Conserved Protein Domain Family
Phage_GPA

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pfam05840: Phage_GPA 
Bacteriophage replication gene A protein (GPA)
This family consists of a group of bacteriophage replication gene A protein (GPA) like sequences from both viruses and bacteria. The members of this family are likely to be endonucleases.
Statistics
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PSSM-Id: 336220
Aligned: 11 rows
Threshold Bit Score: 241.245
Created: 22-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Q8XBG0       179 HQIQTLATMTAAMFSSTFEKLCDgfg----atDGELTMDVTLKAYQMLARM-ALHLHAMP--PHYdal--ttDKDRRNEP 249  Escherichia co...
P41064       139 ADIDLLAADIANFIRAELADIDD---------TGFSELKTLYTWYMRAGFI-SLQFNVTP--PKW-------ERVTKKYF 199  Escherichia vi...
Q8W759       122 DELRDMAFRIAKIMEAYLQLTASrkh----adREEDVDQAVVDAYEALAHFcTQTFGIKA--PRK-----------YQKQ 184  Vibrio virus K139
P51711       204 SKLKKMAYEMATAFIRFQCDCSHflkngiekdNEGDIQGYFYQLYKWCGEI-AFSAGFKI--PHWe------KIENDKRI 274  Haemophilus ph...
Q8Z1E1       193 DQVKRLSTLVAAHMSMCLDAACgdl-----fvSDDVKPEEIRQAWERVAAE-AMRLEVIP--PAFeql--rrKKRRRKPV 262  Salmonella ent...
Q06419       133 KELKKFAARISSQLFMMYEELSDawvdahgekESLFTDEAQAHLYGHVAGA-ARAFNIS---PLYw------KKYRKGQM 202  Escherichia vi...
P25244        49 SEETHLDDETYALYESQTGLLED----------------HMALVRKCAAQL-DNSNTIDHrtP----------------- 94   Escherichia vi...
P03632       115 PDELQLSDEIVEDYRLTVLSIIE----------------ELQECYDVLGQL-DINNTIDHk-P----------------- 159  Escherichia ph...
WP_000252566  74 VDGHKAASDVRDEFVSVTEKLMD----------------ELAQCYNVLPQL-DINNTIDHr-P----------------- 118  eubacteria
Q9XJS3       101 LQRDKRRKDKAKQLALICQQMGIvdfd--ksmTLEQATALVISKYQKLAEF-TINQIDTA--PAYstyeafmKKGGNPEI 175  Pseudoalteromo...
O80256       150 DECVELAKAKAKAFSKTLSKFDE-------------IEEPFTKACELLASL-GLSFR-----PEL----------IKQKR 200  Vibrio phage fs2
Q8XBG0       250 DTELLPGAILRLTCAEWWKRKLWLLRCEWREEQLRAACLVSRKTSPYLSQDALSEFRAQREKTRDFLKSFMLENEDG--F 327  Escherichia co...
P41064       200 CEDEIAPAVMRMFNEVWWRGRLRRIAAAWREHLQIAVGNVSKKRHAYASKNCVTDWREQKRRTREFLKGLDLEDEEG--N 277  Escherichia vi...
Q8W759       185 THLSASSDIMRMISDSWWLGRLVKVRKIMREHLAIAMGQVSNNASPYASWDCVREHQEQQQRNYEAIKNMVLFDEETe-E 263  Vibrio virus K139
P51711       275 KAEHIDSTLIRLTCEKWWFKQMRDIQKRMVEHIAIACGEVRANAASYISNQSFQEWQLQQRKNHDYLRAMIIENIDNpeE 354  Haemophilus ph...
Q8Z1E1       263 PYELIPPSLARMLCADWWYRKLWQMRCEWREEQLRAVCLVNKKASPYVSYEAVIHKREQRRKSLEFFRSHELINEDG--D 340  Salmonella ent...
Q06419       203 TTRQAYSAIARLFNDEWWTHQLKGQRMRWHETLLIAVGEVNKDRSPYASKHAIRDVRARRQANLEFLKSCDLENRETg-E 281  Escherichia vi...
P25244        95 -----------LDPECVFLFEMICPGVRYGK-------TLNSLWSKYAAQWPEKLIRQE----LDMVKPLSFKDEVA--- 149  Escherichia vi...
