6NWR,2UXY,6I00,3WUY,6YPA,1F89,4HG5,1EMS


Conserved Protein Domain Family
CN_hydrolase

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pfam00795: CN_hydrolase 
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Carbon-nitrogen hydrolase
This family contains hydrolases that break carbon-nitrogen bonds. The family includes: Nitrilase EC:3.5.5.1, Aliphatic amidase EC:3.5.1.4, Biotidinase EC:3.5.1.12, Beta-ureidopropionase EC:3.5.1.6. Nitrilase-related proteins generally have a conserved E-K-C catalytic triad, and are multimeric alpha-beta-beta-alpha sandwich proteins.
Statistics
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PSSM-Id: 425873
Aligned: 52 rows
Threshold Bit Score: 68.1512
Created: 21-Mar-2022
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
6NWR_B        223 QVSMVQGDIPqslK--WDEGQLLNTLKIYYNA---------------------------TAPLmgKSSLIIWPESAITdl 273 Escherichia co...
Q44365         66 LAASRGLPQGaanFyaASFWPGFLLWVAASTSfvfvhvalwkkhrsqgasgkkradaagAVRYqaALLLTGLPPFGITg- 144 Agrobacterium ...
P76280          5 KVAAAQYEPr-----kTSLTEQVAHHLEFVRA---------------------------AARQ--QCQLLVFPSLSLLgc 50  Escherichia co...
Q44351         81 LTASRGLPQGvanFyaADFWHGLLLWLAASAGfvavhaafwparlqkrlpgrgalgwgkPVRYlaAAVLMGLPPFGITg- 159 Agrobacterium ...
ABN47151       58 LAASRRLPQGvaaFyqSDIWPGLILWLTASIGfvflhsilw----------spgrdnwsALRYsiVMIVMAVPPFGIVg- 126
Q1M995         58 LAASRGLPQGvaaFyqSDIWPGLILWLVASSGfvfvhvalw----------srqsggwkALRYtiAMVLMALPPFGIVg- 126 Rhizobium legu...
Q1M9U1         58 LAASRGLPQGvaaFysSNIWPGLLLWLGASMSfvtvhsvl-----------wtkypnvrPFRYllAAIVMFIPPFGITg- 125 Rhizobium legu...
Q2K2P5         58 LTASRGLPQGaatFysSDLWPGLLLWLCASAGfvivhtvl-----------wtkrtgarPRRYllAAVLMAVPPFGIAg- 125 Rhizobium etli...
P55416         58 LAASRGLPQGvaaFytSDLWPGLLLWLCASGSfvvvhtvl-----------wtkrsdcrPFRYllAAVLMAVPPMGITg- 125 Sinorhizobium ...
oger:pTiBo205  89 LAASRGLPQGvanFyaADLWPGLALWAMASASfvivhavcwtkprggdssgkrgtdaarALRYllAMALTGLPPFGITg- 167
6NWR_B        274 --eINQQP----------------FLKALDGELRDKGSSLVTGIVDARl-----nKQNRYdtYNTIITLGKGAPYsyesA 330 Escherichia co...
Q44365        145 --wAHPLTaagvlfpawgwwglfvTAAGLTVMTTRLWPAATIMLAAFWlwstatwTPPNLpdGWRGVELQQDQKLgr-dG 221 Agrobacterium ...
P76280         51 dysRRALPapp----------dlsLLDPLCYAATTWRMTIIAGLPVE--------YNDRF--IRGIAVFAPWRKT----P 106 Escherichia co...
Q44351        160 --wAHPLTaagilfpgfgwwglgaTTAGLAMMTSRYWPAAAIALGGFWfwsaatwTQPVLpdGWKGVDLEQGQTLgr-dG 236 Agrobacterium ...
ABN47151      127 --wAHPLTaagvllpgwgwaglaaMAAGLAIMTTRYWPAAAITFAGLWlwsaafwTTPNLgqHWQGVDLALGNSLgr-dN 203
Q1M995        127 --wAHPITaagvlfpgwgwaglaaVTAGLALMTTQYRPAVAITLAGFWlwsaafwTAPDIgrHWQGVDLQLGNRLgr-dN 203 Rhizobium legu...
Q1M9U1        126 --wAHPVTaagvlfpgwgwcglglMTAGLAGLVTRTWPAVAIALIGFWlwsaaiwTDAKLpeGWRGVDLEMGASLgr-eA 202 Rhizobium legu...
Q2K2P5        126 --wAHPITaagvlfpgwgwwglaaATAGLMGLVTRMWPAVAFVLASFWiwsaatwDEPNPpeSWQGIDLEMGASLgr-dA 202 Rhizobium etli...
P55416        126 --wAHPVTaagilfpgwgwwglvaTTAGLMGLVTRMWPAVAIAFTGFWlwsaanwTESKLpaSWQGVDLKLGSTLgr-nT 202 Sinorhizobium ...
oger:pTiBo205 168 --wAHPLTaagvlfpgrgwsglgaTAILLVLMTGRRWQIAVAVLGGLYvwsatnwTPPKLtpGWMAVDLKRGGDLgr-dG 244
6NWR_B        331 DRYNKNHLV---PfgEFVPLESILRPLAPFfdlpm----ssfsRGpyiQPPLSangiELTAAIXYEIILGEQVRDn-fRP 402 Escherichia co...
