Conserved Protein Domain Family
CYP136-like

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cd11045: CYP136-like 
putative cytochrome P450 family 136 and similar cytochrome P450s
This group is composed of Mycobacterium tuberculosis putative cytochrome P450 136 (CYP136) and similar proteins. It belongs to the large cytochrome P450 (P450, CYP) superfamily of heme-containing proteins that catalyze a variety of oxidative reactions of a large number of structurally different endogenous and exogenous compounds in organisms from all major domains of life. CYPs bind their diverse ligands in a buried, hydrophobic active site, which is accessed through a substrate access channel formed by two flexible helices and their connecting loop.
Statistics
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PSSM-Id: 410671
Aligned: 14 rows
Threshold Bit Score: 560.014
Created: 16-Jun-2010
Updated: 25-Oct-2021
Structure
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Aligned Rows:
 
heme bindingputative
Feature 1:heme binding site [chemical binding site]
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                                                                         #   #      #
P9WPM6     78 DYLMFLYKTKGPVVFGDsavlPGVAALGPDAAQVIYSNRnk-dySQQGWVPVIGPffhrGLMLLDFEEHMFHRRIMQEAF 156 Mycobacterium tube...
ABF52384   59 AFARRMVAKYGPVYRNNsfggRSVALYGPEANELVMFDRdkifsSEQGWGPVLNLlfprGLMLMDFEKHRADRKLLSVAF 138 Sphingopyxis alask...
ABP44009   71 EFARERYERFGPVSWAGgigfRVVQLMGPEALETAWINRdkafsSTRGWAPVIGPffhrGIMLLDFEEHRDHRRIMQQAF 150 Mycobacterium gilv...
ACY99256   38 GMARNRYLRFGPVTWGWtlglRTVMVQGPEGAEAILVNKdkafaNGPAWTYYIGPffrrGIMLLDFEEHLHHRRIMQQAF 117 Thermomonospora cu...
ACY21744   70 RSAMQRYERYGPVTWSGslgmNIVTLVGPEAIECAWMNRekafsSEQGWEPMIGPffrrGVMLMDFEEHMHHRRILQQAF 149 Gordonia bronchial...
CAL17832   46 KMVTQQAAKHGLIFKSSvlfqHGVTLLGPDANEFVLKDPehafsSRAAWNPILEKlftdGLMLRDFADHKFHRRIMQQAF 125 Alcanivorax borkum...
EAR10580   32 AFFDRKTRQHGAVFSTQflgeEWIRLTGPDACQWLLQDKdnnfsTKLGWESFVGDlfprGLMLKDGDDHLYHRRIMQSAF 111 Reinekea sp. MED297
ABG32989   43 GTQQDYIKRYGPVYKTKmlgvWRVNLCGPDALQHVLLDKdkifsSTGGWDALRRIyp-gGLILQDFDKHRQDRRILTAAF 121 Roseobacter denitr...
AAN38721   90 DFSRERYDRLGSVSWMGafgtKMVVIAGPDATREAFTSEak-afSQDGWSFLIDAffhrGLMLMSFDEHLMHRRIMQEAF 168 Mycobacterium absc...
EDY52122   54 AFQLQLLRRHGPVSWWQafgrRIVAVSGPDAVQAVLVNKdk--aFATGWPAVIGPwfdgGLLAMDAPAHLADRRVMQTAY 131 Streptomyces clavu...
Feature 1                                                 #                                   
P9WPM6    157 VRSRLAGYLEQMDRVVSRVVADDWVVndarflVYPAMKALTLDIASMVFMGhepgtdheLVTKVNKAFTITTRagnaviR 236 Mycobacterium tube...
ABF52384  139 KPEPMRHYADALNDGIRGRVASWSGRtf---qFYPAIKELTLDLAATSFLGipw---gpEADKVNKAFVDMVQasigivR 212 Sphingopyxis alask...
ABP44009  151 TRSALDGYLTLMRPGISRTVTSWPTAag--fpFYTAIKKLLLDQAAEVFVGavl---gaEADRLSSDFHDTVCggqamiR 225 Mycobacterium gilv...
ACY99256  118 TRPKMRSYLEIMTPGITRGIKAWPTGdg--fqFYKRIKQLMLDLAIDVFVGvdl--eqaEIDRLNGAFIDAVRagtaiiR 193 Thermomonospora cu...
ACY21744  150 TTNRLKGYLGMMTPHIEKTLANWPVGeg--fpMYSRTKDLTLSLATEVFVGasl--neaEAHRLETAFEAAVRggqaiiR 225 Gordonia bronchial...
CAL17832  126 KKPALASYLGRMNGHIGSEISHWPTGke--lrFQDHIKSLLLDVGAQIFFGlem---gpESNKVNQSFIDATDaslavvR 200 Alcanivorax borkum...