P03632       160 -----------LGNDHWNLLYEK---------------PVYKHWYQLVSNRPLKDIRAD----YNYAKAKGVKDECS--- 206  Escherichia ph...
WP_000252566 119 -----------EGDEKWFLENEK---------------TVTQFCRKLAAERPLKDIRDE----YNYPKKKGIKDECS--- 165  eubacteria
Q9XJS3       176 LADKLEIAIRRMTCDKWWQRKLNRARDMTLEHLNITLGLVNKKKSPYASLQAVNEFKYAKKSQQKWLDSMQLESDDGe-T 254  Pseudoalteromo...
O80256       201 QSNELECLTSRAMCENWLRRQLRRRYFAEVEAVRDLL-LVSKNENPYCSAHGLEVMKSRKSATEQVLSNTVCYVEDNpeT 279  Vibrio phage fs2
Q8XBG0       328 TIDLETVYYAGVSNPVHRKAEMMATMKGLELLAEARGDKAVFLTVT-CPSKYHATTENGHPNPK-------WNG-AT-MR 397  Escherichia co...
P41064       278 RISLIEKYDGSVANPAIRRCELMARIRGFENICNELGYVGEFYTLT-APSKYHATTKAGYRNSK-------WNG-AS-PS 347  Escherichia vi...
Q8W759       264 EHDLWDMVKKSVSNPAIRRHELMVRCRGCEDIGNELGLQGLFLTLT-TPSKYHNSYKKGGFIDH-------WNG-AS-PR 333  Vibrio virus K139
P51711       355 QVELFDMFLKSSSNPALRRNEMMVRLRGLEEWAEENNNEALFLTLT-APSSFHA----GNGNKK-------WLG-VN-PR 420  Haemophilus ph...
Q8Z1E1       341 TLDMEDVVNASNSNPAHRRNEMMACVKGLELIAEMRGDCAVFYTIT-CPSRFHATLNNGRPNPK-------WTS-AT-VR 410  Salmonella ent...
Q06419       282 RIDLISKVMGSISNPEIRRMELMNTIAGIERYAAAEGDVGMFITLT-APSKYHPTRQVGKGESKtvqlnhgWNDeAFnPK 360  Escherichia vi...
P25244       150 -KYMEKMQEKT------RKNRMTQKVINEMRIAHQKGWFFVFDTLTlADDRLQAFNEN--------------------PN 202  Escherichia vi...
P03632       207 -KILEESTMKS------RRGFTVQRLMNAMRTAHSKGWYVVFDTLTlADDRLKDFYDN--------------------PN 259  Escherichia ph...
WP_000252566 166 -RLLEASTMKS------RRGFAIQRLMNAMRQAHADGWFIVFDTLTlADDRLEAFYDN--------------------PN 218  eubacteria
Q9XJS3       255 TLDLAEVFKGSVSNPEIRRVELMVRIRGYEEYAQEQGMKAVFYTIT-APSKYHANSKK-------------YNN-AT-PK 318  Pseudoalteromo...
O80256       280 WFTLQELAAKSLSNPTIRRAEMFVRLKAFEDICKESGHVAMFYTVT-APSRFHV-FKGDDINPK-------WLE-AGkPS 349  Vibrio phage fs2
Q8XBG0       398 --DSSDYLVNTFfAAVRKKLNRDGLRWYGIRTVEPHHD--------------GTVHWHMMVFAHP--------------E 447  Escherichia co...
P41064       348 --DTQSYLTGLW-ARIRAKLHREEIRIFGIRVAEPHHD--------------GTPHWHMLMFMLP--------------E 396  Escherichia vi...
Q8W759       334 --DAQAYLNKKW-QLIRAKLNRDEIRWFGVRVAEPHHD--------------GTPHWHLLIWVRK--------------E 382  Vibrio virus K139
P51711       421 --ETQNYLNKVW-QQFRALLSKRNIKFYGMRVAEPHKD--------------GTPHWHALAYVPA--------------E 469  Haemophilus ph...
Q8Z1E1       411 --QSSDYLVDTF-AAFRKAMHKAGLRWYGVRVAEPHHD--------------GTVHWHLLCFMRK--------------K 459  Salmonella ent...
