3BP8,1Z6R,1Z05


Conserved Protein Domain Family
ASKHA_ATPase_ROK_Mlc
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cd24074: ASKHA_ATPase_ROK_Mlc 
ATPase-like domain of protein Mlc and similar proteins
Mlc, also called making large colonies protein, acts as a transcriptional repressor that regulates the expression of proteins that are part of the phosphotransferase system for sugar uptake. It regulates the expression of malT. Members of this subfamily belong to the kinase (ROK) family, a group of proteins that have sugar kinase and/or transcriptional repressor activities.
Links
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Statistics
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PSSM-Id: 466924
Aligned: 13 rows
Threshold Bit Score: 434.432
Created: 15-Dec-2022
Updated: 27-Apr-2023
Structure
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Program:
Drawing:
Aligned Rows:
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Zn binding sitehomodimerEIIBputative
Conserved site includes 4 residues -Click on image for an interactive view with Cn3D
Feature 1: Zn binding site [ion binding site], 4 residue positions
Conserved feature residue pattern:H C C CClick to see conserved feature residue pattern help
Evidence:
  • Structure:3BP8; Escherichia coli Mlc binds Zn2+ ion
Download Cn3D for Viewing 3D StructureScroll to Sequence Alignment Display
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                                                                                         
3BP8_A         84 AWHYLSLRISRgEIFLALRDLsSKLVVEESQELalkddsPLLDRIISHIDQFFIRHQkkLERLTSIAITLPGIIDtENGI 163  Escherichia coli
1Z6R_A         84 AWHYLSLRISRgEIFLALRDLsSKLVVEESQELalkddlPLLDRIISHIDQFFIRHQkkLERLTSIAITLPGIIDtENGI 163  Escherichia coli
1Z05_A        107 GWQFLSMRLGRgYLTIALHELgGEVLIDTKIDIheidqdDVLARLLFEIEEFFQTYAaqLDRVTSIAITLPGLVNsEQGI 186  Vibrio choler...
P50456         84 AWHYLSLRISRgEIFLALRDLsSKLVVEESQELalkddlPLLDRIISHIDQFFIRHQkkLERLTSIAITLPGIIDtENGI 163  Escherichia c...
KGQ13235      313 AWHYLSIRLSRgEISLGLRDLsSKLVVEDTVDLptddpqPLLERILFQVDQFFIRHQqkLERLTAIAITLPGIIDtVRGV 392  Beauveria bas...
GBP45581      383 AWHYLAIRLHRgAMTFTLRDLsSRELAEERLPLpdesaqPLLTSLIEQVDAFFIRHQkkLERLTAIAITLPGLINaASGV 462  Eumeta japonica
WP_032115049   82 GWQFLCVRIDKgSLILSLYELnNKLLHEDITELiandnhSFNEQLLTKIEYFFTCYQgcLERLVAISVITNAIINsIDGI 161  Arsenophonus ...
WP_047256132   84 GWQFLAIRINKqQLIFSLRELnTNLIVEDVFAFtaqgntDFSQQFLDSISLFFSRHQnyLERLTAITIITRANIDpSAGI 163  Moellerella w...
WP_025903144   84 TWHFLVLRITGrFLYITLRDLsGHEVAGSQQDLpadpatCIPDYLSEVVGDFFSRYNalTERLTAITLILPGVIDaASGT 163  Tatumella sp....
APC11964       30 GWQFLAIRIQDkKITISLKEInATTLAQTEYPFkpinndQFINKLSELISHFFASHQsiLERVTAISILSDGVLDpYTGV 109  Providencia r...
XP_023299839   82 GWQFLSIRIEHnSISLSLKQInTQTIIEQDYPFnvkgndEFSSTIATLISDFFSTYArqLERVTAISILLDGLIEpFSGV 161  Australian sh...
GAJ48061       78 RFQFLSMRLGRgYVDMALFDLaGRSLARHRHTFsea-erADLLASLVRAIEGFLPKK--ALRLACIALCLPGQVErHSGM 154  Aeromonas sal...
WP_108650046   80 HFRYLAMRLGRgYVAMASFDLkGRCLRKERYTLlsr-ekESLTRELFSHLETFTQKY--RDRLLAMAVSLPGRVDdEQGW 156  

