Conserved Protein Domain Family
NPR3

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pfam03666: NPR3 
Nitrogen Permease regulator of amino acid transport activity 3
This family, also known in yeasts as Rmd11, complexes with NPR2, pfam06218. This complex heterodimer is responsible for inactivating TORC1. an evolutionarily conserved protein complex that controls cell size via nutritional input signals, specifically, in response to amino acid starvation.
Statistics
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PSSM-Id: 427435
Aligned: 68 rows
Threshold Bit Score: 325.37
Created: 22-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Q6FVA1        243 EFDIDFLAELCCPSREMCNTRFELTVDEYCFLGHPIHVDSSGNWRKSRKRnns-------------lskSKRSGSLtgSR 309  [Candida] gla...
CCF52588      203 GYDIEILASILNPRPELAHQKFELIVDDLAFLGHPVSAGKAGTWGDPENNrdgndkdadddndrskaqtQQRGRSGlrKE 282 
GAC76013      199 GYDIEILASILNPRPELAHQKFELIVDDLAFLGHPVAASKAGTWGEPDNHdghpgatds-ddahaaapsQRRGRSGlrKE 277 
EST05284      203 GYDIELLASILNPRQELTHHKFELMIDDLAFLGHPVSLDRSDILGGQDDEdadaeg--------hdrsaGQRGRSGlrKE 274 
KIS69018      205 GYDIDILASILNPRPELSHKKFELVIDDLAFLGHPVTPNKNGVWGDQDDEsqddrvear--dektaahaQQRGRSGlrKE 282 
EPT01368      133 GYSAEYLAGLLCPQDSMCHQKFELVVDDLAFIGHPVCAEPDGSWRFKPKV-------------------INRGRGSrkGE 193 
EGN98979      132 GYSSEFLASMLCPQRSLCHQKFELRIDDLVFLGHPVGAESDGSWRFKSEKlk----------------sGSRGRGSrnRD 195 
EFI27887      119 GYSGEFLASLLCPQSNKCHQKFELIVDDLAFLGHPVAANERGEWEFRPEPtk----------------gSVRGREGkeKK 182 
XP_007842193   83 GYSSEFLAGILCPHASMCHQKFELVVDDLAFIGHPVCAEAGGIWHFKQEKpk----------------vSSRGREShnRP 146 
EFJ03428      127 GYNAEFLTNLLCPHVSMCHQKFELIVDELAFIGHPVCAYPDGTWKFKPEVgk----------------gLNRGRGSrnRQ 190 
Q6FVA1        310 KRSGSKssnhdkSFSAETPNSPESSKIiEEVGSLHKSRTLSNPQN-------DHFTKDMTMFHVCFIMD-PNLI------ 375  [Candida] gla...
CCF52588      283 VRPYDLqdgeetSKDSTAPTSAKNDKAeLQSSAKSRSISQSCMELttdsttsSKSHAPLSSFHLVLVLDrPDPSaamsgm 362 
GAC76013      278 IRPYDVpdgqtpAKEPDADSAKKGKSEpKTSDTEap---------------aSKAAAPLTQFHLVLVLDrPDPStamsgm 342 
EST05284      275 IRPYDVsdggdaSKDAACSLRQNGGKTeAAAPTKARNASQTRMEQtsd-ssvSRSYAPLTQFHLVLVLDrPDPStamhgm 353 
KIS69018      283 IRPYDPsddrvaSND--------KIDKsAKTGAKSRNASLTRIEQtnd-iptSRSKAPLTQFHLVLILDrPDPStavpgv 353 
EPT01368      194 APKLAEtsltpdRVERHKRp--------------------------------LPDPSWLQTFHLVLVLDrPDPS------ 235 
EGN98979      196 ATQQDDgkseisSIAEKGp---------------------------------PAQSLWLQMFHFVIVLDlPDPS------ 236 
EFI27887      183 AKEGEGsgksksPNPASALAPENGKEGvASSTTTTTAAVk------------PKKPSWMQKFQLAFVLDlPDPS------ 244 
XP_007842193  147 TSRNDSaprndsSPSRSPSNEKSVAVp-------------------------SNKCAWLHTFHLVMVLDlPDPS------ 195 
EFJ03428      191 MSSATNddadpsDAHPAEHl--------------------------------GTKSAWLQSFHVVLVLDlPDPS------ 232 
Q6FVA1        376 EYNKR-----VDDMYQYVVARLSVLLRYLQSKNDYVSEQCELILKEKEKVFKNSKhykslslpseKGRYLYQRLLAKSSL 450  [Candida] gla...
