Conserved Protein Domain Family
MBLAC2-like_MBL-fold

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cd07712: MBLAC2-like_MBL-fold 
uncharacterized human metallo-beta-lactamase domain-containing protein 2 and related proteins; MBL-fold metallo hydrolase domain
Includes the MBL-fold metallo hydrolase domain of uncharacterized human MBLAC2 and related proteins. Members of this subgroup belong to the MBL-fold metallo-hydrolase superfamily which is comprised mainly of hydrolytic enzymes which carry out a variety of biological functions.
Statistics
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PSSM-Id: 293798
Aligned: 24 rows
Threshold Bit Score: 212.104
Created: 19-May-2009
Updated: 2-Oct-2020
Structure
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Aligned Rows:
 
Feature 1:putative active site [active site]
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                                                                          # # ##     
Q68D91     22 RFYESgn--------rANIWLVRGSEQDVVIDTGLGLRSLpeYLYSSGLLqdreakedaarrPLLAVATHVHFDHSGGLY 93  human
NP_229099  14 NVWHIady------rgDSMYLVVGEEKALLVDTGMGEGDLkgFVRSITEK------------PVEVVLTHAHWDHIMQAN 75  Thermotoga maritim...
ACI18657   16 HHISDyr--------gDSFYLIFGDNKAILFDTGMGNGDLkgYIKNLTDK------------EVEVIISHAHWDHIMQAN 75  Dictyoglomus therm...
ADQ78829   39 KVWAIvesa----dtpVNIYLVEGKDSAMVIDTGYGRGDLvtFVRTLTKL------------PLIVVNTHGHGDHDGNDS 102 Paludibacter propi...
AGK98701   12 GFYSIeq-------gfVRSFLIEGDKDALLIDTGVGDGNLkeYVEEITKL------------PVTVIFTHADGDHVGAAW 72  Clostridium pasteu...
AGC68886    3 NIIQIndttwriedngVRFFLLAGTEKALLIDSGMNTPDAkqIAENITKL------------PVMLLNTHADPDHISGNG 70  [Clostridium] ster...
CEA15673   45 WVVETnd--------lTTMYILEGDNQAMLIDTGTKCKSLdkIVREITQK------------PLTVVLTHNHRDHAGNIH 104 Porphyromonadaceae...
CDA75371   36 TYVFEtw-------dyTTMYLLEGDDKAILIDTGTKCADLdkIVKRVTNK------------PFEVVVTHAHPDHAGCIG 96  Bacteroides sp. CA...
CDF08416   19 HIWLLndh------ddGTGYLVTGTDKALVIDTMYGQEDLkeAVKTLTDL------------PLMLVNTHGHFDHTYGNL 80  Firmicutes bacteri...
EFB74485   11 LYILEdd--------rVRQFLLLGPDKAILLDTGFPDSETlpAVRTLTDK------------PVQVLLTHGDFDHTGRLD 70  Subdoligranulum va...
Feature 1                                                                                 ##  
Q68D91     94 QFDrVAVHHAEAEALargdnfetvtwlsdsevvrtpspgwrarqfrvqavQPTLILQDGDVINLGDRQLTVMHMPGHSRG 173 human
NP_229099  76 QFEkVYLNHRDFQIIelfki--------------------------nvnyENFLNVKEGDRFDLGGRTLEVIEVPGHTPG 129 Thermotoga maritim...
ACI18657   76 QFEkVYMNHKDIEIIklfnm--------------------------nidyTNFLDIRDGEIIDLGKRKLEIIEVPGHTPG 129 Dictyoglomus therm...
ADQ78829  103 QFSkIYAHPADFGMInasfnrekrrk--------------tvlpgevvapPTLSPVKDGYIFNLGGRKLEVIEVPGHTHG 168 Paludibacter propi...
AGK98701   73 QFErRFMHPCEFNYYnskn----------------------------ektVPMEPIWEGDVIDLGSYCFEVILIPGHTPG 124 Clostridium pasteu...
AGC68886   71 SFDcFYMHPDEEDNYrah-----------------------------ggvGGILPVKDNDVIDLGNRPLKIIFIPGHTPG 121 [Clostridium] ster...
CEA15673  105 YFEqVYMHPSDTTVAvni-----------------------------qfeGEYKWMADGDVFDLGGRKIEVYLMPGHTPG 155 Porphyromonadaceae...
CDA75371   97 YFDeVWIHPYDSVLIseyc---------------------------kdykGKILDLSDGQVFDLGNRKLEVALMPGHTPG 149 Bacteroides sp. CA...
CDF08416   81 YFDkAYIHSADIGIAnayfkadgfv---------------qmmkesgrkpAEFEPILEGTVIDLGGIELEIYETPGHTPG 145 Firmicutes bacteri...
EFB74485   71 DFAeAWLHEKDWPLVht--------------------------------tARLHPLREGDVFACGAFRLEVVEIPGHTLG 118 Subdoligranulum va...
Feature 1                    #                                          #
Q68D91    174 SICLHDKdrKILFSGDVVYDGSLIdw-lPYSRISDYVGTCERLIELvdrglvEKVLPGH 231 human
NP_229099 130 SIVLLDRenRLLFSGDSVGAGHTWmhlpGCLPLREYLKSLKKLKETds---fEKIYHGH 185 Thermotoga maritima MSB8
ACI18657  130 STVLLDKdnKLLFSGDAIGAGHTWmqlpGCLPLTQYLESLYRLSKRsn--efEKIYHGH 186 Dictyoglomus thermophilum H-6-12
ADQ78829  169 SICLLDAqnRILFAGDNSNTVVWLfl-sDCYPLEVYLKSLQKVEKRsn--eyDIVMPGH 224 Paludibacter propionicigenes WB4
AGK98701  125 SIALLEKdkRFLIGGDSIQIGGIFmf-gNGRDFDAYRASMRKLQGRlk--efDTVYASH 180 Clostridium pasteurianum BC1
AGC68886  122 SIAVLDInnRVLVSGDTVQDGNIFmf-kEHRNMSLYVESLRKLSMYtd--efDTIYPSH 177 [Clostridium] stercorarium subsp. sterc...
CEA15673  156 SVVFVDKsiNAAFTGDAFGSGQVWlqlrPHVPMSEYYASCVRMEKImnehniSKLYVGH 214 Porphyromonadaceae bacterium ING2-E5B
CDA75371  150 SVVLLDKaqGDCYSGDAFGSGEVWlqcvPMSPFSIFNQSCLKIEKMmldgtiSKIWCGH 208 Bacteroides sp. CAG:530
CDF08416  146 SIVLLDRkdRILFSGDTVIEQTWMql-pECCEMNVMLQSLDKLQKLrp--yfDYILCGH 201 Firmicutes bacterium CAG:95
EFB74485  119 SVAFRDRarGLLFSGDSVQKDGPIylfgPHRNVPLYVESERKLAAMag--dfATVFPCH 175 Subdoligranulum variabile DSM 15176

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