1WVA,4G3H


Conserved Protein Domain Family
rocF_arginase
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TIGR01229: rocF_arginase 
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arginase
This model helps resolve arginases from known and putative agmatinases, formiminoglutamases, and other related proteins of unknown specifity. The pathway from arginine to the polyamine putrescine may procede by hydrolysis to remove urea (arginase) followed by decarboxylation (ornithine decarboxylase), or by decarboxylation first (arginine decarboxylase) followed by removal of urea (agmatinase).
Links
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Statistics
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PSSM-Id: 162262
Aligned: 8 rows
Threshold Bit Score: 402.968
Created: 8-Oct-2014
Updated: 25-Oct-2021
Structure
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Program:
Drawing:
Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
1WVA_A         9 GIIGAPFSKGQPRGGVEEGPTVLRKAGLLEKLK------EQECDVKDYGDLP-FADIPNDSP-------FQIVKNPRS-- 72  human
P05089         9 GIIGAPFSKGQPRGGVEEGPTVLRKAGLLEKLK------EQECDVKDYGDLP-FADIPNDSP-------FQIVKNPRS-- 72  human
P40906        19 GVVAVGFSDGQPNQGVD--PSGLIEAGLLDQLRd-----DLEYDIRHDGQVHtYAEFVPEHDp-----nHRGMKKPRT-- 84  Coccidioides po...
P39138         6 SVIGMPMDLGQARRGVDMGPSAIRYAHLIERLS------DMGYTVEDLGDIP--INREKIKN-------DEELKNLNS-- 68  Bacillus subtil...
Q59174         4 KILGLPVQEGTGRKGCNMGPDSYRAAGIADAIR------ELGHECTDLGNLApAAQRPLQHP-------NHAIKALPY-- 68  Brucella melite...
WP_000604403   2 ILVGLEAELGASKRGTDKGVRRLREA-LSATHG------DVIKGMQTITQER--CVLYKEF--------RYAKNFEDY-- 62  Helicobacter py...
P00812        16 SIVLAPFSGGQGKLGVEKGPKYMLKHGLQTSIEdlgwstELEPSMDEAQFVG-KLKMEKDSTtggssvmIDGVKAKRAdl 94  Saccharomyces c...
4G3H_A         2 ILVGLEAELGASKRGTDKGVRRLREA-LSATHG------DVIKGMQTITQER--CVLYKEF--------RYAKNFEDY-- 62  Helicobacter py...

1WVA_A        73 VGKASEQLAGKVAEVKKNGRISLVLGGDHSLAIGSISGHARVHPD-----LGVIWVDAHTDINTPLTTTSGNLHGQPVSF 147 human
P05089        73 VGKASEQLAGKVAEVKKNGRISLVLGGDHSLAIGSISGHARVHPD-----LGVIWVDAHTDINTPLTTTSGNLHGQPVSF 147 human
P40906        85 VSAATQQLSRQVYEHAREGRLVLTLGGDHSIAIGTISGTAKAIRErlgreMAVIWVDAHADINRPEDSDSGNIHGMPLAF 164 Coccidioides po...
P39138        69 VLAGNEKLAQKVNKVIEEKKFPLVLGGDHSIAIGTLAGTAKHYDN-----LGVIWYDAHGDLNTLETSPSGNIHGMPLAV 143 Bacillus subtil...
Q59174        69 AVAWIEAISEAAYRESAEG-FPIFLGGDHLLAAGTVPGIARRAAEkg-rkQFVLWLDAHTDFHTLETTTSGNLHGTPVAY 146 Brucella melite...
WP_000604403  63 YLFCKENLIPCMKEVFEKKEFPLILSSEHANMFGIFQAFRSVHKDk---kIGILYLDAHADIHTAYDSDSKHIHGMPLGM 139 Helicobacter py...
P00812        95 VGEATKLVYNSVSKVVQANRFPLTLGGDHSIAIGTVSAVLDKYPD-----AGLLWIDAHADINTIESTPSGNLHGCPVSF 169 Saccharomyces c...
4G3H_A        63 YLFCKENLIPCMKEVFEKKEFPLILSSEHANMFGIFQAFRSVHKDk---kIGILYLDAHADIHTAYDSDSKHIHGMPLGM 139 Helicobacter py...

