Conserved Protein Domain Family
glyS_dimeric
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TIGR00389: glyS_dimeric 
glycyl-tRNA synthetase, dimeric type
This model describes a glycyl-tRNA synthetase distinct from the two alpha and two beta chains of the tetrameric E. coli glycyl-tRNA synthetase. This enzyme is a homodimeric class II tRNA synthetase and is recognized by pfam model tRNA-synt_2b, which recognizes His, Ser, Pro, and this set of glycyl-tRNA synthetases. [Protein synthesis, tRNA aminoacylation]
Links
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Statistics
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PSSM-Id: 273051
Aligned: 8 rows
Threshold Bit Score: 627.259
Created: 7-Oct-2014
Updated: 25-Oct-2021
Structure
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Aligned Rows:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
AAB68130   7 SERDKLESTLRRRFFYTPSFEIYGGVSGLFDLGPPGCQLQNNLIRLWREHFIMEEN-MLQVDGPMLTPYDVLKTSGHVDK 85  baker's yeast
O27874     4 VNHERTMTVARKRGFLWSSFEIYSGVAGFVDYGPLGATLKNKIMNRWREFYVVREG-FYEIESPTIMPEEALKASGHVDH 82  Methanothermobacter...
Q57681     4 DIYEKIMDLAKRRGYLWSSFEIYGGIAGFVDYGPLGCLLKNNIISKFREQYIIKEG-FYEIESPTVTPYEVLKASGHVDN 82  Methanocaldococcus ...
O29346     1 MHMSEIMEMLIRRGFLWQSFEIYGGMAGFIDYAPLGNNLRRKIENIWRKYFVINER-AAEIDTPTIGIEEVFIASGHATS 79  Archaeoglobus fulgi...
P38088    38 FNREQLESVLRGRFFYAPAFDLYGGVSGLYDYGPPGCAFQNNIIDAWRKHFILEED-MLEVDCTMLTPYEVLKTSGHVDK 116 Saccharomyces cerev...
P75425     5 YSQEVYVQYLKRYGFVFQSSELYNGLANSWDFGPLGAVLKQQIKTALYNFFIKNKRdVLLIDTPIILNEQIWKASGHLAN 84  Mycoplasma pneumoni...
P47493     5 YNQEVYVQFLKQHGFVFQSSEIYNGLNNSWDFGPLGAVLKQQIKQALYNFFIKNKAdVLLVETPIILSELVWKASGHLAN 84  Mycoplasma genitali...
O51344     2 VRMEDIISLAKRKGFVFQSSEVYGGLSGAWDYGPLGVELKKNIKKEWWKSMVYLHEnIVGLDSAIFMRPEIWRASGHVDG 81  Borrelia burgdorfer...

AAB68130  86 FTDWMCRNPKTGEYYRADHLIEQTLKKRLLDkdvnpqdmkn---------------------------------mekilt 132 baker's yeast
O27874    83 FNDPMTQCKECMDVYRADHIIEDATGRDVEG------------------------------------------------- 113 Methanothermobacter...
Q57681    83 FTDPIVECKNCLESFRADHLIEEFVDVDTEG------------------------------------------------- 113 Methanocaldococcus ...
O29346    80 FTDVAIECENCGRVYRADHYVKEKLGIEVD-------------------------------------------------- 109 Archaeoglobus fulgi...
P38088   117 FSDWMCRDLKTGEIFRADHLVEEVLEARLKGdqearglvedanaaakddaekkkrkkkvkqikavkldddvvkeyeeila 196 Saccharomyces cerev...
P75425    85 FTDALVDCKSCKLRFRVDHLDEQIKSATQWN------------------------------------------------- 115 Mycoplasma pneumoni...
P47493    85 FVDTLVDCKSCKYRFRVDQINAEIKAKKDWN------------------------------------------------- 115 Mycoplasma genitali...
O51344    82 FSDSMVDCKDCKSRFRADFIDLSK-------------------------------------------------------- 105 Borrelia burgdorfer...

AAB68130 133 tidgFSGPELNLVMQEYNINDP-VTNDv-LDALTSFNLMFETKIGASG--QLKAFLRPETAQGQFLNFNKLLEINQGKIP 208 baker's yeast
O27874   114 ----LENQELTEIISDEGIRCPrCGGH--LTHVWSYNLMFQTLIGARG--KKTGYLRPETAQGIFIPFKRLLRFFRNRLP 185 Methanothermobacter...
Q57681   114 ----KTLKELDELIRKHNIRCPkCGGE--LGEVKKFNLMFVTSIGPGG--KRTGYMRPETAQGIFIQFRRLAQFFRNKLP 185 Methanocaldococcus ...
O29346   110 ----ETVEAVKEVMEVYDLKCe-CGGR--FKDPAPMNLMFSTTIGPGK--GKKGYLRPETAQGMFVDFKRLANFFREKLP 180 Archaeoglobus fulgi...
P38088   197 kidgYSGPELGELMEKYDIGNP-VTGEt-LESPRAFNLMFETAIGPSG--QLKGYLRPETAQGQFLNFNKLLEFNNSKTP 272 Saccharomyces cerev...
P75425   116 ---------------PKQVNCPnCKANn-WSEVRDFNLLFQTEIGVVNseKRLVYLRPETAQGIFINFKQLLQLKKRPLP 179 Mycoplasma pneumoni...
P47493   116 ---------------SFKVNCPnCHNQn-WSEVRDFNLLFQTEIGVVNndKRLVFLRPETAQGSFINFKNILQAKKRNLP 179 Mycoplasma genitali...
O51344   106 -------------------NCPnCKVGnnFTSPRSFNLMFKTHIGVVEdsSSEVYLRPETAQGIFVNFRNVLDSSRLKIP 166 Borrelia burgdorfer...

