Conserved Protein Domain Family
DUF3020
?
pfam11223: DUF3020 
SPP41, DUF3020
This domain is found in the conserved fungal proteins SPP41 (suppressor of PrP4, there are four members, 1 to 4). In S. cerevisiae it is conserved towards the C-terminus of HMG domains. The function is not known. However, it has been shown that SPP41 is involved in negative regulation of expression of spliceosome components PRP4 and PRP3 and that it relocalizes to the cytosol in response to hypoxia.
Links
?
Statistics
?
PSSM-Id: 402691
Aligned: 34 rows
Threshold Bit Score: 34.5228
Created: 24-Mar-2022
Updated: 17-Oct-2022
Structure
?
Aligned Rows:
Download Cn3D
PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection: 
EPB86713      129 NRERKKKWRIHNEERNKDNDLRCRVN-----KRANKLYGSQDSPA-KQQWVQEEF 177 
EDO18893     1333 NKERKRKWRNANIVKNWENDVRARLK-----KRSKTDFIDLTQDE-KDEWVEVEF 1381
CCE65147     1274 NKERKRKWRSANIVKNWENDVRARLK-----KRSKIELIDLTDEQ-KTNWVNNEF 1322
P38904        376 KKKTKSKTSKAASTANKSPASESTSK-----KKKKKKTVKESNKS-QEAYEDDEF 424  Saccharomyces cerevisiae S288C
CCF56108     1048 gKARKRKWREANVIRNWVHDLRSRLR-----KNASALFDSDKEAE-KNQWIEENF 1096
CCK69701     1255 NKERKRKWREANVGKNWEHDLRSRLK-----KRASMLFENGTAEE-RDRWIEKTF 1303
P38904       1310 nnvRKRRWREMNSTKNWEYDVKSRLK-----KRANAFFGEGESET-KSKWIEERF 1358 Saccharomyces cerevisiae S288C
XP_003673752 1196 NNERKRKWREANATKNWLHDLRSRLK-----KNANAQFGESDSLE-KMQWLEATF 1244
CCD26278     1317 NNERKRKWREANTMKNKIHDLKSRLK-----KRANIVFGPDESSE-KTRWLEETF 1365
XP_001646751  288 AKTSKKLDESKAKSKTQEPKSKSKSKvtdasKKRKKKEKKQSEDIlADSYDDDDF 342  Vanderwaltozyma polyspora DSM 70294
| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap