1M3U,1O66


Conserved Protein Domain Family
Pantoate_transf

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pfam02548: Pantoate_transf 
Ketopantoate hydroxymethyltransferase
Ketopantoate hydroxymethyltransferase (EC:2.1.2.11) is the first enzyme in the pantothenate biosynthesis pathway.
Statistics
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PSSM-Id: 460588
Aligned: 645 rows
Threshold Bit Score: 196.016
Created: 21-Mar-2022
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
1M3U_A                  3 PTTISLLQKYKQEKKRFATI--TAYDYSFAKLFADEGLNVM----LVGDSLGMTVQGHDSTLPVTVADIAYHTAAVRRGA 76 
KHU:HacjB3_07390        1 mptVADIR---AADEPITML--TAYDAPTAELIEAAGIDVI----LVGDSMGNAVLGHDSTLPVTVEEVHSRTGAVTRAT 71 
WP_006053974            1 mtsVRDVREK-AGTTPITML--TAYDATTAGVANEAGIDVL----LVGDSMGNTDLGYDSTLPVTVDEVASRTAAVSRGA 73  Haloge...
CASKLGSI:MRBBS_1269     4 KVTIPRLQQMKKSGDKIVGI--VAWDYQMANIVDRVGVDII----SVGDTVGINLWGQPNPLEVTMDQMVTVAQAVRRGT 77 
dbos:SAR116_2112        9 KVTYKTLLKKMEKGEPITQL--AAYDYRTAVVADRLGMDIL----CVSDTGGMILFGHQSTVSVSFDEVMMMSQAIDRG- 81 
jgi:Shel_24940         17 rkNLAYLQKQKDAGEKLVQMcpAELGPFFAMAAEMVGCDICriphMLSARTGTTAEEDAIASRLTVKKFREYTQII---- 92 
jgi:Namu_2317          13 pIAIPDLFELKRAGRKIVMV--TAYDYPSALAAEAADVDMV----LVGDSGAMTVLGHPSTVEVTVEEMLVLTRATRRGV 86 
WP_012934359           21 pVSLPQLAEKKRLGEPIVMV--TAYDYPSAQVAEKAGVDVV----LVGDSGAMTVLGYPSTVPVSVEEMLMLASAARRGL 94  Conexi...
PRJNA194094:J421_1896   4 pVTTGDLAAMKRRGDPIVMV--TAYDHVTARVAESAGVDAV----LVGDSAAMTVLGYPSTREIGVDELLVLTRAVRRGL 77 
WP_012878411           21 RVTPPSLAALAAAGEKLVMV--TAYDYPAAVAAEKADVDIV----LVGDSGAQVQLGYDSTVPVSVDEMLVLAQAVRRGT 94  Xylani...
1M3U_A                 77 PNC-LLLADLPFMAY-ATPEQAFENAATVMRA-GANMVKIE-GGe-WLVETVQMLTERAVPVCGHLGLTPQSVNIFG-GY 150
KHU:HacjB3_07390       72 EET-LVVADMPFLSFgVEEAESIENAGCMIKEaGADAIKLE-SGp-hTVELTERLVELGIPVMAHLGLTPQRVNQLG-GY 147
WP_006053974           74 DDA-LVVADMPFLSVgVDEATSIENCGRMVKEaGADAVKLE-SGs-hTVELTERLVQLGIPVMTHLGLTPQRVKET--GY 148 Haloge...
CASKLGSI:MRBBS_1269    78 KRA-LVSVDFPFGPLqEGVDAAVRAAIRLVKEaGVDMIKLD-GAa-dFPEAVTALTRAGIPVWAQFGITPQTALQYGiEY 154
dbos:SAR116_2112       82 SQYgLRMVDMPYWSFhVSKEQAVENAGRFVHEaNAEVMKCE-GNr-hHVPAIEAIVNAGIPVQGHIGITPMRMPQLG-GF 158
jgi:Shel_24940         93 ----HLNFYMPISMY-ADKVDAVKFGGELVFH-GADSM-LP-MGv--TNDVLKFMTDNYIPVFGHIGAISGWQTNAT-GY 161
jgi:Namu_2317          87 NHA-MLVADLPFGSYeVSDEQAIATAVRFVKEaRVDAVKLE-RGdpDSVSRARAIVAAGVPVVGHVGLTPQSATALG-GY 163
WP_012934359           95 RTP-LLVADLPFGSFeTSNEQAIMTASRFIKEaGVDAVKIE--AngVAVERARALVGAGIPVMGHVGLTPQTATALG-GY 170 Conexi...
