4WGH,6CIA,5C7H,4XAP,4PMJ


Conserved Protein Domain Family
AKR_YeaE

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cd19138: AKR_YeaE 
Click on image for an interactive view with Cn3D
Escherichia coli YeaE and similar proteins
Escherichia coli YeaE is the prototype of this family. It acts as an aldo-keto reductase (AKR) that catalyzes the reversible reduction of ketones to the respective alcohols using NAD(P)H as a hydride donor.
Statistics
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PSSM-Id: 381364
Aligned: 29 rows
Threshold Bit Score: 386.219
Created: 12-Apr-2018
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
 
active sitecatalytic
Conserved site includes 27 residues -Click on image for an interactive view with Cn3D
Feature 1:active site [active site]
Evidence:
  • Structure:4WGH: Klebsiella pneumoniae aldo/keto reductase in complex with cofactor NADP; contacts at 4A.

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                      ###                           #    #                           
4WGH_A     26 KTVRFGe-QAAVPAIGLGTWYXGehaaqRQQEVAALRAGIDHGlTVIDTAEXYAdggAEEVVGQAIRg---lRDRVVLVS 101 Klebsiella pneumoniae
KXU34062    4 KTVTLPd-GSRVPALGMGSWQLAsgrhpRAQVEEALRVGLSLGlRLIDTAENYSggaSEQLVGSVIAd---qREQVFVVT 79  Opitutaceae bacter...
BAZ23315   15 KTICLPs-GELMPVLGMGTAGLGeaiaqHESEIAALRRGIDLGmTLIDTAEIYGeggAETLIGEAIAn---cRSSVFLVS 90  Scytonema sp. NIES...
KGH20277    1 MHSAISf-LQGHANLGMGSWHLGqgrrsRDEEKAALLTGLQLGlSVIDTAEMYGdglSEELIGDVLRdwppsRPRPFLVS 79  Comamonas testoste...
KMK68207    6 VTLRNSg-DIRMPKIGIGTWHMGeqmqtAETEISALRHACDLGfTHFDTAEMYAdggSEDILGRAMAgq--dRGRLFITS 82  Puniceibacterium s...
OOM76835   16 RKVTLSd-GTKVSALGQGTWYMGesfgkRNQEIESLKLGLKLGmNLIDTAEMYGdglSEELVSKVIEd---cRKDVFLVS 91  Clostridium puniceum
ACZ09222   14 RNVELRd-GSLVNAIGQGTWHMGekhseRAKEIKALRLGIDLGmTLIDTAEMYGsggAEEVTGEAVKg---iRDKIFIVS 89  Sebaldella termitidis
OZG55864    2 KTLSFA--GREMPVIGAGLWGIGeg-idAHAQRRALDAAFDAGlVLLDTAEMYGngaSERVAGAAARsaraqGKDVFVVS 78  Aeriscardovia aeri...
OGR87369    2 KTRDFGpsGMKFTAIGLGTWNMEp---sPAESVKAIRAGIEAGaNHIDTAELYGdgkVEEIAAEALRg---sRDKVRVVS 75  Elusimicrobia bact...
PSR31430    2 HAITFGt-QNAYAPLGQGTWRMGtdpslFAQEVEILRDGIRQNlRVIDTAAMYAdggAEKVVGEAVRp---qRDTVFIVT 77  Sulfobacillus bene...
Feature 1     #                                 #                             ##              
4WGH_A    102 KVYPWHag-kaAXHRACENSLRRLqtDYLDXYLLHWRGd-iPLQETVEAXEKLVAEGKIRRWGVSNLDTEDXQALWRtad 179 Klebsiella pneumoniae
KXU34062   80 KVQPSNarseqSIRRSCERSLRNLgtDYIDLYLLHWRAg-eHLPTVVDTFEALKAEGRIRHWGVSNFYVRGMEELYAipg 158 Opitutaceae bacter...
BAZ23315   91 KVAPRNat-qqGAIAACENSLRRLqtDYLDLYLLHWRGg-vPLSETLSAFETLKQSGKIRDYGVGNFDVKDMEEASAlpg 168 Scytonema sp. NIES...
KGH20277   80 KVLPMHas-rkGVVRAFEASAHKLgvDCIDLYLLHWRGn-mPLAETVAAFEDLKTQGKIRHWGVSNFDTDDMQELWQvpg 157 Comamonas testoste...
