2XF4


Conserved Protein Domain Family
YcbL-like_MBL-fold
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cd07737: YcbL-like_MBL-fold 
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Salmonella enterica serovar typhimurium YcbL and related proteins; MBL-fold metallo hydrolase domain
This subgroup includes Salmonella enterica serovar typhimurium YcbL which has type II hydroxyacylglutathione hydrolase (EC 3.1.2.6, also known as glyoxalase II) activity, and has a single metal ion binding site, and Thermus thermophilus TTHA1623 which does not have GLX2 activity and has two metal ion binding sites with a glyoxalase II-type metal coordination. Members of this subgroup belong to the MBL-fold metallo-hydrolase superfamily which is comprised mainly of hydrolytic enzymes which carry out a variety of biological functions.
Links
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Statistics
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PSSM-Id: 293823
Aligned: 35 rows
Threshold Bit Score: 276.741
Created: 24-Jun-2009
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
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Conserved site includes 8 residues -Click on image for an interactive view with Cn3D
Feature 1:putative active site [active site]
Evidence:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                                                             # # ##                  
2XF4_A      3 YRIIPVTAFSQNCSLIWCEqtrLAALVDPGG---DAEKIKQEVdasgvtLMQILLTHGHLDHVGAASELaqhygVPVIGP 79  Salmonella enterica
ABM02082    8 IIVIPVTPYQQNCSLIICEetkIAAIVDPGG---DPLRILNIVekqgvkVDKIILTHGHLDHVGGTQAVagklnVPVIGP 84  Psychromonas ingra...
NP_275039   5 YEIFPVTPFRQNCTLIWDDesgEAVLTDVGG---DVPFLLQALanrkltLTAIWLTHGHLDHAGGVVEMlkthkVPVLGP 81  Neisseria meningit...
AIY65467    4 VITQPVTPFAQNSNLLVCQttrQAVIIDPGG---DVEKLMQVIesanckLIAILLTHGHLDHVGGAEQLaqhcnIDIVGP 80  Pseudoalteromonas ...
CEG10319   12 ATIIPVTPFQQNCMLLWCEttkKAVVVDPGG---DVLDILNAIkqagvkVEHIWLTHGHVDHVGGADELrehlkVPITGP 88  cat scratch diseas...
GAN79464    5 IGIIPVTPFQQNCTLVWDDetkSGAVIDPGG---DVSLIKDQIdklglsISEIFLTHGHIDHAGGAGELseqldARIVGP 81  Acidocella aminoly...
KJY99104    3 ITTIPVTPFMQNCRILQCAqsaQAAIIDPGG---DSDKIIRALtqrgiePSVIWLTHGHLDHVGAADTLrkhyqIDIVGP 79  Pseudoalteromonas ...
KHM46406    3 IITIPVTAFAQNSRIIWCSetkHAVVIDPGG---DTDKIITVLnenklaLSAIWLTHGHLDHVGGADILrnqfnVQIIGP 79  Pseudoalteromonas ...
EFY06268    4 IATIPTTAFAQNTRIIADEnkhIAVVSDPGGnasDLYKILNTHel---tLKVIILTHGHLDHVGGAAELsrltgAKIIGP 80  Succinatimonas hip...
CCX91073    4 YQVVRVTPFAQNCRIFINQekkQAVVSDPGA---RADDIYTALhdsnieLKAIIITHMHLDHVGGVARLhelsnAKIYGS 80  Succinatimonas sp....

Feature 1                                                           ##                 #      
2XF4_A     80 eKEDEFWLqglpaqsr-mfgldecqPLTPDRWLNDGDRVSvg-nvTLQVLHCPGHTPGHVVFFDEqsQLLISGDVIFKgG 157 Salmonella enterica
ABM02082   85 eKEDLFWLeqleaqsr-rfglptteSFSPNRWLTEGEVLEvg-kiKLKVLRIPGHTPGHIALYDKqsKQVIVGDILFNgG 162 Psychromonas ingra...
NP_275039  82 hPDDEFLLqslpqtta-qygfpvspAFAPNRWLEEGETLTvg-ryAFQVLHIPGHTPGHIVFYCAeaELLIAGDVLFYeT 159 Neisseria meningit...
AIY65467   81 hLGDKFWLdalpkqse-mfnfpmaeVFSPAKWLEEGEQFTfg-elTLEVRFTPGHTPGHVIFVEHstKRIFVGDVLFKgS 158 Pseudoalteromonas ...
CEG10319   89 hIADKFLLdhvvdsar-rygltglrDVTPDTWLSEGDKVSvg-elTFELLHCPGHSPGSMVFFNPamKFAIMGDVLFNgS 166 cat scratch diseas...
GAN79464   82 gIEDKFLLddlaaqga--ryglkarDCHPDRWLQQGDIITmg-geAFQVRHCPGHTPGHMVFLSKplNFGIVGDVLFRgS 158 Acidocella aminoly...
KJY99104   80 -QRDEQFWfdalaqqaqmfgfapqvPFLPDTWLEHGQTISlg-eqQFEVRHCPGHTPGHVIFVCHshKLAIVGDVIFKgS 157 Pseudoalteromonas ...
KHM46406   80 -QKDEHFWfenlpmqaqmfgfkpiePFYPDIWLNHNDTVSvg-klSFLVKHCPGHTPGHIVFYQQenECVIVGDVIFKgS 157 Pseudoalteromonas ...
EFY06268   81 sNEDSFLIeslnsqae--lfglsssGDFTPSYVKDNDVLKlfddyEFKVITTPGHTPGGVCYFCEkaGFLLAGDSLFAgS 158 Succinatimonas hip...
CCX91073   81 sIEDSPLLlsldkqak--afgldnaPVFDTQYLKDGEIITpmhdfSLKVLSTPGHTPGGVSYYCEkeKYVLTGDTLFEgS 158 Succinatimonas sp....

Feature 1                                        #
2XF4_A    158 VGRSDFPRgdh-tqLIDAIKRKLLPLgDDVTFIPGH 192 Salmonella enterica
ABM02082  163 IGRFDFPRgnr-slLVSGIKEKLLTLpPETTVYPGH 197 Psychromonas ingrahamii 37
NP_275039 160 IGRTDFPRgnh-adLINNIRNKLFTLpETVQVVAGH 194 Neisseria meningitidis MC58
AIY65467  159 VGRTDFPGgna-aqLKQSIESKIYSLpDDYTVFPGH 193 Pseudoalteromonas sp. OCN003
CEG10319  167 IGRTDLPGgdh-etLLASIRDKVLPLgDEVGFICGH 201 cat scratch disease bacillus
GAN79464  159 VGRTDLGDygdheqLIASIQRELLVLpDEFSFLCGH 194 Acidocella aminolytica 101 = DSM 11237
KJY99104  158 IGRTDFPKgdg-ptLIASIKREVLSLdDDYRLLSGH 192 Pseudoalteromonas ruthenica
KHM46406  158 VGRTDFPKgns-eqLIESIKTHILTLpDNTKILAGH 192 Pseudoalteromonas flavipulchra NCIMB 2033 = ATCC BAA-314
EFY06268  159 IGRCDFPRsnm-ddLLTSLKEKILILpDDTKVLSGH 193 Succinatimonas hippei YIT 12066
CCX91073  159 VGRTDFYLgnt-ddLMLSIKEKLFTLpPETTVLSGH 193 Succinatimonas sp. CAG:777

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