Conserved Protein Domain Family
Toxin_15

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pfam07906: Toxin_15 
ShET2 enterotoxin, N-terminal region
The members of this family are are sequences that are similar to the N-terminal half of the ShET2 enterotoxin produced by Shigella flexneri and Escherichia coli. This protein was found to confer toxigenicity in the Ussing chamber, and the N-terminal region was found to be important for the protein's enterotoxic effect. It is thought to be a hydrophobic protein that forms inclusion bodies within the bacterial cell, and may be secreted by the Mxi system. Most members of this family are annotated as putative enterotoxins, but one member is a regulator of acetyl CoA synthetase, and another two members (Swiss:P76205 and Swiss:P23325) are annotated as ankyrin-like regulatory proteins and contain Ank repeats (pfam00023).
Statistics
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PSSM-Id: 369588
Aligned: 5 rows
Threshold Bit Score: 326.847
Created: 22-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
LANL:CH61_3201   8 NLYNKE---------LYSNSPThpafdkskpyisELKSReEKNLNGEVNfkDNVDKLIMCRHLSSQYILDSLsDEdtgkV 78 
P23325         117 TLDKQE---------LNLKSDR------------KEKEFpRIKLNGQCYfpGRPQNRIVCRHIAAQYINDIY-QN----V 170 Escherichia c...
Q327D9           1 MINKDN---------VSVETIQsllhskqlpyfsDKRSF-LLNLNCQVT--DLSGRLIVCRHLASYWIAQF--NKssghV 66  Shigella dyse...
Q327I5          26 SVNRDNrtitssimrVSNSSELiqfknktapyfsEKRNV-KVNINGVAK--DIYGRQIVCRHLASYWEMNFM--EtngkV 100 Shigella dyse...
LANL:CH45_2876   9 PVYDKN---------NSDNTLKetelfkevpylsAR-------LGEQAY--EYSGGDISNYHLSIQYIMDVLaDQakgkV 70 
LANL:CH61_3201  79 DLDK----FSSKDIIANRIT-SNVEELYEQLQLQAKEIYFIPNNEFGICLSKIFKSMERKSENTQSILLESFNHAMAVRL 153
P23325         171 DYKPhqddYSSAEKFLTHFNkKCKNQTLALVSSRPEGRCVAACGDFGLVMKAYFDKMESNGISVMAAILLVDNHALTVRL 250 Escherichia c...
Q327D9          67 DYHH----FAFPDEIKNYVSvSEEEK----AINVPGIIYFVENGSWGDIIYHIFNEMIFHAEKNRALEISTSNHNMALGL 138 Shigella dyse...
Q327I5         101 NYQL----LSTPDAIAKNVClEKTED----FSKSPAYIYFVENKKWGTVITNFFYNMKKNGDFVRTLSACTLNHQMALGL 172 Shigella dyse...
LANL:CH45_2876  71 DLSH----FSSEETLSSHVSlEKNEHNYHCFNQHASTVYHINNNDFGRTLVDLFEQMNNSGENVRALKIDSSQHSMAARL 146
LANL:CH61_3201 154 RIKENENNNtkRYVISVYDPNMTNVTVRCEV--DDLVKVRDFQVKDFINHHLFGNFYKSYNp--TESSEISTLYICKKPA 229
P23325         251 RIKNTTEGCt-HYVVSVYDPNVTNDKIRIMS--ESKENIKHYSLMDFMNVDYSLLKWSNDH---VINQSVAIIPALPKEQ 324 Escherichia c...
Q327D9         139 KIKETKNGG--RFVIQLYDPNHTATHLRAEFnnFNLDKIKKLTVDNFLDEKHQ-------EcygLISDGMSIFVDRHTPT 209 Shigella dyse...
Q327I5         173 KIKRVQESE--KWVVQFFDPNRTVTHKRTVFtcDSHFELSQLSAKDFFDDFYW-------KiygLEQPGQVIFEDRHN-- 241 Shigella dyse...
LANL:CH45_2876 147 YIKDTEQGQ--RFVVNFYDPNITDKTVRCEV--DDALKLNDYSLRNFISNQTYLSSYVDAEissIIVCDQADIHDQHKVK 222
LANL:CH61_3201 230 NESVPECTGKKITfydw----ialPASSINLYTFLIEGFSQEIKNLKNQLEI--IYKKNpekLMEILTAKS 294
P23325         325 LLMLKGSVDEITP-----------PLSPATMNLLMAIGQNHQLTQLMIQLQK--MPELH---RTEMLTAYN 379 Escherichia coli K-12
Q327D9         210 SMSSiirw-------------pnnLLHPKVIYHAMRMGLTELIQKVTRVVQLsdLSDNT---LELLLAAKN 264 Shigella dysenteriae S...
Q327I5         242 -----------SPltntvkllpdeLINSRVIYHAITKNLTEVLFILMEKYKNgeISQSK---LVNLLATRS 298 Shigella dysenteriae S...
LANL:CH45_2876 223 ENRALTPLSQSSPl----------PLSVARLDLLLTDNFAAGIQTMAEEVKN--LSESErntFFNQLLQPR 281
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