O53703 171 LGAWLEA----TMARWPRRRsmr-feSSPHGKRIDLRATMNASRSTGWE---------SVLLARIRp-R-RRPRRVLLLC 234 Mycobacterium tub... Q9Y9R7 129 LYRSLALlrrrLGLEEGRRR------VPRRRGRIDFKRSMRRSLRTFGE---------TVRLVRAS--RkRSKTDILVLL 191 Aeropyrum pernix Q9KX26 168 AAHAVAA----RLAKAMRVRltrreqSRRTGRRIDLRRTIHKNIAHGGM---------PLELVWRQ--RkHKPLRLVVLL 232 Oligotropha carbo... Q9XAH6 941 LATRLRP----TLTGLTTPRp-----TRRPGGPLDLPRTLRANLAHIRRredgrvevvPERPVFRTrtArRNDWRLILVV 1011 Streptomyces coel... Q9RJY6 1094 LATRLRP----ALHGTVVPRp-----SRRPGGGLDLPRTLRANLASAHRgpdgtvrvlPEHPVFRTraRrSADWRLVLVT 1164 Streptomyces coel... Q9KY59 149 LVTRTRA----TLSGALDRSar---tARPRPHDIDWNRTIGANLKHYLPeyrtvvperLVGYGRAS--RsVRK-DIVLCV 218 Streptomyces coel... P33352 151 LAKEVRQ----AFSGVRDRRrr---sFIPLARNFDFKSTLRANLQHWHPqhgklyiesPRFNSRIK--RqSEQWQLVLLV 221 Escherichia coli ... O27843 123 LGIKIAN-----------RRsr--rlRQSRRMKPDIRRSIRKNIKHGGT---------VLELIRSEp-ReRKS-QHIFLS 178 Methanothermobact... P71923 252 MRRVVAPlartLATRLAARR------RRARAGSIDLRKTLRKSMSTGGV---------PIDLVLHKp-RpARP-ELVVLC 314 Mycobacterium tub... Q8XZD6 161 LQHMIRR----RRVHLAQERtrr-lkAASRGRHPDLRATARQAVRAGGE---------WTAWKYRQp-VdRTP-PLVLLL 224 Ralstonia solanac... Q92PJ9 163 ARKALSA----ILLPLDRVRtrr-yrRSHRPVRIDPRSTMRDAMRFGGD---------FILPRFREp-RlVHP-PLVVLA 226 Sinorhizobium mel... BAC50927 179 alRAVER----MRLPQAELLtrr-hrPDSRGLRLDLRRTLRASLRTGGD---------IIDIHRLG--RiEKPAPIVALL 242
O53703 235 DVSRSMQPYAAIYLRLMRAAVLRRAggHPEVFAFSTSLTRLTSVL-SHRSAEMALHRA--NARVTD-RYGGTFIGRSVAA 310 Mycobacterium tub... Q9Y9R7 192 DVSNSMKDYWPWILGILNALRRLPPg-SYEAFLFSTRLVRATPMV-EAAGGAEDLRRL--LSRVEGlWGSGTRISQSVEE 267 Aeropyrum pernix Q9KX26 233 DASGSMSMYSAVFLRFMHGILDNFR--EAEAFVFHTRLIHISPAL-RERDATRSVERM--SLLAQG-VGGGTRIGESLAT 306 Oligotropha carbo... Q9XAH6 1012 DVSASMET-SVVWSALTAAILGGAPtlSTHFLTFSTQVADLTGLV-A--DPLSLLLEV--K------VGGGTHIAAGLAH 1079 Streptomyces coel... Q9RJY6 1165 DVSGSMEA-STVWAALTASVLAGVPtlSTHFLAFSTEVIDLTDHV-D--DPLSLLLEV--S------VGGGTHIAAGLRH 1232 Streptomyces coel... Q9KY59 219 DQSGSMAA-SLVYASVFGAVLASMRsiDTRLVVFDTAVADLTDQL-D--DPVDVLFGT--R------LGGGTDINRALAY 286 Streptomyces coel... P33352 222 DQSGSMVD-SVIHSAVMAACLWQLPgiRTHLVAFDTSVVDLTADV-A--DPVELLMKV--Q------LGGGTNIASAVEY 289 Escherichia coli ... O27843 179 DVSGSCDWISNWFFCIIYAAQRTFY--RSRFFDFDSRIVETTHLL-DEDDLYDAFRNLreSRIRNLmIHGTSNMYTAFRD 255 Methanothermobact... P71923 315 DVSGSVAGFSHFTLLLVHALRQQFS--RVRVFAFIDSTDEVTHMFgPESDLAIAIQRItrEAGVYA-RDGHSDYGNAFVS 391 Mycobacterium tub... Q8XZD6 225 DISGSMSRYSRAVLYYCHALAQSRE--RIQAFLFGTRLTSVSRQL-RERDPDVAVQAI--AQQVPD-WSGGTRIGAALAE 298 Ralstonia solanac... Q92PJ9 227 DISGSMSKYTRIFLHFLHALTEQRH--RVHTFLFGTRLTNVTRQM-RNRDPDEALDDC--IAAVKD-WSGGTRIGETLHD 300 Sinorhizobium mel... BAC50927 243 DISGSMNEYTRLFLHFLHAIGDARK--RVSVFLFGTRLTNVTRAL-RQRDPDEALASC--SASVED-WAGGTRISASLHN 316