KMK68207   83 KVYPWNaa-rnDMITACERSLDRLqtDYVDLYLLHWPGs-vPFDETLEGARALLDQSKIRAFGVSNFDTRGIQQLIGegl 160 Puniceibacterium s...
OOM76835   92 KVYPHNsg-mkSISRACENSLKRLktDHLDLYLLHWRGg-vPLEETIEGMERLKKEGKILRWGVSNFDTDDMEALLDksk 169 Clostridium puniceum
ACZ09222   90 KVYPQNag-kkRAVLSCENSLKRLgtDYIDLYLLHWRGg-iPLHETVEVMEQLVKEGKIKRWGVSNFDTKDMEELWKipd 167 Sebaldella termitidis
OZG55864   79 KVLPSNar-pqLMRTALTRSLHNLglDYLDMYLLHWRSt-aDLALVAQQMHEFVQEGLIRHWGVSNFDVADMQELLAvpy 156 Aeriscardovia aeri...
OGR87369   76 KVMPVNas-yeGTLKACERSLKRLqtDHLDVYLLHWREedtRIGETFRAFEKLKEQGKILGWGVSNFGVKDLEEAERamg 154 Elusimicrobia bact...
PSR31430   78 KVWPTHas-ydGVLSSLKNSLERLgtDYVDLFLLHWPSahyPLKETMRAMAAVYDKGWAKAIGVSNFNVDLLRQAQQllg 156 Sulfobacillus bene...
Feature 1            #                            #######                          #          
4WGH_A    180 geHCATNQVLYHLASRGi-EYDLLPWCQQHsLPVXAYCPLAQAgrlrd--glfqHSDIINXANARGiTVAQLLLAWVIRh 256 Klebsiella pneumoniae
KXU34062  159 gkNCAANQVRYSLSDRSieALGLVDWAAQHgLPLMAYSPLGSGggl------lsNPVLGEVAARHGvSAAAVALAWTMRs 232 Opitutaceae bacter...
BAZ23315  169 geAIATNQIPYNLQHRNs-EWKLLSWCGQRgIPIMAHSPLLQGel-------lkHPKLQSIAQQRGvTVAQVAIAWLLHq 240 Scytonema sp. NIES...
KGH20277  158 grNCVVNQVLYNVFSRGi-EYDLLPWCQKNgVTVMAYCPLGHGel-------ieHSLLAEIGDRHGvSASVVALAWALRs 229 Comamonas testoste...
KMK68207  161 adLVTVNQVMHNIPNRGv-ELDLFPLMAEHgIAAVAYSPLEVGpt-------raIPGMQDLAREEGlSVAQLILAWHMSr 232 Puniceibacterium s...
OOM76835  170 geNCTINEVLYHLGSRGi-EFDLLPWQRKRnIPTIAYCPLAQGgrlkr--dllkNEELNEIAKEHNvKPLQIALSWTIRe 246 Clostridium puniceum
ACZ09222  168 gsNCAVNQVLYHLGSRGi-EYDLLPWCREKkLPVMAYCPVAQGgilrk--ellaNKTVRRIAGERGiSEVQVLLAWTVRe 244 Sebaldella termitidis
OZG55864  157 geECACDQNLYNLANRGm-DHDLMPWLRDHhIPLMAYSPLGDGgpagt-rvmvnNTEVKKVAARHHaSAQQVMLAWCVRd 234 Aeriscardovia aeri...
OGR87369  155 kgKMVCNQVLYHLKERAi-EFEVIPWCKAHgVAVMGYSPFSQGglpaspagrpeSPALKKISKELGaTPAQVTLAYLTRd 233 Elusimicrobia bact...
PSR31430  157 siPLTANQVEYSLMARAa-EITVIPYCQDHnMTVMAYSPIKHLnllph--hsaeRTTLKDIAAQYGvTEQTIALGWVIRh 233 Sulfobacillus bene...
Feature 1          ######  #  ##                 
4WGH_A    257 pGVLAIPKAASIEHVVQNAAAlDIVLSGEELAQLD 291 Klebsiella pneumoniae
KXU34062  233 gSVVSIPESGRVAHTRENARAaGLTLDADDLAKLD 267 Opitutaceae bacterium CAG34
BAZ23315  241 -EVIVFPKASSIAHVEENRAAlDIKLTKEELSALD 274 Scytonema sp. NIES-4073
KGH20277  230 gKVLAIPESGSEDHIRDNARAlQLKLGPEELALID 264 Comamonas testosteroni
KMK68207  233 gLAAPIPKSSRIEHLNDLAAAaQTQLSSTTLERID 267 Puniceibacterium sp. IMCC21224
OOM76835  247 nDVISIPKASSVDHVIENAKAaSIILSSEDIERLD 281 Clostridium puniceum
ACZ09222  245 kDIISIPKAVQENHIYENAETaGIFLSGEEIRDLE 279 Sebaldella termitidis
OZG55864  235 gNTLAIPQSANPEHLVQDFHSgSLELDEHDFAALD 269 Aeriscardovia aeriphila
OGR87369  234 pAVFGIPKSSHADRTLENLRSaDLALSKKDIEAIE 268 Elusimicrobia bacterium RIFCSPLOWO2_01_FULL_60_11
PSR31430  234 sGVIAIPKTSHKDHLLSNLRAiNIHLTKEDIKRLD 268 Sulfobacillus benefaciens

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