Conserved Protein Domain Family
DUF3533

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pfam12051: DUF3533 
Protein of unknown function (DUF3533)
This family of transmembrane proteins is functionally uncharacterized. This protein is found in bacteria and eukaryotes. Proteins in this family are typically between 393 to 772 amino acids in length.
Statistics
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PSSM-Id: 432289
Aligned: 25 rows
Threshold Bit Score: 199.071
Created: 24-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
ABN67592        6 VYISIFSVFIGILSIYWGTLYRRDTRYKNMGFLVVSEDLPfe-vdGSRLDPFLNDAFLSMIQNNETVinl----akWEQI 80 
Q4WCV7         14 AFVLLQLLFLANMSYLYGSAYHDSYRISSMNVLFVDYDQG-----------VIGESVAAAYSQMQGDsf-----ptLRQH 77  Aspergillus fu...
Q5B7F2         84 SGIILTLLFLSLFSYLFGSLYQLTGHTHNLNVVLVDYDGG-----------VIGDAVRQAYQQLRSDsfpt-----iinH 147 Aspergillus ni...
Q0CRK0         10 NLILLQILFLSLLCYLFGSLYQETTHVHNINVLYVDYDGG-----------AIGDAVREAYTQLQGPgfpn-----lieR 73  Aspergillus te...
CAK47968       34 NLLILQLLFLGLFCYLFGSIFQQTTHIHNLNVLFVDYDGG-----------AIGRAVRTAYQQLQGAgfptlreqsAEVY 102
jgi:Lreu_1896  12 LPIIVALFIGAYFS--ITAIPSTHVKVNDLPIAIVNEDSG-----------VTGENLAKQITEATSSsnssamsikWTVF 78 
KIS65668       71 AAMLIMVVIWTIVSIYWGSVYKEIDLSPNLNAWVINRDTG-----------AVGSAVQQALLDTNNSaarp--rstWTVI 137
CAK46476       36 TVLILCVFILCILSLFWAVQFHAESRFSALTVWVVDFDGQle--pYRNETPIVGPIVTEVVDHILDTste---hlgYTIK 110
EAW13432       47 VVLMLCVFILCILSLYWAVQFRAEDRLPALTVWVVDFDNQvepykNDTLTAIVGPVVTDVARQAVQSnrk---gvgYTIK 123
Q2U0W5         42 TVLTLCVFILCILSLYWAVQFRVEQNLHSLTVWVVDFDGMvd--pYRDTKPIVGPAVTDVAENLIQTpetg--rlgYTIK 117 Aspergillus or...
ABN67592       81 TLSEFQEsarahnnnITAEVYRKVHHQKYWAAVHIKPNASQLIYRSLATANFSLTASGEitELIDVVYESGRQYSALSQY 160
Q4WCV7         78 PPSEYP---------SQYSIRQAVCEGHFWGAIYANPGASSRLSSALSSPDVAQTYDSS--QALTYVWNGVKY-ASYAQI 145 Aspergillus fu...
Q5B7F2        148 PPSQYP---------QPAALRSTVCNIEYWGALYISGGASDRLATAISNAQAAASYNRS--DVLTWIWNEARYPTVIDTL 216 Aspergillus ni...
Q0CRK0         74 SQRDYP---------TPNDLEGTICDIEYWAAFYTSPNASDRFTAALAGGSLASSYNRS--DVLTMVWNEARYPSVSDSV 142 Aspergillus te...
CAK47968      103 P--------------NPASIVSTVCNIHYWGGFYIAANASSRLSAAL-TGIRTATYNTS--DVMTLVWNEARYSTVVDSA 165
jgi:Lreu_1896  79 D--------------SEKKLLKDMNREKYYGAIVIPKDFSEKLQSLTAPNAQK--------AELKIIINQGMG-TTVTTQ 135
KIS65668      138 DPARFPT--------QDQIDYEVTNALSTWLVVTVVENATAKLEQAR--ANGDSSWDPR--SLVSLTYATSRNFQVVPSM 205
CAK46476      111 SPADFNN--------DPWAVRQSVYDEHAYAAVIINANATALLRNAV--INGNSSYDPY--GAAEFVTISARDPTTYYDY 178
EAW13432      124 SPADFDF--------DPWAVRQGVYDEHAYAAVIVNPNATALLYDAV--RNGNSSYDPS--GAAQFITISARDQTTYSSY 191
Q2U0W5        118 SPDEFNY--------DPWAVRQGVYDEHAYAAIIVNANATTLLHDAV--KNGNSSYDPT--GAAQFVVITARDETTYSSY 185 Aspergillus or...