AAB68130 209 FASASIGKSFRNEISPRSGLLRVREFLMAEIEHFVDPLNKSHAKFNEVLNEEIPLLS--RRLQESGevqlp-vkmtIGEA 285 baker's yeast
O27874   186 FGVVQLGKSYRNEISPRQGVIRLREFTQAEAEIFVDPEHKTHPDFEEVKEDILRLYPagRQMEESGtvd-----mtAAEA 260 Methanothermobacter...
Q57681   186 FGVVQIGKSYRNEISPRQGVIRLREFTQAEIEYFVHPERKEHEKFDLVKDEVVPLLPaeRQMDENLsddekvikisIGEA 265 Methanocaldococcus ...
O29346   181 FGVAQIGRAYRNEISPRQGVIRLREFNQAELEFFVHPGEKKHPHFSLYAKDVVKLVDkfDSQHEIT----------LEEA 250 Archaeoglobus fulgi...
P38088   273 FASASIGKSFRNEISPRAGLLRVREFLMAEIEHFVDPLDKSHPKFNEIKDIKLSFLP--RDVQEAGstep--ivktVGEA 348 Saccharomyces cerev...
P75425   180 FGVAQFGKSFRNEVTPGNFLFRVREFEQFEMEWFCNP-QASLSVFE--SQQQ---------------------------- 228 Mycoplasma pneumoni...
P47493   180 FAIAQFGKSFRNEITPGNFLFRTREFEQFEIEWFCKP-DDANSLFE--KQLI---------------------------- 228 Mycoplasma genitali...
O51344   167 FGIAQVGKAFRNEIVTKNFIFRTCEFEQMEMQFFVHP-KQIDEWFCYWQQNR---------------------------- 217 Borrelia burgdorfer...

AAB68130 286 VNSGMVENETLGYFMARVHQFLLNIG-INKDKFRFRQHLKNEMAHYATDCWDGEILTS-YGWIECVGCADRAAFDLTVHS 363 baker's yeast
O27874   261 LEAGVISSEVLTYHLCLAKRFLMDIG-IPEDALRFRQHLPSEMAHYAIDCWDVEAFTDsYGWIEIIGIADRTDYDLRSHS 339 Methanothermobacter...
Q57681   266 VEKGIIRHQTIAYFIALTKRFLEAIG-IDKDKIRFRQHLPNEMAHYAIDCWDAEIYTErFGWIECVGIADRTDYDLRSHS 344 Methanocaldococcus ...
O29346   251 VEKGIIANQILAYFIGKTRRFLLEIG-IKDEKLRFRQHKDVERAHYATDCWDAEVLTS-YGWIEVVGIADRTNYDLKRHS 328 Archaeoglobus fulgi...
P38088   349 VASRMVDNETLGYFIARIYQFLMKIG-VDESKLRFRQHMANEMAHYAADCWDGELKTS-YGWIECVGCADRSAYDLTVHS 426 Saccharomyces cerev...
P75425   229 ----------------AIAHFLFKVLqLNPALVKQYEYDKNELAHYANKTVDFLFQFP-HGLRELWGLADRGTFDLEQHQ 291 Mycoplasma pneumoni...
P47493   229 ----------------MVEQFLQTVLkINPELLKKHEYDQSELAHYAKKTTDFLFNFP-HGLKELWGLANRGDFDLKQHQ 291 Mycoplasma genitali...
O51344   218 ------------------MNFFIETLkISPDRLRFKAHDSTQLAHYAKAAFDIEYEFP-FGFQEVEGIHNRGNYDLTQHA 278 Borrelia burgdorfer...

