Conserved Protein Domain Family
NleF_casp_inhib
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pfam16809: NleF_casp_inhib 
NleF caspase inhibitor
Binds to and inhibits caspase-9, caspase-8 and caspase-4. therefore preventing caspase-induced apoptosis in the host cell.
Links
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Statistics
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PSSM-Id: 293414
Aligned: 4 rows
Threshold Bit Score: 163.094
Created: 26-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
WP_002211945    35 NKNIINAETQHTINDIKQKLSLIQERYNASTTAEFYFVE---------NQLTDMHESISQRKEDLYEP-EDYSLSGVQER 104 Yersinia pseu...
LANL:CH62_2005  37 NKDIKTEETEQFLEEIDAQMKVICAWEMDSTTVDQCIKEl-------cDKIGALYNDVLTTRSQVYEMvLNYGTESGQMV 109
LANL:CH44_3776  35 DKNRLTLEQEKGLKDIKSSIDDCYHNGISTSTGRKKIKEl-------rNKVTQYINSVESYRDKIYDViIDKRTGRGEKI 107
LANL:CH59_346   56 KYNKIDQDTQETLKNINDKLHRAF-----LLTSPEQIEEkqkiidavsDDLEKMKRNVLSERGDLYCG-EEVKLHGKMRT 129

WP_002211945   105 ELKKGKTAQDRNNLVKDLVALYQIKNAIKEMIpeDKTKTIDDYSTYYPKPIHNGKVldihhpfyslveesvkhklFSDLY 184 Yersinia pseu...
LANL:CH62_2005 110 RLREGCNAADRDRYLEKLIAYNHIRQAVSDKV--AKIEKHTDSVKRMVDLHHYDYI-------------------CGDLK 168
LANL:CH44_3776 108 ILKSGCDETHRNSYLKGIIYLSKLQDLIRNEIdnAPIK-YKKSLSKVFDVMGKGAV-------------------YGDIK 167
LANL:CH59_346  130 TLSEHITVERRDNFIKSLVNLYQIVRGVKATItnAPNNTISSLINSNANESYNGLVqvd-------------avlARDFN 196

WP_002211945   185 AIENNRKVPYV 195 Yersinia pseudotuberculosis complex
LANL:CH62_2005 169 ALNKNGDVPKQ 179
LANL:CH44_3776 168 ALNEDRKLPDF 178
LANL:CH59_346  197 AIEKNNRVPNV 207
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