Q44365        222 SLAYQRNLIatvHrtIAEHPEAQVVVLPESalgfwtptvenvwRD---GLRGAdvtvLAGAAVIGRQGYDNIMVSi-tAD 297 Agrobacterium ...
P76280        107 GIYHQSH----------------------------------------------------GA--CLGRRSRTITVVdeqPQ 132 Escherichia co...
Q44351        237 SLDHHRDLIatvR--AAAGAETRVIVLPESalglwtptvarlwQA---GLRGAdvtvIAGAAVIDPGGYDNVMVTv-sEG 310 Agrobacterium ...
ABN47151      204 SLVRHSDLAatvL--NQRRDGAAVILLPEStlgfwtptverfwRT---RLARSgltvVAGAAIVGPGGYDNVLISi-sGH 277
Q1M995        204 SLARHSDLVatlR--SERRPGSTFMLLPESalgfwtpsvervwRQ---QLAEAdlsvIAGAAVVDREGYDNVLVRv-sAT 277 Rhizobium legu...
Q1M9U1        203 GLQRQRDMIatvR--GAASDGVRFVVLPESalgfwtptvarlwTG---ASGDTdatvIVGAVMVDPKGYDNVLVAi-dRR 276 Rhizobium legu...
Q2K2P5        203 SIERHRDLIatvT--DRASGGARSIVLPESslgfwtptvkrlwVR---ALQATdatvIAGAAVVDAGGYDNVLIAi-sGD 276 Rhizobium etli...
P55416        203 SIQRHRDLIatvK--DRASGGVRNVVLPESalgfwtptferlwVK---ALQGTeisvISGAAAIDATGYDNVLVTl-sAD 276 Sinorhizobium ...
oger:pTiBo205 245 SLNYHRDLIatvRrtIAEQPDVYVAVLPESalgfwtptvarlwRE---GLRGSdlivIAGAAVVDPKGYDNAMVAi-sAD 320
6NWR_B        403 DTDYLLTisNDAWFGKSIGPWQHFQMARMRALELARPLLRSTNNGI-------------------TAVIGPQGEIQAMIP 463 Escherichia co...
Q44365        298 EAKIVYR--ERMPVPVSMWQPWLEWTGQGGGASAHFFANPFAEVAGirnaplicyeqlilwpvlqSMLYSPEVIVAVGNG 375 Agrobacterium ...
P76280        133 GMDMDPTc-SLFTTGQCLGEPDLLASARRLQFFSHQYSIAVLMANArg----------------nSALWDEYGRLIVRAD 195 Escherichia co...
Q44351        311 ETRILYR--ERMPIPVSMWQPWLQWTGQGGGAQAHFFANPAVDLAGtriaplicyeqlivwpilhSMLFSPAAIVATGNG 388 Agrobacterium ...
ABN47151      278 GAEVMYN--ERMPVPGSMWQPWLSFVGRDGGARAHFFANPVAPVGNsltaplicyellliwpilqSMIYEPDLIVAAGNG 355
Q1M995        278 DSEILYR--ERMPVPGSMWQPWLAPIGKSGGARADFFANPVVSVGGqrvaplicyeqliiwpvlqSMLHDPDLVVAVGND 355 Rhizobium legu...
Q1M9U1        277 RGRILYR--ERMPVPGSMWQPWRSWFGENGGARADFFANPVVSIGAgraaplicyeqlivwpvlqSMLHDPDFIIAVGNG 354 Rhizobium legu...
Q2K2P5        277 AARLLYR--ERMPVPGSMWQPWRPLLGASGGARAHFFSNPVVTVAGgriaplicyeqlivwpvlqSMLQEPDILVAVGNG 354 Rhizobium etli...
P55416        277 GGRVLYR--ERMPVPGSMWQPWGSWLGESDGARAHFFANPVVTVGNsrvaplicyeqlvvwptlqSMLYEPDLIVAVGNG 354 Sinorhizobium ...
oger:pTiBo205 321 KSNILYR--ERMPVPGSMWQPWLPWTGQGGGARADFFGNPVVEVDGarvaplicyeqlilwpvlqSMLHSPEVIVAVGNG 398
6NWR_B        464 QFTREVLTTNVT-PTTGLTPY 483 Escherichia coli K-12
Q44365        376 WWTEGTSIVAIQrASVTAWAK 396 Agrobacterium tumefaciens
P76280        196 RGSL-LLVGQRSsQGWQGDII 215 Escherichia coli K-12
Q44351        389 WWTEGTSIVAIQqAGVIAWAK 409 Agrobacterium fabrum str. C58
ABN47151      356 WWTKGTNIVAIQrASAVAWAR 376
Q1M995        356 WWTKGTAIIGIQrASAEAWAR 376 Rhizobium leguminosarum bv. viciae 3841
Q1M9U1        355 WWTDGTSIVPIQrAVTTAWAK 375 Rhizobium leguminosarum bv. viciae 3841
Q2K2P5        355 WWTKGTSIVAIQrASTQAWAR 375 Rhizobium etli CFN 42
P55416        355 WWTKGTSIVAIQrVNAIAWAK 375 Sinorhizobium fredii NGR234
oger:pTiBo205 399 WWTENTSIVAIQkASVSAWAR 419
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