CCF52588      363 DLSSW-----LQLFYDNIVFKMTAALFAEQSKSDYVGCETEKLLSLRERCMDDGQ----------AYAAYAAQCLGISSL 427 
GAC76013      343 DLSSW-----LQLFYDNIVFKMTAALFAEQSKSDYVGRETEKLLALRERCMDDGQ----------AYSAYAAQCLGISSL 407 
EST05284      354 DISSW-----LQLFYDNIIFKMTSALFAEQRESDYIGRETEKLLALRERCMDDGQ----------AYAAYAAQCLGISSL 418 
KIS69018      354 DLSSW-----LQLFYDNIVFKMTAALFAEQSKSDYVGRETEKLLALRERCMDDGQ----------AYAAYAAQCLGISSL 418 
EPT01368      236 SSTSGtiwkyFDTIYEQIAFTTTAVLYQEQVLHNFVEDECDVLGALRDEYSRRGE----------QFADYLREALNMSSL 305 
EGN98979      237 SSASGnvakyFDVIYEQIAFTVTAVLFQEQVLSNFVEAECDILVSLKDEYIDKGE----------PYSEFNAQALLRSSL 306 
EFI27887      245 SSASGnvlkyFDIIYEQVVFTFTAVLFQEQVLSNFVEAECDVLIPMKESFAEQGQ----------PYKEFVNQALQASSI 314 
XP_007842193  196 SSAAGnvskyFDVIYEQAAFIVSAVLFQEQVVSNYVEKECDQLGSLRDDCMKKGT----------SFSEFSSQALELSSL 265 
EFJ03428      233 SSNSGnvwkyFDIIYERIAFNLTAVLFREQVLSNFVEMECEQLMSIRESCIAKGE----------HFSTYMTQALAQTSI 302 
Q6FVA1        451 ARALTECVEKIKKNEIACLEITDHRTVSLQIPIQNEFSilpqyklypvlkgSFLTSIQN--------------------- 509  [Candida] gla...
CCF52588      428 ARCIRDLHKSISTSSDAFLTINDRIEVHLQLPPILQDP-------------TNLPKTVDieteldpndpiflsgggfagl 494 
GAC76013      408 ARCIRDLHKSISTSSDAFLTINDRIEVHLQLPPILQDP-------------VNLPKTVDieteldpndpiflsgggfagl 474 
EST05284      419 ARCIRDLYKSISTSSDAFLTINDNIEVHLQLPPILQDP-------------SNLLKTVDietdldkndpiflsgggfsgl 485 
KIS69018      419 ARCIRDLHKSISISSDAFLTINDRIEVHLQLPPILQDP-------------SSLAKTVDieteldpndpiflsgggfegl 485 
EPT01368      306 AASMKTLYESIKEKTIAQITI-HELPLELQLP-------------------PFLDSMLQaqdeleldavn----prsedg 361 
EGN98979      307 APAMKTLYEAIQSSTMAYITI-HDLPLELQLP-------------------PYLDHLLHseeeydldfvd----ykeddd 362 
EFI27887      315 ASAMKCVYEAIKTRSIAYVTL-NNIPIELQLP-------------------PYLDTLLHndseldpdsie-----rpdde 369 
XP_007842193  266 ASAMKTLFEAIKASSIAYISL-NDLPLEIQLP-------------------PYLDLLLHndeeadfngfm-----vgdee 320 
EFJ03428      303 APAMQVLFDAIKTSTIAYITI-HDLPMELQLP-------------------PYLDSLLKvesdddvdel-------qeqd 355 
Q6FVA1        510 -----N-----------------------------KFLEKsaniddnhhaksardtnlisdhvntfsngqtkneifyskn 555  [Candida] gla...
