2PYU,2MJP


Conserved Protein Domain Family
TIGR00042
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TIGR00042: TIGR00042 
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non-canonical purine NTP pyrophosphatase, RdgB/HAM1 family
Saccharomyces cerevisiae HAM1 protects against the mutagenic effects of the base analog 6-N-hydroxylaminopurine, which can be a natural product of monooxygenase activity on adenine. Methanococcus jannaschii MJ0226 and E. coli RdgB are also characterized as pyrophosphatases active against non-standard purines NTPs. E. coli RdgB appears to act by intercepting non-canonical deoxyribonucleotide triphosphates from replication precursor pools. [DNA metabolism, DNA replication, recombination, and repair]
Links
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Statistics
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PSSM-Id: 272870
Aligned: 11 rows
Threshold Bit Score: 229.945
Created: 7-Oct-2014
Updated: 25-Oct-2021
Structure
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Program:
Drawing:
Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
2PYU_A        23 KVVLATGNVGKVRELASLLSDFGL--DIVAQTDLGv-dSAEETGLTFIENAILKARHAAKVTA--LPAIADASGLAVDVL 97  Escherichia col...
P44598         4 KIVLATGNKGKVKEMADVLSDFGF--EVIAQTDLGi-eSPEETGLTFVENALLKARYASEKSG--LPAIADDSGLVVSAL 78  Haemophilus inf...
P94558         6 EAIIATHNPGKVKEFKEILEPRGY--DVKSLAEIGfteEIEETGHTFEENAIMKAEAVAKAVN--KMVIADDSGLSIDNL 81  Bacillus subtil...
P74432         3 TLIVATGNPGKLAEMQTYLEPLGC--QLTLKPTEI---EVEETGSTFYENACLKASQVAKAVN--QWAIADDSGLAVDAL 75  Synechocystis s...
O51263         3 TLFFATTNENKINEVKNILDIPNL--NLIVPQNFN----IKETGKTFKENSLLKAKALFEILNnnQNVFGEDSGLCIEAL 76  Borrelia burgdo...
Q57679         2 KIYFATGNPNKIKEANIILKDLKD--VEIEQIKIS---YPEIQG-TLEEVAEFGAKWVYNILK--KPVIVEDSGFFVEAL 73  Methanocaldococ...
P47119         5 EIVFVTGNANKLKEVQSILTQEVDnnNKTIHLINEaldLEELQDTDLNAIALAKGKQAVAALGkgKPVFVEDTALRFDEF 84  Saccharomyces c...
P52061         3 KVVLATGNVGKVRELASLLSDFGL--DIVAQTDLGv-dSAEETGLTFIENAILKARHAAKVTA--LPAIADDSGLAVDVL 77  Escherichia col...
WP_010877036   2 KVTFITGNKHKLSEAEKIFHGTG---IELMHADLG---YPELQG-TLEEVARYGAEHAARIMD--GPVIVEDAGLFIRAL 72  Methanothermoba...
2MJP_A        10 KIYFATGNPNKIKEANIILKDLKD--VEIEQIKIS---YPEIQG-TLEEVAEFGAKWVYNILK--KPVIVEDSGFFVEAL 81  Methanocaldococ...
WP_010879726   1 -MYFITSNEGKFREVREMASKYG---IEIEWLKME---YIEPQGSSLEEIARLSAEMLAEKVE--GEFVIEDSGLFVEAL 71  Archaeoglobus f...

