Conserved Protein Domain Family
KCH

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pfam16944: KCH 
Fungal potassium channel
KHC is a family of fungal proteins carrying three transmembrane domains. It is a member of the fungal potassium channel family of transporters, and includes a pair of homologous sequences that localize to distinct zones of the yeast plasma membrane and are induced during the response to mating pheromones. Together KCH1 and KCH2 promote low-affinity K+ uptake and are essential for K+-dependent activation of HACS - a high-affinity Ca2+ influx system that activates calcineurin and is essential for cell survival - in S. cerevisiae cells responding to mating pheromones.
Statistics
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PSSM-Id: 435670
Aligned: 86 rows
Threshold Bit Score: 249.353
Created: 26-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Q0CJR3        17 KWDYINLNDFKSESCWTPFSYFF-IYVFLLISLAVYAVDTFTAVNLLAFSRWAGQ-IKPTIPFTISRWIFAVCIIISFVL 94  Aspergillus ter...
CCK68479      16 RFPDVDIDLFKNYRLKTVLSYAVgTWAFGLLKLALFISDLYTCIKLLAYNSWSNNiVKPYLPFRISKWLFSGCILASILL 95 
CCF58094      14 TFDDVDLYLFFNFRFTTILSYAFgTWFFIFLKCASFVSDIYTCIKLLAFNTWSNSiIKPYLSFNISRWLFSGCILASIVL 93 
Q6CXI0        14 TFDVLDLELFKNYRFKTVVSYVFiFWGLTILKVVLFASDIYTCIKLLAFNSWSNNiIKPYLSFKISKWLFSGCILASIAL 93  Kluyveromyces l...
Q6FVS3        14 TFDDLEEEEFKNYKFKTVLSYIFeIGVMNGLKVAFFVSDIYTCVKLLAYNSWSNNvIKPYISFKVTKWLFTACIFASIVI 93  [Candida] glabrata
EDO16318      14 TFDDLDASEFKNKKRGTVCSYIFfVLILNFLKTALFISDVYTCIKLLAFNSWSNNiVQPYLPFRISKWLFSACILFSIVL 93 
XP_003686259  14 TFADLNERKFKNYRFGTLASYLFfVIIMNILKVALFISDIYTCVKLLAFNSWGNNlIKPYLSFKISKWLFSGCIFFSIVL 93 
XP_002498205  14 TFESIDLSLFRNTKFWTVLNCIIfVWGIIILKFLLFASDIYTCIKLLAFNSWSNNiIQPYLPFRISKWLFSSCILASVIL 93 
XP_003682087  15 TFDNVDPSLFRNFRFCTLFNYIVwSWGLTLLKVALFVSDVYTCIKLLAYNPWSNNiIQPYLPFRISKWLFSGCILASIVL 94 
XP_002552356  14 TFDALDCSLFRNFKFMTVVNYAFfVLFLTAMKIALFISDVYTCIKLLAFNSWSNNvVPPYIPFRISKWLFSGCILASIVL 93 
Q0CJR3        95 LVLRWLHAIRAIRSGSIAQCYLDSLAVRVQSIRpgkrgrGWRRFIVFAELtKSKKGAEYVALFAYFSFESWMNTVFADGP 174 Aspergillus ter...
CCK68479      96 LLWNVIHAIRIYRTKNIALCYVNNICRNSISFV------NYPKFCIFDRI-SSKGTFQWFAFFVFFELKDCLGLLFTDTP 168
CCF58094      94 LIWEIISGIRVYRTRNIALCYINNFSRNLYSMT------SYQKFCVLNKI-SAKSFFQKTSFFVYFEIRDCIRLIFADTP 166
Q6CXI0        94 MLWEVINGIRIYRTRSIALTYVNNFSRMVNSIT------NYNIFCVYNKI-TPKGRFQKISFYTFFEFKDCVRLLFTDTP 166 Kluyveromyces l...