CCF52588      495 gkegaDedggggtydrlldlaphqlsfeewcrttgPYLLP---------------------------------------- 534 
GAC76013      475 gkegaDedggggtydrllelaphqlsfeewcrttgPYLLP---------------------------------------- 514 
EST05284      486 gkegqDedggggthdrllglepnqlsfeewcrttgPYLLP---------------------------------------- 525 
KIS69018      486 gkegaHqdgsggtykrrmamtpaqlsfeewcrttgPYLLP---------------------------------------- 525 
EPT01368      362 llnpwGsmsv---------------------gwrlPALKP---------------------------------------- 380 
EGN98979      363 esrawGremsf--------------------gwrlPALAP---------------------------------------- 382 
EFI27887      370 eqqnwGpelsf--------------------gwrlPALAP---------------------------------------- 389 
XP_007842193  321 dyrawGpemsf--------------------gwrlPALVP---------------------------------------- 340 
EFJ03428      356 aaemwGphmsy--------------------gwrlETLAP---------------------------------------- 375 
Q6FVA1        556 menaltaqndyddddllLYSiLLL-DDPDKIIADLD------------------NySSNDD---IGGVILKQLVK-VIQP 612  [Candida] gla...
CCF52588      535 -----------------WKTlLLLhDQADETLARGRqtpgnsspagmaspggggStGPEAHgfeQLARNFTSLFRlNLNH 597 
GAC76013      515 -----------------WKTlLLLhDQPDEA-ARGRrtpgsasp---aghltpaEqAPETHgfeQLARNFTSLFRpDLMH 573 
EST05284      526 -----------------WKTlLLLhDHAD--PGRDRntagsssp---sgalspsGqAPETHgfeQLTRNFTALFQpNLYH 583 
KIS69018      526 -----------------WKTlLLLhDQVDEAPNRERaksdtcspaglaspgegaSqALEAHgfdQLARKFTSFFTpSLYN 588 
EPT01368      381 -----------------WKSlLRL-DDEDERGKNelyrr-----------lrapQlTAEDN---ELAEQLVKFLE-IADV 427 
EGN98979      383 -----------------WKSlLLL-DGDQGLdpymn--------------lrgpHvRPEER---TLAQGLIKFLE-TASV 426 
EFI27887      390 -----------------WKSlLLL-DGSDELedpia-------------slrgpHvSVEDR---ALAEGLIRFLE-TASI 434 
XP_007842193  341 -----------------WKSlLLL-DNIDDFdpfsd--------------lrgpHvSPDDR---SLAEGLLKFLE-TANV 384 
EFJ03428      376 -----------------WKSiLLL--EKDGFdpfas--------------lrgpHvSVNDR---PLVDGLIRFLE-VASI 418 
Q6FVA1        613 NVPLLSYQYIINELLAEkplsssttankskqnkdnktntfysalLRSCALHLIYWRHARAILPISF--KNTYIVSPLSPV 690  [Candida] gla...