Feature 1                                                                                         
3BP8_A        164 VHRMPFyedvKEMPLGEALEQHTGVPVYIQHDISAWTMAEALFGasr-gaRDVIQVVIDHNVGAGVITDGHLLHAGsSSL 242  Escherichia coli
1Z6R_A        164 VHRXPFyedvKEXPLGEALEQHTGVPVYIQHDISAWTXAEALFGasr-gaRDVIQVVIDHNVGAGVITDGHLLHAGsSSL 242  Escherichia coli
1Z05_A        187 VLQMPHyn-vKNLALGPEIYKATGLPVFVANDTRAWALAEKLFGhsq-dvDNSVLISIHHGLGAGIVLDGRVLQGRhGNI 264  Vibrio choler...
P50456        164 VHRMPFyedvKEMPLGEALEQHTGVPVYIQHDISAWTMAEALFGasr-gaRDVIQVVIDHNVGAGVITDGHLLHAGsSSL 242  Escherichia c...
KGQ13235      393 IHRMPFyd-vCDMPLGEALGNHTGVPVFIQHDISAWTMAEGLFGasq-gaRDVIQVVIDHNVGAGVITDGRLLHAGsSSL 470  Beauveria bas...
GBP45581      463 VHRLPGyq-vRDMPLGDALAARIGLPVFVQHDISAWTLAESLFGasr-gaQDVIQIVIDETVGAGVISGGQLLHKSgRAL 540  Eumeta japonica
WP_032115049  162 IVSSPYyn-iKNFPLKERLEARIGLPIYLQSCTTAWTMSEFFSGask-yrKNIIQIVIDDHINACIITKGSILALGnSHA 239  Arsenophonus ...
WP_047256132  164 INQLDDyn-iKNLPITVQIENKIGLPVYLQKDIYAWTLTESFMGaak-dcANILHIILDDQINAGVITNNHLIHADnSRT 241  Moellerella w...
WP_025903144  164 VHRIPYyh-aRDIPLAQSLHQRTGLTIYVQQDLKASLLAEHFFGaak-gsDDIIYLVAGRQIEAAVISSGRLLHKNsTTQ 241  Tatumella sp....
APC11964      110 IHHHAHfn-iNQLAIGEYLTEHTGLPIYLHPSVDALALKDYFSHlakrkaKNIIYLQLQDVVNITVLNHGITLDANtQRP 188  Providencia r...
XP_023299839  162 IYKLASyd-iENLSLGNFLTEKTGLPTYIQPYVNALALTDYFSLhtkrtaKNIIYLQIDEIVSAAIINNGVALDSStRRA 240  Australian sh...
GAJ48061      155 VKDFPFyd-lRNWPLGPTLQQAFAVPVLVSGDVRTWIQAEREWGaak-ncADAVLVFVHNDIGVGMVVNGQLIESEsALL 232  Aeromonas sal...
WP_108650046  157 VHHFPFyd-iHDWPLKQLLEQTFSIPCFVSSSIHPWIMAERAWGaaq-ksQNALLILIQEDIGAGVILDGQLVNSRqSRI 234  

Feature 1             #          # #    #                                                         
3BP8_A        243 VEIGHTQVdp-yGKRCYCGNHGCLETIASvDSILELAQLRLnqsmssm-lhgqpltVDSLCQAALRGDLLAKDIITGVGA 320  Escherichia coli
1Z6R_A        243 VEIGHTQVdp-yGKRCYCGNHGCLETIASvDSILELAQLRLnqsxssx-lhgqpltVDSLCQAALRGDLLAKDIITGVGA 320  Escherichia coli
1Z05_A        265 GELGHIQIdp-qGKRCHCGNYGCLETVASsQAIRDQVTARIqagepsclatveeisIEDICAAAADGDPLAVDVIQQLGR 343  Vibrio choler...
P50456        243 VEIGHTQVdp-yGKRCYCGNHGCLETIASvDSILELAQLRLnqsmssm-lhgqpltVDSLCQAALRGDLLAKDIITGVGA 320  Escherichia c...
KGQ13235      471 VEIGHTQVdp-yGKRCYCGNHGCLETIASvESVLELAQQRMsqsmgsm-lhgqplsVESLCDAALSGDLLAKDIIIGVGQ 548  Beauveria bas...
GBP45581      541 VEIGHTQIdp-yGQQCYCGNHGCLETVAStGSLLALAAQRLpaqpdsl-lnnqpltLQSLCAAAQSGDRLARDTIASVGH 618  Eumeta japonica
WP_032115049  240 IEIGHINInf-aGLDCYCGNQGCLETHIAiPQILKKAQSIAkqypdss-lnkekisINDFCQAINLEDPIAVNTLEKVGR 317  Arsenophonus ...
WP_047256132  242 IELAHMQInr-eGIKCSCGNIGCLKTVASiPNLLKRVNILLeqypqsi-lhqqeitIEHFCQAITAKDPLCLEILGDFSR 319  Moellerella w...
WP_025903144  242 AEVGHTVMdp-gGRRCDCGHYGCLNTLAGsSPLTERWRQSAaesgpp---llpgteIAALCHAALSGHLPSQSIIRYSGE 317  Tatumella sp....
APC11964      189 NLFAHTQYkktqNIPCYCGGVGCLETHTSlPAILQQANNLLcnysdsy-lqhniisIDSICSGVKLGDTLCIQLIDNIAQ 267  Providencia r...
XP_023299839  241 IHFGHVKIeg-hNENCYCGRTGCLESVISiPAILAKLNQSQeqlslsn-ltsrdisFNHFCHGVENQDPHCLYVLKYVAK 318  Australian sh...
GAJ48061      233 GDLSHLQLep-yGQRCYCGGFGCACTLVTnQALEAQYRDLRermqeyd--lpesvtIRELCELALAGNSLCQDILHQAAG 309  Aeromonas sal...
WP_108650046  235 GSLNHLPTad-gQLPCYCGHQGCARTEVTtSALERSYLELTgdr----------lsAREICELALAEEGKARELLITLGH 303  