EAR10580  112 QKSALARYQQMMHKQMPELLQEMPSQqs--fdAADQVRNLLLDIASNVFIGesd---vnARDKLQKAFRTTVAatmaiiR 186 Reinekea sp. MED297
ABG32989  122 RASAIRDYRMRMGEIMLDLLQHWPKDap--fdFYEAIKDLTLRMGGAVFMGlpl--dgdLAKQINRAITDEIRasvtpiR 197 Roseobacter denitr...
AAN38721  169 TRPRLTGYVEQVTPCVRSAVPAWPVGps--vrIYPLLKELTLDIATDVFMGgrg---kdESDAVNKAFVATVRaasslvR 243 Mycobacterium absc...
EDY52122  132 GEEAIAGYVLRMAEDAEAALARWPLGra--ftAVPAIRELSSEVTPRAILGvay---epAGRRIMRAVEECIHaetaavR 206 Streptomyces clavu...
Feature 1                                                                   ##  ##  ##  #     
P9WPM6    237 TSVPPFTWWRGLRARELLENYFTARVKERREasgNDLLTVLCQTEDDdgnrfSDADIVNHMIFLMMAAHDTSTSTATTMA 316 Mycobacterium tube...
ABF52384  213 RPLPFTAMGRGAKGRAFLVDYFSRMVPERREgagEDMFSQICRTRDDngdymPVDAIVDHMNFLMMAAHDTITSSITTLV 292 Sphingopyxis alask...
ABP44009  226 ADVPGGTWARGLRARERLERYFAAQIPDRRAgtgADLFSMMCRSRSEdgdsfSDADIVNHMIFLLMAAHDTSAIAISMLV 305 Mycobacterium gilv...
ACY99256  194 TSVPGLRWHKGLQARKELEAFFYRHLPAKRRdggDDLFAALCQAETEdghrfTDEDVVNHMIFALMAAHDTSTITMTTMA 273 Thermomonospora cu...
ACY21744  226 ADVKFGTWARGLRGREALQRYFRSEIAARRAgdgDDLFSVLCHSESPegdtfTDEDVVNHMIFVMMAAHDTSTIALSMLT 305 Gordonia bronchial...
CAL17832  201 LPIPGLLWHRGMKGRRYLEKFVTGLIPQKRAsntPDFFSELCKAADEeg-glSDKDVMNHMIFLLFAAHDTTTSTLCSIV 279 Alcanivorax borkum...
EAR10580  187 KPIPGTLYKRGLDSRAYLERYFLAKVPQKRNdesGNLFAALTRAKDEdgnnfSDQEIADHMIFLLMAAQDTTSSALTSLF 266 Reinekea sp. MED297
ABG32989  198 TAIPFTPMWRGIRGRDFLRETFRKMIPERRArggDDFFSQMCMAKDEdgkgwSEDEILNHFNLLIMAAHDTTATSLTVIM 277 Roseobacter denitr...
AAN38721  244 APLPGTRFRAGVQGRRVLEDYFFRHLPAARAgetEDLFAALCQATTEdgerfSDEDVVNHMIFLMMAAHDTSTITTTAVT 323 Mycobacterium absc...
EDY52122  207 LRIPGTSWYRAHRARRLLLAGLTRAVPAAREragDDFLSVLSRIGGPdgdrfSTRQLAEHALFTLIASHDTTVVATLASF 286 Streptomyces clavu...
Feature 1                                                  #        # #                      #
P9WPM6    317 YQLAAHPEWQQRCRDEsdrhgd--gpldiESLEQLESLDLVMNESIRLVTPVQWAMRQTVRDTELlGYYLPKGTNVIAYP 394 Mycobacterium tube...
ABF52384  293 WELARHPDWQDRLREEmlavapagegvghNSLGELELTEWAFKEALRLVPPVPSFPRRALKDFEFgGYRIPAGTSVGVSP 372 Sphingopyxis alask...
ABP44009  306 YELGRNLRWQDALRDEadagd---glglaDLDGAYPLLDAAFKEILRMYAPAGTLFRQTVTDTEVcGHYIPRRTQVAINV 382 Mycobacterium gilv...
ACY99256  274 YYLAKHPEWQERVREEsqalgk--ptldfDDIDKLVSLDLVMKEALRLVPPVPALPRRAVKDTSIlGYHIPKGTTVVVAA 351 Thermomonospora cu...
ACY21744  306 YFLGRHPEWQDRLRAEslalgk--dtldyEDIDALTSLDLAFKETIRINAPVGMLFRKAVRDTDIlGHYVPAGTLVAIHP 383 Gordonia bronchial...