ABN67592      161 VSKHISQIEDVWLSSYVSQMIYePIIKSLNDTQRLALLANnntisILASKPAFNIIDLRPSPSSAVLGPSELGLIYALLF 240
Q4WCV7        146 ISSSLQMLAHAATGAYQQINGT-KAMGAVDTLNPAIAH-------TLLNPIAASSIDIKPTNQGVRFYYNTVSMVMPILQ 217 Aspergillus fu...
Q5B7F2        217 AQQITSLSEAARVA---------YVQLNGTGAVQSLDATSpaavaAYSNPWELTSINIQPTTQGSRVVYNTLVVVLILIQ 287 Aspergillus ni...
Q0CRK0        143 ISDPIRKLSEVARIAFTDRGGK-QMIQALNTSSPAAIS-------VLSSPWMLTSVDIQPTTQGSRMIYNTLVILLILIQ 214 Aspergillus te...
CAK47968      166 IQSNILSLSEAARIVYTTTNGP-SILQTVNTSDQTAIT-------TLADPWTLSTINIQPTTQGSRLIYNTLVVILILIQ 237
jgi:Lreu_1896 136 VNTALTQMTTQLNNKLSTNLLQnVANRSTSIPATMAL--------NLSNPLTIKKEKVNKTGDLANGGA----------- 196
KIS65668      206 VLSPAMTTLNKAVAQLSSQMAAqYLSTVAGNQTAISNLANap--qTITQPIILNQRDLRPYDVPVAIAVLVVGLIYQCIL 283
CAK46476      179 INPFLYDLDMAVRSSFGLRWIQ-YVAQQGYNISQVPQ--------AINPGIGFTSVDLRPFAPAVITPAVSIGLIYLIIL 249
EAW13432      192 IDPALSSFQLAALAEFGPKWVQ-TLAAQSVNISRVPQ--------AVNPAIGFQQVDLRPFGPAAATPSVTIGLIYLIII 262
Q2U0W5        186 ITPGLTAFASTVLAEFGPRWVQ-TVAQESLNISNVPQ--------AINPAIGFNTVDLRPFGPAAATPSVTIGLIYLIII 256 Aspergillus or...
ABN67592      241 SFHQFNFSLEIYNYI-----RTKLKFRHY------LVWRFVASQINCLVLALVYSLIT-IAFQVPT-------------N 295
Q4WCV7        218 QFFFIMALNGLTAEFgv--vLRTMSLRGS------IVLRLTLSVLYTFIAALCMTGYI-WGFREAW-------------A 275 Aspergillus fu...
Q5B7F2        288 EFFFLATINGLYVQFg---iFRRINPKRM------IVFRFIISAVYTLAGSICATGAI-WAFRAGW-------------Q 344 Aspergillus ni...
Q0CRK0        215 EFFYLGCINSLYLQFr---lYTAVSPHRI------VVVRIIISAVYTFIGSLCVTGAI-WAFRNGW-------------H 271 Aspergillus te...