O53703 311 LLAPPHgNAL-RGAVVIIASD-----GWDSDPPDVLVHALTRVRRRAELLVWLNPR--AAHPEFQPRa-gSMAAALPYCD 381 Mycobacterium tub... Q9Y9R7 268 LLESHT-PALhRGAAVLVFSD-----GWDLGDLGRLASALAELRRRAGFLVWVTPEspRRDAGGEPS---TMRIIRRHAD 338 Aeropyrum pernix Q9KX26 307 FNRWHAkRAIhSRTCVMIVSD-----GYDTGPAEQLEREMSALRRRCRRIAWLNPM--IGWRGYAPEa-aGMKAALPHVD 378 Oligotropha carbo... Q9XAH6 1080 ARSLVTvPD---RTLVVVVSD-----FEEGAAVEGLLAEVGALVSAGVRLLGCAAPadGGTPRYSVPvtrRLVAAGMPVA 1151 Streptomyces coel... Q9RJY6 1233 ARELVTvPS---RTLVVVVSD-----FEEGYPLGGLLAEVRALVGAGCHVLGCASLddAGRPRYSTGvagRLVAAGMPVA 1304 Streptomyces coel... Q9KY59 287 CQSRITrPA---DTVVVLISD-----LYEGGIREEMLKRVAAMRVAGVRFVTLLALsdEGTPAYDREhaaALAALGAPAF 358 Streptomyces coel... P33352 290 GRQLIEqPA---KSVIILVSD-----FYEGGSSSLLTHQVKKCVQSGIKVLGLAALdsTATPCYDRDtaqALVNVGAQIA 361 Escherichia coli ... O27843 256 FIEGVTfTG---KSYIVILSDcrdwaGPRRDGIPESVELVAEMSERARKVLILNPEpeKKWDVVDSCv-sLYRDAGASVM 331 Methanothermobact... P71923 392 FMQGFP-NVLsPRSSLLVLGD-----G-RTNYRNPATDVLADMVTASRHAHWLNPEpkHLWGSGDSAvprYQEVITMH-- 462 Mycobacterium tub... Q8XZD6 299 FNRRWArRTLsGRATVLLVTD-----GLDHEHIDLLDAEMARLARFAHRIVWLNPL--LRFAGFEPRa-rGVRAILPHVD 370 Ralstonia solanac... Q92PJ9 301 FNRRWSrRVLgQGAVVLLMTD-----GLERDDTAELETEIDRLHRSCRRLVWLNPL--LRFDGFEARa-rGVRAMLPHVD 372 Sinorhizobium mel... BAC50927 317 FNKLWArRVLsQGAIVLLISD-----GLEREADSRLAFEMDRLHRSCRRLIWLNPL--LRFGGFEAKa-qGIKMMLPHVD 388
O53703 382 LFLPAHSLAGL 392 Mycobacterium tuberculosis Q9Y9R7 339 LTIDLETLLNT 349 Aeropyrum pernix Q9KX26 379 LFAPAHNLESL 389 Oligotropha carboxidovorans Q9XAH6 1152 ALGPLSLARWV 1162 Streptomyces coelicolor Q9RJY6 1305 ALSPLELARWV 1315 Streptomyces coelicolor Q9KY59 359 ACTPDLFPEVM 369 Streptomyces coelicolor P33352 362 AMTPGELASWL 372 Escherichia coli K-12 O27843 332 EVRTLRQLAEV 342 Methanothermobacter thermautotrophicus str. Delta H P71923 463 ECRSAKQLATV 473 Mycobacterium tuberculosis Q8XZD6 371 TMVPAHHFDSL 381 Ralstonia solanacearum Q92PJ9 373 EFRPIHNLESV 383 Sinorhizobium meliloti BAC50927 389 EFRPVHNLSSi 399
Jiyao W et al.(2023). "The conserved domain database in 2023.",