Conserved Protein Domain Family
AKR_AKR9C1

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cd19081: AKR_AKR9C1 
AKR9C family of aldo-keto reductase (AKR)
Haloferax volcanii aldo-keto reductase is a founding member of aldo-keto reductase family 9 member C1 (AKR9C1).
Statistics
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PSSM-Id: 381307
Aligned: 32 rows
Threshold Bit Score: 388.111
Created: 19-Apr-2018
Updated: 2-Oct-2020
Structure
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Aligned Rows:
Conserved Features/SitesClick to see Conserved Features Help
 
putative activecatalytic
Feature 1:putative active site [active site]
Evidence:
  • Comment:Based on the structure evidence that Rattus norvegicus voltage-dependent K+ channel beta subunit (3EAU) in complex with cortisone and cofactor NADPH.

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                   ###                                 #    #                        
AAB71807   13 PFGQTGLQTSELQFGTWRFGKeteqgnveiDEERAHELLDAYEAAGGRFIDTADIYg-------gGASERWIGDWLEdr- 84 
PEH88547    7 PLGQSPLMVSPLCFGGNVFGWt-------vDPSTSFALLDAWLGSGMNFVDTADVYsrwvpghvgGESETLIGQWLQksg 79  Comamonas terrigena
PHM08920    8 KLGHSGLEVSPLSFGGNVFGWt-------iDENSSFEILDRFIAAGGNFIDTADVYsrwvagnlgGESETILGKWLKqrg 80  Nostoc sp. 'Peltig...
EEF60782    5 KLGNSGLEVAPLALGTNVFGWt-------iDEPTAFKILDAFVAAGLNLLDTADVYsrwapgnkgGESETIIGNWLKrtg 77  Pedosphaera parvula
KPL90261    5 QLGKSELRIPRLVIGGNVFGWt-------vDRAQSFRLLDAFVDAGLNAIDTADVYsawvegnqgGESETIIGEWIKqrq 77  Herpetosiphon geys...
OWK42328    7 KLGTTGLTVGPVAFGGNVFGWt-------aDEATSFKLLDACVAAGFNLIDTADVYsrwapgnqgGESETVIGNWLKktg 79  Planctomycetaceae ...
NP_599352   7 VIKGTEFDVFPLNLGGNTFGWt-------sNREQTFAVLDAFVAAGGNFVDTADSYsawvegnegGESERELGAWIKer- 78  Corynebacterium gl...
CNE50105    1 MKKIGDLDVFPLCLGGNVFGWt-------aGKERSFEILDAYAAAGGNFIDTSDSYtasapgnsgGESEAIIGEWAAsrg 73  Mycobacterium tube...
SDK75291   65 PIADTDLLVHPLALGCSVFGWt-------iDGSAAMRVLDRHRDLGGNFLDTADSYa-------aGRSEVIIGSWLRsrg 130 Cryobacterium psyc...
AKT42503   80 ENTMQNIDVGPIVLGGNVFGWt-------vERDDAFRILDAFVDKGGRAIDTADVYpawaegrkgGESEQMIGEWLAarg 152 Chondromyces crocatus
Feature 1              #                                         ##                           
AAB71807   85 dRERFTIASKIywqirdgdpnsrGTNRKNVRHRIDALLDRLdTDYVDVLYIHRWDdeTPTREMMKTLNGLVEDGKVHYLG 164
PEH88547   80 kRKQLVLATKLgkdmg---dgkvGLHPKYIKQAVDASLTRLqTDYIDLYQTHDDDpnIPLEDVLGTLGELIQAGKVRAIG 156 Comamonas terrigena
PHM08920   81 nRDQVVIATKVgndmg---vrgkGLSRKHIQQAVEDSLQRLqTDYIDLYQSHIDDetTPLEETLETYAELIRQGKVRAIG 157 Nostoc sp. 'Peltig...
EEF60782   78 nRSNVIIATKVgmema---pdkkGLSKAHILRAAEDSLKRLqTDHIDLYQAHQDDpnTPLEETLEAFAQLIKQGKVKAIG 154 Pedosphaera parvula
KPL90261   78 rRDDLLILSKVga--------gtGLSKANIAQAIDGSLQRLqTEYLDLYQAHVDDaeTPLAETLTAFGELIQQGKVRAIG 149 Herpetosiphon geys...
OWK42328   80 nRDKVVIATKVgldmg---gsdkGLSRAYVLRAVERSLNRLqIDTIDLYQSHRDDg-TPQEETLGAYAELIKQGKVRAIG 155 Planctomycetaceae ...
NP_599352  79 gADKLIIATKSgale-----pvaGRSREATFKAVEGSLERLgVESIDIFYYHYDDeaVSIDEQVAIANDLIAQGKIKHLA 153 Corynebacterium gl...
CNE50105   74 nRDDIVIATKVgrhp-----rrqGLAPANIKAAADDSLRRLrTDRIDLYFTHFDDpsVPVEDIMTALDELVTAGKVRHIG 148 Mycobacterium tube...
SDK75291  131 aRGDTVIATKIgrnr-----dhpGLSAESITGAVQASLERLgTDYIDLLYFHLDDpeVPLEESLGAIDVLIRRGQVRYLA 205 Cryobacterium psyc...