CCF52588      598 SLNLSEVADMLGWNLYEd--------------------------VYPMVRHLIYYRQARVIDIPRV--HHVYAISPLFDF 649 
GAC76013      574 SLNFSEVADMLGWDLYEd--------------------------VYPMVRHLIYYRQARVIDIPRP--GHVYAISPLFDF 625 
EST05284      584 TLNFSDVADMLGWELYEd--------------------------IYPMVRHLIYYRQARVIDIPKP--GHVYAISPLFDF 635 
KIS69018      589 TPNFSQVADMLGWDLYDd--------------------------VYPMVRHLIYYRQARVIDVPRP--GHVYAISPLFDF 640 
EPT01368      428 TLSLSDMASLLDWDLETr--------------------------IYPTVRWLVHHRRAKVVDIVHPglRTIFTVPLKFTA 481 
EGN98979      427 TLSLADMASLLDWDLENq--------------------------IYPTVRWLVHHRRAKVVDIVHSglKTIFTLPPRFEA 480 
EFI27887      435 TLSLADMASLLDWDLESq--------------------------VYPVVRWLVQHRRAKIVDIVNPglKTIFALPSKFPA 488 
XP_007842193  385 TLSLTDLTSLMDWDLESq--------------------------VYPIVRWLVQHRRAKVVDIVHSglKTVFMLPPKFDY 438 
EFJ03428      419 TLSLADMSSLLDWDLDTq--------------------------IYPVVRWLVEHRRAKIVDVVHPglKTVFTLPPKFEQ 472 
Q6FVA1        691 EadnsemikgnrkpsitdlnvtsnssskipVIYLNQQSFKLKF--PSLPSLPTFLNILSLGK-----PKAFGNIIPSKEH 763  [Candida] gla...
CCF52588      650 A-----------------------------RLGPLSTIWAQTF--PDMVPLPVFLSQLSSS------ARPLSTYFPSRHQ 692 
GAC76013      626 G-----------------------------RLGALSRVWAHTF--PELAPLPVFLSQLSSS------SRALSALFPGRHQ 668 
EST05284      636 A-----------------------------RLGPLSHVWARSF--PDVAPLPVFLSQLSSS------SRAFYALFPARHQ 678 
KIS69018      641 A-----------------------------RLGSLSYNWAQTF--PDVAPLPVFLSQLSSST-----SRTLSNLFPARHQ 684 
EPT01368      482 P------------------------------MSALSADFDRRFaeHDVPPLPKILSMVSMSIhqqsaNHFYGTVVGSKER 531 
EGN98979      481 S------------------------------LSSLSIDFKREFphPSIPHLPTILSNVSTATskqsdNHFFATVVQSKEL 530 
EFI27887      489 S------------------------------LSTLSHQFNQQFnhPAIPSLPRILAAISYSLaqqsnNHFFAAVVQRKEL 538 
XP_007842193  439 P------------------------------LSQLIKEFERDFseSNLPPLPQILSAISTSSanqsgNHFFASVVQSKDM 488 
EFJ03428      473 P------------------------------LSELTAEFEQEFtdPSVASLPEILSLISTAPskqsdNHFYATVVQSRDL 522 
Q6FVA1        764 KPIYMAALIWLIQKGYLTQLLTFVYIRVDKKIKM 797  [Candida] glabrata CBS 138
CCF52588      693 RELALDVLIWLLRREVVVKMHIRLRLIATENVKR 726 
GAC76013      669 RELALEVLIWLLRRDVVVKMHIRLRLFATEAVKR 702 
EST05284      679 RELALDVLIWLLRREVVVKMHIRLRLIATESVKR 712 
KIS69018      685 RELALEVLIWLLRHEVVVKMHIRLRLIATESVKR 718 
EPT01368      532 IPLYQDVVVWMLKRDLLLTLHLRIRIVATEELKH 565 
EGN98979      531 IPLYHDVVLWMLKHELLLTLHLRIRIVATSELKK 564 
EFI27887      539 IPMYHDVVLWMLKRELLITLHLRIRIVVTPEIKQ 572 
XP_007842193  489 IPTYHEVVVWMLKRDMLTTLHLRIRIVATAQLKA 522 
EFJ03428      523 IPIYHDVVLWMLKRGLLIRLSLRIRIVATRELKE 556 
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