Conserved Protein Domain Family
Acr2p

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cd01531: Acr2p 
Eukaryotic arsenate resistance proteins are members of the Rhodanese Homology Domain superfamily. Included in this CD is the Saccharomyces cerevisiae arsenate reductase protein, Acr2p, and other yeast and plant homologs.
Statistics
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PSSM-Id: 238789
Aligned: 7 rows
Threshold Bit Score: 166.05
Created: 6-Jul-2004
Updated: 2-Oct-2020
Structure
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Aligned Rows:
 
active site
Feature 1:active site
Evidence:
  • Comment:The (CxxxxxR) motif is required for catalytic activity of Saccharomyces cerevisiae arsenate reductase Acr2p.

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                                                                                     
Q06597      2 VSFITSRQLKGLIenq-----rkdFQVVDLRRe--DFArDHITNAWHVPVtaqiTEKQLNQLikglsdt------fsssq 68  baker's yeast
NP_983285   9 IRYLEPAELFRWIkqacg-adsqpFQVLDVRGs--DYIgGHIAGAWNYPYq--rLKHESAALdelraqllethaaaagtg 83  Eremothecium gossypii
EAK93464   10 LKFIKPKTLKSWFtngss--phgkFCVVDVRDs--DFVgGHIKGCYHYPAa--nFHYTLNELyqkiy----------qnk 73  Candida albicans S...
P42937      9 VKYLDPTELHRWMqeghtttlrepFQVVDVRGs--DYMgGHIKDGWHYAYs--rLKQDPEYLrelkhrlle--kqadgrg 82  baker's yeast
NP_568119  21 ISYITSTQLLPLHrr-------pnIAIIDVRDeerNYD-GHIAGSLHYASg--sFDDKISHLvqnv------------kd 78  thale cress
AAK20061    5 VSYVSAAKLLAMArsn------prVAIIDVRDeerSYQ-AHIGGSHHFSSr--sFAARLPELarat------------gd 63  Japanese rice
NP_595247   4 LSYVSPDALKGWLmes-----pneISIIDVRDy--DYEgERIPGSVRIPSd--tFLASVDQHvddl------------mk 62  fission yeast
Feature 1            #######                                                    
Q06597     69 fVKVIFHCTGSKNRGPKVAAKFETYLQEedi---------------tskFESCILVGGFYAWETHC 119 baker's yeast
NP_983285  84 pIHCVFHCAQSQQRGPASAMRFLRALSDgdl----------------pqFEVWVLRGGFNLWQSMY 133 Eremothecium gossypii
EAK93464   74 iQDIVFHCALSQVRGPSSTLKFLRGIDDitdskvk-------syfnddnIRVYVLHGGFTKWQEEY 132 Candida albicans SC5314
P42937     83 aLNVIFHCMLSQQRGPSAAMLLLRSLDTael----------------srCRLWVLRGGFSRWQSVY 132 baker's yeast
NP_568119  79 kDTLVFHCALSQVRGPTCARRLVNYLDEkked--------------tgiKNIMILERGFNGWEASG 130 thale cress
AAK20061   64 kDTVVFHCALSKVRGPSCAKMFSDYLSEtkee--------------sgtKNIMVLERGFNGWELSG 115 Japanese rice
NP_595247  63 kRSLIVHCTYSQVRGPKAARVLSEILRNriteskeklslsqkeklfqnlPTVYILHGGFSAWKRRY 128 fission yeast

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