CAK47968      238 EFFYLGYLNGLYQQFh---lYTSVDAHRI------AIIRQLISGIYTFIGSLCTTGAI-WAFRYGW-------------H 294
jgi:Lreu_1896 197 HFFQSVWLGSLGTSMllgfaFSKIRFKSLkekfsaLFVQLIAAGISALVIGYGVPALQsWILDVNI-------------- 262
KIS65668      284 AFVFTMANFGARQAL-----QPYLRFRSL------VAMRFAAPLVCYFFLSLMISLLN-IPFEVPF-------------G 338
CAK46476      250 AFFNTPFMMPIHIQFik-gnHPPLKIPQW------LLWRILSNIGTYFFLSLFYSFVS-LAFQIPFsnpsapdtqvaynP 321
EAW13432      263 AFFNFPFLMPVHVQLik-gdHPPLKGPQW------LLWRLCSNITAYFFLSLFYSFVS-LAFQVPFsnhpasetllvsnP 334
Q2U0W5        257 AFFNSPFLMPIHAQFlk-gnHPPLKIPQW------LLWRVCSNITAYFFLSLFYSFVS-LAFQIPFsnspapdtvsasnP 328 Aspergillus or...
ABN67592      296 VAFGH-SGFVVLWMFMYLYISASGGINENVVTVIlafdQKVFLAPWMIFNIVINISSTFAPFVLMPGFYRYGFAL-PMYN 373
Q4WCV7        276 VTGGQ---FALTWMAIWLVMHLNFLLIDAVTSVL----PMKFMPFAILTWIIINVSSTIGPFDLSPGFYRLGYAL-PAYE 347 Aspergillus fu...
Q5B7F2        345 VNGNQ---WALTWITLWLFAHLNFLTLDVFAVWL----PPPYVPMSLITWVVLNITSILVPFELSPAFYKWAYAL-PAHA 416 Aspergillus ni...
Q0CRK0        272 VDGSQ---FMLNWMILWLFAHLNFLTLDVFSIWA----PPPYVPMALITWIVLNVTSILLPFELSPAFFQVGYIF-PAHS 343 Aspergillus te...
CAK47968      295 VNGGQ---FMITWMALWLFAHLNFLVLDVFTIWL----APPFVPMALISWVVLNVSSILLPFELSPGFYKWGYAL-PAHA 366
jgi:Lreu_1896 263 ------PNFTELGLFMSLCAFAFIIFINGVESWV----GIISIPVFMLLLFFAAPLLTAVPESLN-GFYSTLADWlPMSY 331
KIS65668      339 RTFSYgAGFMTWWCATFIAMCVLGFVTECFISIV----GPRFIGFTLVFWIIINVSVANLPIELSPSFYKYGYSM-PFYS 413
CAK46476      322 NGYGH-GSFVVYWMLNWAGMCALGFPCENMAMII----GLPWSALFLIFWVITNVATGFYALDLAPGFFRWGYAW-PLHR 395
EAW13432      335 NAYGH-GSFVVFWMLNWVGMAALGLPCENMGMIL----GFPWSALFLIFWVISNVATGFYALDLAPAFFRWGYAW-PLHR 408
Q2U0W5        329 NAYGH-GSFVVFWMLNWVGMSALGFPLENMAMVL----GFPWSSLFLIFWVISNVATGFYALDLAPGFFRWGYAW-PLHR 402 Aspergillus or...
ABN67592      374 TYEALKVV---FFDTWK-GNLGRNLGVLVIWIVVMNI 406
Q4WCV7        348 LYQLLLDI---WTEGCN-PPLYRELPILFAWWVVGFV 380 Aspergillus fumigatus
Q5B7F2        417 CFNILIDI---WSGGCN-PQLGYALPVLFAYELSSGI 449 Aspergillus nidulans
Q0CRK0        344 VFQVLMDI---WSGGCN-PQLNYALPVLFSWEILSLA 376 Aspergillus terreus NIH2624
CAK47968      367 IFQVMVDI---WSGGCN-PQLDYALPVLFAYEVVGMV 399
jgi:Lreu_1896 332 MYRGVKSImyfNHGPANsVVMGLIYTIITGLILIITA 368
KIS65668      414 IRQIYVKI---IFDVGErVEMLKWFGILWAWLAVVML 447
CAK46476      396 IVEAIRTI---LFDTHS--RIGLDFGVLFAWIGFSIC 427
EAW13432      409 IVEALRTI---LFDTHS--RIGLDFGVLFAWVGVSIL 440
Q2U0W5        403 IVEALRTI---LFGTHS--RIGLDFGVLFAWIGVSIL 434 Aspergillus oryzae
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