Q06419       361 --DAQRYLCHIW-SLMRTAFKDNDLQVYGLRVVEPHHD--------------GTPHWHMMLFCNP--------------R 409  Escherichia vi...
P25244       203 --ALRDYFRTVGrAVLRAE---------GRSVKDSYNDcyrylcvpefggqhGRLHWHVVHMVRTlplgshdpnfgrpvR 271  Escherichia vi...
P03632       260 --ALRDYFRDIGrMVLTAE---------GRSVHDSSSDcyqyfcvpeygtqhGRLHFHAVHLMRTlplgsldpnfgklvR 328  Escherichia ph...
WP_000252566 219 --ALRDYFRDIGrMVLAAE---------GRKANDSHADcyqyfcvpeygtanGRLHFHAVHFMRTlptgsvdpnfgrrvR 287  eubacteria
Q9XJS3       319 --ETQAFLVNQW-AKARAELNKIDVPVFGVRVVEPHHD--------------ATPHWHMLLFMLP--------------E 367  Pseudoalteromo...
O80256       350 aiDAHHHLMGVT-NAFRKALDKAKIKIYGLRIVEPHHD--------------GTPHNHFLFFMLP--------------E 400  Vibrio phage fs2
Q8XBG0       448 EIDTIVSHTRDI--------AIQEDRHELGDDI-------------------TPRFKAEYVDGSKGTPTX-YIATYIGKN 499  Escherichia co...
P41064       397 DVERVRLIIRDY--------AWEEDHYELRSDKa-----------------kKARFHAEAIDPEKGSATG-YVAKYISKN 450  Escherichia vi...
Q8W759       383 DISAVRDTFITY--------ATEEDRGELHPEFekekqkpfrkgvyvgpldyRPRCDFGYIDPTKGTATG-YIAKYISKN 453  Vibrio virus K139
P51711       470 HKEEVIRLFKQK--------ALELDGNE---KGa-----------------aEHRCKVEKCDKTKGSATA-YIAKYIAKN 520  Haemophilus ph...
Q8Z1E1       460 DRRSITALLRKF--------AIREDREELGANT-------------------GPRFKPELINPRKGTPTS-YIAKYISKN 511  Salmonella ent...
Q06419       410 QRNQIIEIMRRY--------ALKEDGDE---RGa-----------------aRNRFQAKHLN--QGGAAG-YIAKYISKN 458  Escherichia vi...
P25244       272 NYRQINSFRGMWpygftqpiAVRYQHDAYSRKGwl----------------wPVDKSGKAMQSKPYQAVAwYVTKYVAKQ 335  Escherichia vi...
P03632       329 INRQINSLQNTWpygysmpiAVRYSQDAFSRAGwl----------------wPVDSKGEPLKATSYMAVGfYVAKYVNKK 392  Escherichia ph...
WP_000252566 288 NRRQLNSLQNTWpygysmpiAVRYTQDAFSRSGwl----------------wPVDAKGEPLKATSYMAVGfYVAKYVNKK 351  eubacteria
Q9XJS3       368 HEQVTTKALRGY--------AMQIDGDE---KGa-----------------eQARFTAENIDPSKGSAVG-YIAKYISKN 418  Pseudoalteromo...
O80256       401 HESVVTRILGDC--------ALSDSPNE---SGa-----------------kKYRFKAEKIDFKKGSAVG-YVAKYLSKN 451  Vibrio phage fs2
Q8XBG0       500 LDSR 503  Escherichia coli O157:H7
P41064       451 IDGY 454  Escherichia virus 186
Q8W759       454 IDGY 457  Vibrio virus K139
P51711       521 IDGF 524  Haemophilus phage HP1c1
Q8Z1E1       512 IDGR 515  Salmonella enterica subsp. enterica serovar Typhi
Q06419       459 IDGY 462  Escherichia virus P2
P25244       336 SDQR 339  Escherichia virus phiK
P03632       393 SDID 396  Escherichia phage G4
WP_000252566 352 SDMD 355  eubacteria
Q9XJS3       419 INAN 422  Pseudoalteromonas virus PM2
O80256       452 IDGQ 455  Vibrio phage fs2
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