Conserved Protein Domain Family
PSRA_1

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cd02558: PSRA_1 
Pseudouridine synthase, a subgroup of the RluA family.
This group is comprised of bacterial proteins assigned to the RluA family of pseudouridine synthases. Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi). No cofactors are required. The RluA family is comprised of proteins related to Escherichia coli RluA.
Statistics
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PSSM-Id: 211332
Aligned: 15 rows
Threshold Bit Score: 371.991
Created: 3-Mar-2005
Updated: 2-Oct-2020
Structure
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Aligned Rows:
 
probable active
Feature 1:probable active site [active site]
Evidence:
  • Comment:D of active site is key conserved residue

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                                                                                       
YP_056974    38 GRFVDESGRTFRRDSpftpqtfVFFHRd--LPTETPVPAGigILYSDErILVVDKPHFLSSIPRGRHVLESVVVRLRTQL 115 Propionibacteriu...
ZP_00379840  60 GDMRDEVGEPIRWDDavvpggfYFFHRp--VPAEERIPFEisVVFEDDdLLVVDKPHFLASTPNGRFVRECVVTRARLDF 137 Brevibacterium l...
CAB59478     57 GVFVGADGRPVAGDApyepgmfVWFHRe--LPAEVPVPFPleIVYRDAhIVVADKPHFLATTPRGGHVTQTALARLRREL 134 Streptomyces coe...
BAC00339     57 DLVVNHYGEPYAPDTmvqpdddIWFYRm--PAAERPIPYKihVIHEDDdILVIDKPPYLATMPRGRHITETALVKMRVLT 134 Corynebacterium ...
NP_639523    49 GRVLDAQQQALEVSApyrlgaeIYYFRe--VADEPTISAVetVVHADGqIVVACKPHFLPVVPAGAYVRETLLARLVRRF 126 Xanthomonas camp...
F70533       47 GEVVDDDGAVVDSGTvlppgsvVHLYRd--LPDEVPVPFDvpVLHQDAdIVVVDKPHFLATMPRGRHVAQTALVRLRREL 124 Mycobacterium tu...
CAB84348     55 GFVVGSDGAALDEHSlfepgkvMFYYRetsRESEPRIPFEekILHIDEhLIVVDKPHFLPVIPSGRFLRETLLTRLRLRP 134 Neisseria mening...
NP_250733    49 GRVLDAEGRALGPQAayreglrVHYFRe--LPVEAPIPFEarILYRDEhLLVADKPHFLPVMPAGGYVEQTLLARLARST 126 Pseudomonas aeru...
YP_116958    54 GAIVDLDGPIAPDAPyvp-ggaVWFHRd--LPDEVEVPFDltVVHRDEtVLVVDKPHFLATIPRGQHIRQTALVRLREQL 130 Nocardia farcini...
NP_940580    89 QVIIGPRFRIASPDSvlrtnddVWFYRi--PAPEPTIPYSctVVYEDDtLLVADKPPFLATMPRGKHITNSATVQLRRST 166 Corynebacterium ...
Feature 1                    ####                                                               
YP_056974   116 Gl-----pELTVAHRLDRVTAGVLLLTReRKWRRPYQEIFERREVVKKYRLVAPVvhdpagegvtatksGWQVRSRIIKE 190 Propionibacteriu...
ZP_00379840 138 Dq-----pDLVAIHRLDRVTAGLLILSKrPETRGRYQRLFQDRLVTKTYRALAAMppad-------lelPLVKESRLVKP 205 Brevibacterium l...
CAB59478    135 Di-----pALGAAHRLDRLTAGLVLFTVrPGERGAYQGLFADRRVHKVYEAVAPYdaa--------lalPRTVRSRILKE 201 Streptomyces coe...
BAC00339    135 Gn-----nDLTPAHRLDRLTSGVLVMVKkPELRGAYQTLFARREASKTYEAIAEFvpgl------lddgPAIWESRIEKE 203 Corynebacterium ...
NP_639523   127 Dn-----pSLVPLHRIDRDTAGLVLFSAnPATRGIYQALFRERRIHKHYLAVAPPlpa--------ltfPYVHRSRLEPG 193 Xanthomonas camp...
F70533      125 Gl-----pELSPAHRLDRLTAGVLLFTTrREVRGSYQTMFARGLVRKTYLARAPVapg--------lalPRLVRSRIVKR 191 Mycobacterium tu...