CAL17832  280 YMLAKHPNWQDILVKEieglnk--etldyDDLAKMEKTDWVFRETLRMRPALTTFPRRTVKEIEYqGYTLPKNTLVSIST 357 Alcanivorax borkum...
EAR10580  267 YMLAEHPQWQERLREEyqais----eftyESLEQMPQTSWVFKEVLRMCTPGAVIPRRSLREVEYnGYRIPADTIVSVSP 342 Reinekea sp. MED297
ABG32989  278 AALGTHGDWQQRLIDEvdglgd--gdldeEALGQMKETDKVFREALRLVPPVPFIPRMATRDFHWhGYDIPAGTSLALNP 355 Roseobacter denitr...
AAN38721  324 YFLAKYPQWQEAAAAEaaaigd--glpdiEALEKMTVIDRVIKEALRLLAPVPLVMRKTVRDVAIdGYHIPSNTLCAITP 401 Mycobacterium absc...
EDY52122  287 YFLGRNPEWQARARAQslarpg--gpptvEALGGLDVLERVVKESMRLVSPSPINMRVAVKDTEVlGHFIPAGQLVSVCT 364 Streptomyces clavu...
Feature 1                                         ###   #####  ##                             
P9WPM6    395 GMNHrLPEIWtDPLTFDPERFteprnehkRHRYAFTPFGGGVHKCIGMVFDQLEIKTILHRLLRRYRleLSRPDYQPRWd 474 Mycobacterium tube...
ABF52384  373 AFTHmMEEHWpEPERFDPMRFspev-argRHKYAWVPFGGGAHMCLGLHFAYMQAKIFFHHVVTTHRi-SVAPGYAPEWq 450 Sphingopyxis alask...
ABP44009  383 YASLrLADWWpDPDRFDPGRFlgggdaaaVHRYAFAPFGGGVHKCIGQQFADMNVKLVMHQLLRQFRw-RVAPGYRPLMt 461 Mycobacterium gilv...
ACY99256  352 LTNHrMPEIWkDPERFDPERFaehrredkVHRYAWAPFGGGAHKCIGMHFAGVQIKSVLHQVLLNYR--WSVPRGYEWPl 429 Thermomonospora cu...
ACY21744  384 WATMlREEWWpNPTHWDPERFsperredkVHRFAWAPFGGGAHKCIGLYFGGMEVKAIMHQMLQRFE--WSVPAGYFPEl 461 Gordonia bronchial...
CAL17832  358 LYTHyMEDYWsNPTTFDPERFsderaehkKHFYQWVPFGGGHHKCLGLNFAELQTKTFLFQFLKRYRv-SVKPGYELPTq 436 Alcanivorax borkum...
EAR10580  343 IHNHyLPEYWtSPDTFDPERFsperaedkQHPYLFAPFSGGVHKCIGLHFAEMEIKVILFHLLQRFQ--ISRDESEKVNw 420 Reinekea sp. MED297
ABG32989  356 GVTMlSPELFsNPTQFDPDRFapdraedrIHRFAWTPFGGGAHKCIGMHFATMQVKLFIATLLRQRR--IELPGGAPEWh 433 Roseobacter denitr...
AAN38721  402 AVNHfDRTIWnDPERFDPSRFdeprredqHHRFAWVPFGGGAHKCIGMQFGTLEVKAILHRMLRSFT--WKVPENYHVRw 479 Mycobacterium absc...
EDY52122  365 GVNQlMPELWhEPQRFDPDRFapdrnedrVHRLAWAPFGSGAHKCIGLHVGMLKVKATLDAMVRRFH--WEFPAGYEAAw 442 Streptomyces clavu...
Feature 1                     
P9WPM6    475 y-sAMPIPMDGMPIVL 489 Mycobacterium tuberculosis CDC1551
ABF52384  451 m-lPIPRPKDGLTVTF 465 Sphingopyxis alaskensis RB2256
ABP44009  462 w-gTGPTPADGLPISL 476 Mycobacterium gilvum PYR-GCK
ACY99256  430 dttSLPSPKDGLPVRL 445 Thermomonospora curvata DSM 43183
ACY21744  462 eygTGPTPADGLPIDF 477 Gordonia bronchialis DSM 43247
CAL17832  437 q-vPLIMPKDGLPVVL 451 Alcanivorax borkumensis SK2
EAR10580  421 qkaPVWQPKGGLTVQL 436 Reinekea sp. MED297
ABG32989  434 r-mPIPKPKGGLPVLL 448 Roseobacter denitrificans OCh 114
AAN38721  480 dntSLPIPVDGLPLEM 495 Mycobacterium abscessus
EDY52122  443 rfsSLPAPSDGMPVVL 458 Streptomyces clavuligerus ATCC 27064

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