Q6FVS3        94 LLIEAAIGFRIYRTRNISLTYVNNFSRNTYSIK------SYSKFCVYNKI-TPKGFFQKVSFFTFFELRNCIRLLFTDTP 166 [Candida] glabrata
EDO16318      94 LIWELIRGLRVFRTKNIALSYVNNFCQTYYSLK------SYSTFCVFNKI-TADNRFQKIAFFTFFELKNCFRILFADTP 166
XP_003686259  94 LIWEFIRSIRVYKTKNIALSYINGFCKHYYSLK------NYAIFCFFEEL-SVDSKFQQVAFFTFFEMKSCFRFLFADTP 166
XP_002498205  94 LIWEFIRGIRIYRTRNISLTYVNNFSRTAYSMF------DYSKYCIYFKI-TPKGKFQKSAFFTFFELKDSLRLLFADTP 166
XP_003682087  95 LIWETISGIRIYRTRNIALTYINDFSRTAYSLS------NYNFFCVLNKI-SPTGAYQKVAFYTFFEIKSCIRLLFTDTP 167
XP_002552356  94 IAWEIINGIRIYRTRNISLTYVNNFSRGAYSLS------QYNKFCVYNRI-SPSGAYQKIAFFTFFELKDCLRLLVADTP 166
Q0CJR3       175 RQVVNAITLYSVMRMDLLPGgehAhka-nddTPGVVQFFDNVKILAEENNLRALVLFGMLFTLVIWVLSVLKLLLAIILY 253 Aspergillus ter...
CCK68479     169 RQVINGLTLWSVLVTVHSDLd-nNmdl--gdLESFQGLINKIKGIAQSNHQEAVLLSFMLFSFIVWMFFMAKLIFAMICS 245
CCF58094     167 RQVINGLTLWSVLITT-QE----Dydl--gdLESIQGFANKIKMIAETNKEEAILLIFMFLSFILWAFFITKFICAVICS 239
Q6CXI0       167 RQVINGLTLWSVLVTN-NN----Ganl--gqLENFDGLITKIKIIADTNHQEAVLLSFMLLSFAIWTVFMAKLIVAVIFA 239 Kluyveromyces l...
Q6FVS3       167 RQVFNALTLWSVLVTV-NN----Gadl--grLETFHGLINKIKTIADTNHAEAVILSFMLFSFVLWAFFMFKFCLALLSS 239 [Candida] glabrata
EDO16318     167 RQVINGLTLWSVLITT-SD----Gatl--gdLETINGLLQKIKNIAQTNHAEAVILSLMLFSFVIWCIFITKLTVAMICS 239
XP_003686259 167 RQVINGLTLWSVLISE-SN----Gknl--sdLESASNLLQKIKYIAQTNHEEAILLSFMLFSFAIWCIFFIKFTIAVICL 239
XP_002498205 167 RQVINGLTLWSVLITVNNE----NsniahghLESFNGLITKLKTIAKTNHEEAVILSFMLFSFAIWAIFITKLAIAMIMS 242
XP_003682087 168 RQVINGLTLWSVLVTV-KP----Nssl--gdLESFDGLIAKIRTIAQTNHEEAVLLSFMLFSFIIWAFFISRLVLALLCS 240
XP_002552356 167 RQVINGLTLWSVVVTV-DQ----Ssdl--grVESFSGLVAKIKTIAQTNHEEAVLLSFMLFSFVIWAFFITKFVAACLCS 239
Q0CJR3       254 LIFLFHHIPSED-GSLKAYCRRKINNR 279 Aspergillus terreus NIH2624
CCK68479     246 VFVYFRLIHEKEyAGLRDYVCIAICRH 272
CCF58094     240 PFVYFALIKEAKySSLREYVCMSISDH 266
Q6CXI0       240 PFVYHTIYSNYSvRGLKELVCTTVNKR 266 Kluyveromyces lactis
Q6FVS3       240 IFVYYNLIRRHRyGSLKAFVCITIDKK 266 [Candida] glabrata
EDO16318     240 IFVYHELIMMNKfNGLREYVCVTVNIK 266
XP_003686259 240 LYVYHKLITKQKyKGLREYVCISINNK 266
XP_002498205 243 VYVYYKLIQGQQySGLKEFVCVTINHN 269
XP_003682087 241 VYVYYKLINKHRhSGLREFVCVTISRN 267
XP_002552356 240 IYVYYRIFNERNaSGLKEYVCVTVSEH 266
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