PRJNA194094:J421_1896  78 VRP-LLVGDLPYASYeASDAQALGTARRFVDA-GCAAVKMEgAGp--IADRARALVRAGIPVMGHVGLTPQASAGPE-GY 152
WP_012878411           95 TTA-LVVVDLPFGSYeVSDEQAVATAIRFVKEaGADAVKLE-GGgrVPAARIRAITAAGIPVMGHVGLTPQTAVALG-GF 171 Xylani...
1M3U_A                151 -KVQGR-GDEAG---DQLLSDALALEAAGAQLLVLECVPVELAKRITEALAIPVI-GIGAGNVTDGQILVMHDAFGITGG 224
KHU:HacjB3_07390      148 -GRQGT-TREAA---TEIAELAVAHEEAGAFSLVLEHVPANLAARITEELSVPTI-GIGAGPDCDGQVLVITDVIGL-GE 220
WP_006053974          149 -TQQGT-TRDEG---HEILDLARKHEEAGAFALVLEHIPANLAAQVTDALSIPTI-GIGAGSDCDGQVLVVDDVLGL-SS 221 Haloge...
CASKLGSI:MRBBS_1269   155 sTMSQAgAQVPDgmlERLVAEAKMLEKAGAVLLDFTNSGPVVGPAATAAVDIPVIgGFGGGPWLDGRVRMGHAAIGYSAK 234
dbos:SAR116_2112      159 -IAQGK-TAARA---QELVDDAKAMYDAGCFSILCEVTTSEVAEYLAETLPVPVI-SLGAGNCADGVHIISSDLFHLWEE 232
jgi:Shel_24940        162 -KKVGK-TAEDA---FKIFKWGYEYQENGMGAMTIELTPMEVSQAIAEKLRVPVI-SIAGGAPCDGSEMVDMDTFGVM-- 233
jgi:Namu_2317         164 -RAQGR-SAESA---VRITDGLLALQDAGCFCIVLEAVPNALTAEIMPLTTVPII-GIGAGPATDGQVLVFHDLLGIREG 237
WP_012934359          171 -RAQGR-TAERA---LDVARDALALEEAGCFSIVFEAIPAPVAAILMEQMEVPII-GIGAGSSTDGQVLVFHDLLGIREG 244 Conexi...
PRJNA194094:J421_1896 153 -RVRGA-TADEV---LGIRRDVDALVDAGCFAIVFEAIPAAVAALLVPAIPVPVI-GIGAGPATDGQVLVFHDLVGLSEG 226
WP_012878411          172 -AAQGR-TVEAA---RRVRDEALAVQEAGAFSLVLEAIPSDLAAAIRPQLTIPAI-GIGAGPAVDGQVLVLHDLLGLTEG 245 Xylani...
1M3U_A                225 HIPK---FAKNFLAETGDIRAAVRQYMAEVESGVYPGE 259
KHU:HacjB3_07390      221 WTPP---FSEQFGDVRGEIESAVGAYKEAVEGGEFPAE 255
WP_006053974          222 YSPP---FSKQYGNVREQMLDAVSAYREDVESGGFPAD 256 Halogeometricum borinquense
CASKLGSI:MRBBS_1269   235 HLDE---EIETYANVAKITYDAITAFSNDVRSArqikg 269
dbos:SAR116_2112      233 HVPK---HSRIYTDLIPIMEDVITRYMNDVKTRNYPGP 267
jgi:Shel_24940        234 --PKpasHAVCTAELLPFLCEAYADWADMVREGDYPED 269
jgi:Namu_2317         238 KGAK---FVRRYADLLDAMADGVAAYARETRAVSFPAP 272
WP_012934359          245 VGAR---FVKRYADIQDEMVAGVRAYADDVRHQRYPAP 279 Conexibacter woesei
PRJNA194094:J421_1896 227 RAPR---FVKRYAALGPLMVDAVARYAAETRAREFPAP 261
WP_012878411          246 RAAK---FVKRYATVLDAMTEGIGAYAADVRSGAYPGP 280 Xylanimonas cellulosilytica
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