CAB84348    135 ElqhlnveDITPLHRLDKDTAGVMLLSHnPATRGAYQTMFQNKTVWKTYEALAPTrtd--------lpyPLDVVSRLVRG 206 Neisseria mening...
NP_250733   127 Gn-----rDLVPLHRIDRHTAGLVLFSTnPGSRGRYQALFRERRIDKCYEAIAPAlpq--------ldfPLLRRTRLVPG 193 Pseudomonas aeru...
YP_116958   131 Gl-----pDLVPAHRLDRVTAGLILFVVdPARRGAYQTMFHRRTVRKQYEAIAPFdpe--------lalPRVVRSRIVKE 197 Nocardia farcini...
NP_940580   167 Gi-----dELSPAHRLDRLTSGLLLFTKrKRVRGAYQTLFSERNVRKTYVATAQYnps--------itpGTIWRSHMTKT 233 Corynebacterium ...
Feature 1                                                                        #              
YP_056974   191 RGIlqarevpGVPNAVTDIALIGEhg----------------------gwGLYEASPRTGRTHQIRLHMQRLGAPIVNDP 248 Propionibacteriu...
ZP_00379840 206 RGGrqvleveGEPNAFSKISLLGErtppsprwsdateppprrsvgecpsiGEYQLEPLTGKTHQLRVHMNSLGLPILGDP 285 Brevibacterium l...
CAB59478    202 RGVlaarevaGEPNAVTRVELLAHrpe--------------------hglGRYRLVPGTGQTHQLRVHLNALGVPILGDP 261 Streptomyces coe...
BAC00339    204 RGIvqafvveGPVNARTELVSVTPvedaeqsile-------emhgplprqARYVLAPSTGKTHQLRIHMRDFAAPILGDP 276 Corynebacterium ...
NP_639523   194 EPFfrmregvGEPNSETVIDVVARga----------------------dmWTYRLEPVTGRKHQLRVHMAALGVPILHDR 251 Xanthomonas camp...
F70533      192 RGHlqavcepGVPNAETLVERIARd-------------------------GLYRLTPTTGRTHQLRVHMAALGIPIMGDP 246 Mycobacterium tu...
CAB84348    207 EKFfttqeaeGEPNAHTTVELIENrg----------------------efSLYRLTPHTGKKHQLRVHMMGLGMPLLNDA 264 Neisseria mening...
NP_250733   194 EPFfrmregeGEPNSETRIEVVERng----------------------rwWRYRLYPVTGKKHQLRVHLAALGAGIQNDG 251 Pseudomonas aeru...
YP_116958   198 KHVlaareveGEPNAETLVELLEHrd----------------------glGRYRLTPHTGRTHQLRLHMNSLGVPILGDD 255 Nocardia farcini...
NP_940580   234 AGEiqghiidAPPNAETLVSAIERidaptqqhlh-------alhgtdvdlAHYTLKPHTGKTHQLRLHMLAAGVPILGDT 306 Corynebacterium ...
Feature 1                                                    
YP_056974   249 FYPVVLdtp--vdDFTHPLQLQAWRMGFTDPVTGDPRAFTSRLRL 291 Propionibacterium acnes KPA171202
ZP_00379840 286 VYPVDRapd--pyDFSSPLQLLAASIGFDDPLTGRPRRFESGLSL 328 Brevibacterium linens BL2
CAB59478    262 LYPEVAapv-pagDFRRPLQLLARELGFTDPVTGREHRFRSGRSL 305 Streptomyces coelicolor A3(2)
BAC00339    277 LYPVLHavd--deDYTTPMHLIARTLTFVDPQTNEERTFVSNRPT 319 Corynebacterium glutamicum ATCC 13032
NP_639523   252 FYPELEdqr--pdDPERPLQLFAHMLAFDDPITGEPRRFTATVGP 294 Xanthomonas campestris pv. campestris str. ATCC 33913
F70533      247 LYPNVIsva--ahDFSTPLQLLAQRIEFDDPLTGSHREFASTRTL 289 Mycobacterium tuberculosis
CAB84348    265 LYPVPSeag--seDYRKPLKLLAKKIAFADPLSGRERVFCSGFCL 307 Neisseria meningitidis Z2491
NP_250733   252 FYPELLdaegspdDYLRPLKLLARGLCFDDPLSGERRMFESGLRL 296 Pseudomonas aeruginosa PAO1
YP_116958   256 FYPVLTdkp--vhEFTRPLQLLAAVLEFTDPVTGEPRRFETTRSL 298 Nocardia farcinica IFM 10152
NP_940580   307 IYPTILaed--aeDYSRPMHLTSTELEFIDPLTGRPRLFTGAVIQ 349 Corynebacterium diphtheriae NCTC 13129

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