2PYU_A        98 GGAPGIYSARYSGed-----aTDQKNLQKLLETMKDVPddQRQARFHCVLVYLRHAED--PtpLVCHGSWPGVITREPAG 170 Escherichia col...
P44598        79 NGAPGLYSARYAGee-----gNDAKNREKLLAELAHIAqeQRQAKFVSCIVFLQHPTDpsP--IIAEGECCGVIGFEEKG 151 Haemophilus inf...
P94558        82 GGRPGVYSARYAGeq-----kDDQANIEKVLSELKGIEkeQRTARFRCALAVSIPGEE--T--KTVEGHVEGYIAEEPRG 152 Bacillus subtil...
P74432        76 DGAPGLYSARYGN--------TDRERIAKLLQALEGVS--QRQAQFICVVSIAAPDGSi-Q--LSTKGICSGEITHSPRG 142 Synechocystis s...
O51263        77 NLEPGIYSKRYDTyklckklsTNEKN-QLILDLMKNEK--NRKAYFICNISYISKNGQ--I--LNFEGIIKGKIALSLND 149 Borrelia burgdo...
Q57679        74 NGFPGTYSKFVQE--------T-IGN-EGILKLLEGKD--NRNAYFKTVIGYCD-ENG--V--RLFKGIVKGRVSEEIRS 136 Methanocaldococ...
P47119        85 NGLPGAYIKWFLK----------SMGLEKIVKMLEPFE--NKNAEAVTTICFADSRGE--Y--HFFQGITRGKIVPS-RG 147 Saccharomyces c...
P52061        78 GGAPGIYSARYSGed-----aTDQKNLQKLLETMKDVPddQRQARFHCVLVYLRHAEDptP--LVCHGSWPGVITREPAG 150 Escherichia col...
WP_010877036  73 KWFPGPYSAYVQD--------T-IGN-RGILKLMENVE--DRYAEFRSAVGFCTPNSE--P--EVFLGVVKGRIGTEERG 136 Methanothermoba...
2MJP_A        82 NGFPGTYSKFVQE--------T-IGN-EGILKLLEGKD--NRNAYFKTVIGYCDENG---V--RLFKGIVKGRVSEEIRS 144 Methanocaldococ...
WP_010879726  72 KGFPGPYSSYVFK--------T-IGN-EGILKLMEGVE--NRKAYFMAVVAYFD-GKE--V--RTFTGKVEGEISREMRG 134 Archaeoglobus f...

2PYU_A       171 --TGGFGYDPIFFVPS-EGKTAAELTREEKSAISHRGQALKLLLDAL 214 Escherichia coli K-12
P44598       152 --ENGFGYDSLFFSPE-QGCTFAELETAEKKKISHRAKALSVLKSKL 195 Haemophilus influenzae Rd KW20
P94558       153 --EYGFGYDPIFIVKD-KDKTMAELTSDEKNKISHRADALKKLSKLL 196 Bacillus subtilis subsp. subtilis str. 168
P74432       143 --DQGFGYDPIFWLPE-HKKTFAEMTKVEKQKVSHRGKAFNKLIHQW 186 Synechocystis sp. PCC 6803 substr. Kazusa
O51263       150 kkNYGFGYDSIFLTKN--NKKLSDLTLEEKNKISHRGIAFLKFKKFL 194 Borrelia burgdorferi B31
Q57679       137 k-GYGFAYDSIFIPEE-EERTFAEMTTEEKSQISHRKKAFEEFKKFL 181 Methanocaldococcus jannaschii DSM 2661
P47119       148 --PTTFGWDSIFEPFDsHGLTYAEMSKDAKNAISHRGKAFAQFKEYL 192 Saccharomyces cerevisiae S288c
P52061       151 --TGGFGYDPIFFVPS-EGKTAAELTREEKSAISHRGQALKLLLDAL 194 Escherichia coli K-12
WP_010877036 137 --TMGFAFDPLFYPEG-MDKSFGELSTSEKNRFSHRSRALKKFAEWY 180 Methanothermobacter thermautotrophicus
2MJP_A       145 k-GYGFAYDSIFIPEE-EERTFAEMTTEEKSQISHRKKAFEEFKKFL 189 Methanocaldococcus jannaschii
WP_010879726 135 --TQGFGYDPIFLYG---NKTFAEMATEEKNQVSHRRKAFEEFFRWL 176 Archaeoglobus fulgidus
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