2Y8P,4CFO,4HJV


Conserved Protein Domain Family
LT_MltC_MltE
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cd16893: LT_MltC_MltE 
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membrane-bound lytic murein transglycosylases MltC and MltE, and similar proteins
MltC and MltE are periplasmic, outer membrane attached lytic transglycosylases (LTs), which cleave beta-1,4-glycosidic bonds joining N-acetylmuramic acid and N-acetylglucosamine in the cell wall peptidoglycan, yielding 1,6-anhydromuropeptides. Proteins similar to this family include the soluble and insoluble membrane-bound LTs in bacteria and the LTs in bacteriophage lambda
Links
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Statistics
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PSSM-Id: 381614
Aligned: 45 rows
Threshold Bit Score: 203.174
Created: 12-Aug-2016
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
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sugar bindingcatalytic
Conserved site includes 15 residues -Click on image for an interactive view with Cn3D
Feature 1:sugar binding site [chemical binding site]
Evidence:
  • Structure:4HJV: Escherichia coli MltE binds bulgecin and murodipeptide; contacts at 4A
  • Structure:4CFO: Escherichia coli MltC binds a tetrasaccharide; contacts at 4A
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                                #        # #      ###  ##                               
2Y8P_A        23 MPISQKAGAawgVDPQLITAIIAIESGGNPnAVSkSNAIGLMQLKASTSGrDVYRRmgwsge-pttseLKNPERNISMGA 101 Escherichia col...
4CFO_A       175 LGMVRQASRkygVDESLILAIMQTQSSFNPyAVSrSDALGLMQVVQHTAGkDVFRSqgksgt-psrsfLFDPASNIDTGT 253 Escherichia coli
4HJV_A        40 MPISQKAGAawgVDPQLITAIIAIESGGNPnAVSkSNAIGLMQLKASTSGrDVYRRmgwsge-pttseLKNPERNISMGA 118 Escherichia col...
WP_024911293  41 SAIEDAAGQy-gIDKKLITAMIQVESSFNPnAVSkSNAIGLMQLKAGSAG-CDAYRfkgksgcpddnqLRDPEINIDLGT 118 Chania multitud...
ERG54038     220 NAVLAAAKRy-nIDAALIYAVIETESAFNPyAVSrSNAYGLMQIMPATAGrDVFKLekgktgqpskaqLMQPNYNIDIGT 298 Pseudoalteromon...
AGH81497     221 GFVQAASKRy-nIKESLIYAIIKTESSFNPyAVShANAYGLMQVIPRTAGkDVFYKikkrndtptknyLFSAQNNIDTGT 299 Psychromonas sp...
ABF13866     176 TIVSNEARKy-kIDQSLILAIIQTESSFNPyAIShANAVGLMQIMQNSAGrDVFKMkgkcgq-psrkyLLNPKNNINIGT 253 Baumannia cicad...
AFA40939     191 NFIYKASKKy-nIDKSLILAIIEAESNFNPyAISsSKAVGLMQIVQNTAGrDVFKMqgklgs-pskkiLLNPEKNIDIGT 268 Wigglesworthia ...
NP_230104    209 SIVRKASRKy-dIPEDLIYAIIKTESSFNPyAVSwANAYGLMQVVPKTAGrDVFKLvknrsgepspeyLFNPENNIDTGT 287 Vibrio cholerae...
YP_002347402  55 SDVIKQAAShygVDETLIKAIIQVESGYNPdVVSrSNAVGLMQIKASTAGrDAYRMkgrngq-pssreLKDPVKNIDIGA 133 Yersinia pestis...

Feature 1         #                         ####                                      #   #      
2Y8P_A       102 AYLNILETGPLagieDPKVLQYALVVSYANGAGALLRTFssdrkKAISKINdldadefLEHVARNHPAPQAPRYIYKLEQ 181 Escherichia col...
4CFO_A       254 AYLAMLNNVYLggidNPTSRRYAVITAYNGGAGSVLRVFsndkiQAANIINtmtpgdvYQTLTTRHPSAESRRYLYKVNT 333 Escherichia coli
4HJV_A       119 AYLNILETGPLagieDPKVLQYALVVSYANGAGALLRTFssdrkKAISKINdldadefLEHVARNHPAPQAPRYIYKLEQ 198 Escherichia col...
WP_024911293 119 AYLASLQRQLGgi-dNPVTLRYATEVAYANGAGALLRTFssdrqKAISMINnlspaafHWHVRQHHPSPQAPRYMAKVEA 197 Chania multitud...
ERG54038     299 AYLKILNTRYLkgvaNKKSREYTVISAYNGGAGNVLKTYhsnrdTAVKLINrqspgavYQRLRHHHPRQESRRYLEKVTN 378 Pseudoalteromon...
AGH81497     300 AYLHILKTQYLkgikNDTGRHYAIISAYNGGSGNVFKTFsynreNALKVINkknsqqvYNDLHTKNPISEARHYLYKVHK 379 Psychromonas sp...
ABF13866     254 AYLAMLQNNYLsgiiDLTSRRYVMIVAYNSGVSSALKVFssnpnKALNMINnlkpdevYHILSTQHPSAESRNYLNKVNA 333 Baumannia cicad...
AFA40939     269 AYLSLLRDTYLsaiiNPISKKYATIASYHGGVTAMLEVFsrnqiKAFQIINhlhpddvYQLICKRHSSLESRRYLFKVYH 348 Wigglesworthia ...
NP_230104    288 AYFYILKNRYLkevrHPTSLEYSMISAYNGGTGGVLSTFssdrqRAMRDLNalqpnqvYWALTKKHPNAEARRYLEKVTK 367 Vibrio cholerae...
YP_002347402 134 AYINILQNQQLaginDPQTLRYATIVSYANGAGAMLRTFssdkrLAVNKINslspnefYQHIQKKHPAAQAPRYLWKVDT 213 Yersinia pestis...

Feature 1           
2Y8P_A       182 ALD 184 Escherichia coli K12
4CFO_A       334 AQK 336 Escherichia coli
4HJV_A       199 ALD 201 Escherichia coli K-12
WP_024911293 198 AYS 200 Chania multitudinisentens
ERG54038     379 AKQ 381 Pseudoalteromonas spongiae UST010723-006
AGH81497     380 NEK 382 Psychromonas sp. CNPT3
ABF13866     334 LQQ 336 Baumannia cicadellinicola str. Hc (Homalodisca coagulata)
AFA40939     349 LEK 351 Wigglesworthia glossinidia endosymbiont of Glossina morsitans morsitans (Yale colony)
NP_230104    368 FKK 370 Vibrio cholerae O1 biovar El Tor str. N16961
YP_002347402 214 AYR 216 Yersinia pestis CO92

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