AKT42503  153 hRSKLVIATKVakwk-----erpGLSPANIRTAIEGSLRRLqTDHVDIYYAHEDDqnVQQAEYLDAFDRLVKEGKVRALG 227 Chondromyces crocatus
Feature 1      ##                          #                            #######               
AAB71807  165 ASTLrpnAWKVARANEIARAegwepFTVAQPRYNLVDRe-IEGDYLEMTRSyGIAVCPWSPLGQGFLTGKYTRedgltge 243
PEH88547  157 ASNYs--AQRLAEALDCSDRhrlarFDSLQPLYNLYDRavFEKELQPLCVArNVGVINFYALAAGFLTGKYRSeadvgks 234 Comamonas terrigena
PHM08920  158 ASNYs--AERLTQALEISRQhgyprYESLQPRYNLYDRdgYEQDLQQICQEhSIGVISYSSLCSGFLSGKYRSekdlsis 235 Nostoc sp. 'Peltig...
EEF60782  155 ASNYt--GVRLSQALQVSKQlnlprYESLQPLYNLYDRaeFEKDLEPVCLQnHLGVICYYSLASGFLTGKYRSqkdlaks 232 Pedosphaera parvula
KPL90261  150 ASNYs--AERLQAALDISQQhnlprYESLQPLYNLYDRdsYEGDVEAVCQQaDVGVIPYSTLASGFLTGKYRSeadlsqs 227 Herpetosiphon geys...
OWK42328  156 ASNYt--ADRLAESLRISKQhslpaYQCLQPEYNLYDRtgFEAGLEPLCRAeNIGVITYFSLAAGFLTGKYRSeadlgks 233 Planctomycetaceae ...
NP_599352 154 LSNYs--AERLAEFFEKSVGtp-aqPVALQPHYNLVSRkdYEENVQPLAEKhGVAVFPYFALAAGLLTGKYTSkedisgk 230 Corynebacterium gl...
CNE50105  149 VSNId--LDRLEASLEFSERagtarYVAIQPHYNLVSRdtYEGARRDIAERhGLAALPYYGLASGFLTGKYRPaakvdsv 226 Mycobacterium tube...
SDK75291  206 ASNFt--AERLMEARVLSANgl-prFVALETHYNLVHRepFESSLALVTHAqGMTVLPYFALAHGFLAGRYRTraeaagt 282 Cryobacterium psyc...
AKT42503  228 ASNFt--PERLASALALSRAnglrpFQFSQDHWNLVERg-IEKTLVPLLQKeGLKELPYWSLASGFLTGKYRPgqkvdsm 304 Chondromyces crocatus
Feature 1                                         #                ######  #  ##              
AAB71807  244 sraaessrfeeSYLTEENFDVHDELDAVAGEVDatPAQTALAWLMHrDGVTAPIVGARTVEQLTENLEAATIDLTDEQVD 323
PEH88547  235 l---rgakttsLYLNPRGLRIVDALEQVAAQYKaqPSEVAIAWLLQqAGIAAPIASATSLVQLQSLVTAATLQLDAAALA 311 Comamonas terrigena
PHM08920  236 ----lrgssvkRYLNPRGLRILEALDEVAKIYNatPTQVSLAWLIAnPTITAPIVSATKVEQLNDIIKAVNINLDQDAID 311 Nostoc sp. 'Peltig...
EEF60782  233 ----prgakaaTYLNDRGLRILKALDEVSQRFNstPARVALAWLIArPSVTAPIASATSLEQLDDLIAATKLQLDQAAIQ 308 Pedosphaera parvula
KPL90261  228 ----argsrvrSYLNERGWAILKALDEVAAELQatPGQVALAWQIArPSITAPIASATTLDQVNDLIKAAKLELTPAALD 303 Herpetosiphon geys...
OWK42328  234 ----prgakvkNYLNDRGFRILAALDEVAGRYQstPGRVALAWLFAkPAVTAPIASATSLEQFADLVEATKLELDAQAVA 309 Planctomycetaceae ...
NP_599352 231 ----aragqldRYASDEAFAVVTELRAVADELGvaPTTVALAWLVA-HGVTAPIASVSKVEQLKDLMAVKDVELSAEQLA 305 Corynebacterium gl...
CNE50105  227 ----ragraaeYLETERGRNVLAALDIVAEEQGtaVATVALAWLAAqPTVAAPIASARTLDQLPPIVESARTTLTDDQLK 302 Mycobacterium tube...
SDK75291  283 ----araeraaGYLNRHALRTLAVVDRIADEHGvePATIALAWLLArDGTFVPVAGASLPEQVDALVAAAGIRLGRGEMV 358 Cryobacterium psyc...
AKT42503  305 ----ragsagkYLTDPKNVTLLGALDEISAAHKtsVAAVALAWLHAqPVVAAPLASARTIEQLGPLFDAASLRLTAEEVS 380 Chondromyces crocatus
Feature 1        
AAB71807  324 RLT 326
PEH88547  312 TLD 314 Comamonas terrigena
PHM08920  312 LLN 314 Nostoc sp. 'Peltigera malacea DB3992 cyanobiont'
EEF60782  309 LLN 311 Pedosphaera parvula
KPL90261  304 YLN 306 Herpetosiphon geysericola
OWK42328  310 ALD 312 Planctomycetaceae bacterium SP5
NP_599352 306 RLD 308 Corynebacterium glutamicum ATCC 13032
CNE50105  303 RLT 305 Mycobacterium tuberculosis
SDK75291  359 ELD 361 Cryobacterium psychrotolerans
AKT42503  381 KLS 383 Chondromyces crocatus

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