AAB68130 364 KKTGRSLTVKQKLDTPKERTEWVVEVNKKFFGSKFKQKAKLIESvlsKFS-QDELIRRHEELEKNgeftc--qvngqIVK 440 baker's yeast
O27874   340 QHSGEDLRVFIEYDEPRRIRKRAVKPDMGKLGPKFRKDAARIAS---ALS-EVDVEEIEKALDEEgrfi-----legEFE 410 Methanothermobacter...
Q57681   345 AHSGVELSVFVELDEEREIETYEINLNYKVVGKIFKKDTKAIEAyinNLS-EKEKEEFVKNIENDgkvii--nidgkEFE 421 Methanocaldococcus ...
O29346   329 KFSGEDLSVFVPYEEPVKVKRRKIVPILSKLGPEFRQKAKKVAEaleALNvEADLDEVEVEVDGE------------KVK 396 Archaeoglobus fulgi...
P38088   427 KKTKEKLVVRQKLDNPIEVTKWEIDLTKKLFGPKFRKDAPKVEShllNMS-QDDLASKAELLKANgkftikvdgvdgEVE 505 Saccharomyces cerev...
P75425   292 KYAKKPLDFFDGE----------------------------------NN------------------------------- 306 Mycoplasma pneumoni...
P47493   292 EFSKKSMSFFDSE----------------------------------LN------------------------------- 306 Mycoplasma genitali...
O51344   279 KFSNK-PKVFEYHD---------------------------------LLT------------------------------ 294 Borrelia burgdorfer...

AAB68130 441 LDSSLVTIKMKTTLQHIREYIPNVIEPSFGLGRIIYCIFDHCFQvr--vDSESRGFFSFPLQIAPIKVFVTTISNNDGFP 518 baker's yeast
O27874   411 ILPDDVSFEDVEEVVTGRKVYPHVIEPSFGIDRIIYTLLLHSLV-----DDGERTYFRLPPHVAPVEVTVLPLVNREEMV 485 Methanothermobacter...
Q57681   422 ILKDYVEIKKVKKVIKGEKVIPHVIEPSYGIDRITYCLLEHSYR-----EEEDRVYLDLKPSIAPIKAYVLPLVNKDDMP 496 Methanocaldococcus ...
O29346   397 VTKEFFEIQEVEEEVTGEKVIPHVIEPSFGLDRITYSVLEHAFDkd-vvDGEERRVLRLKRWVSPIEVAVLPLLSREPFE 475 Archaeoglobus fulgi...
P38088   506 LDDKLVKIEQRTKVEHVREYVPSVIEPSFGIGRIIYSVFEHSFWnr--pEDNARSVLSFPPLVAPTKVLLVPLSNHKDLV 583 Saccharomyces cerev...
P75425   307 -----------------EHFIPAVVEPSVGIERLFYALIVSSYQqe-qlEGEMREVLRLPFHLCPEQIVVLPLVNK--LK 366 Mycoplasma pneumoni...
P47493   307 -----------------QHFLPFIIEPAVGIERLFYALIVSSYRre-iiNEEEREVLSLPFDLCPEQIIVLPLVNK--LK 366 Mycoplasma genitali...
O51344   295 ----------------KEKYVPYVIETSAGLTRSVLMTLCDAYSeeelsDGDKRIVLRLHPKLAPYKIAIFPLVKKVELT 358 Borrelia burgdorfer...

AAB68130 519 AILKRISQALRKREIYFKIDDSNTsIGKKYARNDELGTPFGITIDFETIKDQTVTLRERNSMRQVRGTITDVISTIDKML 598 baker's yeast
O27874   486 MTALEIERNLRRSGFIAEFDSSGT-IGRRYARADEIGVPFAVTVDHETLEDGTVTLRNRDDCSQVRVKIEELVPTLEKLR 564 Methanothermobacter...
Q57681   497 KIAKEIEQMLRENGIIAEYDDSGA-IGRRYMRADEIGVPFCITVDGQTLEDRTVTVRERNTREQVRVKIDELVDYLKERL 575 Methanocaldococcus ...
O29346   476 SKGMEIVQMLREEGIFTDYDDSGS-IGRRYRRFDEIGTPFCVTVDHQTFEDETVTIRDRDTTAQVRVKLGELPSILKELL 554 Archaeoglobus fulgi...
P38088   584 PVTTEVAKILRKSQIPFKIDDSGVsIGKRYARNDELGTPFGVTIDFESAKDHSVTLRERDSTKQVRGSVENVIKAIRDIT 663 Saccharomyces cerev...
P75425   367 ETAQTLFEALSQTHWRIGFESAGS-IGKRYRKADAIGTKFAITFDFESLEDQAVTIRERDSLKQVRVPIKELKAWFAQHD 445 Mycoplasma pneumoni...
P47493   367 KEAFSVFETLAKTRWRVCFETTGS-IGKRYRKADAIGIKYAVTFDFESLEDNAVTIRDRDTLVQQRIAIKELPQWFMKNG 445 Mycoplasma genitali...
O51344   359 EIARRIYMELCDD-FHIFYDDSGT-IGKRYRRQDEIGTPYCVTIDYNTIEDETVTVRERNSMTQKRIFINDLYSYIKTEI 436 Borrelia burgdorfer...
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