1WVA_A       148 LLKeLKGKI-PDVP----------G----------FSWVTP--CISAKDIVYIGLRDVDPGEHYILKTLGIKYFSMTEVD 204 human
P05089       148 LLKeLKGKI-PDVP----------G----------FSWVTP--CISAKDIVYIGLRDVDPGEHYILKTLGIKYFSMTEVD 204 human
P40906       165 LTGlAKDDN-EDMF----------G------------WLQPdnLISPRKLVYIGLRDVDRAEKRLLREHGIKAFSMHDID 221 Coccidioides po...
P39138       144 SLG-IGHESlVNLE----------G-------------YAPk--IKPENVVIIGARSLDEGERKYIKESGMKVYTMHEID 197 Bacillus subtil...
Q59174       147 YTGqKGFEG--YFP----------K-------------LAAp--IDPHNVCMLGIRSVDPAEREAVKKTEVIVYDMRLID 199 Brucella melite...
WP_000604403 140 VLNrVRSGFnRMSE----------SeekawqklcsLGLEKGglEIDPKCLVYFGVRSTEQSERDVIRELQIPLFSVDAIR 209 Helicobacter py...
P00812       170 LMG-LNKDV-PHCP----------Es---------LKWVPG--NLSPKKIAYIGLRDVDAGEKKILKDLGIAAFSMYHVD 226 Saccharomyces c...
4G3H_A       140 VLNrVRSGFnRMSEseekawqklcS----------LGLEKGglEIDPKCLVYFGVRSTEQSERDVIRELQIPLFSVDAIR 209 Helicobacter py...

1WVA_A       205 RLGIGKVMEETLSYLLGRKk--rPIHLSFDVDGLDPSFTPATGTPVVGGLTYREGLYITEEIYK--T--GLLSGLDIMEV 278 human
P05089       205 RLGIGKVMEETLSYLLGRKk--rPIHLSFDVDGLDPSFTPATGTPVVGGLTYREGLYITEEIYK--T--GLLSGLDIMEV 278 human
P40906       222 KYGIGRVVEMALAHIGQDT----PIHLSFDVDALDPQWAPSTGTPVRGGLTLREGDFIAESIHE--T--GSLVAMDLVEV 293 Coccidioides po...
P39138       198 RLGMTKVIEETLDYLSACDg----VHLSLDLDGLDPNDAPGVGTPVVGGISYRESHLAMEMLYD--A--GIITSAEFVEV 269 Bacillus subtil...
Q59174       200 EHGVAALLRRFLERVKAEDg---lLHVSLDVDFLDPSIAPAVGTTVPGGATFREAHLIMEMLHD--S--GLVTSLDLVEL 272 Brucella melite...
WP_000604403 210 EN-MQEVVQKTKESLKAVD----IIYLSLDLDIMDGKLFTSTGVRENNGLSFDELKQLLGLLLEsfK--DRLKAVEVTEY 282 Helicobacter py...
P00812       227 KYGINAVIEMAMKAVHPETngegPIMCSYDVDGVDPLYIPATGTPVRGGLTLREGLFLVERLAE--S--GNLIALDVVEC 302 Saccharomyces c...
4G3H_A       210 EN-MQEVVQKTKESLKAVD----IIYLSLDLDIMDGKLFTSTGVRENNGLSFDELKQLLGLLLE--SfkDRLKAVEVTEY 282 Helicobacter py...

1WVA_A       279 NPSLGKTpeEVTRTVNTAVAITLACFGLARE 309 human
P05089       279 NPSLGKTpeEVTRTVNTAVAITLACFGLARE 309 human
P40906       294 NPTLETl--GASETIRAGCSLVRSALGDTLL 322 Coccidioides posadasii C735 delta SOWgp
P39138       270 NPILD----HKNKTGKTAVELVESLLGKKLL 296 Bacillus subtilis subsp. subtilis str. 168
Q59174       273 NPFLD----ERGRTAAVMVDLMASLLGRSVM 299 Brucella melitensis
WP_000604403 283 NPTVSIK--HNNEEEKQVLEILDLIINSCKI 311 Helicobacter pylori
P00812       303 NPDLAIHdiHVSNTISAGCAIARCALGETLL 333 Saccharomyces cerevisiae S288c
4G3H_A       283 NPTVSIK--HNNEEEKQVLEILDLIINSCKI 311 Helicobacter pylori 26695
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