----------------------wiftkptYEIPSLHTA 149 Methanocaldococc...
ZP_00145129  83 RAIFLAVVSt-fIFVIFPMKFYFSKPEISSPIFkilfhil------------------------glldsrfNQCPSLHVS 137 Fusobacterium nu...
ZP_00831314  88 VMASLVACL---GFLLFPLKFSFVRPVTDGPFGwlfqqle-------------------------lfdlpyNQAPSLHIM 139 Yersinia frederi...
P76093       84 LILATVMACc--GFLLYPLKFSFIRPEVSGVTGwlfsqle-------------------------lfdlpyNQSPSLHII 136 Escherichia coli
Feature 1                                         #     #   #                   
P36107      258 CATMEALFFCYCFpk----lKPLFIAYVCWLWWSTMYLTHHYFVDLMAGSVLSYVIFQYTKYTH 317 baker's yeast
ZP_00563632 197 LSLMTMLIVLARTkny--glKALAVFTTISIQFTILYLGIHWITDLIGGIMLAFTSYYIATRYR 258 Methanococcoides burtonii DSM 6242
ABB13875    197 LSVSFFYLAFKLRdk---rlTGVLGVSSSLIVISTIYLGIHWIIDIIAGIFLGVGVVYFYTYQI 257 Carboxydothermus hydrogenoforman...
ABA90016    147 LRTLLADTYARHTrg---llRLTVHIWFSLIGLSTVLTWQHHVIDVAGGFTLALLCFYLIRQPF 207 Pelobacter carbinolicus DSM 2380
AAZ70944    201 LSVMATMFILFKTdlr--ryKVFAVGTTIFILFSILYLGIHWITDMIGGIILALVSYFVAIRIF 262 Methanosarcina barkeri str. fusaro
NP_795262   142 LLVVLWVCYDRYArhfhvawRWLLHSWFALIGLSVLTTWQHHFVDLPTGALAGWFCVWLWPDEG 205 Pseudomonas syringae pv. tomato ...
Q58076      150 YSFLLALHFKDEKp-----lNYIYFALAILIPISTLIMGMHWIVDVITGVLYGYIIYKFPKTIH 208 Methanocaldococcus jannaschii
ZP_00145129 138 FAFLSVTVYCREIksk--flKVFLCLWGFLLAISILFVYQHHFIDFVGGTLIFFIICIIFPRKK 199 Fusobacterium nucleatum subsp. v...
ZP_00831314 140 LAWLLWLRFWPHCqg---ilRWLMSGWFALIAISVLTTWQHHVIDIVTGLAAGVVVSYLIPINS 200 Yersinia frederiksenii ATCC 33641
P76093      137 LCWLLWRHFRQHLae---rwRKVCGGWFLLIAISTLTTWQHHFIDVITGLAVGMLIDWMVPVDR 197 Escherichia coli

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