1XFJ,1T8H,1RV9,1Z9T,1RW0,1U05,1XAF


Conserved Protein Domain Family
YfiH
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cd16833: YfiH 
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protein of unknown function YfiH
This subfamily contains YfiH, a protein of unknown function from Shigella flexneri, E. coli, and many similar proteins which collectively are often called DUF152. The structure of YfiH reveals a distant homology to Rho-activating toxins cytotoxic necrotizing factor 1 (CNF1) as well as chemotaxis protein CheD that stimulates methylation of methyl-accepting chemotaxis proteins (MCPs), all having an invariant Cys-His pair forming a catalytic dyad, and is required by the CNF-1 toxins for deamidation activity.
Links
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Statistics
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PSSM-Id: 319354
Aligned: 966 rows
Threshold Bit Score: 99.1959
Created: 28-Feb-2012
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
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putative
Conserved site includes 2 residues -Click on image for an interactive view with Cn3D
Feature 1: putative catalytic site [active site], 2 residue positions
Conserved feature residue pattern:[CS] HClick to see conserved feature residue pattern help
Evidence:
  • Comment:by similarity to other members of this family
Scroll to Sequence Alignment Display
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                                                       #                #            
1XFJ_A     69 DLNVCYQIHs---TIAIVadgswg-darpegDAVVSktpGVICGAXa-ADCAPVLLVDpearIVAAAHAGWRGalDGVVQ 143 Caulobacter vibrio...
AKQ43090   42 EPVFVRQVHs---ARVLNvdkpfkrenipeaDAMVTt-hRALMLGIvtADCAPILFEDveagVIGAAHAGWRGaqAGIAH 117 Erythrobacter sp. ...
ADE40438   79 RLYGLRQCHs--aKAVLValdqda-gqrpdaDAHVTt-iAEYGLAIltADCTPVLFADreagVIGAAHAGWRGacGGVLE 154 alpha proteobacter...
ETO91411   59 KVCTLQQRHtn-kVFILNsasecd--heihaDAIVTn-iLSIPIVVytADCVPIFFADvqkgVIAICHAGWRGtlNGIIE 134 Candidatus Xenolis...
ETZ05479   70 KMMFPCQVHgg-dVFIVTkdips---dapdcDGLVTd-vPGITLCVstADCAPVMFWDte-sVVGICHAGWKGvfLGVLE 143 Holospora undulata...
EHI47831   73 RMAGLYQIHs---ARCVTltdqtdcaqrpeaDAYVTa-lSGVGLAIltADCLPVLFCDarqgVIGAAHAGWRGaaAGVIE 148 SAR 116 cluster al...
AEQ52185   66 EVALVRQVHg---THVLTvdgtfdlqqrpeaDAMVTd-rSGIALGIvtADCAPILLADpkagIIGAAHAGWKGavGGILA 141 Pelagibacterium ha...
AHX11119   47 EYVFPKQVH----SNICMftrtps-anslkcDAIVTd-qPNLTLVVktADCVPILLSDpvnhIIGVVHAGWKGlnSGVIQ 120 Neorickettsia helm...
AFS48988   54 NLIIPDQYHs--sKCLVAkannp----ypkcDALVTs-dNSLILGIttADCLPIIFYDpknqVIGIAHAGWKGlvKGVIQ 126 alpha proteobacter...
EKE10524   29 SLVTLKQVHgikvHRITEtrkd-----apegDGLVTn-vRGIVLGIftADCGPVLFYDpeanIIGACHAGWRGakAGILQ 102 uncultured bacterium

Feature 1                                                                                     
1XFJ_A    144 SAVDRXvelgaspaNITGVVGPCIGPKSYEVg----lEFLHRFEAdcpgsgrffkp-----gasedkrffdlPAFVLDRL 214 Caulobacter vibrio...
AKQ43090  118 ATVSEMeklgasrrAIRASIGPCIRQDSYEVd-----DAFREYFVfpqddeffstgrdghwqfdlagyvaaqLVSLLGGD 192 Erythrobacter sp. ...
ADE40438  155 ATINRMckagatcdNITAVIGPCIRQHSYQVg----gDLRDEALAstedaavffaadq-esgkyrfdlagyiAMRLKGCR 229 alpha proteobacter...
ETO91411  135 NTVDTMkhlgsnihDIKVLIGPSIQQHSYEVq----kDFYDTFLNeskynnkffktkd-namffdlvgyaihRLRSLSIQ 209 Candidatus Xenolis...
ETZ05479  144 NTLAAVrsvsksplKVQACIGPTIRLKNYEVs----cDFYHSFIKedpescnffqkee--klffdlpgyiafRLSKKECK 217 Holospora undulata...
EHI47831  149 ATVQAMqglgadirQIVMVIGPGIRQPSYQIsaemreEIISSYPEavscfmadpaaed--kflfdlpgfakgLGQAAGLS 226 SAR 116 cluster al...
AEQ52185  142 NTIAAMerlgasraNIVAAIGPAISAENYEIgeemanEIRTQFPDaadfivtdgwpk----phfdvpglvlaQAKSLGIG 217 Pelagibacterium ha...
AHX11119  121 NAIAKMidigsqskYINVAIGPCILRENYEVq----eDFLEAFGStgkefsrlkqgk----yyfdllgccqdILKKEGIR 192 Neorickettsia helm...
AFS48988  127 NTVKKMislgaqnkSIKSIIGPCIRVKSYEVn----eEFVNKLKTqyqrfairqtqk----iyfdlpklakyILSESNIS 198 alpha proteobacter...
EKE10524  103 ATLREMeilgaqrsRIHASLGPTIQQKNYEVgpefpdLIRESYDTyfvpsdkkghh------yfnlplyicqQLKAEGVK 176 uncultured bacterium

Feature 1                                                       
1XFJ_A    215 atagverREWVGRDTra---eeEWFFSNRRaflnn--dgdyGRLLSAITL 259 Caulobacter vibrioides
AKQ43090  193 s------VEITGIDTya---naEHFHSFRRathl---gkasQGRQYSLIA 230 Erythrobacter sp. s21-N3
ADE40438  230 -------INTIHDCQrdtysesDQFFSHRFatha---gdsdSGRLISVIA 269 alpha proteobacterium IMCC1322
ETO91411  210 c------IYDCKINTys----nFNFASFRKnkhl---dlinLGIMMLVNK 246 Candidatus Xenolissoclinum pacificiensis L6
ETZ05479  218 -------VFDTLEDTy-----eSRFFSRRHhkkqnfcceygFGSMIGLPI 255 Holospora undulata HU1
EHI47831  227 q------IYDSGCDTyt---deTHFFSHRRathr---kepdSGRLISVIT 264 SAR 116 cluster alpha proteobacterium HIMB100
AEQ52185  218 t------VESVGSCTya---hpDLYFSHRYathn----ntrAGRQIALIA 254 Pelagibacterium halotolerans B2
AHX11119  193 e------IHTSEVDTyt----nTGISSYRRtrhl---nnpdTYRNISAIV 229 Neorickettsia helminthoeca str. Oregon
AFS48988  199 s------VHDIKKNTfl----dKNYFSFREskkk---kyrdYGRNINLIS 235 alpha proteobacterium HIMB59
EKE10524  177 g------IYDIGCDTf------TSYFASRRrs-------laEGYEEISID 207 uncultured bacterium

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