Feature 1                                                                                         
3BP8_A        321 HVGRILAIMVNLFNPQKILIGSPLskaaDILFPVISDSIRQQALPAYsqHISVESTQFs-nQGTMAGAALVKDAMYNGSL 399  Escherichia coli
1Z6R_A        321 HVGRILAIXVNLFNPQKILIGSPLskaaDILFPVISDSIRQQALPAYsqHISVESTQFs-nQGTXAGAALVKDAXYNGSL 399  Escherichia coli
1Z05_A        344 YLGAAIAIVINLFNPEKILIGGVInqakSILYPSIEQCIREQSLPVYhqDLKLVESRFy-kQATMPGAALIKQALYDGLL 422  Vibrio choler...
P50456        321 HVGRILAIMVNLFNPQKILIGSPLskaaDILFPVISDSIRQQALPAYsqHISVESTQFs-nQGTMAGAALVKDAMYNGSL 399  Escherichia c...
KGQ13235      549 NVGRILAIMVNLFNPQKILIGSPLnraaAILHPAITDCIRQQALPAYs-SHTVVESTQfnnRGTMAGAALALSASGKSVV 627  Beauveria bas...
GBP45581      619 HVGRILAMMVNIFNPQHILIGSPLnaaaDVLFPAVSNTILQQSLPAYsaGIQLAPTEFs-ePGTLGGAALIKDALYNGHL 697  Eumeta japonica
WP_032115049  318 QIGNTLAVMVNIFNPQLILIGSPLnevkNQLFPVISKQIRQKSLPCYqnNVSLVATKFn-nEGTILATAIIKDALYNGSL 396  Arsenophonus ...
WP_047256132  320 DLGRAIAPLINIFGPEVIVIGSPLntvaEIFYPQLAAIIKLTSVPKYtsNLQFMSAKYa-nTGTYNSSALIKQSLYNGEL 398  Moellerella w...
WP_025903144  318 QIGRSLAMLVNLFNPEYILIDSALnnaaEIFYPALYSTIKKESVARRrgSLIIKPASFs-gADTRPGTALIKEALYSGEL 396  Tatumella sp....
APC11964      268 LLAKPLALMVNVLGTELILINSPInqisELFFDKLHHYIDQQSIPLYssKITIEKSTL---SVSDSESSLIQRALYDGSL 344  Providencia r...
XP_023299839  319 ILANQLSQLINIFGTELILINSPLnnisDQFNSLLRQYCISQSIPLYcnELQIENSII---TKKDSETALILQALYDGSL 395  Australian sh...
GAJ48061      310 RLSRVLSNLICLLNPGKLLLGEEItradRLLFPMLHQSLASQLPAEYlvRLQIESTHFy-eDPTKPTSVQVHKALRDGSL 388  Aeromonas sal...
WP_108650046  304 ELGALLATLVIFFNPQTLLFSGELlaaaSILFPLFRQEISARVPREYfeHLSIEATCFy-eDPTRPTAILVQEALFDGFL 382  

Feature 1                
3BP8_A        400 LIRLLQG 406  Escherichia coli
1Z6R_A        400 LIRLLQG 406  Escherichia coli
1Z05_A        423 LMKVVEG 429  Vibrio cholerae O1 biovar El Tor str. N16961
P50456        400 LIRLLQG 406  Escherichia coli K-12
KGQ13235      628 GYKPVAK 634  Beauveria bassiana D1-5
GBP45581      698 LFVTGTD 704  Eumeta japonica
WP_032115049  397 LAKLMAG 403  Arsenophonus endosymbiont of Nilaparvata lugens
WP_047256132  399 LLKLLQG 405  Moellerella wisconsensis
WP_025903144  397 LHQLLQG 403  Tatumella sp. UCD-D_suzukii
APC11964      345 LMQLLQG 351  Providencia rettgeri
XP_023299839  396 LLQLLQG 402  Australian sheep blowfly
GAJ48061      389 LLDLLRG 395  Aeromonas salmonicida subsp. masoucida NBRC 13784
WP_108650046  383 LSRVTQP 389

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